DK2139483T3 - Kombinationsterapier, der omfatter en quinoxalin-inhibitor af PI3K-alfa, til anvendelse til behandling af cancer - Google Patents

Kombinationsterapier, der omfatter en quinoxalin-inhibitor af PI3K-alfa, til anvendelse til behandling af cancer

Info

Publication number
DK2139483T3
DK2139483T3 DK08742674.8T DK08742674T DK2139483T3 DK 2139483 T3 DK2139483 T3 DK 2139483T3 DK 08742674 T DK08742674 T DK 08742674T DK 2139483 T3 DK2139483 T3 DK 2139483T3
Authority
DK
Denmark
Prior art keywords
pi3k
quinoxaline
cancer
inhibitor
alpha
Prior art date
Application number
DK08742674.8T
Other languages
English (en)
Inventor
Peter Lamb
David Matthews
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc filed Critical Exelixis Inc
Application granted granted Critical
Publication of DK2139483T3 publication Critical patent/DK2139483T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK08742674.8T 2007-04-11 2008-04-08 Kombinationsterapier, der omfatter en quinoxalin-inhibitor af PI3K-alfa, til anvendelse til behandling af cancer DK2139483T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92316407P 2007-04-11 2007-04-11
PCT/US2008/004570 WO2008127594A2 (en) 2007-04-11 2008-04-08 Combination therapies comprising quinoxaline inhibitors of pi3k-alpha for use in the treatment of cancer

Publications (1)

Publication Number Publication Date
DK2139483T3 true DK2139483T3 (da) 2014-01-13

Family

ID=39864581

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08742674.8T DK2139483T3 (da) 2007-04-11 2008-04-08 Kombinationsterapier, der omfatter en quinoxalin-inhibitor af PI3K-alfa, til anvendelse til behandling af cancer

Country Status (34)

Country Link
US (1) US8481001B2 (da)
EP (1) EP2139483B9 (da)
JP (2) JP5726515B2 (da)
KR (1) KR101586774B1 (da)
CN (2) CN103202842A (da)
AU (1) AU2008239668B2 (da)
BR (1) BRPI0810208A2 (da)
CA (1) CA2684056A1 (da)
CO (1) CO6140024A2 (da)
CR (1) CR11099A (da)
CY (1) CY1114608T1 (da)
DK (1) DK2139483T3 (da)
EA (1) EA019064B1 (da)
EC (1) ECSP099723A (da)
ES (1) ES2438998T3 (da)
GT (1) GT200900263A (da)
HK (1) HK1140141A1 (da)
HR (1) HRP20131081T1 (da)
IL (1) IL201211A (da)
MA (1) MA31335B1 (da)
ME (1) ME00937B (da)
MX (1) MX2009010929A (da)
MY (1) MY150797A (da)
NI (1) NI200900184A (da)
NZ (1) NZ580009A (da)
PL (1) PL2139483T3 (da)
PT (1) PT2139483E (da)
RS (1) RS53020B (da)
SI (1) SI2139483T1 (da)
SV (1) SV2009003390A (da)
TN (1) TN2009000399A1 (da)
UA (1) UA98141C2 (da)
WO (1) WO2008127594A2 (da)
ZA (1) ZA200906765B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140105621A (ko) * 2005-10-07 2014-09-01 엑셀리시스, 인코포레이티드 ＰＩ３Ｋα의 피리도피리미디논 억제제
EA024305B1 (ru) * 2005-10-07 2016-09-30 Экселиксис, Инк. Ингибиторы фосфатидилинозит-3-киназы и их применение
AU2007284562B2 (en) 2006-08-16 2013-05-02 Exelixis, Inc. Using PI3K and MEK modulators in treatments of cancer
WO2008124161A1 (en) * 2007-04-10 2008-10-16 Exelixis, Inc. Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha
JP5687903B2 (ja) * 2008-11-10 2015-03-25 協和発酵キリン株式会社 キヌレニン産生抑制剤
DE102009049679A1 (de) 2009-10-19 2011-04-21 Merck Patent Gmbh Pyrazolopyrimidinderivate
WO2011100319A1 (en) 2010-02-09 2011-08-18 Exelixis, Inc. Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k and mtor in combination with autophagy inhibitors
UY33498A (es) 2010-07-09 2013-01-03 Sanofi Aventis Combinaciones de inhibidores de quinasas para el tratamiento de cancer
AU2011302196B2 (en) 2010-09-14 2016-04-28 Exelixis, Inc. Inhibitors of PI3K-delta and methods of their use and manufacture
US20130211076A1 (en) 2010-10-20 2013-08-15 Merck Serono S.A. Geneva Method for preparing substituted N-(3-amino-quinoxalin-2-yl)-sulfonamides and their intermediates N-(3-chloro-quinoxalin-2-yl)-sulfonamides
DE102010048800A1 (de) 2010-10-20 2012-05-10 Merck Patent Gmbh Chinoxalinderivate
DE102010049595A1 (de) 2010-10-26 2012-04-26 Merck Patent Gmbh Chinazolinderivate
WO2012065057A2 (en) 2010-11-12 2012-05-18 Exelixis, Inc. Phosphatidylinositol 3-kinase inhibitors and methods of their use
TW201325592A (zh) * 2011-09-14 2013-07-01 Exelixis Inc 用於治療癌症之磷脂醯肌醇－３激酶抑制劑
CN104024257A (zh) * 2011-10-04 2014-09-03 吉利德卡利斯托加有限责任公司 Pi3k的新的喹喔啉抑制剂
WO2013056067A1 (en) 2011-10-13 2013-04-18 Exelixis, Inc. Compounds for use in the treatment of basal cell carcinoma
EP2770999A1 (en) * 2011-10-28 2014-09-03 Novartis AG Method of treating gastrointestinal stromal tumors
BR112014010492A2 (pt) * 2011-11-01 2017-04-25 Exelixis Inc n-(3-{[(3-{[2-cloro-5-(metóxi)fenil]amino}quinoxalin-2-il)amino]sulfonil}fenil)-2-metilalaninamida como inibidor de fosfatidilinositol 3-cinase para o tratamento de malignidades linfoproliferativas
WO2013067306A1 (en) * 2011-11-02 2013-05-10 Exelixis, Inc. Phosphatidylinositol 3-kinase inhibitors for the treatment of childhood cancers
US20150010545A1 (en) * 2011-12-27 2015-01-08 Kadmon Corporation, Llc Methods for treatment of breast cancer nonresponsive to trastuzumab
CN103467482B (zh) 2012-04-10 2017-05-10 上海璎黎药业有限公司 稠合嘧啶类化合物，其制备方法，中间体，组合物和应用
JP6193374B2 (ja) 2012-08-13 2017-09-06 武田薬品工業株式会社 Ｇｐｒ６モジュレーターとしてのキノキサリン誘導体
JP6441910B2 (ja) 2013-09-30 2018-12-19 シャンハイ インリ ファーマシューティカル カンパニー リミティド 縮合ピリミジン化合物、中間体、その調製方法、組成物及び使用
EP3059238B1 (en) 2013-10-16 2020-05-27 Shanghai Yingli Pharmaceutical Co. Ltd. Fused heterocyclic compound, preparation method therefor, pharmaceutical composition, and uses thereof
EP3105230B1 (en) 2014-02-14 2021-04-07 Takeda Pharmaceutical Company Limited Pyridopyrazines modulators of gpr6
US9950194B2 (en) 2014-09-09 2018-04-24 Mevion Medical Systems, Inc. Patient positioning system
WO2019119206A1 (en) * 2017-12-18 2019-06-27 Merck Sharp & Dohme Corp. Purine inhibitors of human phosphatidylinositol 3-kinase delta

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006515885A (ja) * 2003-01-17 2006-06-08 スレッシュオールド ファーマシューティカルズ， インコーポレイテッド 癌の処置のための併用療法
CN101296909B (zh) * 2005-08-26 2011-10-12 默克雪兰诺有限公司 吡嗪衍生物及其作为pi3k抑制剂的应用
EA024305B1 (ru) 2005-10-07 2016-09-30 Экселиксис, Инк. Ингибиторы фосфатидилинозит-3-киназы и их применение
KR20140105621A (ko) 2005-10-07 2014-09-01 엑셀리시스, 인코포레이티드 ＰＩ３Ｋα의 피리도피리미디논 억제제
AU2007284562B2 (en) 2006-08-16 2013-05-02 Exelixis, Inc. Using PI3K and MEK modulators in treatments of cancer
KR20090110950A (ko) * 2007-02-22 2009-10-23 메르크 세로노 에스. 에이. (피라진 유도체) 퀴녹살린 화합물 및 이의 용도
WO2008124161A1 (en) 2007-04-10 2008-10-16 Exelixis, Inc. Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha
JP4623164B2 (ja) * 2008-08-21 2011-02-02 セイコーエプソン株式会社 プロジェクタ

Also Published As

Publication number Publication date
US20110123434A1 (en) 2011-05-26
MY150797A (en) 2014-02-28
KR101586774B1 (ko) 2016-01-19
SV2009003390A (es) 2010-05-21
WO2008127594A2 (en) 2008-10-23
JP2014074031A (ja) 2014-04-24
RS53020B (en) 2014-04-30
HK1140141A1 (en) 2010-10-08
SI2139483T1 (sl) 2013-11-29
EP2139483B9 (en) 2014-05-21
EP2139483A2 (en) 2010-01-06
UA98141C2 (ru) 2012-04-25
PT2139483E (pt) 2013-12-27
CO6140024A2 (es) 2010-03-19
MA31335B1 (fr) 2010-04-01
AU2008239668A1 (en) 2008-10-23
IL201211A0 (en) 2010-05-31
CR11099A (es) 2010-01-19
ES2438998T3 (es) 2014-01-21
CY1114608T1 (el) 2016-10-05
CN101959516B (zh) 2013-05-08
JP2010523669A (ja) 2010-07-15
ECSP099723A (es) 2010-03-31
WO2008127594A3 (en) 2009-04-30
KR20100019436A (ko) 2010-02-18
ME00937B (me) 2012-06-20
EA200970935A1 (ru) 2010-04-30
GT200900263A (es) 2014-01-15
CN101959516A (zh) 2011-01-26
JP5726515B2 (ja) 2015-06-03
TN2009000399A1 (fr) 2010-12-31
ZA200906765B (en) 2010-05-26
AU2008239668B2 (en) 2013-11-07
BRPI0810208A2 (pt) 2014-10-21
EA019064B1 (ru) 2013-12-30
MX2009010929A (es) 2010-01-20
EP2139483B1 (en) 2013-09-18
HRP20131081T1 (hr) 2013-12-20
CA2684056A1 (en) 2008-10-23
NI200900184A (es) 2011-09-08
IL201211A (en) 2015-09-24
CN103202842A (zh) 2013-07-17
PL2139483T3 (pl) 2014-02-28
US8481001B2 (en) 2013-07-09
NZ580009A (en) 2012-06-29

Similar Documents

Publication Publication Date Title
DK2139483T3 (da) Kombinationsterapier, der omfatter en quinoxalin-inhibitor af PI3K-alfa, til anvendelse til behandling af cancer
DK3517534T3 (da) Forbindelser, der er anvendelige til behandling af cancer
DK3567035T3 (da) N-substituerede 2,5-dioxo-azolin-forbindelser til anvendelse ved behandling af cancer
DK2205257T3 (da) Doseringsforskrifter for LAG-3Ig (IMP321) til anvendelse ved behandling af cancer
DK2195015T3 (da) Sammensætning til behandling af prostatacancer
CL2007002783S1 (es) Inhalador multidosis.
DK2101805T3 (da) Integrinligander til anvendelse i behandling af cancer
DK2154971T3 (da) Synergistisk farmaceutisk kombination til behandling af cancer
DK2187878T3 (da) Anvendelse af en betablokker til fremstilling af et medikament til behandling af hæmangiomer
BRPI0814889A2 (pt) tratamento com ligantes alfa7-seletivos.
DK2504005T3 (da) Anvendelse af 1,3-diphenylprop-2-en-1-on-derivater til behandling af lever-sygdomme
BRPI0813235A2 (pt) Combinação anti-helmíntica.
DK3424932T3 (da) Bronophthalider til terapeutisk anvendelse
DK2473510T3 (da) Jak-2-hæmmere og anvendelse heraf til behandling af myeloproliferativesygdomme og cancer
EP2195010A4 (en) TREATMENT WITH INHIBITORS OF KALLIKREINE
EP2195011A4 (en) TREATMENT WITH CALLICINE INHIBITORS
DK2144905T3 (da) Terapeutiske midler
BRPI0814736A2 (pt) inalador.
DK2235002T3 (da) 4-pyridinonforbindelser og anvendelse heraf til behandling af cancer
DK2164572T3 (da) Carbamoyl-cyclohexaner til behandling af akut mani
BRPI0818170A2 (pt) 5-cianotienopiridinas para o tratamento de tumores.
DK2033675T3 (da) Inhalationsapparat
BRPI0818598A2 (pt) agentes terapêuticos - 802
BRPI0814248A2 (pt) Inalador
DK2129422T3 (da) Doseringsinhalator