JP5615352B2 - Ｃ型肝炎ウイルス阻害剤 - Google Patents
Ｃ型肝炎ウイルス阻害剤 Download PDFInfo
- Publication number
- JP5615352B2 JP5615352B2 JP2012513170A JP2012513170A JP5615352B2 JP 5615352 B2 JP5615352 B2 JP 5615352B2 JP 2012513170 A JP2012513170 A JP 2012513170A JP 2012513170 A JP2012513170 A JP 2012513170A JP 5615352 B2 JP5615352 B2 JP 5615352B2
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- JP
- Japan
- Prior art keywords
- alkyl
- mmol
- hydrogen
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *C(N(CCC1)[C@@]1C(Nc1n[o]c(cc2)c1cc2-c(cc1)ccc1-c1cnc([C@](CCC2)N2C(*)=O)[n]1)=O)=O Chemical compound *C(N(CCC1)[C@@]1C(Nc1n[o]c(cc2)c1cc2-c(cc1)ccc1-c1cnc([C@](CCC2)N2C(*)=O)[n]1)=O)=O 0.000 description 3
- BGMYWBQEKIMHGU-UHFFFAOYSA-N Nc(c1c2)n[o]c1ccc2Br Chemical compound Nc(c1c2)n[o]c1ccc2Br BGMYWBQEKIMHGU-UHFFFAOYSA-N 0.000 description 2
- SXOBMSVMFHBZSI-LBPRGKRZSA-N CC(C)(C)OC(N(CCC1)[C@@H]1C(Nc(c1c2)n[o]c1ccc2Br)=O)=O Chemical compound CC(C)(C)OC(N(CCC1)[C@@H]1C(Nc(c1c2)n[o]c1ccc2Br)=O)=O SXOBMSVMFHBZSI-LBPRGKRZSA-N 0.000 description 1
- TUIJUTOJKKYOJT-UPVQGACJSA-N CC(C)(C)OC(N(CCC1)[C@@H]1C(Nc1n[o]c2cc(-c(cc3)ccc3-c3cnc([C@H]4NCCC4)[nH]3)ccc12)=O)=O Chemical compound CC(C)(C)OC(N(CCC1)[C@@H]1C(Nc1n[o]c2cc(-c(cc3)ccc3-c3cnc([C@H]4NCCC4)[nH]3)ccc12)=O)=O TUIJUTOJKKYOJT-UPVQGACJSA-N 0.000 description 1
- ZQEBQGAAWMOMAI-ZETCQYMHSA-N CC(C)(C)OC(N(CCC1)[C@@H]1C(O)=O)=O Chemical compound CC(C)(C)OC(N(CCC1)[C@@H]1C(O)=O)=O ZQEBQGAAWMOMAI-ZETCQYMHSA-N 0.000 description 1
- VJHWUEWJEIGNSC-QMMMGPOBSA-N CC(C)[C@@H](C(O)=O)Nc1cncnc1 Chemical compound CC(C)[C@@H](C(O)=O)Nc1cncnc1 VJHWUEWJEIGNSC-QMMMGPOBSA-N 0.000 description 1
- STGLLFIORWBERO-HNNXBMFYSA-N CC1(C)OB(c(cc2)ccc2-c2cnc([C@H]3NCCC3)[nH]2)OC1(C)C Chemical compound CC1(C)OB(c(cc2)ccc2-c2cnc([C@H]3NCCC3)[nH]2)OC1(C)C STGLLFIORWBERO-HNNXBMFYSA-N 0.000 description 1
- VLICAFHSCJAZIV-UHFFFAOYSA-N CCN(CC)C(COC)C(O)=O Chemical compound CCN(CC)C(COC)C(O)=O VLICAFHSCJAZIV-UHFFFAOYSA-N 0.000 description 1
- ZUCSUKWYYWJTHM-LLVKDONJSA-N CCN(CC)[C@@H](C(O)=O)c1ccccc1 Chemical compound CCN(CC)[C@@H](C(O)=O)c1ccccc1 ZUCSUKWYYWJTHM-LLVKDONJSA-N 0.000 description 1
- UJWHTPUQSUHEGZ-UHFFFAOYSA-N CCc1c(C(OC)=O)nc[s]1 Chemical compound CCc1c(C(OC)=O)nc[s]1 UJWHTPUQSUHEGZ-UHFFFAOYSA-N 0.000 description 1
- SWBDIYBLPKMZTK-JTQLQIEISA-N COC(N[C@@H](CC(OCc1ccccc1)=O)C(O)=O)=O Chemical compound COC(N[C@@H](CC(OCc1ccccc1)=O)C(O)=O)=O SWBDIYBLPKMZTK-JTQLQIEISA-N 0.000 description 1
- JPCXGAHSWZKCCO-RXMQYKEDSA-N COC(N[C@H](C1COC1)C(O)=O)=O Chemical compound COC(N[C@H](C1COC1)C(O)=O)=O JPCXGAHSWZKCCO-RXMQYKEDSA-N 0.000 description 1
- IMUBLSNDJPIVQO-UHFFFAOYSA-N N#Cc1nc(C(O)=O)c(cccc2)c2c1 Chemical compound N#Cc1nc(C(O)=O)c(cccc2)c2c1 IMUBLSNDJPIVQO-UHFFFAOYSA-N 0.000 description 1
- JXCVMJKEIAJDTR-PMACEKPBSA-N O=C([C@H]1NCCC1)Nc1n[o]c(cc2)c1cc2-c(cc1)ccc1-c1cnc([C@H]2NCCC2)[nH]1 Chemical compound O=C([C@H]1NCCC1)Nc1n[o]c(cc2)c1cc2-c(cc1)ccc1-c1cnc([C@H]2NCCC2)[nH]1 JXCVMJKEIAJDTR-PMACEKPBSA-N 0.000 description 1
- ZLAKPURGNBLUCC-VUWPPUDQSA-N OC(C(c1ccccc1)N(CC1)C[C@H]1F)=O Chemical compound OC(C(c1ccccc1)N(CC1)C[C@H]1F)=O ZLAKPURGNBLUCC-VUWPPUDQSA-N 0.000 description 1
- ZPZQHSNTACFFLT-UHFFFAOYSA-N OC(C(c1ccccc1)N1C2CCC1CC2)=O Chemical compound OC(C(c1ccccc1)N1C2CCC1CC2)=O ZPZQHSNTACFFLT-UHFFFAOYSA-N 0.000 description 1
- USHNXHNIVWSXTR-UHFFFAOYSA-N OC(c1c(cccc2)c2cc(F)n1)=O Chemical compound OC(c1c(cccc2)c2cc(F)n1)=O USHNXHNIVWSXTR-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18216209P | 2009-05-29 | 2009-05-29 | |
| US61/182,162 | 2009-05-29 | ||
| PCT/US2010/036033 WO2010138488A1 (en) | 2009-05-29 | 2010-05-25 | Hepatitis c virus inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012528166A JP2012528166A (ja) | 2012-11-12 |
| JP2012528166A5 JP2012528166A5 (enExample) | 2013-06-06 |
| JP5615352B2 true JP5615352B2 (ja) | 2014-10-29 |
Family
ID=42990555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012513170A Expired - Fee Related JP5615352B2 (ja) | 2009-05-29 | 2010-05-25 | Ｃ型肝炎ウイルス阻害剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8211928B2 (enExample) |
| EP (1) | EP2435429B1 (enExample) |
| JP (1) | JP5615352B2 (enExample) |
| CN (1) | CN102459250B (enExample) |
| WO (1) | WO2010138488A1 (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG172353A1 (en) | 2008-12-23 | 2011-07-28 | Abbott Lab | Anti-viral compounds |
| RU2505540C2 (ru) | 2008-12-23 | 2014-01-27 | Эббви Инк. | Антивирусные соединения |
| US8314135B2 (en) | 2009-02-09 | 2012-11-20 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole antivirals |
| US8188132B2 (en) | 2009-02-17 | 2012-05-29 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| US8394968B2 (en) | 2009-02-17 | 2013-03-12 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8242156B2 (en) | 2009-02-17 | 2012-08-14 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| US9765087B2 (en) | 2009-02-27 | 2017-09-19 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| US8673954B2 (en) | 2009-02-27 | 2014-03-18 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| US8101643B2 (en) | 2009-02-27 | 2012-01-24 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| US8796466B2 (en) | 2009-03-30 | 2014-08-05 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| TW201038559A (en) | 2009-04-09 | 2010-11-01 | Bristol Myers Squibb Co | Hepatitis C virus inhibitors |
| US8143414B2 (en) | 2009-04-13 | 2012-03-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9278922B2 (en) | 2009-04-15 | 2016-03-08 | Abbvie Inc. | Anti-viral compounds |
| KR101503752B1 (ko) | 2009-05-13 | 2015-03-18 | 길리애드 파마셋 엘엘씨 | 항바이러스 화합물 |
| US8138215B2 (en) | 2009-05-29 | 2012-03-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
| US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
| US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
| US8691938B2 (en) | 2009-06-11 | 2014-04-08 | Abbvie Inc. | Anti-viral compounds |
| US8221737B2 (en) | 2009-06-16 | 2012-07-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8609648B2 (en) | 2009-07-02 | 2013-12-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| JP2012533569A (ja) | 2009-07-16 | 2012-12-27 | ヴァーテックス ファーマシューティカルズ、 インコーポレイテッド | フラビウイルス感染症を治療又は予防するためのベンゾイミダゾール類似体 |
| CA2771327A1 (en) | 2009-09-04 | 2011-03-10 | Glaxosmithkline Llc | Chemical compounds |
| US8927709B2 (en) | 2009-09-11 | 2015-01-06 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8815928B2 (en) | 2009-09-11 | 2014-08-26 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US9156818B2 (en) | 2009-09-11 | 2015-10-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8759332B2 (en) | 2009-09-11 | 2014-06-24 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8822700B2 (en) | 2009-09-11 | 2014-09-02 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8703938B2 (en) | 2009-09-11 | 2014-04-22 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US20110274648A1 (en) | 2009-11-11 | 2011-11-10 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US20110269956A1 (en) | 2009-11-11 | 2011-11-03 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US20110281910A1 (en) | 2009-11-12 | 2011-11-17 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| WO2011081918A1 (en) | 2009-12-14 | 2011-07-07 | Enanta Pharmaceuticals, Inc | Hepatitis c virus inhibitors |
| US8377980B2 (en) | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8362020B2 (en) | 2009-12-30 | 2013-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8933110B2 (en) | 2010-01-25 | 2015-01-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| EP2528436A4 (en) | 2010-01-25 | 2013-07-10 | Enanta Pharm Inc | INHIBITORS OF HEPATITIS C VIRUS |
| US8178531B2 (en) | 2010-02-23 | 2012-05-15 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
| US8623814B2 (en) | 2010-02-23 | 2014-01-07 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
| JP2013521279A (ja) | 2010-03-04 | 2013-06-10 | エナンタ ファーマシューティカルズ インコーポレイテッド | Ｈｃｖ複製の阻害剤としての医薬併用剤 |
| MX2012010918A (es) | 2010-03-24 | 2013-01-18 | Vertex Pharma | Analogos para el tratamiento o prevencion de infecciones por flavivirus. |
| WO2011127350A1 (en) | 2010-04-09 | 2011-10-13 | Enanta Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
| US8778938B2 (en) | 2010-06-04 | 2014-07-15 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
| US8697704B2 (en) | 2010-08-12 | 2014-04-15 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8552047B2 (en) | 2011-02-07 | 2013-10-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9546160B2 (en) | 2011-05-12 | 2017-01-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| WO2012158861A2 (en) | 2011-05-18 | 2012-11-22 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of 5-azaspiro[2.4]heptane-6-carboxylic acid and its derivatives |
| SG10201602044WA (en) | 2011-09-16 | 2016-04-28 | Gilead Pharmassett Llc | Methods For Treating HCV |
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| CN104684910B (zh) * | 2012-07-12 | 2016-10-12 | 诺华股份有限公司 | 补体途经调节剂及其用途 |
| AU2014202687A1 (en) | 2013-01-31 | 2014-08-14 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
| US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
| US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
| US9775831B2 (en) | 2013-07-17 | 2017-10-03 | Bristol-Myers Squibb Company | Combinations comprising biphenyl derivatives for use in the treatment of HCV |
| SI3038601T1 (sl) | 2013-08-27 | 2020-07-31 | Gilead Pharmasset Llc | Formulacija kombinacije dveh protivirusnih spojin |
| EP3089757A1 (en) | 2014-01-03 | 2016-11-09 | AbbVie Inc. | Solid antiviral dosage forms |
| PT3578547T (pt) * | 2015-02-16 | 2021-06-22 | The Provost Fellows Found Scholars And Other Members Of Board Of College Of Holy And Undivided Trini | Sulfonilureias e compostos relacionados e uso dos mesmos |
| US10617675B2 (en) | 2015-08-06 | 2020-04-14 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| JP2021505526A (ja) | 2017-10-31 | 2021-02-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 少なくとも１つのスプライソソームモジュレーターと、ｂｃｌ２阻害剤、ｂｃｌ２／ｂｃｌｘｌ阻害剤及びｂｃｌｘｌ阻害剤から選択される少なくとも１つの阻害剤とを含む組合せ、並びに使用の方法 |
| CA3219397A1 (en) | 2021-05-21 | 2022-11-24 | Gilead Sciences, Inc. | Tetracyclic compounds for the treatment of zika virus infection |
| KR20240012476A (ko) | 2021-05-21 | 2024-01-29 | 길리애드 사이언시즈, 인코포레이티드 | 지카 바이러스 저해제로서의 펜타사이클릭 유도체 |
| US20250206724A1 (en) * | 2022-03-30 | 2025-06-26 | Nerviano Medical Sciences S.R.L. | Substituted 3-amino indazole derivatives as kinase inhibitors |
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| JP5314053B2 (ja) | 2008-02-12 | 2013-10-16 | ブリストル−マイヤーズ スクイブ カンパニー | Ｃ型肝炎ウイルス阻害剤 |
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- 2010-05-25 JP JP2012513170A patent/JP5615352B2/ja not_active Expired - Fee Related
- 2010-05-25 WO PCT/US2010/036033 patent/WO2010138488A1/en not_active Ceased
- 2010-05-25 CN CN201080034457.4A patent/CN102459250B/zh not_active Expired - Fee Related
- 2010-05-25 EP EP10720511.4A patent/EP2435429B1/en not_active Not-in-force
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|---|---|
| CN102459250B (zh) | 2015-05-06 |
| CN102459250A (zh) | 2012-05-16 |
| EP2435429B1 (en) | 2014-07-02 |
| US20110130433A1 (en) | 2011-06-02 |
| US8211928B2 (en) | 2012-07-03 |
| EP2435429A1 (en) | 2012-04-04 |
| JP2012528166A (ja) | 2012-11-12 |
| WO2010138488A1 (en) | 2010-12-02 |
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