JP5602625B2 - 結合物質のディスプレイ - Google Patents

結合物質のディスプレイ Download PDF

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Publication number
JP5602625B2
JP5602625B2 JP2010513575A JP2010513575A JP5602625B2 JP 5602625 B2 JP5602625 B2 JP 5602625B2 JP 2010513575 A JP2010513575 A JP 2010513575A JP 2010513575 A JP2010513575 A JP 2010513575A JP 5602625 B2 JP5602625 B2 JP 5602625B2
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binding
antibody
library
cells
modular
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Japanese (ja)
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JP2010531144A5 (enExample
JP2010531144A (ja
Inventor
ヒムラー ゴットフリード
リューカー フローリアン
ウォズニアク−クノップ ゴルダナ
ムッデ ヘールト
レードル ゲルダ
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F Star Biotechnologische Forschungs und Entwicklungsges mbH
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F Star Biotechnologische Forschungs und Entwicklungsges mbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2010513575A 2007-06-26 2008-06-26 結合物質のディスプレイ Active JP5602625B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US94628707P 2007-06-26 2007-06-26
US60/946,287 2007-06-26
US4982608P 2008-05-02 2008-05-02
US61/049,826 2008-05-02
PCT/AT2008/000232 WO2009000006A1 (en) 2007-06-26 2008-06-26 Display of binding agents

Publications (3)

Publication Number Publication Date
JP2010531144A JP2010531144A (ja) 2010-09-24
JP2010531144A5 JP2010531144A5 (enExample) 2011-05-19
JP5602625B2 true JP5602625B2 (ja) 2014-10-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010513575A Active JP5602625B2 (ja) 2007-06-26 2008-06-26 結合物質のディスプレイ

Country Status (9)

Country Link
US (3) US8921279B2 (enExample)
EP (2) EP3241842B1 (enExample)
JP (1) JP5602625B2 (enExample)
CN (1) CN101802006B (enExample)
DK (1) DK2158220T3 (enExample)
ES (2) ES2975748T3 (enExample)
HU (1) HUE066143T2 (enExample)
PL (1) PL3241842T3 (enExample)
WO (1) WO2009000006A1 (enExample)

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