JP5602134B2 - 擬似脂質複合体及びこれを含む皮膚外用剤組成物 - Google Patents
擬似脂質複合体及びこれを含む皮膚外用剤組成物 Download PDFInfo
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- JP5602134B2 JP5602134B2 JP2011517327A JP2011517327A JP5602134B2 JP 5602134 B2 JP5602134 B2 JP 5602134B2 JP 2011517327 A JP2011517327 A JP 2011517327A JP 2011517327 A JP2011517327 A JP 2011517327A JP 5602134 B2 JP5602134 B2 JP 5602134B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
nは1又は2であり、
R及びR’はそれぞれC9-C21の飽和又は不飽和脂肪族鎖である。
m及びnはそれぞれ独立して1乃至3の整数であり、
k及びlはそれぞれ独立して1又は2であり、
jは0又は1であり、
R及びR’はそれぞれ独立して少なくとも一つのヒドロキシ基を有する、直鎖又は分枝鎖の飽和又は不飽和C1-C31炭化水素基であり、
A1、A2及びA3はそれぞれ独立して水素又は下記構造の置換基のうちのいずれか一つであり、ただし、A1、A2及びA3が同時に水素ではない。
R及びR’はそれぞれ独立して任意に少なくとも一つのヒドロキシ基を有する、直鎖又は分枝鎖の飽和又は不飽和C10-C32炭化水素基であり、
R3及びR4はそれぞれ独立して水素、C1-C4アルキル基又はC1-C4ヒドロキシアルキル基であり、
R5は-A又は-CH2CH2OAであり、ここでAは下記構造の置換基のうちのいずれか一つである。
m及びnはそれぞれ独立して1乃至4の整数であり、
R及びR’はそれぞれ独立して任意に少なくとも一つのヒドロキシ基を有する、直鎖又は分枝鎖の飽和又は不飽和C1-C31炭化水素基であり、
A1及びA2はそれぞれ独立して水素又は下記構造の置換基のうちのいずれか一つである。
m及びnはそれぞれ独立して1乃至3の整数であり、
k及びlはそれぞれ独立して1又は2であり、
jは0又は1であり、
A1、A2及びA3はそれぞれ独立して水素又は下記構造の置換基のうちのいずれか一つである。
Rは下記構造を有する置換基である。
下記表1の組成で実施例1及び比較例1の皮膚外用剤組成物を水中油エマルジョンの剤形に製造したのであり、表2の組成で実施例2及び比較例2の皮膚外用剤組成物をジェル剤形に製造した。実施例1及び2において、擬似セラミド、コレステロール及びステアリン酸は複合体の総重量を基準としてそれぞれ40重量%、20重量%及び40重量%(重量比:1:0.5:1)の量で使用された。
(1)油相成分を70乃至75℃で加熱しながら均一に混合した。
(2)水相成分1を70乃至75℃で加熱しながら均一に溶解及び混合した。
(3)前記(2)の混合物に前記(1)の混合物を70乃至75℃の温度を維持した状態で撹拌して投入してエマルジョンを製造し、水相成分2を連続して投入した。得られた混合物を28乃至30℃まで冷却して水中油エマルジョンを得た。
(1)水相成分1を30℃で均一に混合した。
(2)アルコール成分を30℃で均一に混合した。
(3)前記(1)の混合物に水相成分2を撹拌して徐々に投入した後、連続して混合物(2)を投入してジェル剤形を得た。
実施例1、2及び比較例1、2の組成物における皮膚障壁機能の回復能力を下記のように評価した。
前記実施例1、2及び比較例1、2で製造した水中油エマルジョン及び可溶化ジェル剤形の保湿効果を次のように試験した。
50〜60代の成人男女40名を4つの組に分け、実施例1、2及び比較例1、2の化粧料組成物を4週間、毎日2回ずつ顔面に塗布した。塗布開始前と塗布後1週間、2週間、4週間経過した時点、それと塗布を中止してから2週間が経過した時点(総6週間経過)で24℃、相対湿度40%の下で皮膚の水分量を測定するコルネオメーターを利用して皮膚の電気伝導度を測定した。表3の結果は組成物の塗布後の水分量増加を示す。
前記(1)の試験が終了して間もなく、本発明の組成物の効能を主観的な方式で評価した。その結果を下記表4に示した。
Claims (4)
- 請求項1の複合体を含む皮膚外用剤組成物。
- 前記複合体が組成物の総重量を基準として0.01乃至40重量%の量で使用される請求項2の皮膚外用剤組成物。
- 前記組成物が化粧料組成物又は薬学組成物である請求項2の皮膚外用剤組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020080067676A KR101018818B1 (ko) | 2008-07-11 | 2008-07-11 | 유사지질 복합체 및 이를 함유하는 피부 외용제 조성물 |
KR10-2008-0067676 | 2008-07-11 | ||
PCT/KR2008/005144 WO2010005144A1 (en) | 2008-07-11 | 2008-09-02 | Pseudolipid complex mixture and a skin external application composition containing same |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011527674A JP2011527674A (ja) | 2011-11-04 |
JP5602134B2 true JP5602134B2 (ja) | 2014-10-08 |
Family
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Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011517327A Active JP5602134B2 (ja) | 2008-07-11 | 2008-09-02 | 擬似脂質複合体及びこれを含む皮膚外用剤組成物 |
Country Status (5)
Country | Link |
---|---|
US (1) | US8546361B2 (ja) |
EP (2) | EP2769709B1 (ja) |
JP (1) | JP5602134B2 (ja) |
KR (1) | KR101018818B1 (ja) |
WO (1) | WO2010005144A1 (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101936685B1 (ko) * | 2011-11-16 | 2019-01-11 | (주)아모레퍼시픽 | 글리코실 세라마이드 유사 화합물, 이의 제조방법 및 이를 함유하는 화장료 조성물 |
JP6469517B2 (ja) * | 2015-05-12 | 2019-02-13 | 大東化成工業株式会社 | 表面処理粉体及びその粉体を配合した化粧料 |
KR20170003189A (ko) * | 2015-06-30 | 2017-01-09 | (주)아모레퍼시픽 | 지방산 및 중화제를 포함하는 다층 세라마이드 라멜라 구조체 |
KR102406009B1 (ko) | 2015-11-30 | 2022-06-08 | (주)아모레퍼시픽 | 지질 복합층으로 코팅된 복합 분체 및 이를 포함하는 화장료 조성물 |
KR102485259B1 (ko) * | 2018-03-27 | 2023-01-06 | (주)아모레퍼시픽 | 모발 상태 개선용 액상 지질 복합 조성물 |
JP6629421B1 (ja) * | 2018-12-28 | 2020-01-15 | ちふれホールディングス株式会社 | 液晶形成用組成物、液晶含有乳化剤及びクリーム状又はフィルム状を呈する液晶含有化粧料 |
KR102261829B1 (ko) * | 2019-09-26 | 2021-06-07 | 대봉엘에스 주식회사 | 유사 세라마이드의 신규한 합성방법 및 그에 관한 중간체 화합물 |
Family Cites Families (17)
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BR9306564A (pt) | 1992-06-19 | 1999-01-12 | Univ California | Processo para o tratamento da epiderme de um mamífero terrestre sofrendo de uma condição constitída por uma função de barreira epidérmica perturbada |
FR2730410B1 (fr) * | 1995-02-15 | 1997-03-21 | Oreal | Composition cosmetique comprenant une association de ceramides et son utilisation |
JPH0967224A (ja) * | 1995-09-04 | 1997-03-11 | Kao Corp | 化粧料 |
US6060612A (en) * | 1996-12-26 | 2000-05-09 | Pacific Corporation | Ceramide-like compounds and a method for preparation thereof, and a cosmetic composition containing the same |
JP3532738B2 (ja) * | 1997-08-05 | 2004-05-31 | 花王株式会社 | 撥水処理粉体及びそれを含有する粉体化粧料 |
JPH11149634A (ja) * | 1997-11-18 | 1999-06-02 | Kao Corp | 磁気記録媒体の製造方法及び塗料 |
JP2001270816A (ja) * | 2000-03-23 | 2001-10-02 | Ichimaru Pharcos Co Ltd | 化粧料組成物 |
KR100352986B1 (ko) * | 2000-04-28 | 2002-09-18 | 주식회사 태평양 | 세라미드 유사 화합물 및 이의 제조방법, 및 이를함유하는 화장료 조성물 |
KR100458701B1 (ko) | 2000-10-06 | 2004-12-03 | 주식회사 웰스킨 | 스핑고리피드 또는 그 대사산물을 함유하는 미백 화장료조성물 |
CN1298700C (zh) * | 2002-02-26 | 2007-02-07 | 高丽雅娜化妆品股份有限公司 | 新型假神经酰胺和包含它的化妆品组合物 |
US20040219177A1 (en) * | 2003-04-29 | 2004-11-04 | Jacobs Randy J. | Depleted skin barrier replenishing skin creams composition and method of application |
KR101153576B1 (ko) * | 2003-06-10 | 2012-06-11 | 가오 가부시키가이샤 | 수중유형 유화 화장료 |
JP4220838B2 (ja) | 2003-06-10 | 2009-02-04 | 花王株式会社 | 皮膚外用剤 |
WO2006053912A1 (en) * | 2004-11-22 | 2006-05-26 | Symrise Gmbh & Co. Kg | Formulations comprising ceramides and/or pseudoceramides and (alpha-)bisabolol for combating skin damage |
JP4778256B2 (ja) | 2005-04-06 | 2011-09-21 | 花王株式会社 | 水中油型エマルション及びその製造方法 |
KR100693292B1 (ko) | 2005-10-06 | 2007-03-13 | 주식회사 바이오랜드 | 신규한 유사 세라마이드 및 이를 함유하는 조성물 |
KR100839016B1 (ko) | 2006-12-27 | 2008-06-17 | (주)네오팜 | 세라마이드 유도체 및 그 제조방법과 이를 포함하는 아토피 피부염 치료제 |
-
2008
- 2008-07-11 KR KR1020080067676A patent/KR101018818B1/ko active IP Right Grant
- 2008-09-02 US US13/003,519 patent/US8546361B2/en active Active
- 2008-09-02 WO PCT/KR2008/005144 patent/WO2010005144A1/en active Application Filing
- 2008-09-02 JP JP2011517327A patent/JP5602134B2/ja active Active
- 2008-09-02 EP EP14169290.5A patent/EP2769709B1/en active Active
- 2008-09-02 EP EP08811637A patent/EP2323616A4/en not_active Withdrawn
Also Published As
Publication number | Publication date |
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EP2769709A1 (en) | 2014-08-27 |
EP2323616A1 (en) | 2011-05-25 |
WO2010005144A1 (en) | 2010-01-14 |
EP2769709B1 (en) | 2018-03-28 |
EP2323616A4 (en) | 2012-08-15 |
KR101018818B1 (ko) | 2011-03-04 |
JP2011527674A (ja) | 2011-11-04 |
KR20100007169A (ko) | 2010-01-22 |
US8546361B2 (en) | 2013-10-01 |
US20110118222A1 (en) | 2011-05-19 |
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