JP5567557B2 - テトラヒドロイソキノリンの製造方法 - Google Patents

テトラヒドロイソキノリンの製造方法 Download PDF

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JP5567557B2
JP5567557B2 JP2011512646A JP2011512646A JP5567557B2 JP 5567557 B2 JP5567557 B2 JP 5567557B2 JP 2011512646 A JP2011512646 A JP 2011512646A JP 2011512646 A JP2011512646 A JP 2011512646A JP 5567557 B2 JP5567557 B2 JP 5567557B2
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compound
solution
added
mmol
mixture
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JP2011524346A (ja
Inventor
ポール・ロッベン
ルリン・チャオ
ベイ・ワン
チェン・バン−チ
シュアン・リュー
フ・ミン
ユー−リン・アレン・ヤン
マシュー・イシャーウッド
ラシドゥル・アミン
クイ・ウェンゲ
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Bristol Myers Squibb Co
Curia Global Inc
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Bristol Myers Squibb Co
Albany Molecular Research Inc
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
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    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/20—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated the carbon skeleton being saturated and containing rings
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    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
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    • C07C223/00—Compounds containing amino and —CHO groups bound to the same carbon skeleton
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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JP2011512646A 2008-06-04 2009-06-04 テトラヒドロイソキノリンの製造方法 Expired - Fee Related JP5567557B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5871708P 2008-06-04 2008-06-04
US61/058,717 2008-06-04
PCT/US2009/046259 WO2009149259A2 (en) 2008-06-04 2009-06-04 Processes for preparing tetrahydroisoquinolines

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JP2014100580A Division JP2014169312A (ja) 2008-06-04 2014-05-14 テトラヒドロイソキノリンの製造方法

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JP2011524346A JP2011524346A (ja) 2011-09-01
JP5567557B2 true JP5567557B2 (ja) 2014-08-06

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JP2011512645A Pending JP2011522827A (ja) 2008-06-04 2009-06-04 ６−［（４ｓ）−２−メチル−４−（２−ナフチル）−１，２，３，４−テトラヒドロイソキノリン−７−イル］ピリダジン−３−アミンの結晶形
JP2011512646A Expired - Fee Related JP5567557B2 (ja) 2008-06-04 2009-06-04 テトラヒドロイソキノリンの製造方法
JP2014100580A Pending JP2014169312A (ja) 2008-06-04 2014-05-14 テトラヒドロイソキノリンの製造方法

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JP2011512645A Pending JP2011522827A (ja) 2008-06-04 2009-06-04 ６−［（４ｓ）−２−メチル−４−（２−ナフチル）−１，２，３，４−テトラヒドロイソキノリン−７−イル］ピリダジン−３−アミンの結晶形

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US (4) US8445494B2 (OSRAM)
EP (2) EP2280956A2 (OSRAM)
JP (3) JP2011522827A (OSRAM)
KR (1) KR20110011653A (OSRAM)
CN (2) CN102112464A (OSRAM)
AR (1) AR071997A1 (OSRAM)
ES (1) ES2652462T3 (OSRAM)
TW (1) TW201002682A (OSRAM)
WO (2) WO2009149258A2 (OSRAM)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
JP2014169312A (ja) * 2008-06-04 2014-09-18 Bristol Myers Squibb Co テトラヒドロイソキノリンの製造方法

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EP1963323B1 (en) * 2005-12-06 2010-07-14 Neurosearch A/S Novel diazabicyclic aryl derivatives and their medical use
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
ES2446971T3 (es) 2009-05-12 2014-03-11 Albany Molecular Research, Inc. Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso
JP5739415B2 (ja) * 2009-05-12 2015-06-24 ブリストル−マイヤーズ スクウィブ カンパニー （Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用
CA2760837C (en) * 2009-05-12 2018-04-03 Albany Molecular Research, Inc. 7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
WO2012024397A2 (en) 2010-08-17 2012-02-23 Albany Molecular Research, Inc. 2,5-methano-and 2,5-ethano-tetrahydrobenzazepine derivatives and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
NO2686520T3 (OSRAM) 2011-06-06 2018-03-17
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
US20160022675A1 (en) * 2013-03-14 2016-01-28 Bristol-Myers Squibb Company Processes for preparing tetrahydroisoquinolines
CN103601699A (zh) * 2013-11-04 2014-02-26 南京大学 一类1,3,4-噻二唑-2-酰胺衍生物及其制备方法
TWI846166B (zh) 2013-11-15 2024-06-21 美商阿克比治療有限公司 {[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基}乙酸之固體型式，其組合物及用途
AU2019265629B2 (en) 2018-05-09 2024-09-12 Akebia Therapeutics, Inc. Process for preparing 2-((5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl)amino)acetic acid
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid

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