JP5563455B2 - Ｔｌｒ９の新規な合成アゴニスト - Google Patents

Ｔｌｒ９の新規な合成アゴニスト Download PDF

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JP5563455B2
JP5563455B2 JP2010520185A JP2010520185A JP5563455B2 JP 5563455 B2 JP5563455 B2 JP 5563455B2 JP 2010520185 A JP2010520185 A JP 2010520185A JP 2010520185 A JP2010520185 A JP 2010520185A JP 5563455 B2 JP5563455 B2 JP 5563455B2
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disorder
disease
tlr9
immunomodulatory
oligonucleotide
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JP2010535242A5 (enExample
JP2010535242A (ja
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カンディマラ，エカンバー，アール．
プッタ，マリカージュナ レッディー
ワン，ダキン
ユ，ドン
ラクシュミ，バガット
アグラワル，サディール
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Aceragen Inc
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Idera Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12—Antivirals
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    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
JP2010520185A 2007-08-01 2008-07-31 Ｔｌｒ９の新規な合成アゴニスト Active JP5563455B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US95325107P 2007-08-01 2007-08-01
US60/953,251 2007-08-01
US98360107P 2007-10-30 2007-10-30
US60/983,601 2007-10-30
US98715107P 2007-11-12 2007-11-12
US60/987,151 2007-11-12
US1529207P 2007-12-20 2007-12-20
US61/015,292 2007-12-20
PCT/US2008/071738 WO2009018431A2 (en) 2007-08-01 2008-07-31 Novel synthetic agonists of tlr9

Related Child Applications (1)

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JP2014120860A Division JP5816720B2 (ja) 2007-08-01 2014-06-11 Ｔｌｒ９の新規な合成アゴニスト

Publications (3)

Publication Number Publication Date
JP2010535242A JP2010535242A (ja) 2010-11-18
JP2010535242A5 JP2010535242A5 (enExample) 2013-05-02
JP5563455B2 true JP5563455B2 (ja) 2014-07-30

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JP2010520185A Active JP5563455B2 (ja) 2007-08-01 2008-07-31 Ｔｌｒ９の新規な合成アゴニスト
JP2014120860A Active JP5816720B2 (ja) 2007-08-01 2014-06-11 Ｔｌｒ９の新規な合成アゴニスト

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US (2) US7960362B2 (enExample)
EP (3) EP2173912A4 (enExample)
JP (2) JP5563455B2 (enExample)
KR (1) KR20100053598A (enExample)
CN (3) CN105177014B (enExample)
AU (1) AU2008282172B2 (enExample)
BR (1) BRPI0813981A2 (enExample)
CA (1) CA2693266C (enExample)
ES (2) ES2585239T3 (enExample)
IN (1) IN2010KN00195A (enExample)
RU (1) RU2468819C2 (enExample)
WO (1) WO2009018431A2 (enExample)

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WO2016044839A2 (en) 2014-09-19 2016-03-24 The Board Of Regents Of The University Of Texas System Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds
MX391478B (es) * 2014-10-10 2025-03-21 Idera Pharmaceuticals Inc Composiciones de agonista de tlr9 e inhibidores de punto de control para usarse en la respuesta inmune contra el cáncer.
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WO2017052403A1 (ru) * 2015-09-25 2017-03-30 Анатолий Викторович ЗАЗУЛЯ Изготовление таблетки с механизмом повышения терапевтической эффективности лекарственного средства нанодозой микрорнк
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CN109206481B (zh) 2017-07-05 2023-08-18 尚华医药科技(江西)有限公司 一种肽类化合物、其应用及含其的组合物
EP3690030A4 (en) 2017-09-28 2021-06-23 Industry-Academic Cooperation Foundation, Yonsei University PROCESS FOR THE PRODUCTION OF SUPPRESSIVE CELLS OF MYELOID ORIGIN, SUPPRESSIVE CELLS OF MYELOID ORIGIN THUS PRODUCED AND THEIR USES
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EP2821488A2 (en) 2015-01-07
CN105177014B (zh) 2018-04-06
WO2009018431A3 (en) 2009-12-30
JP2014205691A (ja) 2014-10-30
CN102864151A (zh) 2013-01-09
HK1216430A1 (zh) 2016-11-11
EP2650369B1 (en) 2015-04-29
RU2468819C2 (ru) 2012-12-10
CA2693266A1 (en) 2009-02-05
KR20100053598A (ko) 2010-05-20
US8361986B2 (en) 2013-01-29
AU2008282172A1 (en) 2009-02-05
EP2821488B1 (en) 2016-07-27
ES2539353T3 (es) 2015-06-30
EP2173912A2 (en) 2010-04-14
CN105177014A (zh) 2015-12-23
ES2585239T3 (es) 2016-10-04
WO2009018431A2 (en) 2009-02-05
EP2173912A4 (en) 2013-03-20
CA2693266C (en) 2015-06-30
CN101878311A (zh) 2010-11-03
JP5816720B2 (ja) 2015-11-18
RU2010107207A (ru) 2011-09-10
EP2821488A3 (en) 2015-04-29
US7960362B2 (en) 2011-06-14
CN102864151B (zh) 2015-07-08
BRPI0813981A2 (pt) 2017-05-09
EP2650369A1 (en) 2013-10-16
AU2008282172B2 (en) 2014-05-22
US20110311518A1 (en) 2011-12-22
JP2010535242A (ja) 2010-11-18
US20090053206A1 (en) 2009-02-26
IN2010KN00195A (enExample) 2015-08-28

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