JP5560393B2 - 心筋細胞系列細胞への霊長類多能性幹細胞の分化 - Google Patents

心筋細胞系列細胞への霊長類多能性幹細胞の分化 Download PDF

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JP5560393B2
JP5560393B2 JP2008518339A JP2008518339A JP5560393B2 JP 5560393 B2 JP5560393 B2 JP 5560393B2 JP 2008518339 A JP2008518339 A JP 2008518339A JP 2008518339 A JP2008518339 A JP 2008518339A JP 5560393 B2 JP5560393 B2 JP 5560393B2
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ジョゼフ ディー. ゴールド,
モハマッド ハッサニポーア,
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アステリアス バイオセラピューティクス インコーポレイテッド
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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JP2008518339A 2005-06-22 2006-06-20 心筋細胞系列細胞への霊長類多能性幹細胞の分化 Expired - Fee Related JP5560393B2 (ja)

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US69314105P 2005-06-22 2005-06-22
US60/693,141 2005-06-22
PCT/US2006/024060 WO2007002136A2 (en) 2005-06-22 2006-06-20 Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12316846B2 (en) 2011-06-16 2025-05-27 Dolby Video Compression, Llc Entropy coding of motion vector differences

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8106004B2 (en) * 2006-07-28 2012-01-31 Children's Memorial Hospital Methods of inhibiting tumor cell aggressiveness using the microenvironment of human embryonic stem cells
JP5693004B2 (ja) * 2006-07-28 2015-04-01 チルドレンズ メモリアル ホスピタル ヒト胚性幹細胞の微小環境を使用して腫瘍細胞の悪性度を抑制する方法
JP5801187B2 (ja) 2008-03-27 2015-10-28 マウント シナイ スクール オブ メディスン ヒト心血管前駆細胞
EP3255142A1 (en) 2009-10-19 2017-12-13 Cellular Dynamics International, Inc. Cardiomyocyte production
US9181529B2 (en) 2010-10-19 2015-11-10 Cellular Dynamics International, Inc. Titration of differentiation medium components
EP2640829A4 (en) 2010-11-17 2014-06-11 Univ Kyoto CARDIOMYOCYTE AND / OR CARDIOVORA CELL PROLIFERATING AGENTS AND METHOD FOR PROLIFERATING CARDIOMYOCYTES AND / OR CARDIOVORA CELLS
CA2829804A1 (en) 2011-03-29 2012-10-04 Geron Corporation Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells
CA2831609C (en) 2011-03-30 2019-06-11 Cellular Dynamics International, Inc. Priming of pluripotent stem cells for neural differentiation
JP5840855B2 (ja) 2011-03-30 2016-01-06 学校法人東京女子医科大学 胚性幹細胞から心筋シートを製造する方法
EP2691513A4 (en) 2011-03-31 2014-09-03 Iheart Japan Corp NEW CARDIOMYOCYTE MARKER
KR101966208B1 (ko) 2011-07-21 2019-04-09 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 환자로부터 유도 만능 줄기 세포들로부터의 심근 세포 및 그 사용 방법
GB201121101D0 (en) * 2011-12-08 2012-01-18 Nhs Blood & Transplant A method of preparing isolated cells and uses
EP2826855B1 (en) 2012-03-15 2018-08-29 iHeart Japan Corporation Myocardial sheet
US20150184129A1 (en) 2012-07-17 2015-07-02 Kyoto University Novel cardiomyocyte marker
WO2014185358A1 (ja) 2013-05-14 2014-11-20 国立大学法人京都大学 効率的な心筋細胞の誘導方法
WO2014192312A1 (ja) * 2013-05-31 2014-12-04 国立大学法人 東京医科歯科大学 正常な内向きのカリウム電流特性を有するiPS細胞由来心筋モデル細胞
KR101870174B1 (ko) 2013-05-31 2018-06-22 아이하트 재팬 가부시키가이샤 하이드로겔을 포함하는 적층화된 세포 시트
AU2014278178B2 (en) 2013-06-11 2021-01-21 President And Fellows Of Harvard College SC-beta cells and compositions and methods for generating the same
US10538740B2 (en) 2014-03-20 2020-01-21 Kyoto University Method for sorting cardiomyocytes
CA2943035A1 (en) * 2014-05-06 2015-11-12 F. Hoffmann-La Roche Ag Method for differentiation of pluripotent stem cells into cardiomyocytes
US10696948B2 (en) 2014-09-16 2020-06-30 Osaka University Method for preparing pluripotent stem cell-derived cardiomyocyte population
US10443042B2 (en) 2014-12-18 2019-10-15 President And Fellows Of Harvard College Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof
ES2985135T3 (es) 2014-12-18 2024-11-04 Harvard College Procedimientos para generar células ß derivadas de células madre y usos de las mismas
CN107614678B (zh) 2014-12-18 2021-04-30 哈佛学院校长同事会 干细胞来源的β细胞的产生方法及其使用方法
US10556388B2 (en) * 2015-04-22 2020-02-11 Eastman Chemical Company Polyester-based tape composites for wood reinforcement
EP3294342A4 (en) 2015-05-08 2018-11-07 President and Fellows of Harvard College Universal donor stem cells and related methods
WO2019099725A1 (en) 2017-11-15 2019-05-23 Semma Therapeutics, Inc. Islet cell manufacturing compositions and methods of use
WO2019169351A1 (en) 2018-03-02 2019-09-06 Semma Therapeutics, Inc. Methods of enhancing stem cell differentiation into beta cells
JP7344486B2 (ja) 2018-03-30 2023-09-14 国立大学法人京都大学 心筋細胞成熟促進剤
CN111971392A (zh) 2018-03-30 2020-11-20 国立大学法人京都大学 细胞的制造方法
JP7257698B2 (ja) 2018-03-30 2023-04-14 オリヅルセラピューティクス株式会社 複素環化合物
WO2020032184A1 (ja) 2018-08-10 2020-02-13 武田薬品工業株式会社 カチオン性脂質
EP3833365A4 (en) 2018-08-10 2022-05-11 Vertex Pharmaceuticals Incorporated Stem cell derived islet differentiation
JP7436990B2 (ja) 2018-08-10 2024-02-22 国立大学法人京都大学 カチオン性脂質を用いた心筋細胞へのトランスフェクション方法
JP7728747B2 (ja) 2019-08-23 2025-08-25 サナ バイオテクノロジー,インコーポレイテッド Cd24発現細胞およびそれらの用途
AU2021325941A1 (en) 2020-08-13 2023-03-09 Sana Biotechnology, Inc. Methods of treating sensitized patients with hypoimmunogenic cells, and associated methods and compositions
US20240226164A1 (en) 2021-05-27 2024-07-11 Sana Biotechnology, Inc. Hypoimmunogenic cells comprising engineered hla-e or hla-g
CA3225283A1 (en) 2021-07-14 2023-01-19 Sonja SCHREPFER Altered expression of y chromosome-linked antigens in hypoimmunogenic cells
AU2022325231A1 (en) 2021-08-11 2024-02-08 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions
AU2022326565A1 (en) 2021-08-11 2024-02-08 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy
AU2022325955A1 (en) 2021-08-11 2024-02-08 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions
US20260053851A1 (en) 2021-08-11 2026-02-26 Sana Biotechnology, Inc. Inducible systems for altering gene expression in hypoimmunogenic cells
KR20230073749A (ko) 2021-11-19 2023-05-26 주식회사 로킷헬스케어 박동형 심근 패치의 제조방법 및 이를 이용하여 제조된 박동형 심근 패치
WO2023183313A1 (en) 2022-03-22 2023-09-28 Sana Biotechnology, Inc. Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods
EP4678737A1 (en) 2023-03-03 2026-01-14 Kyoto University Method for producing primed pluripotent stem cells
WO2024243236A2 (en) 2023-05-22 2024-11-28 Sana Biotechnology, Inc. Methods of delivery of islet cells and related methods
WO2025054202A1 (en) 2023-09-05 2025-03-13 Sana Biotechnology, Inc. Method of screening a sample comprising a transgene with a unique barcode
WO2025061158A1 (zh) 2023-09-20 2025-03-27 士泽生物医药(苏州)有限公司 一种表达mcl1的低免疫原性细胞及其制备方法
WO2025089333A1 (ja) 2023-10-26 2025-05-01 公益財団法人京都大学iPS細胞研究財団 細胞製造装置の包装体、細胞製造方法およびそのための管理システム
KR20260115082A (ko) 2023-12-04 2026-07-23 고에키자이단호진 교토다이가쿠 아이피에스 사이보겐큐자이단 인공 다능성 줄기세포의 제조 방법
AU2025208175A1 (en) 2024-01-12 2026-06-25 Sana Biotechnology, Inc. Safety switches to control in vitro and in vivo proliferation of cell therapy products

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491632A (en) 1979-10-22 1985-01-01 The Massachusetts General Hospital Process for producing antibodies to hepatitis virus and cell lines therefor
US4444887A (en) 1979-12-10 1984-04-24 Sloan-Kettering Institute Process for making human antibody producing B-lymphocytes
DE3167442D1 (en) 1980-07-07 1985-01-10 Nat Res Dev Improvements in or relating to cell lines
GB2197915B (en) 1986-11-19 1990-11-14 Rolls Royce Plc Improvements in or relating to fluid bearings
WO1992013066A1 (en) 1991-01-24 1992-08-06 Loyola University Of Chicago Mammalian cardiac myocyte cell line
US5543318A (en) * 1991-06-12 1996-08-06 Smith; David A. Method of isolation, culture and proliferation of human atrial myocytes
US5523226A (en) * 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
US5602301A (en) 1993-11-16 1997-02-11 Indiana University Foundation Non-human mammal having a graft and methods of delivering protein to myocardial tissue
US6015671A (en) 1995-06-07 2000-01-18 Indiana University Foundation Myocardial grafts and cellular compositions
DE4441327C1 (de) 1994-11-22 1995-11-09 Inst Pflanzengenetik & Kultur Embryonale Herzmuskelzellen, ihre Herstellung und ihre Verwendung
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
DE69735622T2 (de) 1996-08-16 2007-04-12 MCW Research Foundation, Inc., Milwaukee Knochen morphogenetisches protein und fibroblasten wachstumsfaktor enthaltende zusammensetzungen und methoden zur induzierung der kardiogenese
US20020061837A1 (en) * 1996-09-05 2002-05-23 Lough John W. Bone morphogenetic protein and fibroblast growth factor compositions and methods for the induction of cardiogenesis
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
JP2001508302A (ja) 1997-01-10 2001-06-26 ライフ テクノロジーズ,インコーポレイテッド 胚性幹細胞血清置換
US6331406B1 (en) 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
US6110459A (en) 1997-05-28 2000-08-29 Mickle; Donald A. G. Transplants for myocardial scars and methods and cellular preparations
US6099832A (en) 1997-05-28 2000-08-08 Genzyme Corporation Transplants for myocardial scars
WO1999003973A1 (en) 1997-07-14 1999-01-28 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
WO1999020740A2 (en) 1997-10-23 1999-04-29 Geron Corporation Methods and materials for the growth of primate-derived primordial stem cells
DE19755800A1 (de) * 1997-12-16 1999-06-17 Merck Patent Gmbh Cyclopeptidderivate
EP1064356A2 (en) 1998-03-23 2001-01-03 ZymoGenetics, Inc. Cardiac-derived stem cells
JP2002517982A (ja) 1998-04-09 2002-06-25 ブレサゲン リミテッド 細胞の分化/増殖および維持因子ならびにそれらの使用
WO2001051611A1 (en) 2000-01-14 2001-07-19 Bresagen Limited Cell production
ATE382681T1 (de) 1998-07-31 2008-01-15 Genzyme Corp Verbesserung der herzfunktion durch transplantation mesenchymaler stammzellen
US7410798B2 (en) 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
US6667176B1 (en) * 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US20020168766A1 (en) 2000-01-11 2002-11-14 Gold Joseph D. Genetically altered human pluripotent stem cells
IL129966A (en) 1999-05-14 2009-12-24 Technion Res & Dev Foundation ISOLATED HUMAN EMBRYOID BODIES (hEB) DERIVED FROM HUMAN EMBRYONIC STEM CELLS
AU783935B2 (en) 1999-06-18 2006-01-05 Indiana University Research And Technology Corporation Cardiomyocytes with enhanced proliferative potential, and methods for preparing and using same
EP1221956A2 (en) 1999-09-30 2002-07-17 McGILL UNIVERSITY Autologous marrow stem cell (msc) transplantation for myocardial regeneration
US6280718B1 (en) 1999-11-08 2001-08-28 Wisconsin Alumni Reasearch Foundation Hematopoietic differentiation of human pluripotent embryonic stem cells
EP1254952A4 (en) 1999-12-28 2004-09-22 Kyowa Hakko Kogyo Kk CELLS THAT ARE ABLE TO DIFFERENTIZE IN THE HEART MUSCLE CELLS
US20020142457A1 (en) * 1999-12-28 2002-10-03 Akihiro Umezawa Cell having the potentiality of differentiation into cardiomyocytes
US7795026B2 (en) 2000-01-21 2010-09-14 The Johns Hopkins University School Of Medicine Methods for obtaining human embryoid body-derived cells
CA2402245A1 (en) 2000-03-10 2001-09-20 Advanced Research And Technology Institute, Inc. Multipotent cell and cardiomyocyte cell populations, and routes to and uses of same
EP1315510A4 (en) 2000-07-31 2005-08-03 New York Medical College METHOD AND COMPOSITIONS FOR REPAIRING AND / OR REGENERATING THE DAMAGED HEART MUSCLE
WO2002009650A2 (en) 2000-07-31 2002-02-07 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
JP2004504834A (ja) 2000-08-01 2004-02-19 イスム リサーチ ディベロップメント カンパニー 胚性細胞の定方向分化
US6607720B1 (en) 2000-09-05 2003-08-19 Yong-Fu Xiao Genetically altered mammalian embryonic stem cells, their living progeny, and their therapeutic application for improving cardiac function after myocardial infarction
US6534052B1 (en) 2000-09-05 2003-03-18 Yong-Fu Xiao Cardiac function comprising implantation of embryonic stem cell in which differentiation has been initiated
AU3929402A (en) * 2000-11-22 2002-06-11 Geron Corp Tolerizing allografts of pluripotent stem cells
KR100694963B1 (ko) 2001-04-13 2007-03-14 (주)안트로젠 이식용 세포의 생산방법
EP1412479A4 (en) * 2001-07-12 2004-07-28 Geron Corp CELLS WITH CARDIOMYOCYTE GENERATION PRODUCED FROM HUMAN PLURIPOTENT STEM CELLS
US7732199B2 (en) * 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
AU2002354893A1 (en) 2001-07-20 2003-03-03 Technion Research And Development Foundation Ltd. Methods of generating human cardiac cells and tissues and uses thereof
CA2452256A1 (en) 2001-07-24 2003-02-06 Es Cell International Pte Ltd Methods of inducing differentiation of stem cells
CN1630716A (zh) 2001-12-07 2005-06-22 杰龙公司 人胚胎干细胞衍生的造血细胞
US8298606B2 (en) * 2002-03-08 2012-10-30 The Regents Of The University Of California Methods and compositions for stabilizing the myocardium
AU2003225835B2 (en) * 2002-03-15 2008-05-22 Wicell Research Institute, Inc. Method for generating primate trophoblasts
US7247477B2 (en) 2002-04-16 2007-07-24 Technion Research & Development Foundation Ltd. Methods for the in-vitro identification, isolation and differentiation of vasculogenic progenitor cells
US6898272B2 (en) * 2002-08-01 2005-05-24 Spirent Communications System and method for testing telecommunication devices
US7569222B2 (en) * 2002-11-18 2009-08-04 Woerly Stephane Hydrogel membrane composition and use thereof
US20050031598A1 (en) 2002-12-10 2005-02-10 Shulamit Levenberg Engineering three-dimensional tissue structures using differentiating embryonic stem cells
AU2003901099A0 (en) 2003-03-11 2003-03-27 Es Cell International Pte Ltd. Methods of inducing differentiation of stem cells
US20030224411A1 (en) 2003-03-13 2003-12-04 Stanton Lawrence W. Genes that are up- or down-regulated during differentiation of human embryonic stem cells
US20050266554A1 (en) * 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US20050142121A1 (en) 2003-12-24 2005-06-30 Gold Joseph D. System for improving acceptance of tissue grafts made from embryonic stem cells
GB2427873B (en) * 2004-03-19 2008-09-10 Geron Corp Method for making high purity cardiomyocyte preparations suitable for regenerative medicine
US7452718B2 (en) * 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
US20050214938A1 (en) * 2004-03-26 2005-09-29 Gold Joseph D Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function
US8932620B2 (en) * 2005-06-17 2015-01-13 Drexel University Three-dimensional scaffolds for tissue engineering made by processing complex extracts of natural extracellular matrices
CA2674632A1 (en) * 2006-12-29 2008-07-10 University Of Washington Dual-functional nonfouling surfaces and materials
WO2009099552A2 (en) * 2008-01-30 2009-08-13 Corning Incorporated Cell culture article and screening
US9115238B2 (en) * 2009-05-28 2015-08-25 Corning Incorporated Swellable synthetic microcarriers for culturing cells

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12316846B2 (en) 2011-06-16 2025-05-27 Dolby Video Compression, Llc Entropy coding of motion vector differences

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