JP5529876B2 - Ｍｍｐ−１３阻害剤として有用なヘテロアリール置換インドール化合物 - Google Patents

Ｍｍｐ−１３阻害剤として有用なヘテロアリール置換インドール化合物 Download PDF

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JP5529876B2
JP5529876B2 JP2011532175A JP2011532175A JP5529876B2 JP 5529876 B2 JP5529876 B2 JP 5529876B2 JP 2011532175 A JP2011532175 A JP 2011532175A JP 2011532175 A JP2011532175 A JP 2011532175A JP 5529876 B2 JP5529876 B2 JP 5529876B2
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alkyl
methyl
alkoxy
mmol
esi
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JP2012505891A (ja
JP2012505891A5 (OSRAM
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アベイワルダーネ，アシタ
ファーマー，ベネット
ファロー，ニール・アレクサンダー
ガオ，ドンホン・エイ
ハイム−リーター，アレクサンダー
キーナン，ラナ・ルイス・スミス
ミュゲ，インゴ・アンドレアス
テイラー，スティーブン・ジョン
ション，ツァオミン
ユ，ヤン
ツァン，チァン
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ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/42—Oxazoles
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Physical Education & Sports Medicine (AREA)
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  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2011532175A 2008-10-17 2009-10-13 Ｍｍｐ−１３阻害剤として有用なヘテロアリール置換インドール化合物 Expired - Fee Related JP5529876B2 (ja)

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Application Number Priority Date Filing Date Title
US10620708P 2008-10-17 2008-10-17
US61/106,207 2008-10-17
PCT/US2009/060436 WO2010045188A1 (en) 2008-10-17 2009-10-13 Heteroaryl substituted indole compounds useful as mmp-13 inhibitors

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JP2012505891A JP2012505891A (ja) 2012-03-08
JP2012505891A5 JP2012505891A5 (OSRAM) 2012-11-29
JP5529876B2 true JP5529876B2 (ja) 2014-06-25

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US8785489B2 (en) 2014-07-22
WO2010045188A1 (en) 2010-04-22
JP2012505891A (ja) 2012-03-08
US20110275631A1 (en) 2011-11-10
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