JP2012505891A5 - - Google Patents
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- Publication number
- JP2012505891A5 JP2012505891A5 JP2011532175A JP2011532175A JP2012505891A5 JP 2012505891 A5 JP2012505891 A5 JP 2012505891A5 JP 2011532175 A JP2011532175 A JP 2011532175A JP 2011532175 A JP2011532175 A JP 2011532175A JP 2012505891 A5 JP2012505891 A5 JP 2012505891A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- halogen
- pyridinyl
- alkoxycarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 25
- 125000003545 alkoxy group Chemical group 0.000 claims 15
- 229910052736 halogen Inorganic materials 0.000 claims 13
- 150000002367 halogens Chemical class 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 12
- -1 cyano, hydroxyl Chemical group 0.000 claims 11
- 125000004076 pyridyl group Chemical group 0.000 claims 10
- 125000002252 acyl group Chemical group 0.000 claims 9
- 125000004442 acylamino group Chemical group 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
- 125000003226 pyrazolyl group Chemical group 0.000 claims 8
- 125000002883 imidazolyl group Chemical group 0.000 claims 7
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 6
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000000842 isoxazolyl group Chemical group 0.000 claims 5
- 125000002971 oxazolyl group Chemical group 0.000 claims 5
- 125000003373 pyrazinyl group Chemical group 0.000 claims 5
- 125000002098 pyridazinyl group Chemical group 0.000 claims 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000000168 pyrrolyl group Chemical group 0.000 claims 4
- 125000000335 thiazolyl group Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000001786 isothiazolyl group Chemical group 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 201000001245 periodontitis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 150000003462 sulfoxides Chemical class 0.000 claims 1
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10620708P | 2008-10-17 | 2008-10-17 | |
| US61/106,207 | 2008-10-17 | ||
| PCT/US2009/060436 WO2010045188A1 (en) | 2008-10-17 | 2009-10-13 | Heteroaryl substituted indole compounds useful as mmp-13 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012505891A JP2012505891A (ja) | 2012-03-08 |
| JP2012505891A5 true JP2012505891A5 (OSRAM) | 2012-11-29 |
| JP5529876B2 JP5529876B2 (ja) | 2014-06-25 |
Family
ID=41508906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011532175A Active JP5529876B2 (ja) | 2008-10-17 | 2009-10-13 | Ｍｍｐ−１３阻害剤として有用なヘテロアリール置換インドール化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8785489B2 (OSRAM) |
| EP (1) | EP2340243B1 (OSRAM) |
| JP (1) | JP5529876B2 (OSRAM) |
| CA (1) | CA2738929A1 (OSRAM) |
| WO (1) | WO2010045188A1 (OSRAM) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2344480A1 (en) | 2008-10-15 | 2011-07-20 | Boehringer Ingelheim International GmbH | Fused heteroaryl diamide compounds useful as mmp-13 inhibitors |
| JP5529876B2 (ja) | 2008-10-17 | 2014-06-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｍｍｐ−１３阻害剤として有用なヘテロアリール置換インドール化合物 |
| CA2743146A1 (en) | 2008-11-17 | 2010-05-20 | Boehringer Ingelheim International Gmbh | Heteroaryl diamide compounds useful as mmp-13 inhibitors |
| CA2771026A1 (en) * | 2009-09-24 | 2011-03-31 | F. Hoffmann-La Roche Ag | Indole derivatives as crac modulators |
| TWI423962B (zh) * | 2009-10-07 | 2014-01-21 | Lg Life Sciences Ltd | 有效作為黃嘌呤氧化酶抑制劑之新穎化合物、其製備方法及含該化合物之醫藥組成物 |
| KR101913135B1 (ko) | 2011-07-15 | 2018-10-30 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조절 인자로서의 신규의 치환 인돌 유도체 |
| CA2844128C (en) | 2011-08-30 | 2020-09-01 | Chdi Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| US10266490B2 (en) * | 2012-03-16 | 2019-04-23 | Georgetown University | Radioprotector compounds |
| WO2015073481A1 (en) | 2013-11-13 | 2015-05-21 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
| US10730866B2 (en) * | 2014-04-07 | 2020-08-04 | Purdue Pharma L.P. | Indole derivatives and use thereof |
| SG11201700341PA (en) | 2014-07-17 | 2017-02-27 | Chdi Foundation Inc | Methods and compositions for treating hiv-related disorders |
| WO2016026078A1 (en) * | 2014-08-19 | 2016-02-25 | Changzhou Jiekai Pharmatech Co., Ltd. | Heterocyclic compounds as erk inhibitors |
| BR112018011475A2 (pt) | 2015-12-07 | 2018-12-04 | Plexxikon Inc | compostos e métodos para modulação de quinase e indicação para a mesma |
| US10550091B2 (en) | 2016-03-25 | 2020-02-04 | St. Jude Children's Research Hospital | 1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor |
| US10071079B2 (en) | 2016-06-29 | 2018-09-11 | Bristol-Myers Squibb Company | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds |
| AU2017307208B2 (en) | 2016-07-30 | 2021-01-21 | Bristol-Myers Squibb Company | Dimethoxyphenyl substituted indole compounds as TLR7, TLR8 or TLR9 inhibitors |
| US10660877B2 (en) | 2016-09-09 | 2020-05-26 | Bristol-Myers Squibb Company | Pyridyl substituted indole compounds |
| WO2018226846A1 (en) | 2017-06-07 | 2018-12-13 | Plexxikon Inc. | Compounds and methods for kinase modulation |
| US11130756B2 (en) | 2017-08-04 | 2021-09-28 | Bristol-Myers Squibb Company | [1,2,4]Triazolo[4,3-A]pyridinyl substituted indole compounds |
| US11447466B2 (en) | 2017-08-04 | 2022-09-20 | Bristol-Myers Squibb Company | Substituted indole compounds useful as inhibitors of TLR7/8/9 |
| KR102849449B1 (ko) | 2017-11-14 | 2025-08-21 | 브리스톨-마이어스 스큅 컴퍼니 | 치환된 인돌 화합물 |
| BR112020011668A2 (pt) | 2017-12-15 | 2020-11-17 | Bristol-Myers Squibb Company | compostos de éter de indol substituído |
| HUE064473T2 (hu) | 2017-12-18 | 2024-03-28 | Bristol Myers Squibb Co | 4-azaindol vegyületek |
| EP3728253B1 (en) | 2017-12-19 | 2024-03-27 | Bristol-Myers Squibb Company | 6-azaindole compounds |
| MX2020005462A (es) | 2017-12-19 | 2020-09-07 | Bristol Myers Squibb Co | Compuestos de indol sustituidos utiles como inhibidores de receptores tipo toll (tlr). |
| SG11202005700SA (en) | 2017-12-19 | 2020-07-29 | Bristol Myers Squibb Co | Amide substituted indole compounds useful as tlr inhibitors |
| CA3085937A1 (en) | 2017-12-20 | 2019-06-27 | Bristol-Myers Squibb Company | Diazaindole compounds |
| US11420958B2 (en) | 2017-12-20 | 2022-08-23 | Bristol-Myers Squibb Company | Aryl and heteroaryl substituted indole compounds |
| ES2904676T3 (es) | 2017-12-20 | 2022-04-05 | Bristol Myers Squibb Co | Compuestos de amino indol útiles como inhibidores de TLR |
| MA52809A (fr) | 2018-06-07 | 2021-04-14 | Disarm Therapeutics Inc | Inhibiteurs de sarm1 |
| EP3628669A1 (en) * | 2018-09-28 | 2020-04-01 | GenKyoTex Suisse SA | Novel compounds as nadph oxidase inhibitors |
| CN112955450A (zh) | 2018-10-24 | 2021-06-11 | 百时美施贵宝公司 | 经取代的吲哚和吲唑化合物 |
| WO2020086505A1 (en) | 2018-10-24 | 2020-04-30 | Bristol-Myers Squibb Company | Substituted indole dimer compounds |
| US12083114B2 (en) | 2018-12-19 | 2024-09-10 | Disarm Therapeutics, Inc. | Inhibitors of SARM1 in combination with neuro-protective agents |
| EP3965888B1 (en) | 2019-05-09 | 2024-08-21 | Bristol-Myers Squibb Company | Substituted benzimidazolone compounds |
| CN114761404B (zh) | 2019-10-01 | 2025-02-21 | 百时美施贵宝公司 | 经取代的双环杂芳基化合物 |
| KR20220079587A (ko) | 2019-10-04 | 2022-06-13 | 브리스톨-마이어스 스큅 컴퍼니 | 치환된 카르바졸 화합물 |
| JP7652772B2 (ja) * | 2019-11-01 | 2025-03-27 | ブリストル－マイヤーズ スクイブ カンパニー | 置換ピラゾール化合物 |
| CA3190065A1 (en) | 2020-08-19 | 2022-02-24 | David S. Yoon | Imidazo[1,2-a]pyridine and [1,2,4]triazolo[1,5-a]pyridine derivatives as tlr9 inhibitors for the treatment of fibrosis |
| TW202227409A (zh) | 2020-08-19 | 2022-07-16 | 美商必治妥美雅史谷比公司 | 作為tlr9抑制劑之經取代苯并咪唑 |
| CN116947821B (zh) * | 2022-04-20 | 2025-10-17 | 成都肯迪特生物医药科技有限公司 | 一种化合物及其在制备jak激酶抑制剂中的用途 |
| US12516051B1 (en) | 2024-09-30 | 2026-01-06 | St. Jude Children's Research Hospital, Inc. | Small molecule degraders and fluorescent probes of PXR |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08151380A (ja) * | 1994-11-29 | 1996-06-11 | Kyorin Pharmaceut Co Ltd | ビス（トリフルオロメチルピロロインドールカルボン酸エステル）誘導体及びその製造方法 |
| WO2000033836A1 (en) | 1998-12-04 | 2000-06-15 | Ontogen Corporation | 5-membered heterocycles for the treatment of human diseases involving modulators of selectins |
| WO2002010146A1 (en) | 2000-07-31 | 2002-02-07 | Smithkline Beecham P.L.C. | Carboxamide compounds and their use as antagonists of a human 11cby receptor |
| GB0018758D0 (en) | 2000-07-31 | 2000-09-20 | Smithkline Beecham Plc | Novel use and compunds |
| AU2001277621A1 (en) | 2000-08-09 | 2002-03-04 | Astrazeneca Ab | Antiangiogenic bicyclic derivatives |
| US7186723B2 (en) * | 2001-08-30 | 2007-03-06 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| CA2484209C (en) * | 2002-05-03 | 2013-06-11 | Exelixis, Inc. | Protein kinase modulators and methods of use |
| DE10229070A1 (de) | 2002-06-28 | 2004-01-15 | Merck Patent Gmbh | Phenylderivate 5 |
| EA009215B1 (ru) | 2003-05-21 | 2007-12-28 | Прозидион Лимитед | Ингибиторы гликогенфосфорилазы, представляющие собой амиды пирролопиридин-2-карбоновых кислот |
| AU2004265191A1 (en) | 2003-08-14 | 2005-02-24 | Asahi Kasei Pharma Corporation | Substituted arylalkanoic acid derivative and use thereof |
| RU2403247C2 (ru) | 2004-07-20 | 2010-11-10 | СЬЕНА БИОТЕК С.п.А. | Модуляторы никотиновых ацетилхолиновых рецепторов альфа 7 и их терапевтические применения |
| EP1820795A4 (en) * | 2004-12-07 | 2010-10-20 | Toyama Chemical Co Ltd | NEW ANTHRANILIC ACID DERIVATIVE OR SALT FROM IT |
| WO2006066879A2 (en) | 2004-12-21 | 2006-06-29 | Devgen N.V. | Compounds with kv4 ion channel activity |
| GT200600042A (es) | 2005-02-10 | 2006-09-27 | Aventis Pharma Inc | Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a |
| JP5091663B2 (ja) * | 2005-03-16 | 2012-12-05 | 富山化学工業株式会社 | 新規なアントラニル酸誘導体またはその塩 |
| WO2006113458A1 (en) | 2005-04-15 | 2006-10-26 | Bristol-Myers Squibb Company | Heterocyclic inhibitors of protein arginine methyl transferases |
| EP1928442B1 (en) | 2005-08-19 | 2009-11-04 | Aventis Pharmaceuticals Inc. | Combination of a hypnotic agent and substituted bis aryl and heteroaryl compound and therapeutic application thereof |
| EP2002834A1 (de) * | 2007-06-13 | 2008-12-17 | Bayer Schering Pharma Aktiengesellschaft | Aryl/Hetarylamide als Modulatoren des EP2-Rezeptors |
| EP2344480A1 (en) | 2008-10-15 | 2011-07-20 | Boehringer Ingelheim International GmbH | Fused heteroaryl diamide compounds useful as mmp-13 inhibitors |
| JP5529876B2 (ja) | 2008-10-17 | 2014-06-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｍｍｐ−１３阻害剤として有用なヘテロアリール置換インドール化合物 |
| CA2743146A1 (en) | 2008-11-17 | 2010-05-20 | Boehringer Ingelheim International Gmbh | Heteroaryl diamide compounds useful as mmp-13 inhibitors |
-
2009
- 2009-10-13 JP JP2011532175A patent/JP5529876B2/ja active Active
- 2009-10-13 US US13/123,048 patent/US8785489B2/en active Active
- 2009-10-13 EP EP09740801.7A patent/EP2340243B1/en not_active Not-in-force
- 2009-10-13 CA CA2738929A patent/CA2738929A1/en not_active Abandoned
- 2009-10-13 WO PCT/US2009/060436 patent/WO2010045188A1/en not_active Ceased
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