JP5501245B2 - Ｆｖｉｉｉペプチドおよび血友病を寛容化することにおけるその使用 - Google Patents

Ｆｖｉｉｉペプチドおよび血友病を寛容化することにおけるその使用 Download PDF

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JP5501245B2
JP5501245B2 JP2010536523A JP2010536523A JP5501245B2 JP 5501245 B2 JP5501245 B2 JP 5501245B2 JP 2010536523 A JP2010536523 A JP 2010536523A JP 2010536523 A JP2010536523 A JP 2010536523A JP 5501245 B2 JP5501245 B2 JP 5501245B2
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peptide
peptides
fviii
factor viii
hemophilia
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Japanese (ja)
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JP2011505414A (ja
JP2011505414A5 (https=
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デイビッド レイス，
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アピトープ インターナショナル エヌブイ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010536523A 2007-12-04 2008-12-03 Ｆｖｉｉｉペプチドおよび血友病を寛容化することにおけるその使用 Expired - Fee Related JP5501245B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0723712.6A GB0723712D0 (en) 2007-12-04 2007-12-04 Peptides
GB0723712.6 2007-12-04
PCT/GB2008/003996 WO2009071886A1 (en) 2007-12-04 2008-12-03 Fviii peptides and their use in tolerising haemophiliacs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014023217A Division JP6063402B2 (ja) 2007-12-04 2014-02-10 Ｆｖｉｉｉペプチドおよび血友病を寛容化することにおけるその使用

Publications (3)

Publication Number Publication Date
JP2011505414A JP2011505414A (ja) 2011-02-24
JP2011505414A5 JP2011505414A5 (https=) 2012-10-25
JP5501245B2 true JP5501245B2 (ja) 2014-05-21

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ID=38982965

Family Applications (2)

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JP2010536523A Expired - Fee Related JP5501245B2 (ja) 2007-12-04 2008-12-03 Ｆｖｉｉｉペプチドおよび血友病を寛容化することにおけるその使用
JP2014023217A Expired - Fee Related JP6063402B2 (ja) 2007-12-04 2014-02-10 Ｆｖｉｉｉペプチドおよび血友病を寛容化することにおけるその使用

Family Applications After (1)

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JP2014023217A Expired - Fee Related JP6063402B2 (ja) 2007-12-04 2014-02-10 Ｆｖｉｉｉペプチドおよび血友病を寛容化することにおけるその使用

Country Status (25)

Country Link
US (1) US8445448B2 (https=)
EP (1) EP2227488B3 (https=)
JP (2) JP5501245B2 (https=)
KR (1) KR101519840B1 (https=)
CN (2) CN101889024B (https=)
AU (1) AU2008332968B2 (https=)
BR (1) BRPI0820143A2 (https=)
CA (2) CA3005013C (https=)
CY (1) CY1115168T1 (https=)
DK (1) DK2227488T6 (https=)
EA (1) EA019370B1 (https=)
EC (1) ECSP10010327A (https=)
ES (1) ES2458315T7 (https=)
GB (1) GB0723712D0 (https=)
HR (1) HRP20140344T4 (https=)
IL (1) IL205780A (https=)
MX (1) MX2010006084A (https=)
MY (1) MY150995A (https=)
NZ (1) NZ585217A (https=)
PL (1) PL2227488T6 (https=)
PT (1) PT2227488E (https=)
SI (1) SI2227488T1 (https=)
UA (1) UA101003C2 (https=)
WO (1) WO2009071886A1 (https=)
ZA (1) ZA201002997B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102764425B (zh) 2000-08-21 2015-11-25 阿皮托普技术(布里斯托尔)有限公司 肽选择方法
GB0801513D0 (en) * 2008-01-28 2008-03-05 Circassia Ltd Peptides from factor VIII
EP2300497B1 (en) * 2008-06-24 2012-08-08 Octapharma AG A process of purifying coagulation factor viii
GB0908515D0 (en) * 2009-05-18 2009-06-24 Apitope Technology Bristol Ltd Peptide
CA2765657A1 (en) * 2009-06-16 2010-12-23 Tokai University Anti-gram-negative bacteria agent
EP2632479B1 (en) * 2010-10-27 2017-06-14 Baxalta GmbH Fviii peptides for immune tolerance induction and immunodiagnostics
EA038705B1 (ru) 2012-01-12 2021-10-07 Биовератив Терапьютикс Инк. Способы снижения иммуногенности фактора свёртывания крови viii у пациентов, получающих лечение фактором viii
EA036483B1 (ru) * 2012-11-12 2020-11-16 Эпитоп Интернэшнл Нв Пептиды, способные индуцировать толерантность к рекомбинантному fviii, содержащая их композиция, их применение и способ лечения гемофилии
GB201314052D0 (en) * 2013-08-06 2013-09-18 Apitope Int Nv Peptides
EP4212547A1 (en) 2015-12-03 2023-07-19 Juno Therapeutics, Inc. Modified chimeric receptors and related compositions and methods
JP2019536794A (ja) 2016-12-02 2019-12-19 バイオベラティブ セラピューティクス インコーポレイテッド 凝固因子に対する免疫寛容を誘導する方法
US12077607B2 (en) * 2021-09-23 2024-09-03 University Of Utah Research Foundation Functional and therapeutic effects of PAR4 cleavage by cathepsin G

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE902211A1 (en) * 1989-06-20 1991-01-16 Scripps Clinic Res The phospholipid binding domain of factor viii
WO1998031394A2 (en) * 1997-01-22 1998-07-23 Board Of Regents, The University Of Texas System Tissue factor methods and compositions for coagulation and tumor treatment
CN102764425B (zh) * 2000-08-21 2015-11-25 阿皮托普技术(布里斯托尔)有限公司 肽选择方法
AU2002249779A1 (en) * 2000-12-01 2002-08-12 Regents Of The University Of Minnesota Method to treat hemophilia
CN100522242C (zh) * 2001-02-19 2009-08-05 默克专利有限公司 具有降低的免疫原性的人工蛋白质
WO2002098454A2 (en) 2001-05-31 2002-12-12 D. Collen Research Foundation Vzw Onderwijsen Navorsing Campus Gasthuisberg K.U. Leuven Recombinant molecules with reduced immunogenicity, methods and intermediates for obtaining them and their use in pharmaceutical compositions and diagnostic tools
WO2003087161A1 (en) 2002-04-18 2003-10-23 Merck Patent Gmbh Modified factor viii
HUE027902T2 (en) * 2004-02-09 2016-11-28 Human Genome Sciences Inc Corp Service Company Albumin fusion proteins
WO2006003183A1 (de) 2004-07-02 2006-01-12 Alois Jungbauer Peptide zur blockierung von fviii-inhibitoren
IL229645A0 (en) * 2013-11-26 2014-03-31 Omrix Biopharmaceuticals Ltd A dry bandage containing thrombin and pectin

Also Published As

Publication number Publication date
NZ585217A (en) 2012-11-30
DK2227488T6 (en) 2015-02-16
GB0723712D0 (en) 2008-01-16
IL205780A0 (en) 2010-11-30
EA019370B1 (ru) 2014-03-31
ES2458315T3 (es) 2014-04-30
WO2009071886A1 (en) 2009-06-11
CA3005013A1 (en) 2009-06-11
KR101519840B1 (ko) 2015-05-18
EP2227488A1 (en) 2010-09-15
CA2707559A1 (en) 2009-06-11
AU2008332968B2 (en) 2014-03-20
CA3005013C (en) 2021-11-16
ECSP10010327A (es) 2010-09-30
PL2227488T6 (pl) 2015-04-30
SI2227488T1 (sl) 2014-06-30
US8445448B2 (en) 2013-05-21
MY150995A (en) 2014-03-31
MX2010006084A (es) 2010-06-23
EP2227488B3 (en) 2014-11-19
ES2458315T7 (es) 2015-02-18
JP6063402B2 (ja) 2017-01-18
US20100323966A1 (en) 2010-12-23
PT2227488E (pt) 2014-04-21
PL2227488T3 (pl) 2014-07-31
CN103709234B (zh) 2017-01-18
JP2011505414A (ja) 2011-02-24
HRP20140344T1 (en) 2014-05-09
HK1144292A1 (en) 2011-02-11
AU2008332968A1 (en) 2009-06-11
BRPI0820143A2 (pt) 2015-05-12
KR20100087346A (ko) 2010-08-04
EP2227488B1 (en) 2014-01-22
IL205780A (en) 2015-06-30
EA201070681A1 (ru) 2010-10-29
CY1115168T1 (el) 2016-12-14
HRP20140344T4 (hr) 2015-07-31
CN103709234A (zh) 2014-04-09
ZA201002997B (en) 2011-07-27
JP2014088440A (ja) 2014-05-15
CA2707559C (en) 2018-07-03
UA101003C2 (uk) 2013-02-25
CN101889024B (zh) 2014-04-23
DK2227488T3 (da) 2014-04-22
CN101889024A (zh) 2010-11-17

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