EA019370B1 - Пептиды fviii и их применение для индукции толерантности у больных гемофилией - Google Patents
Пептиды fviii и их применение для индукции толерантности у больных гемофилией Download PDFInfo
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- EA019370B1 EA019370B1 EA201070681A EA201070681A EA019370B1 EA 019370 B1 EA019370 B1 EA 019370B1 EA 201070681 A EA201070681 A EA 201070681A EA 201070681 A EA201070681 A EA 201070681A EA 019370 B1 EA019370 B1 EA 019370B1
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- Prior art keywords
- peptide
- peptides
- hemophilia
- cells
- factor viii
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Transplantation (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| GBGB0723712.6A GB0723712D0 (en) | 2007-12-04 | 2007-12-04 | Peptides |
| PCT/GB2008/003996 WO2009071886A1 (en) | 2007-12-04 | 2008-12-03 | Fviii peptides and their use in tolerising haemophiliacs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201070681A1 EA201070681A1 (ru) | 2010-10-29 |
| EA019370B1 true EA019370B1 (ru) | 2014-03-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| EA201070681A EA019370B1 (ru) | 2007-12-04 | 2008-12-03 | Пептиды fviii и их применение для индукции толерантности у больных гемофилией |
Country Status (25)
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|---|---|
| US (1) | US8445448B2 (https=) |
| EP (1) | EP2227488B3 (https=) |
| JP (2) | JP5501245B2 (https=) |
| KR (1) | KR101519840B1 (https=) |
| CN (2) | CN101889024B (https=) |
| AU (1) | AU2008332968B2 (https=) |
| BR (1) | BRPI0820143A2 (https=) |
| CA (2) | CA3005013C (https=) |
| CY (1) | CY1115168T1 (https=) |
| DK (1) | DK2227488T6 (https=) |
| EA (1) | EA019370B1 (https=) |
| EC (1) | ECSP10010327A (https=) |
| ES (1) | ES2458315T7 (https=) |
| GB (1) | GB0723712D0 (https=) |
| HR (1) | HRP20140344T4 (https=) |
| IL (1) | IL205780A (https=) |
| MX (1) | MX2010006084A (https=) |
| MY (1) | MY150995A (https=) |
| NZ (1) | NZ585217A (https=) |
| PL (1) | PL2227488T6 (https=) |
| PT (1) | PT2227488E (https=) |
| SI (1) | SI2227488T1 (https=) |
| UA (1) | UA101003C2 (https=) |
| WO (1) | WO2009071886A1 (https=) |
| ZA (1) | ZA201002997B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2698392C2 (ru) * | 2008-06-24 | 2019-08-26 | Октафарма Аг | Способ очистки фактора свертывания крови viii |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1731912T1 (sl) | 2000-08-21 | 2014-05-30 | Apitope Technology (Bristol) Limited | Postopek izbire peptida |
| GB0801513D0 (en) * | 2008-01-28 | 2008-03-05 | Circassia Ltd | Peptides from factor VIII |
| GB0908515D0 (en) * | 2009-05-18 | 2009-06-24 | Apitope Technology Bristol Ltd | Peptide |
| SG176783A1 (en) * | 2009-06-16 | 2012-01-30 | Univ Tokai | Anti-gram-negative bacteria agent |
| BR112013010362A2 (pt) * | 2010-10-27 | 2016-08-02 | Baxter Healthcare Sa | métodos para induzir uma tolerância imune a fviii, para fazer um peptídeo fviii, e para identificar uma célula t específica de peptídeo fvii, peptídeo, composição, e, proteína de fusão |
| EP3970737A1 (en) | 2012-01-12 | 2022-03-23 | Bioverativ Therapeutics Inc. | Reducing immunogenicity against factor viii in individuals undergoing factor viii therapy |
| RS56069B1 (sr) * | 2012-11-12 | 2017-10-31 | Apitope Int Nv | Faktor viii-izvedenih peptida za upotrebu u lečenju hemofilije a |
| GB201314052D0 (en) * | 2013-08-06 | 2013-09-18 | Apitope Int Nv | Peptides |
| CN108884140B (zh) | 2015-12-03 | 2022-10-25 | 朱诺治疗学股份有限公司 | 修饰的嵌合受体及相关组合物和方法 |
| CN110520149A (zh) | 2016-12-02 | 2019-11-29 | 比奥维拉迪维治疗股份有限公司 | 诱导对凝血因子的免疫耐受性的方法 |
| US12077607B2 (en) * | 2021-09-23 | 2024-09-03 | University Of Utah Research Foundation | Functional and therapeutic effects of PAR4 cleavage by cathepsin G |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990015615A1 (en) * | 1989-06-20 | 1990-12-27 | Scripps Clinic And Research Foundation | The phospholipid binding domain of factor viii |
| WO2002016410A2 (en) * | 2000-08-21 | 2002-02-28 | Apitope Technology (Bristol) Limited | Peptide selection method |
| WO2002060917A2 (en) * | 2000-12-01 | 2002-08-08 | Regents Of The University Of Minnesota | Method to treat hemophilia |
| WO2002098454A2 (en) * | 2001-05-31 | 2002-12-12 | D. Collen Research Foundation Vzw Onderwijsen Navorsing Campus Gasthuisberg K.U. Leuven | Recombinant molecules with reduced immunogenicity, methods and intermediates for obtaining them and their use in pharmaceutical compositions and diagnostic tools |
| WO2003087161A1 (en) * | 2002-04-18 | 2003-10-23 | Merck Patent Gmbh | Modified factor viii |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9806793A (pt) * | 1997-01-22 | 2000-05-16 | Univ Texas | Processos e composições de fator tissular para coagulação e tratamento de tumores. |
| US7189830B2 (en) * | 2001-02-19 | 2007-03-13 | Merck Patent Gmbh | Anti-KSA/IL-2 fusion proteins with reduced immunogenicity |
| ES2567634T3 (es) * | 2004-02-09 | 2016-04-25 | Human Genome Sciences, Inc. | Proteínas de fusión de albúmina |
| WO2006003183A1 (de) | 2004-07-02 | 2006-01-12 | Alois Jungbauer | Peptide zur blockierung von fviii-inhibitoren |
| IL229645A0 (en) * | 2013-11-26 | 2014-03-31 | Omrix Biopharmaceuticals Ltd | A dry bandage containing thrombin and pectin |
-
2007
- 2007-12-04 GB GBGB0723712.6A patent/GB0723712D0/en not_active Ceased
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2008
- 2008-03-12 UA UAA201008194A patent/UA101003C2/uk unknown
- 2008-12-03 US US12/746,141 patent/US8445448B2/en not_active Expired - Fee Related
- 2008-12-03 HR HRP20140344TT patent/HRP20140344T4/hr unknown
- 2008-12-03 DK DK08855772.3T patent/DK2227488T6/en active
- 2008-12-03 BR BRPI0820143 patent/BRPI0820143A2/pt not_active Application Discontinuation
- 2008-12-03 EA EA201070681A patent/EA019370B1/ru not_active IP Right Cessation
- 2008-12-03 EP EP08855772.3A patent/EP2227488B3/en active Active
- 2008-12-03 AU AU2008332968A patent/AU2008332968B2/en not_active Ceased
- 2008-12-03 CN CN200880119313.1A patent/CN101889024B/zh not_active Expired - Fee Related
- 2008-12-03 JP JP2010536523A patent/JP5501245B2/ja not_active Expired - Fee Related
- 2008-12-03 KR KR1020107011743A patent/KR101519840B1/ko not_active Expired - Fee Related
- 2008-12-03 PT PT88557723T patent/PT2227488E/pt unknown
- 2008-12-03 WO PCT/GB2008/003996 patent/WO2009071886A1/en not_active Ceased
- 2008-12-03 CA CA3005013A patent/CA3005013C/en active Active
- 2008-12-03 ES ES08855772.3T patent/ES2458315T7/es active Active
- 2008-12-03 CN CN201310392152.6A patent/CN103709234B/zh not_active Expired - Fee Related
- 2008-12-03 SI SI200831186T patent/SI2227488T1/sl unknown
- 2008-12-03 NZ NZ585217A patent/NZ585217A/xx not_active IP Right Cessation
- 2008-12-03 MY MYPI20102567 patent/MY150995A/en unknown
- 2008-12-03 PL PL08855772T patent/PL2227488T6/pl unknown
- 2008-12-03 CA CA2707559A patent/CA2707559C/en active Active
- 2008-12-03 MX MX2010006084A patent/MX2010006084A/es active IP Right Grant
-
2010
- 2010-04-29 ZA ZA2010/02997A patent/ZA201002997B/en unknown
- 2010-05-13 IL IL205780A patent/IL205780A/en active IP Right Grant
- 2010-07-02 EC EC2010010327A patent/ECSP10010327A/es unknown
-
2014
- 2014-02-10 JP JP2014023217A patent/JP6063402B2/ja not_active Expired - Fee Related
- 2014-04-15 CY CY20141100281T patent/CY1115168T1/el unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990015615A1 (en) * | 1989-06-20 | 1990-12-27 | Scripps Clinic And Research Foundation | The phospholipid binding domain of factor viii |
| WO2002016410A2 (en) * | 2000-08-21 | 2002-02-28 | Apitope Technology (Bristol) Limited | Peptide selection method |
| WO2002060917A2 (en) * | 2000-12-01 | 2002-08-08 | Regents Of The University Of Minnesota | Method to treat hemophilia |
| WO2002098454A2 (en) * | 2001-05-31 | 2002-12-12 | D. Collen Research Foundation Vzw Onderwijsen Navorsing Campus Gasthuisberg K.U. Leuven | Recombinant molecules with reduced immunogenicity, methods and intermediates for obtaining them and their use in pharmaceutical compositions and diagnostic tools |
| WO2003087161A1 (en) * | 2002-04-18 | 2003-10-23 | Merck Patent Gmbh | Modified factor viii |
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| Title |
|---|
| JONES T. D. ET AL.: "Identification and removal of a promiscuous CD4+ T cell epitope from the C1 domain of factor VIII'', JOURNAL OF THROMBOSIS AND HAEMOSTASIS: JTH MAY 2005, vol. 3, no. 5, May 2005 (2005-05), pages 991-1000, XP002518538, ISSN: 1538-7933, table 1 * |
| SUGIHARA T. ET AL.: "IDENTIFICATION OF PLASMA ANTIBODY EPITOPES AND GENE ABNORMALITIES IN JAPANESE HEMOPHILIA A PATIENTS WITH FACTOR VIII INHIBITOR", NAGOYA JOURNAL OF MEDICAL SCIENCE, NAGOYA DAIGAKU IGAKUBU, NAGOYA, JP, vol. 63, no. 1/02, 1 May 2000 (2000-05-01), pages 25-39, XP008014431, ISSN: 0027-7622, table 2 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2698392C2 (ru) * | 2008-06-24 | 2019-08-26 | Октафарма Аг | Способ очистки фактора свертывания крови viii |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |