CN101889024B - Fviii肽和它们用于耐受化血友病患者的用途 - Google Patents

Fviii肽和它们用于耐受化血友病患者的用途 Download PDF

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Publication number
CN101889024B
CN101889024B CN200880119313.1A CN200880119313A CN101889024B CN 101889024 B CN101889024 B CN 101889024B CN 200880119313 A CN200880119313 A CN 200880119313A CN 101889024 B CN101889024 B CN 101889024B
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China
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arg
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Expired - Fee Related
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CN200880119313.1A
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English (en)
Chinese (zh)
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CN101889024A (zh
Inventor
戴维·赖思
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Baimingxinkang Biotechnology Zhejiang Co ltd
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Apitope International NV
Apitope Technology Bristol Ltd
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Priority to CN201310392152.6A priority Critical patent/CN103709234B/zh
Publication of CN101889024A publication Critical patent/CN101889024A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200880119313.1A 2007-12-04 2008-12-03 Fviii肽和它们用于耐受化血友病患者的用途 Expired - Fee Related CN101889024B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201310392152.6A CN103709234B (zh) 2007-12-04 2008-12-03 Fviii 肽和它们用于耐受化血友病患者的用途

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0723712.6A GB0723712D0 (en) 2007-12-04 2007-12-04 Peptides
GB0723712.6 2007-12-04
PCT/GB2008/003996 WO2009071886A1 (en) 2007-12-04 2008-12-03 Fviii peptides and their use in tolerising haemophiliacs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201310392152.6A Division CN103709234B (zh) 2007-12-04 2008-12-03 Fviii 肽和它们用于耐受化血友病患者的用途

Publications (2)

Publication Number Publication Date
CN101889024A CN101889024A (zh) 2010-11-17
CN101889024B true CN101889024B (zh) 2014-04-23

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ID=38982965

Family Applications (2)

Application Number Title Priority Date Filing Date
CN200880119313.1A Expired - Fee Related CN101889024B (zh) 2007-12-04 2008-12-03 Fviii肽和它们用于耐受化血友病患者的用途
CN201310392152.6A Expired - Fee Related CN103709234B (zh) 2007-12-04 2008-12-03 Fviii 肽和它们用于耐受化血友病患者的用途

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CN201310392152.6A Expired - Fee Related CN103709234B (zh) 2007-12-04 2008-12-03 Fviii 肽和它们用于耐受化血友病患者的用途

Country Status (25)

Country Link
US (1) US8445448B2 (https=)
EP (1) EP2227488B3 (https=)
JP (2) JP5501245B2 (https=)
KR (1) KR101519840B1 (https=)
CN (2) CN101889024B (https=)
AU (1) AU2008332968B2 (https=)
BR (1) BRPI0820143A2 (https=)
CA (2) CA3005013C (https=)
CY (1) CY1115168T1 (https=)
DK (1) DK2227488T6 (https=)
EA (1) EA019370B1 (https=)
EC (1) ECSP10010327A (https=)
ES (1) ES2458315T7 (https=)
GB (1) GB0723712D0 (https=)
HR (1) HRP20140344T4 (https=)
IL (1) IL205780A (https=)
MX (1) MX2010006084A (https=)
MY (1) MY150995A (https=)
NZ (1) NZ585217A (https=)
PL (1) PL2227488T6 (https=)
PT (1) PT2227488E (https=)
SI (1) SI2227488T1 (https=)
UA (1) UA101003C2 (https=)
WO (1) WO2009071886A1 (https=)
ZA (1) ZA201002997B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1731912T1 (sl) 2000-08-21 2014-05-30 Apitope Technology (Bristol) Limited Postopek izbire peptida
GB0801513D0 (en) * 2008-01-28 2008-03-05 Circassia Ltd Peptides from factor VIII
KR20160104740A (ko) * 2008-06-24 2016-09-05 옥타파마 아게 응고 인자 ｖｉｉｉ을 정제하는 방법
GB0908515D0 (en) * 2009-05-18 2009-06-24 Apitope Technology Bristol Ltd Peptide
SG176783A1 (en) * 2009-06-16 2012-01-30 Univ Tokai Anti-gram-negative bacteria agent
BR112013010362A2 (pt) * 2010-10-27 2016-08-02 Baxter Healthcare Sa métodos para induzir uma tolerância imune a fviii, para fazer um peptídeo fviii, e para identificar uma célula t específica de peptídeo fvii, peptídeo, composição, e, proteína de fusão
EP3970737A1 (en) 2012-01-12 2022-03-23 Bioverativ Therapeutics Inc. Reducing immunogenicity against factor viii in individuals undergoing factor viii therapy
RS56069B1 (sr) * 2012-11-12 2017-10-31 Apitope Int Nv Faktor viii-izvedenih peptida za upotrebu u lečenju hemofilije a
GB201314052D0 (en) * 2013-08-06 2013-09-18 Apitope Int Nv Peptides
CN108884140B (zh) 2015-12-03 2022-10-25 朱诺治疗学股份有限公司 修饰的嵌合受体及相关组合物和方法
CN110520149A (zh) 2016-12-02 2019-11-29 比奥维拉迪维治疗股份有限公司 诱导对凝血因子的免疫耐受性的方法
US12077607B2 (en) * 2021-09-23 2024-09-03 University Of Utah Research Foundation Functional and therapeutic effects of PAR4 cleavage by cathepsin G

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002060917A2 (en) * 2000-12-01 2002-08-08 Regents Of The University Of Minnesota Method to treat hemophilia
WO2003087161A1 (en) * 2002-04-18 2003-10-23 Merck Patent Gmbh Modified factor viii
CN1492768A (zh) * 2001-02-19 2004-04-28 Ĭ��ר�����޹�˾ 具有降低的免疫原性的人工蛋白质

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990015615A1 (en) 1989-06-20 1990-12-27 Scripps Clinic And Research Foundation The phospholipid binding domain of factor viii
BR9806793A (pt) * 1997-01-22 2000-05-16 Univ Texas Processos e composições de fator tissular para coagulação e tratamento de tumores.
SI1731912T1 (sl) * 2000-08-21 2014-05-30 Apitope Technology (Bristol) Limited Postopek izbire peptida
AU2002312660A1 (en) 2001-05-31 2002-12-16 D. Collen Research Foundation Vzw Onderwijsen Navorsing Campus Gasthuisberg K.U. Leuven Recombinant molecules with reduced immunogenicity, methods and intermediates for obtaining them and their use in pharmaceutical compositions and diagnostic tools
ES2567634T3 (es) * 2004-02-09 2016-04-25 Human Genome Sciences, Inc. Proteínas de fusión de albúmina
WO2006003183A1 (de) 2004-07-02 2006-01-12 Alois Jungbauer Peptide zur blockierung von fviii-inhibitoren
IL229645A0 (en) * 2013-11-26 2014-03-31 Omrix Biopharmaceuticals Ltd A dry bandage containing thrombin and pectin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002060917A2 (en) * 2000-12-01 2002-08-08 Regents Of The University Of Minnesota Method to treat hemophilia
CN1492768A (zh) * 2001-02-19 2004-04-28 Ĭ��ר�����޹�˾ 具有降低的免疫原性的人工蛋白质
WO2003087161A1 (en) * 2002-04-18 2003-10-23 Merck Patent Gmbh Modified factor viii

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Jones T D等.Identification and removal of a promiscuous CD4+ T cell epitope from the c1 domain of factor VIII.《Journal of thrombosis and haemostasis》.2005,第3卷(第5期),991-1000. *
Sugihara T等.Idengtification of plasma antibody epidopes and gene abnormalities in japanense hemophilia.《Nagoya Journal of Medical Science》.2000,第63卷(第1/02期),23-39. *

Also Published As

Publication number Publication date
ES2458315T3 (es) 2014-04-30
AU2008332968B2 (en) 2014-03-20
KR20100087346A (ko) 2010-08-04
JP5501245B2 (ja) 2014-05-21
EA019370B1 (ru) 2014-03-31
US8445448B2 (en) 2013-05-21
PT2227488E (pt) 2014-04-21
UA101003C2 (uk) 2013-02-25
EP2227488B1 (en) 2014-01-22
MX2010006084A (es) 2010-06-23
DK2227488T3 (da) 2014-04-22
IL205780A (en) 2015-06-30
EP2227488B3 (en) 2014-11-19
JP6063402B2 (ja) 2017-01-18
MY150995A (en) 2014-03-31
GB0723712D0 (en) 2008-01-16
CA3005013A1 (en) 2009-06-11
WO2009071886A1 (en) 2009-06-11
JP2011505414A (ja) 2011-02-24
HRP20140344T4 (hr) 2015-07-31
AU2008332968A1 (en) 2009-06-11
CA3005013C (en) 2021-11-16
EP2227488A1 (en) 2010-09-15
DK2227488T6 (en) 2015-02-16
US20100323966A1 (en) 2010-12-23
HRP20140344T1 (en) 2014-05-09
CN103709234B (zh) 2017-01-18
KR101519840B1 (ko) 2015-05-18
JP2014088440A (ja) 2014-05-15
ZA201002997B (en) 2011-07-27
ECSP10010327A (es) 2010-09-30
SI2227488T1 (sl) 2014-06-30
CN101889024A (zh) 2010-11-17
IL205780A0 (en) 2010-11-30
CY1115168T1 (el) 2016-12-14
PL2227488T6 (pl) 2015-04-30
CA2707559A1 (en) 2009-06-11
BRPI0820143A2 (pt) 2015-05-12
HK1144292A1 (en) 2011-02-11
EA201070681A1 (ru) 2010-10-29
NZ585217A (en) 2012-11-30
PL2227488T3 (pl) 2014-07-31
CA2707559C (en) 2018-07-03
CN103709234A (zh) 2014-04-09
ES2458315T7 (es) 2015-02-18

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C06 Publication
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SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: UNIVERSITEIT HASSELT

Free format text: FORMER OWNER: APITOPE TECHNOLOGY (BRISTOL) LTD.

Effective date: 20130118

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20130118

Address after: Di Pentti Beck, Belgium

Applicant after: APITOPE INTERNATIONAL N.V.

Address before: Bristol

Applicant before: APITOPE TECHNOLOGY (BRISTOL) Ltd.

C14 Grant of patent or utility model
GR01 Patent grant
TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20230328

Address after: Room 215, Building 2, No. 198, Peninsula Middle Road, Dipu Street, Anji County, Huzhou City, Zhejiang Province

Patentee after: Baimingxinkang Biotechnology (Zhejiang) Co.,Ltd.

Address before: Belgium Di Pentti Beck

Patentee before: APITOPE INTERNATIONAL N.V.

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20140423