IL205780A - Synthetic peptides capable of suppressing intravenous production of anti-factor inhibitors viii - Google Patents

Synthetic peptides capable of suppressing intravenous production of anti-factor inhibitors viii

Info

Publication number
IL205780A
IL205780A IL205780A IL20578010A IL205780A IL 205780 A IL205780 A IL 205780A IL 205780 A IL205780 A IL 205780A IL 20578010 A IL20578010 A IL 20578010A IL 205780 A IL205780 A IL 205780A
Authority
IL
Israel
Prior art keywords
vivo
factor viii
synthetic peptides
peptides capable
inhibitor antibodies
Prior art date
Application number
IL205780A
Other languages
English (en)
Hebrew (he)
Other versions
IL205780A0 (en
Original Assignee
Apitope Int Nv
Apitope Technology Bristol Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apitope Int Nv, Apitope Technology Bristol Ltd filed Critical Apitope Int Nv
Publication of IL205780A0 publication Critical patent/IL205780A0/en
Publication of IL205780A publication Critical patent/IL205780A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL205780A 2007-12-04 2010-05-13 Synthetic peptides capable of suppressing intravenous production of anti-factor inhibitors viii IL205780A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0723712.6A GB0723712D0 (en) 2007-12-04 2007-12-04 Peptides
PCT/GB2008/003996 WO2009071886A1 (en) 2007-12-04 2008-12-03 Fviii peptides and their use in tolerising haemophiliacs

Publications (2)

Publication Number Publication Date
IL205780A0 IL205780A0 (en) 2010-11-30
IL205780A true IL205780A (en) 2015-06-30

Family

ID=38982965

Family Applications (1)

Application Number Title Priority Date Filing Date
IL205780A IL205780A (en) 2007-12-04 2010-05-13 Synthetic peptides capable of suppressing intravenous production of anti-factor inhibitors viii

Country Status (25)

Country Link
US (1) US8445448B2 (https=)
EP (1) EP2227488B3 (https=)
JP (2) JP5501245B2 (https=)
KR (1) KR101519840B1 (https=)
CN (2) CN101889024B (https=)
AU (1) AU2008332968B2 (https=)
BR (1) BRPI0820143A2 (https=)
CA (2) CA3005013C (https=)
CY (1) CY1115168T1 (https=)
DK (1) DK2227488T6 (https=)
EA (1) EA019370B1 (https=)
EC (1) ECSP10010327A (https=)
ES (1) ES2458315T7 (https=)
GB (1) GB0723712D0 (https=)
HR (1) HRP20140344T4 (https=)
IL (1) IL205780A (https=)
MX (1) MX2010006084A (https=)
MY (1) MY150995A (https=)
NZ (1) NZ585217A (https=)
PL (1) PL2227488T6 (https=)
PT (1) PT2227488E (https=)
SI (1) SI2227488T1 (https=)
UA (1) UA101003C2 (https=)
WO (1) WO2009071886A1 (https=)
ZA (1) ZA201002997B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1731912T1 (sl) 2000-08-21 2014-05-30 Apitope Technology (Bristol) Limited Postopek izbire peptida
GB0801513D0 (en) * 2008-01-28 2008-03-05 Circassia Ltd Peptides from factor VIII
KR20160104740A (ko) * 2008-06-24 2016-09-05 옥타파마 아게 응고 인자 ｖｉｉｉ을 정제하는 방법
GB0908515D0 (en) * 2009-05-18 2009-06-24 Apitope Technology Bristol Ltd Peptide
SG176783A1 (en) * 2009-06-16 2012-01-30 Univ Tokai Anti-gram-negative bacteria agent
BR112013010362A2 (pt) * 2010-10-27 2016-08-02 Baxter Healthcare Sa métodos para induzir uma tolerância imune a fviii, para fazer um peptídeo fviii, e para identificar uma célula t específica de peptídeo fvii, peptídeo, composição, e, proteína de fusão
EP3970737A1 (en) 2012-01-12 2022-03-23 Bioverativ Therapeutics Inc. Reducing immunogenicity against factor viii in individuals undergoing factor viii therapy
RS56069B1 (sr) * 2012-11-12 2017-10-31 Apitope Int Nv Faktor viii-izvedenih peptida za upotrebu u lečenju hemofilije a
GB201314052D0 (en) * 2013-08-06 2013-09-18 Apitope Int Nv Peptides
CN108884140B (zh) 2015-12-03 2022-10-25 朱诺治疗学股份有限公司 修饰的嵌合受体及相关组合物和方法
CN110520149A (zh) 2016-12-02 2019-11-29 比奥维拉迪维治疗股份有限公司 诱导对凝血因子的免疫耐受性的方法
US12077607B2 (en) * 2021-09-23 2024-09-03 University Of Utah Research Foundation Functional and therapeutic effects of PAR4 cleavage by cathepsin G

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990015615A1 (en) 1989-06-20 1990-12-27 Scripps Clinic And Research Foundation The phospholipid binding domain of factor viii
BR9806793A (pt) * 1997-01-22 2000-05-16 Univ Texas Processos e composições de fator tissular para coagulação e tratamento de tumores.
SI1731912T1 (sl) * 2000-08-21 2014-05-30 Apitope Technology (Bristol) Limited Postopek izbire peptida
US20040096456A1 (en) * 2000-12-01 2004-05-20 Conti-Fine Bianca M Method to treat hemophilia
US7189830B2 (en) * 2001-02-19 2007-03-13 Merck Patent Gmbh Anti-KSA/IL-2 fusion proteins with reduced immunogenicity
AU2002312660A1 (en) 2001-05-31 2002-12-16 D. Collen Research Foundation Vzw Onderwijsen Navorsing Campus Gasthuisberg K.U. Leuven Recombinant molecules with reduced immunogenicity, methods and intermediates for obtaining them and their use in pharmaceutical compositions and diagnostic tools
JP2005538694A (ja) * 2002-04-18 2005-12-22 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 修飾されたｖｉｉｉ因子
ES2567634T3 (es) * 2004-02-09 2016-04-25 Human Genome Sciences, Inc. Proteínas de fusión de albúmina
WO2006003183A1 (de) 2004-07-02 2006-01-12 Alois Jungbauer Peptide zur blockierung von fviii-inhibitoren
IL229645A0 (en) * 2013-11-26 2014-03-31 Omrix Biopharmaceuticals Ltd A dry bandage containing thrombin and pectin

Also Published As

Publication number Publication date
ES2458315T3 (es) 2014-04-30
AU2008332968B2 (en) 2014-03-20
KR20100087346A (ko) 2010-08-04
JP5501245B2 (ja) 2014-05-21
EA019370B1 (ru) 2014-03-31
US8445448B2 (en) 2013-05-21
PT2227488E (pt) 2014-04-21
UA101003C2 (uk) 2013-02-25
EP2227488B1 (en) 2014-01-22
MX2010006084A (es) 2010-06-23
DK2227488T3 (da) 2014-04-22
EP2227488B3 (en) 2014-11-19
JP6063402B2 (ja) 2017-01-18
MY150995A (en) 2014-03-31
GB0723712D0 (en) 2008-01-16
CA3005013A1 (en) 2009-06-11
WO2009071886A1 (en) 2009-06-11
JP2011505414A (ja) 2011-02-24
HRP20140344T4 (hr) 2015-07-31
AU2008332968A1 (en) 2009-06-11
CA3005013C (en) 2021-11-16
EP2227488A1 (en) 2010-09-15
DK2227488T6 (en) 2015-02-16
US20100323966A1 (en) 2010-12-23
HRP20140344T1 (en) 2014-05-09
CN103709234B (zh) 2017-01-18
KR101519840B1 (ko) 2015-05-18
JP2014088440A (ja) 2014-05-15
ZA201002997B (en) 2011-07-27
ECSP10010327A (es) 2010-09-30
CN101889024B (zh) 2014-04-23
SI2227488T1 (sl) 2014-06-30
CN101889024A (zh) 2010-11-17
IL205780A0 (en) 2010-11-30
CY1115168T1 (el) 2016-12-14
PL2227488T6 (pl) 2015-04-30
CA2707559A1 (en) 2009-06-11
BRPI0820143A2 (pt) 2015-05-12
HK1144292A1 (en) 2011-02-11
EA201070681A1 (ru) 2010-10-29
NZ585217A (en) 2012-11-30
PL2227488T3 (pl) 2014-07-31
CA2707559C (en) 2018-07-03
CN103709234A (zh) 2014-04-09
ES2458315T7 (es) 2015-02-18

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