PT2227488E - Péptidos fviii e seu uso na tolerização de hemofílicos - Google Patents

Péptidos fviii e seu uso na tolerização de hemofílicos Download PDF

Info

Publication number
PT2227488E
PT2227488E PT88557723T PT08855772T PT2227488E PT 2227488 E PT2227488 E PT 2227488E PT 88557723 T PT88557723 T PT 88557723T PT 08855772 T PT08855772 T PT 08855772T PT 2227488 E PT2227488 E PT 2227488E
Authority
PT
Portugal
Prior art keywords
leu
ser
ile
thr
arg
Prior art date
Application number
PT88557723T
Other languages
English (en)
Portuguese (pt)
Inventor
David Wraith
Original Assignee
Apitope Int Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apitope Int Nv filed Critical Apitope Int Nv
Publication of PT2227488E publication Critical patent/PT2227488E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT88557723T 2007-12-04 2008-12-03 Péptidos fviii e seu uso na tolerização de hemofílicos PT2227488E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0723712.6A GB0723712D0 (en) 2007-12-04 2007-12-04 Peptides

Publications (1)

Publication Number Publication Date
PT2227488E true PT2227488E (pt) 2014-04-21

Family

ID=38982965

Family Applications (1)

Application Number Title Priority Date Filing Date
PT88557723T PT2227488E (pt) 2007-12-04 2008-12-03 Péptidos fviii e seu uso na tolerização de hemofílicos

Country Status (25)

Country Link
US (1) US8445448B2 (https=)
EP (1) EP2227488B3 (https=)
JP (2) JP5501245B2 (https=)
KR (1) KR101519840B1 (https=)
CN (2) CN101889024B (https=)
AU (1) AU2008332968B2 (https=)
BR (1) BRPI0820143A2 (https=)
CA (2) CA3005013C (https=)
CY (1) CY1115168T1 (https=)
DK (1) DK2227488T6 (https=)
EA (1) EA019370B1 (https=)
EC (1) ECSP10010327A (https=)
ES (1) ES2458315T7 (https=)
GB (1) GB0723712D0 (https=)
HR (1) HRP20140344T4 (https=)
IL (1) IL205780A (https=)
MX (1) MX2010006084A (https=)
MY (1) MY150995A (https=)
NZ (1) NZ585217A (https=)
PL (1) PL2227488T6 (https=)
PT (1) PT2227488E (https=)
SI (1) SI2227488T1 (https=)
UA (1) UA101003C2 (https=)
WO (1) WO2009071886A1 (https=)
ZA (1) ZA201002997B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1731912T1 (sl) 2000-08-21 2014-05-30 Apitope Technology (Bristol) Limited Postopek izbire peptida
GB0801513D0 (en) * 2008-01-28 2008-03-05 Circassia Ltd Peptides from factor VIII
KR20160104740A (ko) * 2008-06-24 2016-09-05 옥타파마 아게 응고 인자 ｖｉｉｉ을 정제하는 방법
GB0908515D0 (en) * 2009-05-18 2009-06-24 Apitope Technology Bristol Ltd Peptide
SG176783A1 (en) * 2009-06-16 2012-01-30 Univ Tokai Anti-gram-negative bacteria agent
BR112013010362A2 (pt) * 2010-10-27 2016-08-02 Baxter Healthcare Sa métodos para induzir uma tolerância imune a fviii, para fazer um peptídeo fviii, e para identificar uma célula t específica de peptídeo fvii, peptídeo, composição, e, proteína de fusão
EP3970737A1 (en) 2012-01-12 2022-03-23 Bioverativ Therapeutics Inc. Reducing immunogenicity against factor viii in individuals undergoing factor viii therapy
RS56069B1 (sr) * 2012-11-12 2017-10-31 Apitope Int Nv Faktor viii-izvedenih peptida za upotrebu u lečenju hemofilije a
GB201314052D0 (en) * 2013-08-06 2013-09-18 Apitope Int Nv Peptides
CN108884140B (zh) 2015-12-03 2022-10-25 朱诺治疗学股份有限公司 修饰的嵌合受体及相关组合物和方法
CN110520149A (zh) 2016-12-02 2019-11-29 比奥维拉迪维治疗股份有限公司 诱导对凝血因子的免疫耐受性的方法
US12077607B2 (en) * 2021-09-23 2024-09-03 University Of Utah Research Foundation Functional and therapeutic effects of PAR4 cleavage by cathepsin G

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990015615A1 (en) 1989-06-20 1990-12-27 Scripps Clinic And Research Foundation The phospholipid binding domain of factor viii
BR9806793A (pt) * 1997-01-22 2000-05-16 Univ Texas Processos e composições de fator tissular para coagulação e tratamento de tumores.
SI1731912T1 (sl) * 2000-08-21 2014-05-30 Apitope Technology (Bristol) Limited Postopek izbire peptida
US20040096456A1 (en) * 2000-12-01 2004-05-20 Conti-Fine Bianca M Method to treat hemophilia
US7189830B2 (en) * 2001-02-19 2007-03-13 Merck Patent Gmbh Anti-KSA/IL-2 fusion proteins with reduced immunogenicity
AU2002312660A1 (en) 2001-05-31 2002-12-16 D. Collen Research Foundation Vzw Onderwijsen Navorsing Campus Gasthuisberg K.U. Leuven Recombinant molecules with reduced immunogenicity, methods and intermediates for obtaining them and their use in pharmaceutical compositions and diagnostic tools
JP2005538694A (ja) * 2002-04-18 2005-12-22 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 修飾されたｖｉｉｉ因子
ES2567634T3 (es) * 2004-02-09 2016-04-25 Human Genome Sciences, Inc. Proteínas de fusión de albúmina
WO2006003183A1 (de) 2004-07-02 2006-01-12 Alois Jungbauer Peptide zur blockierung von fviii-inhibitoren
IL229645A0 (en) * 2013-11-26 2014-03-31 Omrix Biopharmaceuticals Ltd A dry bandage containing thrombin and pectin

Also Published As

Publication number Publication date
ES2458315T3 (es) 2014-04-30
AU2008332968B2 (en) 2014-03-20
KR20100087346A (ko) 2010-08-04
JP5501245B2 (ja) 2014-05-21
EA019370B1 (ru) 2014-03-31
US8445448B2 (en) 2013-05-21
UA101003C2 (uk) 2013-02-25
EP2227488B1 (en) 2014-01-22
MX2010006084A (es) 2010-06-23
DK2227488T3 (da) 2014-04-22
IL205780A (en) 2015-06-30
EP2227488B3 (en) 2014-11-19
JP6063402B2 (ja) 2017-01-18
MY150995A (en) 2014-03-31
GB0723712D0 (en) 2008-01-16
CA3005013A1 (en) 2009-06-11
WO2009071886A1 (en) 2009-06-11
JP2011505414A (ja) 2011-02-24
HRP20140344T4 (hr) 2015-07-31
AU2008332968A1 (en) 2009-06-11
CA3005013C (en) 2021-11-16
EP2227488A1 (en) 2010-09-15
DK2227488T6 (en) 2015-02-16
US20100323966A1 (en) 2010-12-23
HRP20140344T1 (en) 2014-05-09
CN103709234B (zh) 2017-01-18
KR101519840B1 (ko) 2015-05-18
JP2014088440A (ja) 2014-05-15
ZA201002997B (en) 2011-07-27
ECSP10010327A (es) 2010-09-30
CN101889024B (zh) 2014-04-23
SI2227488T1 (sl) 2014-06-30
CN101889024A (zh) 2010-11-17
IL205780A0 (en) 2010-11-30
CY1115168T1 (el) 2016-12-14
PL2227488T6 (pl) 2015-04-30
CA2707559A1 (en) 2009-06-11
BRPI0820143A2 (pt) 2015-05-12
HK1144292A1 (en) 2011-02-11
EA201070681A1 (ru) 2010-10-29
NZ585217A (en) 2012-11-30
PL2227488T3 (pl) 2014-07-31
CA2707559C (en) 2018-07-03
CN103709234A (zh) 2014-04-09
ES2458315T7 (es) 2015-02-18

Similar Documents

Publication Publication Date Title
PT2227488E (pt) Péptidos fviii e seu uso na tolerização de hemofílicos
US8703705B2 (en) Modified factor VIII peptides
DK2917232T3 (en) FACTOR VIII DERIVATIVE PEPTIDES TO USE FOR TREATMENT OF HAEMOPHYL A
HK1173358B (en) Fviii-derived peptides
HK1172240B (en) Fviii-derived peptides and their use in tolerising haemophiliacs
HK1172240A (en) Fviii-derived peptides and their use in tolerising haemophiliacs
HK1144292B (en) Fviii peptides and their use in tolerising haemophiliacs