JP5495656B2 - 皮膚用乳化化粧料 - Google Patents
皮膚用乳化化粧料 Download PDFInfo
- Publication number
- JP5495656B2 JP5495656B2 JP2009181281A JP2009181281A JP5495656B2 JP 5495656 B2 JP5495656 B2 JP 5495656B2 JP 2009181281 A JP2009181281 A JP 2009181281A JP 2009181281 A JP2009181281 A JP 2009181281A JP 5495656 B2 JP5495656 B2 JP 5495656B2
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- JP
- Japan
- Prior art keywords
- component
- skin
- emulsified cosmetic
- liposome
- fatty acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002537 cosmetic Substances 0.000 title claims description 45
- 239000002502 liposome Substances 0.000 claims description 60
- -1 fatty acid ester Chemical class 0.000 claims description 44
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 35
- 239000000194 fatty acid Substances 0.000 claims description 35
- 229930195729 fatty acid Natural products 0.000 claims description 35
- 229920001223 polyethylene glycol Polymers 0.000 claims description 31
- 239000002202 Polyethylene glycol Substances 0.000 claims description 30
- 239000000203 mixture Substances 0.000 claims description 29
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 24
- 229940106189 ceramide Drugs 0.000 claims description 21
- 150000003904 phospholipids Chemical class 0.000 claims description 16
- 239000002736 nonionic surfactant Substances 0.000 claims description 13
- 150000004665 fatty acids Chemical class 0.000 claims description 11
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims description 10
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 10
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 10
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 10
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- 238000002156 mixing Methods 0.000 claims description 6
- 238000003860 storage Methods 0.000 description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 13
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- 230000000694 effects Effects 0.000 description 12
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- 238000004519 manufacturing process Methods 0.000 description 10
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- 239000000693 micelle Substances 0.000 description 6
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
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- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 5
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- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
- IZHVBANLECCAGF-UHFFFAOYSA-N 2-hydroxy-3-(octadecanoyloxy)propyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CCCCCCCCCCCCCCCCC IZHVBANLECCAGF-UHFFFAOYSA-N 0.000 description 4
- AERBNCYCJBRYDG-UHFFFAOYSA-N D-ribo-phytosphingosine Natural products CCCCCCCCCCCCCCC(O)C(O)C(N)CO AERBNCYCJBRYDG-UHFFFAOYSA-N 0.000 description 4
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- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 description 4
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- 238000012360 testing method Methods 0.000 description 4
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 235000019482 Palm oil Nutrition 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 238000004945 emulsification Methods 0.000 description 3
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- 150000002632 lipids Chemical class 0.000 description 3
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 3
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- 239000002540 palm oil Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- AERBNCYCJBRYDG-KSZLIROESA-N phytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO AERBNCYCJBRYDG-KSZLIROESA-N 0.000 description 3
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- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical compound CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 description 2
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 2
- FFJCNSLCJOQHKM-CLFAGFIQSA-N (z)-1-[(z)-octadec-9-enoxy]octadec-9-ene Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCCCCCCC\C=C/CCCCCCCC FFJCNSLCJOQHKM-CLFAGFIQSA-N 0.000 description 2
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- ASKIVFGGGGIGKH-UHFFFAOYSA-N 2,3-dihydroxypropyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(O)CO ASKIVFGGGGIGKH-UHFFFAOYSA-N 0.000 description 2
- ZVUNTIMPQCQCAQ-UHFFFAOYSA-N 2-dodecanoyloxyethyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCC ZVUNTIMPQCQCAQ-UHFFFAOYSA-N 0.000 description 2
- MUHFRORXWCGZGE-KTKRTIGZSA-N 2-hydroxyethyl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCCO MUHFRORXWCGZGE-KTKRTIGZSA-N 0.000 description 2
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 2
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- 239000004215 Carbon black (E152) Substances 0.000 description 2
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 description 2
- 239000004166 Lanolin Substances 0.000 description 2
- BBAFBDLICMHBNU-MFZOPHKMSA-N N-(2-hydroxyoctadecanoyl)-4-hydroxysphinganine Chemical compound CCCCCCCCCCCCCCCCC(O)C(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC BBAFBDLICMHBNU-MFZOPHKMSA-N 0.000 description 2
- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 description 2
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- 239000004147 Sorbitan trioleate Substances 0.000 description 2
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 description 2
- CMPDPBDUZTUXAD-UHFFFAOYSA-N [3-hydroxy-2-(16-methylheptadecanoyloxy)propyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCCCCCCCC(C)C CMPDPBDUZTUXAD-UHFFFAOYSA-N 0.000 description 2
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Description
〔1〕リポソームと、非イオン性界面活性剤とを含有してなる皮膚用乳化化粧料であって、該リポソームは、(A)リン脂質、(B)セラミド類および(C)ポリエチレングリコール脂肪酸エステルから形成され、(C)成分が、酸化エチレンの付加モル数が10〜40のモノ脂肪酸ポリエチレングリコールであり、(A)成分、および(C)成分の含有量が、下記含有質量比、
(C)成分/(A)成分=0.01〜1
の範囲を満たすことを特徴とする皮膚用乳化化粧料、
〔2〕(A)成分が、水素添加リン脂質である前記〔1〕に記載の皮膚用乳化化粧料、
〔3〕(A)成分、(B)成分および(C)成分の含有量が、下記含有質量比、
(C)成分/((A)成分+(B)成分)=0.02〜0.34
の範囲を満たすことを特徴とする前記〔1〕又は〔2〕に記載の皮膚用乳化化粧料、
〔4〕前記非イオン性界面活性剤を0.3〜10質量%含有することを特徴とする前記〔1〕〜〔3〕の何れか一つに記載の皮膚用乳化化粧料、
〔5〕前記リポソームが、更に、分岐鎖高級アルコールおよび/又は不飽和鎖高級アルコールから形成される前記〔1〕〜〔4〕の何れか一つに記載の皮膚用乳化化粧料、
〔6〕(A)成分、および前記分岐鎖高級アルコールおよび/又は不飽和鎖高級アルコールの含有量が、下記含有質量比、
(分岐鎖高級アルコールおよび/又は不飽和鎖高級アルコール)/(A)成分=0.01〜1
の範囲を満たすことを特徴とする前記〔5〕に記載の皮膚用乳化化粧料、
並びに、
〔7〕前記〔1〕〜〔6〕の何れか一つに記載の皮膚用乳化化粧料が、前記(A)成分〜(C)成分で形成されてなるリポソームを含む組成物を、前記非イオン性界面活性剤により乳化した組成物に配合されることにより調製されることを特徴とする皮膚用乳化化粧料に関する。
(C)成分/((A)成分+(B)成分)=0.02〜0.34
の範囲を満たすことが好ましく、0.08〜0.27の範囲を満たすことがより好ましい。含有質量比が0.02未満、或いは0.34よりも大きい場合には、リポソームの分散性に劣り、保存安定性に悪影響を及ぼすために好ましくない。
表1および表2に記した組成に従い、製造例1〜10の各リポソームを含有する組成物を常法に準じて調製した。
表3および表4に記した組成に従い、実施例1〜5および比較例1〜5の各皮膚用乳化化粧料を常法に準じて調製し、下記評価に供した。結果を表3および表4に併記する。
各実施例および各比較例で得られた試料の製造直後のリポソームの形態を透過型電子顕微鏡により観察し、以下の評価基準に従って評価した。
尚、透過型電子顕微鏡での観察は、ネガティブ染色法で行った。
○:リポソームの形態が崩壊していない
△:リポソームの形態が一部崩壊しミセル化又は析出している
×:リポソームの形態が全崩壊しミセル化又は析出している
試験例1の評価後、50mL容の透明ガラス容器にそれぞれ封入し、40℃の恒温槽に夫々6週間保存した後のリポソームの形態を透過型電子顕微鏡により観察し、以下の評価基準に従って評価した。
尚、透過型電子顕微鏡での観察は、試験例1と同法で行った。
○:製造直後と全く変化が認められない
△:リポソームの形態が一部崩壊しミセル化している
×:リポソームの形態が全崩壊しミセル化している
Claims (7)
- リポソームと、非イオン性界面活性剤とを含有してなる皮膚用乳化化粧料であって、該リポソームは、(A)リン脂質、(B)セラミド類および(C)ポリエチレングリコール脂肪酸エステルから形成され、(C)成分が、酸化エチレンの付加モル数が10〜40のモノ脂肪酸ポリエチレングリコールであり、
(A)成分、および(C)成分の含有量が、下記含有質量比、
(C)成分/(A)成分=0.01〜1
の範囲を満たすことを特徴とする皮膚用乳化化粧料。 - (A)成分が、水素添加リン脂質である請求項1に記載の皮膚用乳化化粧料。
- (A)成分、(B)成分および(C)成分の含有量が、下記含有質量比、
(C)成分/((A)成分+(B)成分)=0.02〜0.34
の範囲を満たすことを特徴とする請求項1又は2に記載の皮膚用乳化化粧料。 - 前記非イオン性界面活性剤を0.3〜10質量%含有することを特徴とする請求項1〜3の何れか一項に記載の皮膚用乳化化粧料。
- 前記リポソームが、更に、分岐鎖高級アルコールおよび/又は不飽和鎖高級アルコールから形成される請求項1〜4の何れか一項に記載の皮膚用乳化化粧料。
- (A)成分、および前記分岐鎖高級アルコールおよび/又は不飽和鎖高級アルコールの含有量が、下記含有質量比、
(分岐鎖高級アルコールおよび/又は不飽和鎖高級アルコール)/(A)成分=0.01〜1
の範囲を満たすことを特徴とする請求項5に記載の皮膚用乳化化粧料。 - 請求項1〜6の何れか一項に記載の皮膚用乳化化粧料が、前記(A)成分〜(C)成分で形成されてなるリポソームを含む組成物を、前記非イオン性界面活性剤により乳化した組成物に配合されることにより調製されることを特徴とする皮膚用乳化化粧料。
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