JP6632735B2 - 化粧料用組成物 - Google Patents
化粧料用組成物 Download PDFInfo
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- JP6632735B2 JP6632735B2 JP2018542415A JP2018542415A JP6632735B2 JP 6632735 B2 JP6632735 B2 JP 6632735B2 JP 2018542415 A JP2018542415 A JP 2018542415A JP 2018542415 A JP2018542415 A JP 2018542415A JP 6632735 B2 JP6632735 B2 JP 6632735B2
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- cosmetic
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- 239000002537 cosmetic Substances 0.000 title claims description 115
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- 241001135917 Vitellaria paradoxa Species 0.000 description 1
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- 230000004888 barrier function Effects 0.000 description 1
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- RIZIAUKTHDLMQX-UHFFFAOYSA-N cerebroside D Natural products CCCCCCCCCCCCCCCCC(O)C(=O)NC(C(O)C=CCCC=C(C)CCCCCCCCC)COC1OC(CO)C(O)C(O)C1O RIZIAUKTHDLMQX-UHFFFAOYSA-N 0.000 description 1
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- 238000010438 heat treatment Methods 0.000 description 1
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- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
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- 150000002632 lipids Chemical class 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
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- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 150000008105 phosphatidylcholines Chemical class 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
- 150000003905 phosphatidylinositols Chemical class 0.000 description 1
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- AERBNCYCJBRYDG-KSZLIROESA-N phytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO AERBNCYCJBRYDG-KSZLIROESA-N 0.000 description 1
- 229940061570 polyglyceryl-10 stearate Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 229940057910 shea butter Drugs 0.000 description 1
- 235000015500 sitosterol Nutrition 0.000 description 1
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
- 229950005143 sitosterol Drugs 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940083466 soybean lecithin Drugs 0.000 description 1
- 150000003408 sphingolipids Chemical class 0.000 description 1
- GHIZCSMTYWOBQA-BZSCQJQFSA-N spinasterol Natural products CC[C@H](C=C[C@@H](C)[C@@H]1CC[C@@]2(C)C3=CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C)C(C)C GHIZCSMTYWOBQA-BZSCQJQFSA-N 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- HCXVJBMSMIARIN-PHZDYDNGSA-N stigmasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)[C@@]1(C)CC2 HCXVJBMSMIARIN-PHZDYDNGSA-N 0.000 description 1
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- BFDNMXAIBMJLBB-UHFFFAOYSA-N stigmasterol Natural products CCC(C=CC(C)C1CCCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C BFDNMXAIBMJLBB-UHFFFAOYSA-N 0.000 description 1
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- 239000000080 wetting agent Substances 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
- A61K2800/262—Transparent; Translucent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Description
下記成分Aと、下記成分Bと、下記成分Cと、下記成分Dと、下記成分Eと、下記成分Fとを含有し、
上記成分Aに対する上記成分Bの質量比(B/A)が5.5〜18.0である、化粧料用組成物に関する。
成分A:リン脂質
成分B:オキシエチレンの平均付加モル数が15〜50のポリオキシエチレンステロールエーテル及び/又はオキシエチレンの平均付加モル数が15〜50のポリオキシエチレンスタノールエーテル
成分C:分岐鎖を有する炭素数12〜24の1価の脂肪族アルコール
成分D:プロピレングリコール、ジプロピレングリコール及び1,3−ブチレングリコールからなる群より選ばれた一種以上の多価アルコール
成分E:水
成分F:セラミド及び/又はステロール
表1〜3に記した組成に従い、実施例1〜18及び比較例1〜9の各化粧料用組成物を常法に準じて調製した。表1〜3における各成分の値は質量%である。なお、実施例1の化粧料用組成物の25℃でのpHと、上記の測定方法に従い25℃での粘度を測定したところ、pHは6.5であった。
調製直後の、各実施例及び比較例の化粧料用組成物について、分光光度計(島津製作所社製、紫外可視分光光度計、UV−2600)を用い、波長660nmの条件で透過率を測定した。結果を表1〜3に示す。
各実施例及び比較例の化粧料用組成物を、5℃又は40℃で14日間保存した。保存後の各化粧料用組成物の外観を目視観察することによって、各化粧料用組成物の安定性を評価した。具体的には、分離の有無、析出物や澱の発生の有無を評価した。保存後の化粧料用組成物に、分離、析出物又は澱が全く見られなかった場合、保存安定性良好(○)と評価した。一方、保存後の化粧料用組成物に分離、析出物又は澱が見られた場合、保存安定性不良(×)と評価した。結果を表1〜3に示す。
水添リン脂質:水素添加大豆レシチン
POE−25フィトスタノール:日光ケミカルズ社製、商品名「BPSH−25」
POE−20フィトステロール:日光ケミカルズ社製、商品名「BPS−20」
POE−30フィトステロール:日光ケミカルズ社製、商品名「BPS−30」
POE−5フィトステロール:日光ケミカルズ社製、商品名「BPS−5」
POE−10フィトステロール:日光ケミカルズ社製、商品名「BPS−10」
セラミド:セラミド2
ステロール:フィトステロール
成分Aを全く含まない組成物(比較例1)では、製造直後の透過率は高いものの、直ぐに凝集、析出が生じ、低温及び高温での析出物が見られた。成分Bを含まない組成物(比較例2〜4)では、分散物の粒径が大きく明らかに濁っており、透過率が極めて低いだけではなく、低温及び高温での析出物も見られた。成分Cを含まない組成物(比較例5〜6)では、製造直後の透過率は高いものの、経時的に析出が生じ、低温及び高温での析出物が見られた。成分Dに代えて多価アルコールのグリセリンを使用した組成物(比較例7)では、組成物の製造時に配合成分の溶解性が不良であり安定性が悪く、透過率は低く、低温及び高温での析出物も見られた。B/A値が本発明に規定された範囲外である組成物(比較例8〜9)では、組成物の分散性が低下し、透過率はやや不十分であり、低温及び高温での析出物が見られた。
表4に記した組成に従い、実施例19〜21の各化粧水を常法に準じて調製した。
水添リン脂質 0.6質量%
POE−25フィトスタノール 5.0質量%
オクチルドデカノール 0.2質量%
プロピレングリコール 10.0質量%
精製水 残部
セラミド−2 0.2質量%
フィトステロール 0.2質量%
オクトキシグリセリン 0.5質量%
1,2−デカンジオール 0.5質量%
フェノキシエタノール 0.2質量%
香料 0.03質量%
l−メントール 0.05質量%
コメ胚芽油 0.1質量%
合計 100質量%
精製水 残部
グリセリン 10.0質量%
1,3−ブチレングリコール 5.0質量%
キサンタンガム 0.05質量%
カルボマー 0.1質量%
水酸化カリウム 0.05質量%
ベヘニルアルコール 0.3質量%
ステアリン酸ポリグリセリル−10 1.5質量%
ステアリン酸グリセリル 0.5質量%
スクワラン 5.0質量%
トリ−2エチルヘキサン酸グリセリル 5.0質量%
ジメチコン 0.5質量%
フェノキシエタノール 0.2質量%
エタノール 5.0質量%
実施例1で得られた化粧料用組成物 5.0質量%
合計 100質量%
精製水 残部
グリセリン 10.0質量%
1,3−ブチレングリコール 5.0質量%
キサンタンガム 0.08質量%
カルボマー 0.15質量%
水酸化カリウム 0.09質量%
ベヘニルアルコール 0.5質量%
ステアリン酸 1.0質量%
ステアリン酸ポリグリセリル−10 1.5質量%
ステアリン酸グリセリル 1.5質量%
スクワラン 7.0質量%
トリ−2エチルヘキサン酸グリセリル 5.0質量%
シア脂 1.5質量%
ジメチコン 1.0質量%
フェノキシエタノール 0.2質量%
エタノール 5.0質量%
実施例1で得られた化粧料用組成物 5.0質量%
合計 100質量%
Claims (4)
- 下記成分Aと、下記成分Bと、下記成分Cと、下記成分Dと、下記成分Eと、下記成分Fとを含有し、
前記成分Aに対する前記成分Bの質量比(B/A)が5.5〜18.0であり、
前記成分Aに対する前記成分Cの質量比(C/A)が0.05〜1.0であり、
前記成分Aに対する前記成分Dの質量比(D/A)が8.0〜60.0である、化粧料用組成物。
成分A:リン脂質
成分B:オキシエチレンの平均付加モル数が15〜50のポリオキシエチレンステロールエーテル及び/又はオキシエチレンの平均付加モル数が15〜50のポリオキシエチレンスタノールエーテル
成分C:分岐鎖を有する炭素数12〜24の1価の脂肪族アルコール
成分D:プロピレングリコール、ジプロピレングリコール及び1,3−ブチレングリコールからなる群より選ばれた一種以上の多価アルコール
成分E:水
成分F:セラミド及び/又はステロール - 前記成分Aの含有量が0.005〜3.0質量%である、請求項1に記載の化粧料用組成物。
- さらに下記成分Gを含有する、請求項1又は2に記載の化粧料用組成物。
成分G:炭素数5〜10の1,2−アルカンジオール - さらに下記成分Hを含有する、請求項1〜3のいずれか1項に記載の化粧料用組成物。
成分H:グリセリンモノ2−エチルヘキシルエーテル
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PCT/JP2017/033654 WO2018061854A1 (ja) | 2016-09-28 | 2017-09-19 | 化粧料用組成物 |
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