JP7384518B2 - 難溶性成分安定化用組成物及びそれを含む化粧料組成物 - Google Patents
難溶性成分安定化用組成物及びそれを含む化粧料組成物 Download PDFInfo
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- JP7384518B2 JP7384518B2 JP2021527207A JP2021527207A JP7384518B2 JP 7384518 B2 JP7384518 B2 JP 7384518B2 JP 2021527207 A JP2021527207 A JP 2021527207A JP 2021527207 A JP2021527207 A JP 2021527207A JP 7384518 B2 JP7384518 B2 JP 7384518B2
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- Japan
- Prior art keywords
- poorly soluble
- composition
- stabilizing
- hydrogenated lecithin
- anionic surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002552 dosage form Substances 0.000 claims description 43
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- ZCOLJUOHXJRHDI-CMWLGVBASA-N genistein 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 ZCOLJUOHXJRHDI-CMWLGVBASA-N 0.000 description 1
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- NNUVCMKMNCKPKN-UHFFFAOYSA-N glycitein Natural products COc1c(O)ccc2OC=C(C(=O)c12)c3ccc(O)cc3 NNUVCMKMNCKPKN-UHFFFAOYSA-N 0.000 description 1
- LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical compound COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 description 1
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- SZUJJDLBXJCDNT-ZCNNSNEGSA-N n-[(2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl]acetamide Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(C)=O SZUJJDLBXJCDNT-ZCNNSNEGSA-N 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
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- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- UHGIMQLJWRAPLT-UHFFFAOYSA-N octadecyl dihydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCCCOP(O)(O)=O UHGIMQLJWRAPLT-UHFFFAOYSA-N 0.000 description 1
- HMMGMWAXVFQUOA-UHFFFAOYSA-N octamethylcyclotetrasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 HMMGMWAXVFQUOA-UHFFFAOYSA-N 0.000 description 1
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 1
- 229940073665 octyldodecyl myristate Drugs 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229940046947 oleth-10 phosphate Drugs 0.000 description 1
- 229940093440 oleth-3-phosphate Drugs 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
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- 229960003764 polydatin Drugs 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
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- 230000002335 preservative effect Effects 0.000 description 1
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- 229960003471 retinol Drugs 0.000 description 1
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- 229940008424 tetradecamethylhexasiloxane Drugs 0.000 description 1
- BORJONZPSTVSFP-UHFFFAOYSA-N tetradecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)C(C)O BORJONZPSTVSFP-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/49—Solubiliser, Solubilising system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/54—Polymers characterized by specific structures/properties
- A61K2800/542—Polymers characterized by specific structures/properties characterized by the charge
- A61K2800/5424—Polymers characterized by specific structures/properties characterized by the charge anionic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Saccharide Compounds (AREA)
Description
1-1.難溶性成分安定化用組成物の製造
表1に示すように、様々な種類の配合成分を含む化粧料組成物を製造した。
製造例1で製造した難溶性成分安定化用組成物の剤形が透明であるかを確認するために、製造例1で組成物を製造した直後の性状を観察した。剤形性状の比較は、肉眼で濁度の程度を確認し、濁度計を用いて濁度を測定した。濁度の測定は、光散乱法により濁度を測定するHACH社のTL2350モデルを用いて測定し、計5回の測定の平均値で示す。各実施例は25℃で測定した。その結果を表3に示す。
難溶性成分の安定化に適した水添レシチン及びアニオン性界面活性剤の条件を調べるために、実施例1~8の化粧料組成物の経時的な剤形安定性を評価した。実験例1と同様の方法で剤形性状の比較実験を行った。その結果を表4及び表5に示す。
2-1.難溶性成分を含む化粧料組成物の製造
実験例1において、水添レシチンとアニオン性界面活性剤の混合比が1:0.2である実施例4の難溶性成分安定化用組成物が安定性に最も優れることが確認されたので、実施例4の難溶性成分安定化用組成物に難溶性成分を適用して実際に化粧料組成物を製造した。
難溶性効果成分(セドロール)に適した条件を調べるために、実施例9~11、比較例1、2の化粧料組成物の剤形安定性を評価した。安定性評価は、透明プラスチック容器に蓋をして密封し、常温の条件で保管して肉眼及び顕微鏡で評価した。その結果を表7に示す。
3-1.低粘度及び高粘度の透明な化粧料組成物の製造
表8に示す成分及び含有量で低粘度及び高粘度の透明な化粧料組成物を製造した。製造方法は、実験例2-1と同様のものとした。
難溶性効果成分を含む様々な剤形(低粘度及び高粘度の透明な剤形)の安定性を確認するために、実施例12~14の安定性を評価した。安定性評価は、透明プラスチック容器に蓋をして密封し、常温及び-20℃の条件で保管して肉眼で観察した。その結果を表9に示す。
Claims (5)
- 水添レシチン及びアニオン性界面活性剤を有効成分として含む難溶性成分安定化用組成物であって、
前記アニオン性界面活性剤は、ジラウラミドグルタミドリシンナトリウムであり、
前記水添レシチンと前記ジラウラミドグルタミドリシンナトリウムの混合比は、重量で1:0.6~1:0.8であり、
前記水添レシチンは、難溶性成分安定化用組成物の総重量に対して0.5~5重量%含まれ、
前記難溶性成分は、セドロール(cedrol)である、難溶性成分安定化用組成物。 - 前記組成物は、オイルをさらに含む、請求項1に記載の難溶性成分安定化用組成物。
- 請求項1又は2に記載の難溶性成分安定化用組成物及び難溶性成分を含む化粧料組成物。
- 水添レシチンとアニオン性界面活性剤を混合するステップを含む、難溶性成分を化粧料の剤形に安定化させる方法であって、
前記アニオン性界面活性剤は、ジラウラミドグルタミドリシンナトリウムであり、
前記水添レシチンと前記ジラウラミドグルタミドリシンナトリウムの混合比は、重量で1:0.6~1:0.8であり、
前記水添レシチンは、難溶性成分安定化用組成物の総重量に対して0.5~5重量%含まれ、
前記難溶性成分は、セドロール(cedrol)である、難溶性成分を化粧料の剤形に安定化させる方法。 - (S1)溶媒に難溶性成分、水添レシチン及びアニオン性界面活性剤を添加するステップと、
(S2)前記S1ステップの生成物を水相に添加するステップと
を含み、
前記アニオン性界面活性剤は、ジラウラミドグルタミドリシンナトリウムであり、
前記水添レシチンと前記ジラウラミドグルタミドリシンナトリウムの混合比は、重量で1:0.6~1:0.8であり、
前記水添レシチンは、難溶性成分安定化用組成物の総重量に対して0.5~5重量%含まれ、
前記難溶性成分は、セドロール(cedrol)である、難溶性成分が溶解した化粧料組成物の製造方法。
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US20210401711A1 (en) | 2021-12-30 |
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