JP5490811B2 - アポａに対して活性なチエノトリアゾロジアゼピン誘導体 - Google Patents
アポａに対して活性なチエノトリアゾロジアゼピン誘導体 Download PDFInfo
- Publication number
- JP5490811B2 JP5490811B2 JP2011533714A JP2011533714A JP5490811B2 JP 5490811 B2 JP5490811 B2 JP 5490811B2 JP 2011533714 A JP2011533714 A JP 2011533714A JP 2011533714 A JP2011533714 A JP 2011533714A JP 5490811 B2 JP5490811 B2 JP 5490811B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- meta
- och
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 Cc([s]cc1)c1C(C1=CC=C*(*)C=C1)=NC(*)(*)C(N)=S Chemical compound Cc([s]cc1)c1C(C1=CC=C*(*)C=C1)=NC(*)(*)C(N)=S 0.000 description 2
- JWIQYQISCWWDAJ-UHFFFAOYSA-N CC(C)(c1nnc(C)[n]1-c1c2cc[s]1)N=C2c1ccccc1 Chemical compound CC(C)(c1nnc(C)[n]1-c1c2cc[s]1)N=C2c1ccccc1 JWIQYQISCWWDAJ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08167982.1 | 2008-10-30 | ||
| EP08167982 | 2008-10-30 | ||
| PCT/EP2009/064243 WO2010049466A1 (en) | 2008-10-30 | 2009-10-29 | Thienotriazolodiazepine derivatives active on apo a |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012506896A JP2012506896A (ja) | 2012-03-22 |
| JP2012506896A5 JP2012506896A5 (pt-PT) | 2012-12-20 |
| JP5490811B2 true JP5490811B2 (ja) | 2014-05-14 |
Family
ID=40380148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011533714A Expired - Fee Related JP5490811B2 (ja) | 2008-10-30 | 2009-10-29 | アポａに対して活性なチエノトリアゾロジアゼピン誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8569288B2 (pt-PT) |
| EP (1) | EP2362876B1 (pt-PT) |
| JP (1) | JP5490811B2 (pt-PT) |
| KR (1) | KR101633742B1 (pt-PT) |
| CN (1) | CN102292341B (pt-PT) |
| AU (1) | AU2009309691B2 (pt-PT) |
| BR (1) | BRPI0914406A2 (pt-PT) |
| CA (1) | CA2741934C (pt-PT) |
| EA (1) | EA018620B1 (pt-PT) |
| ES (1) | ES2448567T3 (pt-PT) |
| WO (1) | WO2010049466A1 (pt-PT) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2118074T3 (pl) | 2007-02-01 | 2014-06-30 | Resverlogix Corp | Związki chemiczne do celów profilaktyki i leczenia chorób układu sercowo-naczyniowego |
| US9238640B2 (en) | 2009-03-18 | 2016-01-19 | Resverlogix Corp. | Anti-inflammatory agents |
| NZ596117A (en) | 2009-04-22 | 2014-10-31 | Resverlogix Corp | Novel anti-inflammatory agents |
| HUE031073T2 (en) | 2010-05-14 | 2017-06-28 | Dana Farber Cancer Inst Inc | Thieno triazolo-diazepine compounds for the treatment of neoplasia |
| WO2011143651A1 (en) * | 2010-05-14 | 2011-11-17 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for modulating metabolism |
| EP2569434B1 (en) | 2010-05-14 | 2019-09-04 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating leukemia and related disorders |
| US9301962B2 (en) | 2010-05-14 | 2016-04-05 | Baylor College Of Medicine | Male contraceptive compositions and methods of use |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| US9249161B2 (en) | 2010-12-02 | 2016-02-02 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| US9422292B2 (en) | 2011-05-04 | 2016-08-23 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| EP2721031B1 (en) | 2011-06-17 | 2016-01-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| EP2864336B1 (en) | 2012-06-06 | 2016-11-23 | Constellation Pharmaceuticals, Inc. | Benzo[b]isoxazoloazepine bromodomain inhibitors and uses thereof |
| KR20160034379A (ko) | 2013-07-25 | 2016-03-29 | 다나-파버 캔서 인스티튜트 인크. | 전사 인자의 억제제 및 그의 용도 |
| WO2015070020A2 (en) | 2013-11-08 | 2015-05-14 | Dana-Farber Cancer Institute, Inc. | Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors |
| CA2936865A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
| EP3099693A4 (en) | 2014-01-31 | 2017-08-16 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
| AU2015222805B2 (en) | 2014-02-28 | 2020-05-21 | Tensha Therapeutics, Inc. | Treatment of conditions associated with hyperinsulinaemia |
| EP3157928B1 (en) | 2014-06-20 | 2019-02-13 | Constellation Pharmaceuticals, Inc. | Crystalline forms of 2-((4s)-6-(4-chlorophenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide |
| CN106715437A (zh) | 2014-08-08 | 2017-05-24 | 达纳-法伯癌症研究所股份有限公司 | 二氮杂环庚烷衍生物及其用途 |
| CA2955077A1 (en) | 2014-08-08 | 2016-02-11 | Dana-Farber Cancer Institute, Inc. | Dihydropteridinone derivatives and uses thereof |
| BR112017008714A2 (pt) | 2014-10-27 | 2017-12-19 | Tensha Therapeutics Inc | inibidores de bromodomínio |
| CN114984016A (zh) | 2015-03-13 | 2022-09-02 | 雷斯韦洛吉克斯公司 | 用于治疗补体相关疾病之组合物及治疗方法 |
| AU2016276963C1 (en) | 2015-06-12 | 2021-08-05 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| PE20181086A1 (es) | 2015-09-11 | 2018-07-05 | Dana Farber Cancer Inst Inc | Acetamida tienotrizolodiazepinas y usos de las mismas |
| WO2017044849A1 (en) | 2015-09-11 | 2017-03-16 | Dana-Farber Cancer Institute, Inc. | Cyano thienotriazolodiazepines and uses thereof |
| SG10201913450PA (en) | 2015-11-25 | 2020-03-30 | Dana Farber Cancer Inst Inc | Bivalent bromodomain inhibitors and uses thereof |
| KR20210020889A (ko) | 2018-06-13 | 2021-02-24 | 디블라이 아게 | 응축된 트리아제핀 유도체의 제조 및 이의 bet 억제제로서 용도 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4155913A (en) * | 1973-02-08 | 1979-05-22 | Hoffmann-La Roche Inc. | Thienotriazolodiazepine derivatives |
| DE3435973A1 (de) * | 1984-10-01 | 1986-04-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung |
| ATE86256T1 (de) * | 1987-05-28 | 1993-03-15 | Yoshitomi Pharmaceutical | Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben. |
| WO1997009048A1 (en) * | 1995-09-09 | 1997-03-13 | F. Hoffmann-La Roche Ag | Use of a thienotriazolodiazepine to increase apolipoprotein a-i levels |
| US6444664B1 (en) * | 1997-04-18 | 2002-09-03 | Nederlandse Organisatie Voor Toegepast - Natuurweten Schappelijk Onderzoek (Tno) | Method for controlling the plasma level of lipoproteins to treat alzheimeris disease |
-
2009
- 2009-10-29 ES ES09740899.1T patent/ES2448567T3/es active Active
- 2009-10-29 EP EP09740899.1A patent/EP2362876B1/en not_active Not-in-force
- 2009-10-29 US US13/126,600 patent/US8569288B2/en not_active Expired - Fee Related
- 2009-10-29 WO PCT/EP2009/064243 patent/WO2010049466A1/en active Application Filing
- 2009-10-29 JP JP2011533714A patent/JP5490811B2/ja not_active Expired - Fee Related
- 2009-10-29 CN CN200980150891.6A patent/CN102292341B/zh not_active Expired - Fee Related
- 2009-10-29 BR BRPI0914406A patent/BRPI0914406A2/pt active Search and Examination
- 2009-10-29 KR KR1020117012290A patent/KR101633742B1/ko active IP Right Grant
- 2009-10-29 CA CA2741934A patent/CA2741934C/en not_active Expired - Fee Related
- 2009-10-29 EA EA201100698A patent/EA018620B1/ru not_active IP Right Cessation
- 2009-10-29 AU AU2009309691A patent/AU2009309691B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EA201100698A1 (ru) | 2011-12-30 |
| BRPI0914406A2 (pt) | 2015-10-20 |
| EP2362876A1 (en) | 2011-09-07 |
| WO2010049466A1 (en) | 2010-05-06 |
| CN102292341B (zh) | 2014-09-10 |
| AU2009309691B2 (en) | 2015-04-02 |
| KR101633742B1 (ko) | 2016-06-27 |
| CA2741934C (en) | 2016-09-13 |
| KR20110091523A (ko) | 2011-08-11 |
| AU2009309691A1 (en) | 2010-05-06 |
| US20110230460A1 (en) | 2011-09-22 |
| CA2741934A1 (en) | 2010-05-06 |
| EP2362876B1 (en) | 2013-12-11 |
| CN102292341A (zh) | 2011-12-21 |
| JP2012506896A (ja) | 2012-03-22 |
| US8569288B2 (en) | 2013-10-29 |
| ES2448567T3 (es) | 2014-03-14 |
| EA018620B1 (ru) | 2013-09-30 |
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Legal Events
| Date | Code | Title | Description |
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| LAPS | Cancellation because of no payment of annual fees |