JP5479346B2 - ピリミジン置換プリン誘導体 - Google Patents

ピリミジン置換プリン誘導体 Download PDF

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Publication number
JP5479346B2
JP5479346B2 JP2010527915A JP2010527915A JP5479346B2 JP 5479346 B2 JP5479346 B2 JP 5479346B2 JP 2010527915 A JP2010527915 A JP 2010527915A JP 2010527915 A JP2010527915 A JP 2010527915A JP 5479346 B2 JP5479346 B2 JP 5479346B2
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Japan
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group
optionally substituted
substituted
alkyl
optionally
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Japanese (ja)
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JP2010540625A5 (https=
JP2010540625A (ja
Inventor
ナガラジ，ハリシュ・クマー・マイソール
ウィリアムズ，メレディス
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Verastem Inc
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Verastem Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2010527915A 2007-10-05 2008-10-03 ピリミジン置換プリン誘導体 Expired - Fee Related JP5479346B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97772007P 2007-10-05 2007-10-05
US60/977,720 2007-10-05
US7553208P 2008-06-25 2008-06-25
US61/075,532 2008-06-25
PCT/SG2008/000379 WO2009045175A1 (en) 2007-10-05 2008-10-03 Pyrimidine substituted purine derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013253369A Division JP5885729B2 (ja) 2007-10-05 2013-12-06 ピリミジン置換プリン誘導体

Publications (3)

Publication Number Publication Date
JP2010540625A JP2010540625A (ja) 2010-12-24
JP2010540625A5 JP2010540625A5 (https=) 2011-12-01
JP5479346B2 true JP5479346B2 (ja) 2014-04-23

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Family Applications (2)

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JP2010527915A Expired - Fee Related JP5479346B2 (ja) 2007-10-05 2008-10-03 ピリミジン置換プリン誘導体
JP2013253369A Expired - Fee Related JP5885729B2 (ja) 2007-10-05 2013-12-06 ピリミジン置換プリン誘導体

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Country Status (16)

Country Link
US (3) US8247410B2 (https=)
EP (1) EP2209786B1 (https=)
JP (2) JP5479346B2 (https=)
KR (3) KR101643237B1 (https=)
CN (2) CN101889015B (https=)
AU (1) AU2008307798B2 (https=)
BR (1) BRPI0817503B8 (https=)
CA (1) CA2701581C (https=)
DK (1) DK2209786T3 (https=)
ES (1) ES2406129T3 (https=)
IL (2) IL204804A (https=)
MX (1) MX2010003668A (https=)
MY (1) MY150993A (https=)
RU (2) RU2681081C2 (https=)
WO (1) WO2009045175A1 (https=)
ZA (1) ZA201003118B (https=)

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Also Published As

Publication number Publication date
EP2209786B1 (en) 2013-02-27
JP2014139159A (ja) 2014-07-31
MX2010003668A (es) 2010-07-02
AU2008307798A1 (en) 2009-04-09
US20100298319A1 (en) 2010-11-25
AU2008307798B2 (en) 2013-10-03
EP2209786A1 (en) 2010-07-28
CN101889015A (zh) 2010-11-17
KR20100075609A (ko) 2010-07-02
IL204804A0 (en) 2010-11-30
RU2010117737A (ru) 2011-11-10
WO2009045175A1 (en) 2009-04-09
DK2209786T3 (da) 2013-06-03
CN104119336A (zh) 2014-10-29
HK1145832A1 (en) 2011-05-06
CN104119336B (zh) 2016-08-24
IL235555B (en) 2019-08-29
IL204804A (en) 2014-11-30
JP5885729B2 (ja) 2016-03-15
CA2701581C (en) 2016-12-20
BRPI0817503B8 (pt) 2021-05-25
IL235555A0 (en) 2014-12-31
RU2518098C2 (ru) 2014-06-10
ES2406129T3 (es) 2013-06-05
US20140066620A1 (en) 2014-03-06
JP2010540625A (ja) 2010-12-24
MY150993A (en) 2014-03-31
BRPI0817503A2 (pt) 2015-05-05
HK1203488A1 (en) 2015-10-30
RU2681081C2 (ru) 2019-03-04
KR101701109B1 (ko) 2017-02-13
RU2014110894A (ru) 2015-07-10
CN101889015B (zh) 2014-06-04
BRPI0817503B1 (pt) 2019-10-29
ZA201003118B (en) 2011-08-31
US8247410B2 (en) 2012-08-21
US20130079512A1 (en) 2013-03-28
KR101643237B1 (ko) 2016-07-27
KR20160116045A (ko) 2016-10-06
US8609838B2 (en) 2013-12-17
CA2701581A1 (en) 2009-04-09
KR20150063171A (ko) 2015-06-08

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