JP5478894B2 - キナゾリン誘導体、その調製法および使用法 - Google Patents

キナゾリン誘導体、その調製法および使用法 Download PDF

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JP5478894B2
JP5478894B2 JP2008550608A JP2008550608A JP5478894B2 JP 5478894 B2 JP5478894 B2 JP 5478894B2 JP 2008550608 A JP2008550608 A JP 2008550608A JP 2008550608 A JP2008550608 A JP 2008550608A JP 5478894 B2 JP5478894 B2 JP 5478894B2
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chloro
fluorobenzyloxy
phenylamino
quinazoline
give
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JP2009525956A (ja
JP2009525956A5 (https=
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郭建▲輝▼
王猛
姜勇
▲張▼▲曉▼芳
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上▲海▼艾力斯医▲藥▼科技有限公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2008550608A 2006-01-20 2006-10-20 キナゾリン誘導体、その調製法および使用法 Active JP5478894B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN200610023526.7 2006-01-20
CNA2006100235267A CN101003514A (zh) 2006-01-20 2006-01-20 喹唑啉衍生物、其制备方法及用途
PCT/CN2006/002786 WO2007082434A1 (en) 2006-01-20 2006-10-20 Quinazoline derivatives,preparation methods and uses thereof

Related Child Applications (1)

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JP2012173258A Division JP2012214502A (ja) 2006-01-20 2012-08-03 キナゾリン誘導体、その調製法および使用法

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JP2009525956A JP2009525956A (ja) 2009-07-16
JP2009525956A5 JP2009525956A5 (https=) 2012-02-23
JP5478894B2 true JP5478894B2 (ja) 2014-04-23

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JP2008550608A Active JP5478894B2 (ja) 2006-01-20 2006-10-20 キナゾリン誘導体、その調製法および使用法
JP2012173258A Withdrawn JP2012214502A (ja) 2006-01-20 2012-08-03 キナゾリン誘導体、その調製法および使用法

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US (2) US8044063B2 (https=)
EP (2) EP1990337B1 (https=)
JP (2) JP5478894B2 (https=)
CN (2) CN101003514A (https=)
WO (1) WO2007082434A1 (https=)

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CN101003514A (zh) * 2006-01-20 2007-07-25 上海艾力斯医药科技有限公司 喹唑啉衍生物、其制备方法及用途
CN101245050A (zh) * 2007-02-14 2008-08-20 上海艾力斯医药科技有限公司 4-苯胺喹唑啉衍生物的盐
UY31137A1 (es) * 2007-06-14 2009-01-05 Smithkline Beecham Corp Derivados de quinazolina como inhibidores de la pi3 quinasa
CN101347433B (zh) * 2007-07-20 2012-05-02 江苏艾力斯生物医药有限公司 4-苯胺喹唑啉衍生物的制药用途
CN101357905B (zh) * 2007-08-01 2012-06-20 江苏艾力斯生物医药有限公司 4-[3-氯-4-(3-氟-苄氧基)-苯胺基]-6-取代胺基-喹唑啉衍生物的制备方法
CN101544609A (zh) * 2008-03-25 2009-09-30 上海艾力斯医药科技有限公司 4-苯胺喹唑啉衍生物的结晶形式
AU2013231084B2 (en) * 2008-03-25 2015-06-18 Shanghai Allist Pharmaceuticals Co., Ltd. The polymorphs of 4-anilinoquinazoline derivatives, the preparation methods and uses thereof
CN101584696A (zh) 2008-05-21 2009-11-25 上海艾力斯医药科技有限公司 包含喹唑啉衍生物的组合物及制备方法、用途
NZ620000A (en) 2009-03-11 2015-07-31 Auckland Uniservices Ltd Prodrug forms of kinase inhibitors and their use in cancer therapy
CN101899011B (zh) * 2009-05-26 2013-01-16 北京大学 氨基二硫代甲酸酯类化合物、其制备方法和应用
BR112012004720B1 (pt) * 2009-09-02 2021-06-29 Auckland Uniservices Limited Inibidores de cinase, seus usos, profármaco e composição farmacêutica que o compreende
CN102146059A (zh) * 2010-02-08 2011-08-10 上海艾力斯医药科技有限公司 喹唑啉衍生物、制备方法及其应用
CN102153544B (zh) * 2010-02-12 2015-04-29 上海阳帆医药科技有限公司 一类酪氨酸激酶抑制剂的制备及用途
CN101857617A (zh) * 2010-04-28 2010-10-13 中国海洋大学 喹唑啉类糖衍生物及其制备方法和应用
CN101857618B (zh) * 2010-06-13 2015-11-25 中国海洋大学 作为蛋白酪氨酸激酶抑制剂的一系列喹唑啉糖衍生物，其制备方法和应用
WO2013013640A1 (zh) 2011-07-27 2013-01-31 上海医药集团股份有限公司 喹唑啉衍生物、其制备方法、中间体、组合物及其应用
CN103304572A (zh) * 2012-03-09 2013-09-18 上海医药集团股份有限公司 一类3-氰基喹啉类化合物及其药用组合物和应用
CN102659764A (zh) * 2012-04-16 2012-09-12 中国科学院广州生物医药与健康研究院 酪氨酸激酶不可逆抑制剂及其制备方法和用途
CN102702116B (zh) * 2012-06-13 2014-12-31 华南理工大学 4-(3-氯-4-甲氧基苯胺基)-6-(3-胺基苯基)喹唑啉类化合物或其药学上可接受的盐和制备方法与应用
CN102924387B (zh) * 2012-06-13 2015-07-01 黄唯燕 4-(3-氯-4-甲氧基苯胺基)-6-(3,4-取代苯基)喹唑啉及盐和制法与应用
WO2014177038A1 (en) 2013-04-28 2014-11-06 Sunshine Lake Pharma Co., Ltd. Aminoquinazoline derivatives and their salts and methods of use thereof
CN104513229A (zh) * 2013-09-28 2015-04-15 正大天晴药业集团股份有限公司 喹唑啉衍生物及其制备方法
CA2969974C (en) * 2014-12-15 2020-08-04 The Regents Of The University Of Michigan Small molecule inhibitors of egfr and pi3k
JP6704422B2 (ja) 2015-03-20 2020-06-03 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッドChia Tai Tianqing Pharmaceutical Group Co., Ltd. キナゾリン誘導体の塩およびその製造方法
CN105384745A (zh) * 2015-07-27 2016-03-09 北京师范大学 冠醚环状的喹唑啉类化合物及其制备方法和在制备肿瘤治疗与显像药物中的应用
NZ754218A (en) * 2016-11-17 2021-07-30 Guangdong Zhongsheng Pharmaceutical Co Ltd Fgfr4 inhibitor and preparation method and use thereof
US20230271936A1 (en) * 2020-08-10 2023-08-31 Abbisko Therapeutics Co., Ltd Efgr inhibitor, preparation method therefor and application thereof
WO2022140456A1 (en) 2020-12-22 2022-06-30 Mekanistic Therapeutics Llc Substituted aminobenzyl heteroaryl compounds as egfr and/or pi3k inhibitors

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CN101003514A (zh) * 2006-01-20 2007-07-25 上海艾力斯医药科技有限公司 喹唑啉衍生物、其制备方法及用途

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Publication number Publication date
EP1990337B1 (en) 2013-05-08
US20080300248A1 (en) 2008-12-04
WO2007082434A1 (en) 2007-07-26
JP2012214502A (ja) 2012-11-08
JP2009525956A (ja) 2009-07-16
EP1990337A4 (en) 2009-07-22
EP2248806A2 (en) 2010-11-10
EP1990337A1 (en) 2008-11-12
US8309563B2 (en) 2012-11-13
US20110245246A1 (en) 2011-10-06
CN101003514A (zh) 2007-07-25
CN101103005B (zh) 2011-05-04
EP2248806B1 (en) 2013-04-24
CN101103005A (zh) 2008-01-09
US8044063B2 (en) 2011-10-25
EP2248806A3 (en) 2011-02-23

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