JP5452223B2 - Ｉａｐ阻害剤 - Google Patents
Ｉａｐ阻害剤 Download PDFInfo
- Publication number
- JP5452223B2 JP5452223B2 JP2009521950A JP2009521950A JP5452223B2 JP 5452223 B2 JP5452223 B2 JP 5452223B2 JP 2009521950 A JP2009521950 A JP 2009521950A JP 2009521950 A JP2009521950 A JP 2009521950A JP 5452223 B2 JP5452223 B2 JP 5452223B2
- Authority
- JP
- Japan
- Prior art keywords
- cell
- iap
- optionally substituted
- smac
- apoptosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 150000001875 compounds Chemical class 0.000 claims description 55
- 230000006907 apoptotic process Effects 0.000 claims description 46
- 125000001072 heteroaryl group Chemical group 0.000 claims description 38
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- 125000000217 alkyl group Chemical group 0.000 claims description 25
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- 150000002367 halogens Chemical class 0.000 claims description 18
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
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| US82014106P | 2006-07-24 | 2006-07-24 | |
| US60/820,141 | 2006-07-24 | ||
| PCT/US2007/074209 WO2008014252A2 (en) | 2006-07-24 | 2007-07-24 | Iap inhibitors |
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| JP2009544727A JP2009544727A (ja) | 2009-12-17 |
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| JP5230865B2 (ja) | 2004-07-15 | 2013-07-10 | テトラロジック ファーマシューティカルズ コーポレーション | Ｉａｐ結合性化合物 |
| EA012810B1 (ru) | 2005-02-25 | 2009-12-30 | Тетралоджик Фармасеутикалс | Димерные ингибиторы ингибиторов белков апоптоза (iap) |
| WO2006122408A1 (en) | 2005-05-18 | 2006-11-23 | Aegera Therapeutics Inc. | Bir domain binding compounds |
| AU2006308453B9 (en) | 2005-10-25 | 2011-12-01 | Pharmascience Inc. | IAP BIR domain binding compounds |
| TWI504597B (zh) | 2006-03-16 | 2015-10-21 | Pharmascience Inc | 結合於細胞凋亡抑制蛋白（ｉａｐ）之桿狀病毒ｉａｐ重複序列（ｂｉｒ）區域之化合物 |
| ES2525585T3 (es) * | 2006-05-05 | 2014-12-26 | The Regents Of The University Of Michigan | Intermedios para la preparación de miméticos de SMAC bivalentes |
| US8202902B2 (en) * | 2006-05-05 | 2012-06-19 | The Regents Of The University Of Michigan | Bivalent SMAC mimetics and the uses thereof |
| BRPI0711591A2 (pt) | 2006-05-16 | 2011-11-16 | Aegera Therapeutics, Inc. | composto de ligação de domìnio bir da iap |
| TWI499414B (zh) | 2006-09-29 | 2015-09-11 | Lexicon Pharmaceuticals Inc | 鈉與葡萄糖第２型共同運輸體（ｃｏ-ｔｒａｎｓｐｏｒｔｅｒ ２）的抑制物與其應用方法 |
| US7846945B2 (en) * | 2007-03-08 | 2010-12-07 | Lexicon Pharmaceuticals, Inc. | Piperdine-based inhibitors of sodium glucose co-transporter 2 and methods of their use |
| US20100317593A1 (en) * | 2009-06-12 | 2010-12-16 | Astrazeneca Ab | 2,3-dihydro-1h-indene compounds |
| US8283372B2 (en) | 2009-07-02 | 2012-10-09 | Tetralogic Pharmaceuticals Corp. | 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic |
| MY159958A (en) * | 2009-12-18 | 2017-02-15 | Idenix Pharmaceuticals Inc | 5,5-fused arylene or heteroarylene hepatitis c virus inhibitors |
| NZ602368A (en) | 2010-02-12 | 2014-10-31 | Pharmascience Inc | Iap bir domain binding compounds |
| UY33236A (es) * | 2010-02-25 | 2011-09-30 | Novartis Ag | Inhibidores dimericos de las iap |
| UY33794A (es) | 2010-12-13 | 2012-07-31 | Novartis Ag | Inhibidores diméricos de las iap |
| GB201106817D0 (en) * | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compound |
| WO2013027634A1 (ja) | 2011-08-23 | 2013-02-28 | 日産自動車株式会社 | 燃料電池の発電特性推定装置 |
| US20130196927A1 (en) * | 2012-01-27 | 2013-08-01 | Christopher BENETATOS | Smac Mimetic Therapy |
| BR112015005627A2 (pt) * | 2012-10-11 | 2017-08-08 | Hoffmann La Roche | composto, composição farmacêutica, uso de composto, método de tratamento e invenção. |
| GB201218862D0 (en) * | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| CN115368356B (zh) | 2013-12-20 | 2025-05-09 | 阿斯特克斯治疗有限公司 | 双环杂环化合物及其治疗用途 |
| JP2019514900A (ja) * | 2016-04-27 | 2019-06-06 | メッドシャイン ディスカバリー インコーポレイテッド | 新規な二価のｉａｐアンタゴニストとしてのベンズイミダゾール結合インドール化合物 |
| WO2019080928A1 (zh) * | 2017-10-27 | 2019-05-02 | 南京明德新药研发股份有限公司 | 一种iap拮抗剂的晶型及其制备方法 |
| CN111247161B (zh) * | 2017-11-13 | 2021-12-31 | 正大天晴药业集团股份有限公司 | 用作iap抑制剂的smac模拟物及其用途 |
| WO2020228642A1 (zh) * | 2019-05-10 | 2020-11-19 | 正大天晴药业集团股份有限公司 | 一种用作iap抑制剂的smac模拟物的结晶及其制备方法 |
| CN112521372B (zh) * | 2019-09-18 | 2022-07-08 | 南京华威医药科技集团有限公司 | 一种细胞凋亡蛋白抑制剂及其制备方法和用途 |
| CN112972684B (zh) * | 2019-12-02 | 2024-05-31 | 苏州亚盛药业有限公司 | Iap抑制剂与parp或mek抑制剂或其他化学治疗剂的组合 |
| JP2025513461A (ja) * | 2022-04-19 | 2025-04-24 | マインドセット ファーマ インコーポレイテッド | セロトニン作動薬としてのインドリン誘導体に関連する障害の治療に有用なセロトニン作動薬としてのインドリン誘導体 |
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- 2007-07-24 JP JP2009521950A patent/JP5452223B2/ja not_active Expired - Fee Related
- 2007-07-24 EP EP07813281A patent/EP2049524A2/en not_active Withdrawn
- 2007-07-24 CL CL2007002166A patent/CL2007002166A1/es unknown
- 2007-07-24 WO PCT/US2007/074209 patent/WO2008014252A2/en not_active Ceased
- 2007-07-24 US US11/782,315 patent/US8143426B2/en not_active Expired - Fee Related
- 2007-07-24 AR ARP070103285A patent/AR064235A1/es not_active Application Discontinuation
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| CL2007002166A1 (es) | 2008-01-25 |
| WO2008014252A2 (en) | 2008-01-31 |
| US20080021066A1 (en) | 2008-01-24 |
| EP2049524A2 (en) | 2009-04-22 |
| JP2009544727A (ja) | 2009-12-17 |
| AR064235A1 (es) | 2009-03-25 |
| WO2008014252A3 (en) | 2008-03-13 |
| US8143426B2 (en) | 2012-03-27 |
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