JP5419892B2 - キナゾリンおよび関連する複素環式化合物、ならびにそれらの治療的使用 - Google Patents

キナゾリンおよび関連する複素環式化合物、ならびにそれらの治療的使用 Download PDF

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JP5419892B2
JP5419892B2 JP2010541062A JP2010541062A JP5419892B2 JP 5419892 B2 JP5419892 B2 JP 5419892B2 JP 2010541062 A JP2010541062 A JP 2010541062A JP 2010541062 A JP2010541062 A JP 2010541062A JP 5419892 B2 JP5419892 B2 JP 5419892B2
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alkyl
amino
methylpiperazin
quinazoline
phenyl
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JP2011508756A5 (es
JP2011508756A (ja
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ロヒール アドリアーン スミッツ
レホリウス ルールス
エッシュ イワン ヨゼフ フィロメナ デ
Original Assignee
ベレナギング ヴォー クリスタラク ホガー オンダーヴェイル ヴェーテンザパーリク オンダージーク エン パシェンテンゾーク
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P11/02—Nasal agents, e.g. decongestants
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    • A61P11/06—Antiasthmatics
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
JP2010541062A 2008-01-02 2009-01-02 キナゾリンおよび関連する複素環式化合物、ならびにそれらの治療的使用 Expired - Fee Related JP5419892B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08100015.0 2008-01-02
EP08100015A EP2077263A1 (en) 2008-01-02 2008-01-02 Quinazolines and related heterocyclic compounds and their therapeutic use
PCT/EP2009/050012 WO2009083608A1 (en) 2008-01-02 2009-01-02 Quinazolines and related heterocyclic compounds, and their therapeutic use

Publications (3)

Publication Number Publication Date
JP2011508756A JP2011508756A (ja) 2011-03-17
JP2011508756A5 JP2011508756A5 (es) 2013-09-05
JP5419892B2 true JP5419892B2 (ja) 2014-02-19

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JP2010541062A Expired - Fee Related JP5419892B2 (ja) 2008-01-02 2009-01-02 キナゾリンおよび関連する複素環式化合物、ならびにそれらの治療的使用

Country Status (8)

Country Link
US (1) US8530486B2 (es)
EP (2) EP2077263A1 (es)
JP (1) JP5419892B2 (es)
AU (1) AU2009203124B2 (es)
CA (1) CA2711272A1 (es)
ES (1) ES2562674T3 (es)
PL (1) PL2238119T3 (es)
WO (1) WO2009083608A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101987829A (zh) * 2009-08-03 2011-03-23 上海泺安医药技术有限公司 一种2-(氨基)乙基甲基砜新盐及制备
EP2270002A1 (en) 2009-06-18 2011-01-05 Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patiëntenzorg Quinazoline derivatives as histamine H4-receptor inhibitors for use in the treatment of inflammatory disorders
WO2011114916A1 (ja) * 2010-03-18 2011-09-22 森永乳業株式会社 貧血の予防又は治療用組成物
TW201210597A (en) * 2010-06-09 2012-03-16 Gilead Sciences Inc Inhibitors of hepatitis C virus
WO2013060881A1 (en) 2011-10-27 2013-05-02 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg Pyridopyrimidines and their therapeutic use
CN102649841B (zh) * 2012-04-06 2013-09-04 东南大学 苯胺基喹唑啉为靶向配体的聚乙二醇修饰磷脂衍生物及制法
SI2858647T1 (sl) 2012-06-08 2018-11-30 Sensorion Inhibitorji receptorja H4 za zdravljenje tinitusa
CN103819414B (zh) * 2014-02-27 2016-06-01 福建医科大学 一种在水相中催化制备喹唑酮化合物的方法
CN106632091B (zh) * 2015-10-29 2021-05-11 中国科学院上海药物研究所 喹唑啉化合物在调控神经干细胞增殖和分化中的应用
CN107586267B (zh) * 2016-11-01 2020-02-18 华东师范大学 一种牛磺酰胺盐酸盐(2-氨基乙基磺酰胺盐酸盐)的合成方法
KR102603203B1 (ko) * 2018-07-25 2023-11-16 파에스 파마, 에스.에이. 히스타민 h4-수용체 저해제로서 피리도피리미딘류
JP2023084709A (ja) * 2020-04-28 2023-06-20 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 ヒスタミンｈ４受容体調節作用を有する新規二環化合物

Family Cites Families (12)

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DE2121031A1 (en) 1971-04-29 1972-11-02 Dr. Karl Thomae Gmbh, 7950 Biberach Base-substd quinazolines - thrombocyte aggregation inhibitors
US3956495A (en) 1973-10-30 1976-05-11 Eli Lilly And Company 2,4-Diaminoquinazolines as antithrombotic agents
JP2657760B2 (ja) * 1992-07-15 1997-09-24 小野薬品工業株式会社 ４−アミノキナゾリン誘導体およびそれを含有する医薬品
MXPA03008143A (es) 2001-03-09 2005-08-16 Johnson & Johnson Compuestos heterociclicos.
AU2004278372B2 (en) 2003-09-30 2010-02-18 Janssen Pharmaceutica N.V. Quinoxaline compounds
DE602004020364D1 (de) 2003-09-30 2009-05-14 Janssen Pharmaceutica Nv Benzoimidazolverbindungen
US20080269239A1 (en) 2004-11-11 2008-10-30 Argenta Discovery Ltd. Pyrimidine Compounds as Histamine Modulators
US20060111416A1 (en) 2004-11-24 2006-05-25 Lane Charlotte A L Octahydropyrrolo[3,4-C]pyrrole derivatives
KR20080043840A (ko) 2005-09-13 2008-05-19 팔라우 파르마 에스에이 히스타민 ｈ4 수용체 활성의 조정자로서 2-아미노피리미딘유도체
EP1767537A1 (en) * 2005-09-21 2007-03-28 Cellzome (UK) Ltd. Pyrimidine compounds for the treatment of inflammatory disorders
US20100016293A1 (en) 2006-07-03 2010-01-21 Rogier Adriaan Smits Quinazolines and Related Heterocyclic Compounds, and Their Therapeutic Use
WO2009047255A1 (en) 2007-10-09 2009-04-16 Ucb Pharma, S.A. Heterobicyclic compounds as histamine h4-receptor antagonists

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Publication number Publication date
EP2238119A1 (en) 2010-10-13
US8530486B2 (en) 2013-09-10
US20100298322A1 (en) 2010-11-25
JP2011508756A (ja) 2011-03-17
EP2238119B1 (en) 2015-11-25
WO2009083608A1 (en) 2009-07-09
PL2238119T3 (pl) 2016-05-31
AU2009203124B2 (en) 2012-03-15
WO2009083608A9 (en) 2009-09-24
ES2562674T3 (es) 2016-03-07
AU2009203124A1 (en) 2009-07-09
EP2077263A1 (en) 2009-07-08
CA2711272A1 (en) 2009-07-09

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