JP5395058B2 - 幹細胞に由来する網膜色素上皮細胞 - Google Patents

幹細胞に由来する網膜色素上皮細胞 Download PDF

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JP5395058B2
JP5395058B2 JP2010503665A JP2010503665A JP5395058B2 JP 5395058 B2 JP5395058 B2 JP 5395058B2 JP 2010503665 A JP2010503665 A JP 2010503665A JP 2010503665 A JP2010503665 A JP 2010503665A JP 5395058 B2 JP5395058 B2 JP 5395058B2
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cells
rpe
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JP2010524457A (ja
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マシャ イデルソン，
ルズラナ アルパー−ピナス，
アレックス オボレンスキー，
エヤル バニン，
ベンジャミン ルービノフ，
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ハダシット メディカル リサーチ サーヴィシーズ アンド ディヴェロップメント リミテッド
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JP2010503665A 2007-04-18 2008-04-27 幹細胞に由来する網膜色素上皮細胞 Active JP5395058B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90781807P 2007-04-18 2007-04-18
US60/907,818 2007-04-18
PCT/IL2008/000556 WO2008129554A1 (en) 2007-04-18 2008-04-27 Stem cell-derived retinal pigment epithelial cells

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JP2010524457A JP2010524457A (ja) 2010-07-22
JP2010524457A5 JP2010524457A5 (https=) 2011-05-26
JP5395058B2 true JP5395058B2 (ja) 2014-01-22

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US (3) US8956866B2 (https=)
EP (4) EP2147094B2 (https=)
JP (1) JP5395058B2 (https=)
CN (2) CN101688178B (https=)
AU (1) AU2008242106B2 (https=)
CA (1) CA2684460C (https=)
ES (2) ES2530370T5 (https=)
IL (2) IL225163B (https=)
WO (1) WO2008129554A1 (https=)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2929782A1 (en) * 2004-01-23 2015-10-14 Ocata Therapeutics, Inc. Improved modalities for the treatment of degenerative diseases of the retina
US7794704B2 (en) 2004-01-23 2010-09-14 Advanced Cell Technology, Inc. Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
EP1844136B1 (en) * 2004-12-29 2014-08-27 Hadasit Medical Research Services And Development Ltd. Stem cells culture systems
US8597947B2 (en) * 2004-12-29 2013-12-03 Hadasit Medical Research Services & Development Limited Undifferentiated stem cell culture systems
EP2147094B2 (en) 2007-04-18 2018-02-21 Hadasit Medical Research Services & Development Limited Stem cell-derived retinal pigment epithelial cells
DK2209888T3 (da) 2007-10-12 2020-01-20 Astellas Inst For Regenerative Medicine Forbedrede fremgangsmåder til fremstilling af rpe-celler og sammensætninger af rpe-celler
MX2010010165A (es) 2008-03-17 2010-11-25 Scripps Research Inst Procedimientos quimicos y geneticos combinados para generacion de celulas madre pluripotentes inducidas.
JPWO2009148170A1 (ja) 2008-06-06 2011-11-04 独立行政法人理化学研究所 幹細胞の培養方法
CN101580816B (zh) * 2009-04-23 2012-02-29 中国科学院广州生物医药与健康研究院 诱导多能性干细胞快速高效产生的新型无血清培养基以及使用其的方法
EP2470645B1 (en) * 2009-08-24 2019-06-26 Wisconsin Alumni Research Foundation Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same
US20120322670A1 (en) 2009-08-28 2012-12-20 Cellular Dynamics International, Inc. Identifying genetic variation in affected tissues
RU2409663C1 (ru) * 2009-10-14 2011-01-20 Российская Федерация, от имени которой выступает Федеральное Агентство по науке и инновациям Способ получения дедифференцированных клеток ретинального пигментного эпителия глаза взрослого человека
JP5787370B2 (ja) * 2009-11-05 2015-09-30 国立研究開発法人理化学研究所 幹細胞の分化誘導方法
IL281453B (en) * 2009-11-17 2022-07-01 Astellas Inst For Regenerative Medicine Methods for preparing human rpe cells and pharmaceutical preparations of human rpe cells
WO2012149480A2 (en) * 2011-04-29 2012-11-01 University Of Southern California Systems and methods for in vitro and in vivo imaging of cells on a substrate
EP2593117B1 (en) 2010-07-12 2019-03-20 University of Southern California Biocompatible substrate for facilitating interconnections between stem cells and target tissues and methods for implanting same
WO2012012803A2 (en) * 2010-07-23 2012-01-26 Advanced Cell Technology, Inc. Methods for detection of rare subpopulations of cells and highly purified compositions of cells
FI20106354A0 (fi) * 2010-12-20 2010-12-20 Suomen Punainen Risti Veripalvelu Menetelmä ihmisen retinan pigmentti-epiteelisolujen valmistamiseksi
EP2655601A4 (en) 2010-12-22 2014-09-10 Fate Therapeutics Inc CELL CULTURAL PLATFORM FOR INDIVIDUAL CELL SIZING AND IMPROVED RESOLUTION OF IPSCS
US8349005B2 (en) 2011-01-03 2013-01-08 Masatoshi Murata Method for burying implant to choroid
US8877489B2 (en) 2011-12-05 2014-11-04 California Institute Of Technology Ultrathin parylene-C semipermeable membranes for biomedical applications
US10478206B2 (en) 2011-04-29 2019-11-19 University Of Southern California Instruments and methods for the implantation of cell-seeded substrates
JP5985207B2 (ja) * 2011-11-25 2016-09-06 住友化学株式会社 網膜色素上皮細胞の製造方法
EP2784152B1 (en) 2011-11-25 2019-04-10 Sumitomo Chemical Company, Limited Methods for producing retinal tissue and retina-related cell
JP6067232B2 (ja) * 2011-11-25 2017-01-25 住友化学株式会社 網膜層特異的神経細胞を製造する方法
JP5985209B2 (ja) * 2011-11-25 2016-09-06 住友化学株式会社 眼杯様構造体の製造方法
JP5985208B2 (ja) * 2011-11-25 2016-09-06 住友化学株式会社 網膜組織の製造方法
US9248013B2 (en) 2011-12-05 2016-02-02 California Institute Of Technology 3-Dimensional parylene scaffold cage
AU2013216382B2 (en) * 2012-01-31 2018-08-02 Hadasit Medical Research Services And Development Ltd. Methods of selecting retinal pigmented epithelial cells
RU2486603C1 (ru) * 2012-04-11 2013-06-27 Федеральное государственное бюджетное учреждение науки Институт биологии развития им. Н.К. Кольцова РАН (ИБР РАН) Способ моделирования тканевой структуры сетчатки глаза человека
CN103627669A (zh) * 2012-08-22 2014-03-12 复旦大学 一种诱导人多能干细胞分化为视网膜前体细胞的方法
US9265458B2 (en) 2012-12-04 2016-02-23 Sync-Think, Inc. Application of smooth pursuit cognitive testing paradigms to clinical drug development
EP2951290B1 (en) 2013-02-01 2017-11-29 The United States of America, as represented by The Secretary, Department of Health and Human Services Method for generating retinal pigment epithelium (rpe) cells from induced pluripotent stem cells (ipscs)
US9380976B2 (en) 2013-03-11 2016-07-05 Sync-Think, Inc. Optical neuroinformatics
US20160060595A1 (en) * 2013-04-03 2016-03-03 Tampereen Yliopisto Methods and media for differentiating eye cells
KR102297580B1 (ko) * 2013-08-06 2021-09-03 고쿠리쓰 겐큐 가이하쓰 호징 리가가쿠 겐큐소 전안부 조직의 제조 방법
KR102278978B1 (ko) * 2013-08-23 2021-07-19 스미또모 가가꾸 가부시끼가이샤 망막 조직 및 망막 관련 세포의 제조 방법
JP6518878B2 (ja) * 2013-10-09 2019-05-29 株式会社ヘリオス 網膜色素上皮細胞の製造方法
EP3070162B1 (en) * 2013-11-11 2019-09-18 Sumitomo Chemical Company, Limited Method for producing retinal pigment epithelial cells
US20150148383A1 (en) * 2013-11-22 2015-05-28 Regenerative Research Foundation Methods for Inhibiting or Reversing Epiretinal Membrane Formation
MX2016007671A (es) 2013-12-11 2016-10-14 Pfizer Ltd Metodo para producir celulas del epitelio pigmentario retiniano.
CA2941004A1 (en) 2014-03-04 2015-09-11 Peter Flynn Improved reprogramming methods and cell culture platforms
WO2015142855A1 (en) * 2014-03-17 2015-09-24 University Of Virginia Patent Foundation Compositions and methods for treating retinopathy
WO2015175504A1 (en) * 2014-05-12 2015-11-19 The Johns Hopkins University Differentiation of human pluripotent stem cells into retinal pigment epithelium using hif1 inhibitors
EP3211071B1 (en) 2014-10-24 2021-05-05 Sumitomo Dainippon Pharma Co., Ltd. Production method for retinal tissue
TWI810142B (zh) 2014-10-24 2023-08-01 日商住友製藥股份有限公司 神經組織的製造方法
KR102728629B1 (ko) 2014-12-18 2024-11-12 쏘흐본느 유니베흐시테 망막 변성의 치료를 위한 otx2를 과발현하는 형질전환 rpe 세포
EP3240612B1 (en) 2014-12-30 2020-12-23 Cell Cure Neurosciences Ltd. Methods of treating retinal diseases
CA2972575A1 (en) 2014-12-30 2016-07-07 Cell Cure Neurosciences Ltd. Rpe cell populations and methods of generating same
EP3916085A1 (en) 2014-12-30 2021-12-01 Cell Cure Neurosciences Ltd. Assessing retinal pigment epithelial cell populations
WO2017017686A1 (en) 2015-07-29 2017-02-02 Hadasit Medical Research Services And Development Ltd. Large scale production of retinal pigment epithelial cells
US11066642B2 (en) 2015-08-05 2021-07-20 Cell Cure Neurosciences Ltd Preparation of retinal pigment epithelium cells
EP3331995A1 (en) * 2015-08-05 2018-06-13 Cell Cure Neurosciences Ltd. Preparation of photoreceptors for the treatment of retinal diseases
US12385008B2 (en) 2015-09-08 2025-08-12 Sumitomo Pharma Co., Ltd. Method for producing retinal tissue
CN105112368B (zh) * 2015-09-30 2018-09-21 奥思达干细胞有限公司 一种治疗视网膜变性的干细胞制剂及其使用方法
CN117737124A (zh) 2015-10-16 2024-03-22 菲特治疗公司 用于诱导和维护基态多能性的平台
JP6987769B2 (ja) 2015-10-26 2022-01-05 セル キュア ニューロサイエンシズ リミテッド 網膜色素上皮細胞の調製法
CH711966A2 (it) * 2015-12-23 2017-06-30 Pinelli Roberto Cellule staminali retinali.
SG11201809201UA (en) 2016-04-22 2018-11-29 Sumitomo Dainippon Pharma Co Ltd Method for producing retinal tissue
JP2020501543A (ja) 2016-12-07 2020-01-23 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ 網膜色素上皮移植のためのフィブリン支持体を用いた方法及び材料
CN106754718A (zh) * 2016-12-19 2017-05-31 胡其锐 一种人胚胎干细胞快速定向分化至视网膜色素上皮细胞的方法
CN110520139A (zh) 2017-02-08 2019-11-29 哈达西特医疗研究服务和开发有限公司 用于治疗视网膜疾病的感光细胞
WO2018170494A1 (en) 2017-03-16 2018-09-20 Bio Time, Inc. Methods for measuring therapeutic effects of retinal disease therapies
CN108728413A (zh) * 2017-06-13 2018-11-02 中山大学中山眼科中心 一种人多能干细胞来源人视网膜色素上皮细胞的制备和扩增培养方法
WO2019069327A1 (en) 2017-10-05 2019-04-11 Eyestem Research Private Limited UNIFIED CELL DIFFERENTIATION PROTOCOL
WO2019130061A2 (en) 2017-12-29 2019-07-04 Cell Cure Neurosciences Ltd. Retinal pigment epithelium cell compositions
JP7287948B2 (ja) 2018-03-22 2023-06-06 オリエンタル酵母工業株式会社 多分化能性幹細胞分化促進剤
CN108531443A (zh) * 2018-04-04 2018-09-14 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 小分子诱导多能性干细胞分化为视网膜色素上皮细胞的方法
CN110205283B (zh) * 2018-04-18 2021-04-23 浙江大学 一种诱导人羊膜上皮细胞向视网膜色素上皮细胞分化的方法及其应用
JP2021521792A (ja) 2018-04-20 2021-08-30 フジフィルム セルラー ダイナミクス，インコーポレイテッド 眼球細胞の分化方法及びその使用
EP3969570A1 (en) * 2019-05-15 2022-03-23 Novo Nordisk A/S Methods for obtaining eye field progenitor cells from human pluripotent stem cells
EP3754014A1 (en) 2019-06-21 2020-12-23 Centre d'Etude des Cellules Souches (CECS) Automated method for preparing retinal pigment epithelium cells
CA3184790A1 (en) * 2020-05-25 2021-12-02 Lineage Cell Therapeutics, Inc. Methods and compositions for treating retinal diseases and conditions
US20230201267A1 (en) * 2020-05-29 2023-06-29 FUJIFILM Cellular Dynamics, Inc. Retinal pigmented epithelium and photoreceptor dual cell aggregates and methods of use thereof
EP4351334A1 (en) 2021-06-09 2024-04-17 Lineage Cell Therapeutics, Inc. Methods and compositions for treating retinal diseases and conditions
JP2024527986A (ja) 2021-07-28 2024-07-26 リネージ セル セラピューティクス インコーポレイテッド 網膜色素上皮細胞の増殖
WO2023201361A1 (en) 2022-04-15 2023-10-19 Aspen Neuroscience, Inc. Methods of classifying the differentiation state of cells and related compositions of differentiated cells
CN115840045B (zh) * 2023-02-23 2023-04-28 中国农业大学 一种猪胚胎期毛囊基板前体细胞的鉴定方法及其应用
WO2025083169A1 (en) 2023-10-17 2025-04-24 Tenpoint Therapeutics Limited Combination of a vegf inhibitor and a complement pathway inhibitor for treating ocular disorders
WO2025096328A1 (en) * 2023-10-30 2025-05-08 The Jackson Laboratory Cell therapies for retinal diseases
CN117467607A (zh) * 2023-12-19 2024-01-30 南京艾尔普再生医学科技有限公司 一种获取稳定性能rpe细胞的方法、制剂、药物组合物及试剂
CN119709618B (zh) * 2024-12-25 2025-10-28 电子科技大学附属医院·四川省人民医院 一种从iPSC分化的细胞中分选成熟RPE细胞的方法及其应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG49267A1 (en) 1989-08-14 1998-05-18 Photogenesis Inc Surgical instrument and cell isolation and transplantation
US5750342A (en) * 1990-06-11 1998-05-12 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands of tissue target
TW209224B (https=) * 1991-05-27 1993-07-11 Yoshitomi Pharmaceutical
US6045791A (en) 1992-03-06 2000-04-04 Photogenesis, Inc. Retinal pigment epithelium transplantation
DE4219250A1 (de) * 1992-06-12 1993-12-16 Behringwerke Ag Serum-freies Zellkulturmedium
DE69329556D1 (de) * 1993-04-30 2000-11-16 Photogenesis Inc Transplantation des retinalen pigmentepithels
US5755785A (en) 1994-08-12 1998-05-26 The University Of South Florida Sutureless corneal transplantation method
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5941250A (en) 1996-11-21 1999-08-24 University Of Louisville Research Foundation Inc. Retinal tissue implantation method
GB9715584D0 (en) 1997-07-23 1997-10-01 Eisai Co Ltd Compounds
JP3663990B2 (ja) 1999-08-31 2005-06-22 不二製油株式会社 含気チョコレート及びその製造法
GB0001930D0 (en) 2000-01-27 2000-03-22 Novartis Ag Organic compounds
EP2298867A3 (en) 2000-06-20 2013-01-16 ES Cell International Pte Ltd. Method of controlling differentiation of embryonic stem (ES) cells by culturing ES cells in the presence of bmp-2 pathway antagonists
EE200300360A (et) 2001-01-31 2003-12-15 Pfizer Products Inc. PDE4 isosüümide inhibiitoritena kasutatavad nikotiinamiidi biarüülderivaadid
AU2003202988A1 (en) * 2002-01-14 2003-07-30 The Board Of Trustees Of The University Of Illinois Use of modified pyrimidine compounds to promote stem cell migration and proliferation
AU2003201745A1 (en) 2002-02-11 2003-09-04 Pfizer Limited Nicotinamide derivatives and a tiotropium salt in combination for the treatment of e.g. inflammatory, allergic and respiratory diseases
US7288658B2 (en) 2003-07-15 2007-10-30 Hoffmann-La Roche Inc. Process for preparation of pyridine derivatives
US20050019718A1 (en) 2003-07-22 2005-01-27 Hanson G. Herbert Orthodontic devices for use with arch wires
EP2929782A1 (en) * 2004-01-23 2015-10-14 Ocata Therapeutics, Inc. Improved modalities for the treatment of degenerative diseases of the retina
US7794704B2 (en) * 2004-01-23 2010-09-14 Advanced Cell Technology, Inc. Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
DE102004048640A1 (de) * 2004-10-04 2006-04-06 Otmar Fahrion Kette
JP2006113175A (ja) * 2004-10-13 2006-04-27 Konica Minolta Opto Inc 光学フィルム、偏光板及び表示装置
EP1844136B1 (en) * 2004-12-29 2014-08-27 Hadasit Medical Research Services And Development Ltd. Stem cells culture systems
EP2147094B2 (en) 2007-04-18 2018-02-21 Hadasit Medical Research Services & Development Limited Stem cell-derived retinal pigment epithelial cells
EP2401794B1 (en) 2009-02-25 2012-09-05 Philips Intellectual Property & Standards GmbH Output power stabilization for laser diodes using the photon-cooling dependent laser voltage
EP3047017B1 (en) * 2013-10-09 2025-09-10 The Regents of the University of California Methods of mammalian retinal stem cell production and applications

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