JP2010524457A5 - - Google Patents
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- JP2010524457A5 JP2010524457A5 JP2010503665A JP2010503665A JP2010524457A5 JP 2010524457 A5 JP2010524457 A5 JP 2010524457A5 JP 2010503665 A JP2010503665 A JP 2010503665A JP 2010503665 A JP2010503665 A JP 2010503665A JP 2010524457 A5 JP2010524457 A5 JP 2010524457A5
- Authority
- JP
- Japan
- Prior art keywords
- rpe
- cell
- pluripotent stem
- human pluripotent
- culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000003583 retinal pigment epithelium Anatomy 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 8
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 6
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 6
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 6
- 238000012258 culturing Methods 0.000 claims 4
- 229960003966 nicotinamide Drugs 0.000 claims 4
- 235000005152 nicotinamide Nutrition 0.000 claims 4
- 239000011570 nicotinamide Substances 0.000 claims 4
- 239000007640 basal medium Substances 0.000 claims 3
- 230000004069 differentiation Effects 0.000 claims 3
- 239000003550 marker Substances 0.000 claims 3
- 208000017442 Retinal disease Diseases 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 102000012304 Bestrophin Human genes 0.000 claims 1
- 108050002823 Bestrophin Proteins 0.000 claims 1
- 101000729271 Homo sapiens Retinoid isomerohydrolase Proteins 0.000 claims 1
- 102100031176 Retinoid isomerohydrolase Human genes 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 108010023082 activin A Proteins 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 239000002356 single layer Substances 0.000 claims 1
- 230000002269 spontaneous effect Effects 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90781807P | 2007-04-18 | 2007-04-18 | |
| US60/907,818 | 2007-04-18 | ||
| PCT/IL2008/000556 WO2008129554A1 (en) | 2007-04-18 | 2008-04-27 | Stem cell-derived retinal pigment epithelial cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010524457A JP2010524457A (ja) | 2010-07-22 |
| JP2010524457A5 true JP2010524457A5 (https=) | 2011-05-26 |
| JP5395058B2 JP5395058B2 (ja) | 2014-01-22 |
Family
ID=39666210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503665A Active JP5395058B2 (ja) | 2007-04-18 | 2008-04-27 | 幹細胞に由来する網膜色素上皮細胞 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8956866B2 (https=) |
| EP (4) | EP2147094B2 (https=) |
| JP (1) | JP5395058B2 (https=) |
| CN (2) | CN101688178B (https=) |
| AU (1) | AU2008242106B2 (https=) |
| CA (1) | CA2684460C (https=) |
| ES (2) | ES2530370T5 (https=) |
| IL (2) | IL225163B (https=) |
| WO (1) | WO2008129554A1 (https=) |
Families Citing this family (82)
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| EP2147094B2 (en) | 2007-04-18 | 2018-02-21 | Hadasit Medical Research Services & Development Limited | Stem cell-derived retinal pigment epithelial cells |
| DK2209888T3 (da) | 2007-10-12 | 2020-01-20 | Astellas Inst For Regenerative Medicine | Forbedrede fremgangsmåder til fremstilling af rpe-celler og sammensætninger af rpe-celler |
| MX2010010165A (es) | 2008-03-17 | 2010-11-25 | Scripps Research Inst | Procedimientos quimicos y geneticos combinados para generacion de celulas madre pluripotentes inducidas. |
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| EP2470645B1 (en) * | 2009-08-24 | 2019-06-26 | Wisconsin Alumni Research Foundation | Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same |
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| US20160060595A1 (en) * | 2013-04-03 | 2016-03-03 | Tampereen Yliopisto | Methods and media for differentiating eye cells |
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2008
- 2008-04-27 EP EP08738258.6A patent/EP2147094B2/en active Active
- 2008-04-27 AU AU2008242106A patent/AU2008242106B2/en active Active
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