JP5394404B2 - キナーゼ阻害剤として有用な置換イミダゾピリダジン類 - Google Patents

キナーゼ阻害剤として有用な置換イミダゾピリダジン類 Download PDF

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Publication number
JP5394404B2
JP5394404B2 JP2010546068A JP2010546068A JP5394404B2 JP 5394404 B2 JP5394404 B2 JP 5394404B2 JP 2010546068 A JP2010546068 A JP 2010546068A JP 2010546068 A JP2010546068 A JP 2010546068A JP 5394404 B2 JP5394404 B2 JP 5394404B2
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substituted
alkyl
heterocyclo
heteroaryl
cycloalkyl
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Expired - Fee Related
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Japanese (ja)
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JP2011511095A (ja
JP2011511095A5 (enExample
Inventor
ブライアン・イー・フィンク
リビン・チェン
ピン・チェン
ダームパル・エス・ドッド
アシュビニクマー・ブイ・ガバイ
ソン−ホン・キム
ウェイン・バッカロ
リタイ・エイチ・チャン
ユフェン・チャオ
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2010546068A 2008-02-06 2009-02-06 キナーゼ阻害剤として有用な置換イミダゾピリダジン類 Expired - Fee Related JP5394404B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2665108P 2008-02-06 2008-02-06
US61/026,651 2008-02-06
PCT/US2009/033455 WO2009100375A1 (en) 2008-02-06 2009-02-06 Substituted imidazopyridazines useful as kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2011511095A JP2011511095A (ja) 2011-04-07
JP2011511095A5 JP2011511095A5 (enExample) 2011-09-29
JP5394404B2 true JP5394404B2 (ja) 2014-01-22

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JP2010546068A Expired - Fee Related JP5394404B2 (ja) 2008-02-06 2009-02-06 キナーゼ阻害剤として有用な置換イミダゾピリダジン類

Country Status (5)

Country Link
US (1) US8389527B2 (enExample)
EP (1) EP2240488B1 (enExample)
JP (1) JP5394404B2 (enExample)
CN (1) CN101981033B (enExample)
WO (1) WO2009100375A1 (enExample)

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CN106661056B (zh) * 2014-06-19 2019-07-05 百时美施贵宝公司 作为酪蛋白激酶1δ/ε抑制剂的咪唑并哒嗪衍生物
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JP7046827B2 (ja) 2016-04-06 2022-04-04 リソソーマル・セラピューティクス・インコーポレイテッド イミダゾ［１，５－ａ］ピリミジニルカルボキサミド化合物および医学的障害の処置におけるその使用
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CN113348021B (zh) * 2019-01-23 2025-07-11 武田药品工业株式会社 Tyk2抑制剂和其用途
JP7526196B2 (ja) * 2019-03-05 2024-07-31 ブリストル－マイヤーズ スクイブ カンパニー Ｉｌ－１２、ｉｌ－２３、および／またはｉｆｎアルファ応答の調節剤として有用なイミダゾピリダジン化合物
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Also Published As

Publication number Publication date
EP2240488A1 (en) 2010-10-20
US8389527B2 (en) 2013-03-05
EP2240488B1 (en) 2016-11-02
JP2011511095A (ja) 2011-04-07
CN101981033A (zh) 2011-02-23
US20100323994A1 (en) 2010-12-23
WO2009100375A1 (en) 2009-08-13
CN101981033B (zh) 2015-02-04

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