JP5394404B2 - キナーゼ阻害剤として有用な置換イミダゾピリダジン類 - Google Patents

キナーゼ阻害剤として有用な置換イミダゾピリダジン類 Download PDF

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Publication number
JP5394404B2
JP5394404B2 JP2010546068A JP2010546068A JP5394404B2 JP 5394404 B2 JP5394404 B2 JP 5394404B2 JP 2010546068 A JP2010546068 A JP 2010546068A JP 2010546068 A JP2010546068 A JP 2010546068A JP 5394404 B2 JP5394404 B2 JP 5394404B2
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substituted
alkyl
heterocyclo
heteroaryl
cycloalkyl
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Japanese (ja)
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JP2011511095A5 (enExample
JP2011511095A (ja
Inventor
ブライアン・イー・フィンク
リビン・チェン
ピン・チェン
ダームパル・エス・ドッド
アシュビニクマー・ブイ・ガバイ
ソン−ホン・キム
ウェイン・バッカロ
リタイ・エイチ・チャン
ユフェン・チャオ
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2010546068A 2008-02-06 2009-02-06 キナーゼ阻害剤として有用な置換イミダゾピリダジン類 Expired - Fee Related JP5394404B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2665108P 2008-02-06 2008-02-06
US61/026,651 2008-02-06
PCT/US2009/033455 WO2009100375A1 (en) 2008-02-06 2009-02-06 Substituted imidazopyridazines useful as kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2011511095A JP2011511095A (ja) 2011-04-07
JP2011511095A5 JP2011511095A5 (enExample) 2011-09-29
JP5394404B2 true JP5394404B2 (ja) 2014-01-22

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JP2010546068A Expired - Fee Related JP5394404B2 (ja) 2008-02-06 2009-02-06 キナーゼ阻害剤として有用な置換イミダゾピリダジン類

Country Status (5)

Country Link
US (1) US8389527B2 (enExample)
EP (1) EP2240488B1 (enExample)
JP (1) JP5394404B2 (enExample)
CN (1) CN101981033B (enExample)
WO (1) WO2009100375A1 (enExample)

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WO2013142817A2 (en) 2012-03-23 2013-09-26 Dennis Brown Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo
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Also Published As

Publication number Publication date
CN101981033B (zh) 2015-02-04
EP2240488B1 (en) 2016-11-02
CN101981033A (zh) 2011-02-23
EP2240488A1 (en) 2010-10-20
US20100323994A1 (en) 2010-12-23
WO2009100375A1 (en) 2009-08-13
US8389527B2 (en) 2013-03-05
JP2011511095A (ja) 2011-04-07

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