JP5364224B2 - ヒト胚性幹細胞に由来する造血細胞 - Google Patents
ヒト胚性幹細胞に由来する造血細胞 Download PDFInfo
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- JP5364224B2 JP5364224B2 JP2003551273A JP2003551273A JP5364224B2 JP 5364224 B2 JP5364224 B2 JP 5364224B2 JP 2003551273 A JP2003551273 A JP 2003551273A JP 2003551273 A JP2003551273 A JP 2003551273A JP 5364224 B2 JP5364224 B2 JP 5364224B2
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Developmental Biology & Embryology (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33897901P | 2001-12-07 | 2001-12-07 | |
| US60/338,979 | 2001-12-07 | ||
| PCT/US2002/039091 WO2003050251A2 (en) | 2001-12-07 | 2002-12-06 | Hematopoietic cells from human embryonic stem cells |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009265829A Division JP2010075195A (ja) | 2001-12-07 | 2009-11-24 | ヒト胚性幹細胞に由来する造血細胞 |
| JP2013127621A Division JP2013236636A (ja) | 2001-12-07 | 2013-06-18 | ヒト胚性幹細胞に由来する造血細胞 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2005511084A JP2005511084A (ja) | 2005-04-28 |
| JP2005511084A6 JP2005511084A6 (ja) | 2005-08-04 |
| JP2005511084A5 JP2005511084A5 (https=) | 2005-12-22 |
| JP5364224B2 true JP5364224B2 (ja) | 2013-12-11 |
Family
ID=23326944
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003551273A Expired - Fee Related JP5364224B2 (ja) | 2001-12-07 | 2002-12-06 | ヒト胚性幹細胞に由来する造血細胞 |
| JP2009265829A Pending JP2010075195A (ja) | 2001-12-07 | 2009-11-24 | ヒト胚性幹細胞に由来する造血細胞 |
| JP2013127621A Withdrawn JP2013236636A (ja) | 2001-12-07 | 2013-06-18 | ヒト胚性幹細胞に由来する造血細胞 |
| JP2016146156A Pending JP2016187354A (ja) | 2001-12-07 | 2016-07-26 | ヒト胚性幹細胞に由来する造血細胞 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009265829A Pending JP2010075195A (ja) | 2001-12-07 | 2009-11-24 | ヒト胚性幹細胞に由来する造血細胞 |
| JP2013127621A Withdrawn JP2013236636A (ja) | 2001-12-07 | 2013-06-18 | ヒト胚性幹細胞に由来する造血細胞 |
| JP2016146156A Pending JP2016187354A (ja) | 2001-12-07 | 2016-07-26 | ヒト胚性幹細胞に由来する造血細胞 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20030153082A1 (https=) |
| EP (2) | EP1463803B1 (https=) |
| JP (4) | JP5364224B2 (https=) |
| KR (3) | KR101457742B1 (https=) |
| CN (2) | CN1630716A (https=) |
| AU (2) | AU2002366603B2 (https=) |
| CA (1) | CA2469483C (https=) |
| GB (2) | GB2412379B (https=) |
| IL (3) | IL162130A0 (https=) |
| WO (1) | WO2003050251A2 (https=) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
| GB0210539D0 (en) * | 2002-05-08 | 2002-06-19 | Univ Edinburgh | Control of es cell self renewal and lineage specification, and medium therefor |
| US7285415B2 (en) | 2002-07-11 | 2007-10-23 | The Regents Of The University Of California | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
| UA72310C2 (en) * | 2002-09-03 | 2005-02-15 | Oleksandr Leonidovy Kukharchuk | Kukharchuk-radchenko-sirman method for reinstallation of system controlling antigenic homeostasis of the body |
| ES2705683T3 (es) | 2002-12-16 | 2019-03-26 | Technion Res & Dev Foundation | Medio de cultivo de células madre pluripotentes |
| WO2006040615A2 (en) * | 2003-06-11 | 2006-04-20 | Jan Remmereit | Differenciation of stem cells for therapeutic use |
| WO2005049812A1 (en) * | 2003-11-19 | 2005-06-02 | Australian Stem Cell Centre Limited | Methods for producing blood products from pluripotent cells in cell culture |
| US20050221482A1 (en) * | 2004-03-31 | 2005-10-06 | Burt Richard K | Methods and compositions for obtaining hematopoietic stem cells derived from embryonic stem cells and uses thereof |
| JP2008505650A (ja) * | 2004-07-12 | 2008-02-28 | ソリン・グループ・イタリア・ソシエタ・ア・レスポンサビリタ・リミタータ | ヒト細胞を増殖させるための装置及び方法 |
| WO2006017370A2 (en) | 2004-07-13 | 2006-02-16 | Geron Corporation | Medium for growing human embryonic stem cells |
| CA2611809C (en) | 2005-06-22 | 2018-06-19 | Geron Corporation | Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells |
| KR20160116024A (ko) | 2005-06-22 | 2016-10-06 | 아스테리아스 바이오세라퓨틱스, 인크. | 인간 배아 줄기 세포의 현탁 배양 |
| WO2007026353A2 (en) | 2005-08-29 | 2007-03-08 | Technion Research & Development Foundation Ltd. | Media for culturing stem cells |
| KR102651433B1 (ko) * | 2006-04-14 | 2024-03-25 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 혈관 콜로니 형성 세포 |
| EP2059586B1 (en) | 2006-08-02 | 2016-07-20 | Technion Research & Development Foundation Ltd. | Methods of expanding embryonic stem cells in a suspension culture |
| US8058064B2 (en) * | 2006-10-04 | 2011-11-15 | The University Of Tokyo | Sac-like structure enclosing hematopoietic progenitor cells produced from ES cells and method for preparing blood cells |
| US20080108044A1 (en) * | 2006-11-08 | 2008-05-08 | Deepika Rajesh | In vitro differentiation of hematopoietic cells from primate embryonic stem cells |
| US20100291042A1 (en) | 2007-05-03 | 2010-11-18 | The Brigham And Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
| WO2009104825A1 (en) * | 2008-02-18 | 2009-08-27 | Kaist | Method for inducing the defferentiation of embryonic stem cells into hemangioblast |
| KR101946785B1 (ko) * | 2008-03-27 | 2019-02-12 | 아스테리아스 바이오세라퓨틱스, 인크. | 영장류 다능성 줄기 세포의 조혈계 세포로의 분화 |
| JPWO2009119105A1 (ja) * | 2008-03-28 | 2011-07-21 | 国立大学法人 東京大学 | GPIbα+GPV+GPVI+血小板のインビトロ調製法 |
| CN101981181B (zh) | 2008-04-01 | 2013-05-29 | 国立大学法人东京大学 | 由iPS细胞制备血小板的方法 |
| EP2712921B1 (en) | 2008-05-06 | 2018-07-11 | Astellas Institute for Regenerative Medicine | Hemangio colony forming cells and non-engrafting hemangio cells |
| JP5748654B2 (ja) | 2008-05-06 | 2015-07-15 | オカタ セラピューティクス, インコーポレイテッド | 多能性幹細胞に由来する除核赤血球細胞を産生するための方法 |
| WO2010031185A1 (en) * | 2008-09-19 | 2010-03-25 | Protox Therapeutics Inc. | Treating cancer stem cells using targeted cargo proteins |
| KR101720961B1 (ko) * | 2009-02-27 | 2017-03-29 | 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 | 다능성 세포의 분화 |
| US8518397B2 (en) * | 2009-08-14 | 2013-08-27 | Case Western Reserve University | Notch induced natural killer cell generation and therapeutic uses |
| EP2490701B9 (en) | 2009-10-19 | 2017-11-15 | Cellular Dynamics International, Inc. | Cardiomyocyte production |
| EP3633025B1 (en) | 2009-11-12 | 2022-09-14 | Technion Research & Development Foundation Ltd. | Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state |
| ES2608937T3 (es) * | 2010-02-22 | 2017-04-17 | Université Pierre Et Marie Curie (Paris 6) | Medio de cultivo celular para el crecimiento y diferenciación de células del linaje hematopoyético |
| CA2802087A1 (en) | 2010-06-15 | 2011-12-22 | Cellular Dynamics International, Inc. | A compendium of ready-built stem cell models for interrogation of biological response |
| WO2012018933A2 (en) | 2010-08-04 | 2012-02-09 | Cellular Dynamics International, Inc. | Reprogramming immortalized b cells |
| CN102080065A (zh) * | 2010-12-09 | 2011-06-01 | 协和干细胞基因工程有限公司 | 一种用于脐带血造血干细胞扩增的培养体系及其应用 |
| US20140329314A1 (en) | 2011-03-29 | 2014-11-06 | Christopher O'Sullivan | Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells |
| CN102732483B (zh) * | 2011-03-31 | 2014-12-03 | 北京大学 | 造血祖细胞的制备方法及其专用培养基 |
| US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
| KR102246369B1 (ko) | 2011-11-30 | 2021-04-29 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 중간엽 간질 세포 및 이에 관련된 용도 |
| GB201210857D0 (en) | 2012-06-19 | 2012-08-01 | Cambridge Entpr Ltd | Transcription factor mediated programming towards megakaryocytes |
| US9745551B2 (en) | 2012-07-12 | 2017-08-29 | Imstem Biotechnology, Inc. | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
| CA3177929A1 (en) | 2012-12-21 | 2014-06-26 | Astellas Institute For Regenerative Medicine | Methods for production of platelets from pluripotent stem cells and compositions thereof |
| SG11201510177WA (en) | 2013-06-11 | 2016-01-28 | Harvard College | SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME |
| EP3134515B1 (en) | 2014-04-24 | 2019-03-27 | Board of Regents, The University of Texas System | Application of induced pluripotent stem cells to generate adoptive cell therapy products |
| WO2016100909A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF |
| WO2016100898A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof |
| CN107614678B (zh) | 2014-12-18 | 2021-04-30 | 哈佛学院校长同事会 | 干细胞来源的β细胞的产生方法及其使用方法 |
| US10724003B2 (en) * | 2015-01-16 | 2020-07-28 | Agency For Science, Technology And Research | Method of differentiating human pluripotent stem cells into primitive macrophages |
| CN104694471A (zh) * | 2015-03-25 | 2015-06-10 | 奥思达干细胞有限公司 | 体外诱导胚胎干细胞分化为红系细胞的方法 |
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| CA2453187A1 (en) * | 2001-07-10 | 2003-01-23 | J & J Research Pty Ltd | Production of transduced hematopoietic progenitor cells |
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