JP5355383B2 - 環状ナトリウム利尿ペプチド構築物 - Google Patents
環状ナトリウム利尿ペプチド構築物 Download PDFInfo
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- JP5355383B2 JP5355383B2 JP2009503312A JP2009503312A JP5355383B2 JP 5355383 B2 JP5355383 B2 JP 5355383B2 JP 2009503312 A JP2009503312 A JP 2009503312A JP 2009503312 A JP2009503312 A JP 2009503312A JP 5355383 B2 JP5355383 B2 JP 5355383B2
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- 125000004122 cyclic group Chemical group 0.000 title claims abstract description 10
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- 102000004571 Natriuretic peptide Human genes 0.000 title description 40
- 239000000692 natriuretic peptide Substances 0.000 title description 40
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- 102000027424 natriuretic peptide receptors Human genes 0.000 claims abstract description 7
- 108091008599 natriuretic peptide receptors Proteins 0.000 claims abstract description 7
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 5
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- 206010019280 Heart failures Diseases 0.000 abstract description 27
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- LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 description 27
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- NKLCNNUWBJBICK-UHFFFAOYSA-N dess–martin periodinane Chemical compound C1=CC=C2I(OC(=O)C)(OC(C)=O)(OC(C)=O)OC(=O)C2=C1 NKLCNNUWBJBICK-UHFFFAOYSA-N 0.000 description 26
- 239000000047 product Substances 0.000 description 26
- XUJNEKJLAYXESH-UHFFFAOYSA-N Cysteine Chemical compound SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 25
- 125000000217 alkyl group Chemical group 0.000 description 25
- 125000003277 amino group Chemical group 0.000 description 25
- 230000036772 blood pressure Effects 0.000 description 25
- IWELDVXSEVIIGI-UHFFFAOYSA-N piperazin-2-one Chemical compound O=C1CNCCN1 IWELDVXSEVIIGI-UHFFFAOYSA-N 0.000 description 25
- 210000004899 c-terminal region Anatomy 0.000 description 24
- SNDPXSYFESPGGJ-UHFFFAOYSA-N 2-aminopentanoic acid Chemical compound CCCC(N)C(O)=O SNDPXSYFESPGGJ-UHFFFAOYSA-N 0.000 description 23
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- IGUYEXXAGBDLLX-UHFFFAOYSA-N ethyl 3-(3,5-dichlorophenyl)-5-methyl-2,4-dioxo-1,3-oxazolidine-5-carboxylate Chemical compound O=C1C(C(=O)OCC)(C)OC(=O)N1C1=CC(Cl)=CC(Cl)=C1 IGUYEXXAGBDLLX-UHFFFAOYSA-N 0.000 description 14
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- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 13
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- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
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| US74396106P | 2006-03-30 | 2006-03-30 | |
| US74396006P | 2006-03-30 | 2006-03-30 | |
| US60/743,960 | 2006-03-30 | ||
| US60/743,961 | 2006-03-30 | ||
| PCT/US2007/065645 WO2007115175A2 (en) | 2006-03-30 | 2007-03-30 | Cyclic natriuretic peptide constructs |
Publications (3)
| Publication Number | Publication Date |
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| JP2009532384A JP2009532384A (ja) | 2009-09-10 |
| JP2009532384A5 JP2009532384A5 (enExample) | 2010-05-20 |
| JP5355383B2 true JP5355383B2 (ja) | 2013-11-27 |
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| JP2009503312A Expired - Fee Related JP5355383B2 (ja) | 2006-03-30 | 2007-03-30 | 環状ナトリウム利尿ペプチド構築物 |
Country Status (14)
| Country | Link |
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| US (2) | US7622440B2 (enExample) |
| EP (1) | EP2001518B1 (enExample) |
| JP (1) | JP5355383B2 (enExample) |
| KR (1) | KR101434612B1 (enExample) |
| AU (1) | AU2007233116B2 (enExample) |
| BR (1) | BRPI0709427A2 (enExample) |
| CA (1) | CA2647143A1 (enExample) |
| CO (1) | CO6140040A2 (enExample) |
| DK (1) | DK2001518T3 (enExample) |
| EA (1) | EA016804B1 (enExample) |
| ES (1) | ES2430323T3 (enExample) |
| IL (1) | IL194262A (enExample) |
| MX (1) | MX2008012663A (enExample) |
| WO (1) | WO2007115175A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7795221B2 (en) | 2006-03-30 | 2010-09-14 | Palatin Technologies, Inc. | Linear natriuretic peptide constructs |
| US8114844B2 (en) | 2006-03-30 | 2012-02-14 | Palatin Technologies, Inc. | Linear and cyclic melanocortin receptor-specific peptidomimetics |
| US8580746B2 (en) * | 2006-03-30 | 2013-11-12 | Palatin Technologies, Inc. | Amide linkage cyclic natriuretic peptide constructs |
| US7964181B2 (en) * | 2006-03-30 | 2011-06-21 | Palatin Technologies, Inc. | Amino acid surrogates for peptidic constructs |
| EP2001518B1 (en) * | 2006-03-30 | 2013-07-10 | Palatin Technologies, Inc. | Cyclic natriuretic peptide constructs |
| MX2008012649A (es) * | 2006-03-30 | 2008-10-13 | Palatin Technologies Inc | Sustitutos de aminoacido para constructos peptidicos. |
| WO2010141845A2 (en) | 2009-06-05 | 2010-12-09 | 13Therapeutics, Inc. | Immunoregulatory peptides and methods of use |
| US9458198B1 (en) | 2009-06-26 | 2016-10-04 | Shire Orphan Therapies Gmbh | Cyclic peptide-based NPR-B agonists |
| UY32902A (es) * | 2009-09-25 | 2011-02-28 | Alcon Res Ltd | Nuevos agonistas de npr-b |
| AR078446A1 (es) | 2009-12-18 | 2011-11-09 | Alcon Res Ltd | Agonistas de npr-b. uso. |
| IE20100174A1 (en) * | 2010-03-25 | 2012-02-29 | Trinity College Dublin | Transdermal administration of peptides |
| CA2796725A1 (en) * | 2010-04-21 | 2011-10-27 | Palatin Technologies, Inc. | Uses of natriuretic peptide constructs |
| US8580748B2 (en) | 2011-04-06 | 2013-11-12 | 13Therapeutics, Inc. | Peptides for the treatment of hearing |
| KR101867026B1 (ko) | 2011-12-28 | 2018-07-20 | 대우조선해양 주식회사 | 밸러스트 수 처리 시스템의 미처리 수 처리 모듈 |
| EP3983437A1 (en) | 2019-06-12 | 2022-04-20 | Novartis AG | Natriuretic peptide receptor 1 antibodies and methods of use |
| KR20220045206A (ko) * | 2019-08-12 | 2022-04-12 | 바이오마린 파머수티컬 인크. | 연장 방출형 조성물을 위한 소수성 펩티드 염 |
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2007
- 2007-03-30 EP EP07759833.2A patent/EP2001518B1/en active Active
- 2007-03-30 KR KR1020087026715A patent/KR101434612B1/ko not_active Expired - Fee Related
- 2007-03-30 CA CA002647143A patent/CA2647143A1/en not_active Abandoned
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| AU2007233116A1 (en) | 2007-10-11 |
| IL194262A (en) | 2014-05-28 |
| WO2007115175A2 (en) | 2007-10-11 |
| EP2001518B1 (en) | 2013-07-10 |
| CO6140040A2 (es) | 2010-03-19 |
| WO2007115175A3 (en) | 2008-12-11 |
| EA016804B1 (ru) | 2012-07-30 |
| US20070265206A1 (en) | 2007-11-15 |
| ES2430323T3 (es) | 2013-11-20 |
| KR20090025196A (ko) | 2009-03-10 |
| BRPI0709427A2 (pt) | 2011-07-12 |
| EA200802059A1 (ru) | 2009-04-28 |
| HK1134022A1 (en) | 2010-04-16 |
| MX2008012663A (es) | 2008-10-13 |
| EP2001518A2 (en) | 2008-12-17 |
| AU2007233116B2 (en) | 2013-05-09 |
| US8580747B2 (en) | 2013-11-12 |
| JP2009532384A (ja) | 2009-09-10 |
| US20100075895A1 (en) | 2010-03-25 |
| KR101434612B1 (ko) | 2014-08-26 |
| US7622440B2 (en) | 2009-11-24 |
| EP2001518A4 (en) | 2009-11-04 |
| DK2001518T3 (da) | 2013-10-07 |
| CA2647143A1 (en) | 2007-10-11 |
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