JP5345664B2 - 治療薬剤を組織に送出するための装置および方法 - Google Patents
治療薬剤を組織に送出するための装置および方法 Download PDFInfo
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- JP5345664B2 JP5345664B2 JP2011278004A JP2011278004A JP5345664B2 JP 5345664 B2 JP5345664 B2 JP 5345664B2 JP 2011278004 A JP2011278004 A JP 2011278004A JP 2011278004 A JP2011278004 A JP 2011278004A JP 5345664 B2 JP5345664 B2 JP 5345664B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3478—Endoscopic needles, e.g. for infusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B13/00—Oxygen; Ozone; Oxides or hydroxides in general
- C01B13/02—Preparation of oxygen
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B13/00—Oxygen; Ozone; Oxides or hydroxides in general
- C01B13/10—Preparation of ozone
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B1/00—Electrolytic production of inorganic compounds or non-metals
- C25B1/01—Products
- C25B1/13—Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00261—Discectomy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M2005/006—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for gases, e.g. CO2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M2005/3132—Syringe barrels having flow passages for injection agents at the distal end of the barrel to bypass a sealing stopper after its displacement to this end due to internal pressure increase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0216—Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
- A61M5/286—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Inorganic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Electrochemistry (AREA)
- Metallurgy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
48内に装填し、ニードル24は筒32の突出部52に装着する。図4に示すように、スイッチ76をオンにし、電源84によって電気回路が形成される。電源84は電線を通じて加熱部材104を作動させるための電流を供給する。作動時に、加熱部材104はガス発生器88の容器92を加熱し、ゲル96を加熱して温度を上述のように、ただし本実施態様では約37℃に上昇させる。加熱により、ゲル96からオゾン混合物が放出される。ゲル96から放出されたオゾン混合物は容器92の開口部および膜100に向って移動する。ゲル96は容器92内に残存しなから、オゾン混合物は膜100の孔112を通じてアキュムレイター108に移動する。アキュムレイター108にオゾン混合物が蓄積され、非膨張状態から膨張状態となるように膨張する。
20a:装置
20b:装置
20c:装置
24:ニードル
24a:ニードル
28:注射器
28b:注射器
32:筒
32a:筒
32b:筒
32c:筒
36:プランジャ
36a:プランジャ
36c:プランジャ
40:第1の端
40a:第1の端
44:第2の端
44a:第2の端
48:開口部
48a:開口部
52:突出部
52a:突出部
56:出口
60:針突き部材
64:第1の端
68:第2の端
68a:第2の端
72:アクチュエイター
72a:アクチュエイター
76:スイッチ
76a:スイッチ
76c:スイッチ
80:シャフト
84:電源
84a:電源
84c:電源
87c:誘電体
88:ガス発生器
88a:ガス発生器
88b:ガス発生器
88c:コロナ放電装置
89c:電極
92:開放系容器
96:オゾン化ゲル
100:多孔質膜
104:加熱部材
108:アキュムレイター
112:孔
116a:筒32aの内側
116c:筒32cの内側
120a:第2の端
124a:可動ストッパー
128a:出口通路
132a:ベント口
136a:第1の室
140a:第2の室
144a:入口
148a:出口
152a:通路
Claims (7)
- 治療用酸素−オゾン混合ガスを発生するオゾン発生器であって、当該オゾン発生器はプランジャ又は筒の何れかにガス発生器を固定する接続部分を有し、筒はプランジャを受け入れるための第1端とプランジャの加圧によりオゾンをプランジャから送出する第2端を有し、ガス発生器はオゾンを貯蔵するように構成された筒内に配置されるアキュムレイターと連結しており、当該アキュムレイターは第2端に流路的な関係を有する位置に送出を行える構成を有し、当該アキュムレイターは、製造された治療用酸素−オゾン混合ガスにより第2端に向かって膨張し、製造された治療用酸素−オゾン混合ガスの量が所定の量に達した際に、治療用酸素−オゾン混合ガスを蓄積できるような構成から治療用酸素−オゾン混合ガスを送出する構成に筒内で自動的に変化して、筒の第2端から治療用酸素−オゾン混合ガスを送出できるような構成を有することを特徴とするオゾン発生器。
- ガス発生器が、オゾン化ゲルを貯蔵する容器と加熱部材とから成り、加熱部材の作動により、酸素−オゾン混合ガスをオゾン化ゲルから放出させるようにオゾン化ゲルの温度を上昇させる請求項1に記載のガス発生器。
- ガス発生器が、電気化学的セルである請求項1に記載のガス発生器。
- ガス発生器が、コロナ放電装置である請求項1に記載のガス発生器。
- ガス発生器が、UV光源である請求項1に記載のガス発生器。
- ガス状治療薬剤の製造方法であって、注射器の筒内に貯蔵構造を有するアキュムレイターを配置する工程と、アキュムレイター内で治療薬剤を発生させ、筒内でアキュムレイターを膨張させる工程と、ガス状の治療薬剤の量が所定の量に達した際に、アキュムレイターが筒内で貯蔵状態から送出状態に自動的に変化する工程とから成るガス状治療薬剤の製造方法。
- 筒と、当該筒の第1端に挿入され且つ当該筒の第2端から薬剤を送出するためのプランジャと、貯蔵状態の際に、酸素から酸化ガスを発生させるコロナ放電装置と連結した酸素を貯蔵できる構成を有する筒内に配置されるアキュムレイターから成る注射器であって、当該アキュムレイターは、製造された当該ガス状の治療薬剤によって筒内でアキュムレイターが第2端に向かって膨張し、治療薬剤の量が所定の量に達した際に、第2端からアキュムレイター内のガス状の治療薬剤を送出できるようなガス送出構成を有することを特徴とする注射器。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/193,339 US8777889B2 (en) | 2004-06-15 | 2005-08-01 | Apparatus and method for administering a therapeutic agent into tissue |
US11/193,339 | 2005-08-01 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008525006A Division JP4926174B2 (ja) | 2005-08-01 | 2006-07-20 | 治療薬剤を組織に送出するための装置および方法 |
Publications (2)
Publication Number | Publication Date |
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JP2012101089A JP2012101089A (ja) | 2012-05-31 |
JP5345664B2 true JP5345664B2 (ja) | 2013-11-20 |
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Application Number | Title | Priority Date | Filing Date |
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JP2008525006A Expired - Fee Related JP4926174B2 (ja) | 2005-08-01 | 2006-07-20 | 治療薬剤を組織に送出するための装置および方法 |
JP2011278004A Active JP5345664B2 (ja) | 2005-08-01 | 2011-12-20 | 治療薬剤を組織に送出するための装置および方法 |
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JP2008525006A Expired - Fee Related JP4926174B2 (ja) | 2005-08-01 | 2006-07-20 | 治療薬剤を組織に送出するための装置および方法 |
Country Status (6)
Country | Link |
---|---|
US (5) | US8777889B2 (ja) |
EP (1) | EP1909956A4 (ja) |
JP (2) | JP4926174B2 (ja) |
AU (1) | AU2006276039B2 (ja) |
CA (1) | CA2612541C (ja) |
WO (1) | WO2007015966A2 (ja) |
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AU2006276039A1 (en) | 2007-02-08 |
US20130220801A1 (en) | 2013-08-29 |
US20070025890A1 (en) | 2007-02-01 |
US20100312171A1 (en) | 2010-12-09 |
CA2612541A1 (en) | 2007-02-08 |
US20140288484A1 (en) | 2014-09-25 |
JP2012101089A (ja) | 2012-05-31 |
AU2006276039B2 (en) | 2011-08-11 |
EP1909956A4 (en) | 2013-12-25 |
US8777889B2 (en) | 2014-07-15 |
EP1909956A2 (en) | 2008-04-16 |
JP2009502421A (ja) | 2009-01-29 |
JP4926174B2 (ja) | 2012-05-09 |
US20100307928A1 (en) | 2010-12-09 |
WO2007015966A3 (en) | 2007-10-04 |
WO2007015966A9 (en) | 2007-05-03 |
CA2612541C (en) | 2013-12-10 |
WO2007015966A2 (en) | 2007-02-08 |
US8986520B2 (en) | 2015-03-24 |
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