JP5331002B2 - Ｃｂ１受容体モジュレーターとしての１，５−ジフェニル−３−ベンジルアミノ−１，５−ジヒドロピロリジン−２−オン - Google Patents
Ｃｂ１受容体モジュレーターとしての１，５−ジフェニル−３−ベンジルアミノ−１，５−ジヒドロピロリジン−２−オン Download PDFInfo
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- JP5331002B2 JP5331002B2 JP2009533586A JP2009533586A JP5331002B2 JP 5331002 B2 JP5331002 B2 JP 5331002B2 JP 2009533586 A JP2009533586 A JP 2009533586A JP 2009533586 A JP2009533586 A JP 2009533586A JP 5331002 B2 JP5331002 B2 JP 5331002B2
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Classifications
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
Landscapes
- Health & Medical Sciences (AREA)
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| PCT/US2007/082042 WO2008070306A2 (en) | 2006-10-23 | 2007-10-22 | 1,5-diphenyl-3-benzylamin0-1,5-dihydr0pyrr0lidin-2-0ne as cb1 receptor modulators |
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| JP2010507590A JP2010507590A (ja) | 2010-03-11 |
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| TW200825067A (en) * | 2006-10-23 | 2008-06-16 | Lilly Co Eli | CB1 compounds |
| BRPI0910775A2 (pt) | 2008-04-22 | 2015-09-29 | Lilly Co Eli | compostos 1,5-difenil pirrolidin-2-ona como ligantes cb-1 |
| US8426448B2 (en) | 2008-04-22 | 2013-04-23 | Eli Lilly And Company | 1,5-diphenyl-pyrrolidin-2-one compounds as CB-1 ligands |
| WO2010057000A2 (en) * | 2008-11-13 | 2010-05-20 | The Trustees Of Columbia University In The City Of New York | Neuraminidase inhibitors and uses thereof |
| WO2012007847A2 (en) * | 2010-07-15 | 2012-01-19 | Oleg Iliich Epshtein | Pharmaceutical compositions and methods of treatment |
| US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| US20240158384A1 (en) * | 2020-12-14 | 2024-05-16 | The Board Of Trustees Of The Leland Stanford Junior University | Cb2 receptor agonists |
| WO2023205180A1 (en) | 2022-04-19 | 2023-10-26 | Nurix Therapeutics, Inc. | Biomarkers for cbl, and compositions and methods for their use |
| WO2023250097A1 (en) | 2022-06-22 | 2023-12-28 | Nurix Therapeutics, Inc. | Combination therapies with cbl-b inhibitor compounds and antiemetic agents |
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| TW200533657A (en) * | 2004-02-17 | 2005-10-16 | Esteve Labor Dr | Substituted pyrazoline compounds, their preparation and use as medicaments |
| AU2005214084B2 (en) * | 2004-02-19 | 2010-06-03 | Solvay Pharmaceuticals B.V. | Imidazoline derivatives having CB1-antagonistic activity |
| US20060035245A1 (en) * | 2004-04-20 | 2006-02-16 | Ason Brandon L | Modulators of enzymatic nucleic acid elements mobilization |
| WO2007020502A2 (en) * | 2005-08-16 | 2007-02-22 | Pharmacia & Upjohn Company Llc | Cannabinoid receptor ligands and uses thereof |
| TW200825067A (en) * | 2006-10-23 | 2008-06-16 | Lilly Co Eli | CB1 compounds |
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