ES2398388T3 - 1,5-Difenil-3-piridinilamino-1,5-dihidropirrolidin-2-onas como moduladores del receptor CB1 - Google Patents
1,5-Difenil-3-piridinilamino-1,5-dihidropirrolidin-2-onas como moduladores del receptor CB1 Download PDFInfo
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- ES2398388T3 ES2398388T3 ES07871196T ES07871196T ES2398388T3 ES 2398388 T3 ES2398388 T3 ES 2398388T3 ES 07871196 T ES07871196 T ES 07871196T ES 07871196 T ES07871196 T ES 07871196T ES 2398388 T3 ES2398388 T3 ES 2398388T3
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86254006P | 2006-10-23 | 2006-10-23 | |
| US862540P | 2006-10-23 | ||
| PCT/US2007/082041 WO2008070305A2 (en) | 2006-10-23 | 2007-10-22 | 1, 5-diphenyl-3-pyridinylamino-1, 5-dihydropyrrolidin-2-one as cbl' receptor modulator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2398388T3 true ES2398388T3 (es) | 2013-03-15 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES07871196T Active ES2398388T3 (es) | 2006-10-23 | 2007-10-22 | 1,5-Difenil-3-piridinilamino-1,5-dihidropirrolidin-2-onas como moduladores del receptor CB1 |
| ES07871197T Active ES2356025T3 (es) | 2006-10-23 | 2007-10-22 | 1,5-difenil-3-bencilamino-1,5-dihidropirrolidin-2-onas como moduladores del receptor cb1. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES07871197T Active ES2356025T3 (es) | 2006-10-23 | 2007-10-22 | 1,5-difenil-3-bencilamino-1,5-dihidropirrolidin-2-onas como moduladores del receptor cb1. |
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| Country | Link |
|---|---|
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| EP (2) | EP2099784B1 (enExample) |
| JP (2) | JP5331002B2 (enExample) |
| KR (2) | KR101088236B1 (enExample) |
| CN (2) | CN101528732B (enExample) |
| AR (1) | AR063497A1 (enExample) |
| AT (1) | ATE492543T1 (enExample) |
| AU (1) | AU2007329808B2 (enExample) |
| BR (1) | BRPI0717347A2 (enExample) |
| CA (2) | CA2667210C (enExample) |
| CL (1) | CL2007003002A1 (enExample) |
| CY (1) | CY1111140T1 (enExample) |
| DE (1) | DE602007011495D1 (enExample) |
| DK (2) | DK2099784T3 (enExample) |
| EA (2) | EA015745B1 (enExample) |
| ES (2) | ES2398388T3 (enExample) |
| MX (2) | MX2009004053A (enExample) |
| PE (1) | PE20080926A1 (enExample) |
| PL (2) | PL2094684T3 (enExample) |
| PT (2) | PT2094684E (enExample) |
| SI (2) | SI2099784T1 (enExample) |
| TW (1) | TW200825067A (enExample) |
| WO (2) | WO2008070306A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20080926A1 (es) * | 2006-10-23 | 2008-07-19 | Lilly Co Eli | Compuestos cb1 |
| CN102119029B (zh) | 2008-04-22 | 2013-03-13 | 伊莱利利公司 | 作为cb-1配体的1，5-二苯基-吡咯烷-2-酮化合物 |
| JP5539323B2 (ja) * | 2008-04-22 | 2014-07-02 | イーライ リリー アンド カンパニー | Ｃｂ−１リガンドとしての１，５−ジフェニル−ピロリジン−２−オン化合物 |
| WO2010057000A2 (en) * | 2008-11-13 | 2010-05-20 | The Trustees Of Columbia University In The City Of New York | Neuraminidase inhibitors and uses thereof |
| NZ606768A (en) * | 2010-07-15 | 2015-08-28 | Oleg Iliich Epshtein | Pharmaceutical compositions and methods of treatment |
| WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| US20240158384A1 (en) * | 2020-12-14 | 2024-05-16 | The Board Of Trustees Of The Leland Stanford Junior University | Cb2 receptor agonists |
| WO2023205180A1 (en) | 2022-04-19 | 2023-10-26 | Nurix Therapeutics, Inc. | Biomarkers for cbl, and compositions and methods for their use |
| WO2023250097A1 (en) | 2022-06-22 | 2023-12-28 | Nurix Therapeutics, Inc. | Combination therapies with cbl-b inhibitor compounds and antiemetic agents |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200533657A (en) | 2004-02-17 | 2005-10-16 | Esteve Labor Dr | Substituted pyrazoline compounds, their preparation and use as medicaments |
| AU2005214084B2 (en) * | 2004-02-19 | 2010-06-03 | Solvay Pharmaceuticals B.V. | Imidazoline derivatives having CB1-antagonistic activity |
| US20060035245A1 (en) * | 2004-04-20 | 2006-02-16 | Ason Brandon L | Modulators of enzymatic nucleic acid elements mobilization |
| WO2007020502A2 (en) * | 2005-08-16 | 2007-02-22 | Pharmacia & Upjohn Company Llc | Cannabinoid receptor ligands and uses thereof |
| PE20080926A1 (es) * | 2006-10-23 | 2008-07-19 | Lilly Co Eli | Compuestos cb1 |
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2007
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- 2007-10-18 TW TW096139051A patent/TW200825067A/zh unknown
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- 2007-10-22 JP JP2009533586A patent/JP5331002B2/ja not_active Expired - Fee Related
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- 2007-10-22 BR BRPI0717347-4A2A patent/BRPI0717347A2/pt not_active IP Right Cessation
- 2007-10-22 CA CA2667210A patent/CA2667210C/en not_active Expired - Fee Related
- 2007-10-22 SI SI200731118T patent/SI2099784T1/sl unknown
- 2007-10-22 ES ES07871196T patent/ES2398388T3/es active Active
- 2007-10-22 WO PCT/US2007/082042 patent/WO2008070306A2/en not_active Ceased
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- 2007-10-22 AU AU2007329808A patent/AU2007329808B2/en not_active Ceased
- 2007-10-22 JP JP2009533585A patent/JP5331001B2/ja not_active Expired - Fee Related
- 2007-10-22 CN CN2007800394497A patent/CN101528732B/zh not_active Expired - Fee Related
- 2007-10-22 PT PT07871197T patent/PT2094684E/pt unknown
- 2007-10-22 PL PL07871197T patent/PL2094684T3/pl unknown
- 2007-10-22 MX MX2009004053A patent/MX2009004053A/es active IP Right Grant
- 2007-10-22 EP EP07871196A patent/EP2099784B1/en not_active Not-in-force
- 2007-10-22 DK DK07871196.7T patent/DK2099784T3/da active
- 2007-10-22 EP EP07871197A patent/EP2094684B1/en not_active Not-in-force
- 2007-10-22 CA CA2667372A patent/CA2667372C/en not_active Expired - Fee Related
- 2007-10-22 DK DK07871197.5T patent/DK2094684T3/da active
- 2007-10-22 SI SI200730538T patent/SI2094684T1/sl unknown
- 2007-10-22 US US12/441,570 patent/US8168659B2/en not_active Expired - Fee Related
- 2007-10-22 MX MX2009004054A patent/MX2009004054A/es active IP Right Grant
- 2007-10-22 WO PCT/US2007/082041 patent/WO2008070305A2/en not_active Ceased
- 2007-10-22 AT AT07871197T patent/ATE492543T1/de active
- 2007-10-22 PT PT78711967T patent/PT2099784E/pt unknown
- 2007-10-22 EA EA200970405A patent/EA015175B1/ru not_active IP Right Cessation
- 2007-10-22 PL PL07871196T patent/PL2099784T3/pl unknown
- 2007-10-22 ES ES07871197T patent/ES2356025T3/es active Active
- 2007-10-22 KR KR1020097008216A patent/KR101088229B1/ko not_active Expired - Fee Related
- 2007-10-22 US US12/444,692 patent/US7998985B2/en not_active Expired - Fee Related
- 2007-10-22 CN CN2007800394514A patent/CN101528733B/zh not_active Expired - Fee Related
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2011
- 2011-01-27 CY CY20111100093T patent/CY1111140T1/el unknown
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