JP5311704B2 - 皮膚化粧料 - Google Patents
皮膚化粧料 Download PDFInfo
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- JP5311704B2 JP5311704B2 JP2004341305A JP2004341305A JP5311704B2 JP 5311704 B2 JP5311704 B2 JP 5311704B2 JP 2004341305 A JP2004341305 A JP 2004341305A JP 2004341305 A JP2004341305 A JP 2004341305A JP 5311704 B2 JP5311704 B2 JP 5311704B2
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- LYBIZMNPXTXVMV-UHFFFAOYSA-N propan-2-yl prop-2-enoate Chemical compound CC(C)OC(=O)C=C LYBIZMNPXTXVMV-UHFFFAOYSA-N 0.000 description 1
- 229940069949 propolis Drugs 0.000 description 1
- NHARPDSAXCBDDR-UHFFFAOYSA-N propyl 2-methylprop-2-enoate Chemical compound CCCOC(=O)C(C)=C NHARPDSAXCBDDR-UHFFFAOYSA-N 0.000 description 1
- PNXMTCDJUBJHQJ-UHFFFAOYSA-N propyl prop-2-enoate Chemical compound CCCOC(=O)C=C PNXMTCDJUBJHQJ-UHFFFAOYSA-N 0.000 description 1
- 239000003531 protein hydrolysate Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 235000019423 pullulan Nutrition 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000037393 skin firmness Effects 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 230000036558 skin tension Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229960002668 sodium chloride Drugs 0.000 description 1
- 229960004025 sodium salicylate Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 229960004492 suprofen Drugs 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical class NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 description 1
- 230000005068 transpiration Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Description
(1)(a)成分として、式(I)で示される2−(メタ)アクリロイルオキシエチルホスホリルコリンに基づく構成単位と、(メタ)アクリル酸アルキルエステルに基づく構成単位とを100/0〜10/90のモル比で含み、両構成単位の合計重量%が60〜100%である共重合体0.005〜10重量%、(b)成分として、スベリヒユ抽出エキスを乾燥重量として0.0005〜2重量%含有することを特徴とする皮膚化粧料。
表1に示す透明または半透明化粧水である皮膚化粧料を調製し、7つの評価項目について下記評価基準により評価を行なった。但し、共通添加成分として表2に示す5成分を使用した。なお、表1中、各左欄に示される括弧書内の有効分とは、例えば、表の左欄に示されるPCポリマー1等の各成分が使用された場合に、そのうちに含まれる実際に有効な所望の成分(PCポリマー1では、(a)成分)の割合をいい、その重量%は、水溶液中に含まれる(a)、(b)および(c)の各成分の重量%を示している。例えば、実施例1では、中欄に示されるように、(a)成分として、PCポリマー1を1重量%用いているが、(a)成分を含むPCポリマーは、表1の左欄の(有効分:40重量%)により、40重量%の(a)成分を含んでおり、実施例1で実際に用いられる(a)成分は、1×0.4=0.4重量%となる。このような実際に含まれる(a)、(b)または(c)成分は、各欄の括弧書にて示している。
注2;「Lipidure−PMB」(日本油脂(株)製)「MPC80重量%、メタクリル酸ブチル20重量%の構成比で重量平均分子量約60万のポリマー5重量%含有水溶液」
(MPC:2−メタクリロイルオキシエチルホスホリルコリン))
注3;「POTURACA EXTRACT」(バイオランド社製Lot.NMP-L-150603)
注4;「POTURACA EXTRACT」(バイオランド社製Lot.NMP-L-202223)
注5;「グリチリチンK2」(丸善製薬(株))
注6;「アラントイン」(川研ファインケミカル(株))
(1)使用時の感触
20名の女性(21才〜35才)をパネラーとし、洗顔した後に皮膚化粧料(約2g)を使用した時の感触について下記のように判定し、20名の平均値を求めて、平均値1.5点以上を使用時の感触の軽い化粧料であると評価した。
2点:使用時にべたつきも無く肌へのなじみが良いと感じた場合。
1点:使用時にややべたつきが有ったりやや肌へのなじみが悪いと感じた場合。
0点:使用時にべたつきが有るもしくは肌へのなじみが悪いと感じた場合。
20名の女性(21才〜35才)をパネラーとし、洗顔した後に皮膚化粧料(約2g)を使用して10分後の肌の感触について下記のように判定し、20名の平均値を求めて、平均値1.5点以上を使用後のべたつきがない化粧料であると評価した。
2点:肌がべたつきが無いと感じた場合。
1点:肌がややべたつくと感じた場合。
0点:肌が非常にべたつくと感じた場合。
20名の女性(21才〜35才)をパネラーとし、洗顔した後に皮膚化粧料(約2g)を使用して2時間後の肌のうるおいについて下記のように判定し、20名の平均値を求めて、平均値1.5点以上を保湿効果の持続性の良好な化粧料であると評価した。
2点:使用直後と変わらず肌が十分うるおっていると感じた場合。
1点:使用直後と比べてやや肌のうるおいが足りないと感じた場合。
0点:使用直後と比べて明らかに肌のうるおいが足りないと感じた場合。
肌荒れを生じている10名の女性(24才〜34才)をパネラーとし、皮膚化粧料を一日2回ずつ連日2週間にわたって使用した時の肌の状態について官能検査し、下記のように判定し、10名の平均値を求めて、平均値1.5点以上を肌荒れ改善効果のある化粧料であると評価した。
2点:肌荒れが明らかに治ってきたと感じた場合。
1点:肌荒れがやや治ってきたと感じた場合。
0点:肌荒れ改善効果が全く見られないと感じた場合。
20名の女性(21才〜35才)をパネラーとし、皮膚化粧料を一日2回ずつ連日2週間にわたって使用した時の肌の状態について官能検査し、下記のように判定し、20名の平均値を求めて、平均値1.5点以上をしわ抑制効果に優れた化粧料であると評価した。
2点:しわが明らかに目立たなくなったと感じた場合。
1点:しわがやや目立たなくなったと感じた場合。
0点:しわ抑制効果が全く無いと感じた場合。
20名の女性(21才〜35才)をパネラーとし、皮膚化粧料を一日2回ずつ連日2週間にわたって使用した時の肌の状態について官能検査し、下記のように判定し、20名の平均値を求めて、平均値1.5点以上を肌にはりを与える効果のある化粧料であると評価した。
2点:明らかに肌にはりがでたと感じた場合。
1点:やや肌にはりがでたと感じた場合。
0点:肌にはりがでないと感じた場合。
化粧料を透明ガラス容器に密封して0℃、25℃、40℃で3ヶ月間保存し、その外観を観察して、下に示す3段階で評価した。
○:安定性良好(いずれの温度においても外観の変化がない。)
△:安定性やや不良(いずれかの温度において若干の外観の変化があり、沈殿を生じるまたは若干着色を生じる。)
×:安定性不良(いずれかの温度において外観の変化があり、沈殿を生じるまたは分離する。もしくは着色が著しい。)
表3に示す水中油型乳液である皮膚化粧料を調製し、実施例1〜3と同様の方法により評価を行なった。但し、共通添加成分としては、表4に示す14成分を使用した。なお、表3中に表される各用語の意義は、前述の表1と同様である。
注2;「Lipidure−PMB」(日本油脂(株)製)「MPC80重量%、メタクリル酸ブチル20重量%の構成比で重量平均分子量約60万のポリマー5重量%含有水溶液」
注3;「POTURACA EXTRACT」(バイオランド社製Lot.NMP-L-150603)
注4;「POTURACA EXTRACT」(バイオランド社製Lot.NMP-L-202223)
注5;「グリチリチンK2」(丸善製薬(株))
注6;「アラントイン」(川研ファインケミカル(株))
表5に示す水中油型クリームである皮膚化粧料を調製し、評価項目(1)〜(6)は実施例1〜3の方法により、そして評価項目(7)の経時安定性については下記の検査により評価を行なった。但し、共通添加成分として表6に示す13成分を使用した。なお、表5中に表される各用語の意義は、前述の表1と同様である。
注2;「Lipidure−PMB」(日本油脂(株)製)「MPC80重量%、メタクリル酸ブチル20重量%の構成比で重量平均分子量約60万のポリマー5重量%含有水溶液」
注3;「POTURACA EXTRACT」(バイオランド社製Lot.NMP-L-150603)
注4;「POTURACA EXTRACT」(バイオランド社製Lot.NMP-L-202223)
注5;「グリチリチンK2」(丸善製薬(株))
注6;「アラントイン」(川研ファインケミカル(株))
注7;「シーオーグレチノール」(丸善製薬(株))
化粧料を透明ガラス容器に密封して−5℃、25℃、45℃で1ヶ月間保存したときの状態を調査し、下に示す3段階で評価した。
○:安定性良好(いずれの温度においても外観の変化がなくブツ等も生じない。)
△:安定性やや不良(いずれかの温度において僅かに沈殿を生じるか僅かに分離が見られる。または僅かにブツ、ダマを生じている。)
×:安定性不良(いずれかの温度において明らかに沈殿を生じるか分離する。)
表5に示す油中水型クリームである皮膚化粧料を調製し、実施例7、8に示す評価方法により評価を行なった。但し、共通添加成分として表7に示す11成分を使用した。
Claims (1)
Priority Applications (2)
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JP2004341305A JP5311704B2 (ja) | 2004-11-25 | 2004-11-25 | 皮膚化粧料 |
KR1020050107423A KR100698356B1 (ko) | 2004-11-25 | 2005-11-10 | 피부 화장료 |
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JP2004341305A JP5311704B2 (ja) | 2004-11-25 | 2004-11-25 | 皮膚化粧料 |
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JP5311704B2 true JP5311704B2 (ja) | 2013-10-09 |
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JP2010043018A (ja) * | 2008-08-12 | 2010-02-25 | Sunstar Inc | スキンケア組成物 |
JP5703850B2 (ja) * | 2011-03-04 | 2015-04-22 | 日油株式会社 | 化粧料用リポソーム及び化粧料 |
KR102178890B1 (ko) * | 2014-11-06 | 2020-11-16 | 주식회사 엘지생활건강 | 마치현 추출물을 포함하는 히알루론산 생성 촉진용 조성물과 이의 이용 |
KR101865542B1 (ko) * | 2016-09-06 | 2018-06-08 | 주식회사 피코스텍 | 반지련 추출물을 포함하는 피지 과다분비 또는 지루성 습진의 억제 또는 개선용 조성물 |
JP6935684B2 (ja) * | 2017-04-17 | 2021-09-15 | 日油株式会社 | 水性化粧料 |
JP7312527B2 (ja) * | 2017-05-16 | 2023-07-21 | 小林製薬株式会社 | 乳化組成物 |
JP7471085B2 (ja) * | 2017-11-30 | 2024-04-19 | 株式会社 資生堂 | コレステロール合成促進剤 |
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JPS63192705A (ja) | 1987-02-05 | 1988-08-10 | Shiseido Co Ltd | 皮膚外用剤 |
JP3689494B2 (ja) * | 1996-07-31 | 2005-08-31 | 日本油脂株式会社 | 経皮吸収用製剤用の基剤 |
JP4126819B2 (ja) | 1999-06-23 | 2008-07-30 | 日油株式会社 | 皮膚化粧料 |
JP2002060332A (ja) | 2000-08-17 | 2002-02-26 | Nof Corp | 皮膚化粧料 |
US7060303B2 (en) * | 2002-12-31 | 2006-06-13 | Avon Products, Inc. | Use of purslane to treat facial wrinkles |
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