JP5494142B2 - 皮膚外用剤 - Google Patents
皮膚外用剤 Download PDFInfo
- Publication number
- JP5494142B2 JP5494142B2 JP2010084249A JP2010084249A JP5494142B2 JP 5494142 B2 JP5494142 B2 JP 5494142B2 JP 2010084249 A JP2010084249 A JP 2010084249A JP 2010084249 A JP2010084249 A JP 2010084249A JP 5494142 B2 JP5494142 B2 JP 5494142B2
- Authority
- JP
- Japan
- Prior art keywords
- skin
- weight
- acid
- arginine
- effect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001483 arginine derivatives Chemical class 0.000 claims description 17
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- 125000002091 cationic group Chemical group 0.000 claims description 3
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- 239000004475 Arginine Substances 0.000 description 14
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Description
しかし、上記化合物は強い界面活性能を有する「界面活性剤」であり、皮膚へ残存すると様々な弊害が予想されるだけでなく、保湿や整肌効果を与えるものではなかった。
すなわち、本発明は、
a.下記一般式(1)で示されるアルギニン誘導体0.05〜20重量%、
b.炭素数4〜8のグリコール2〜15重量%、c.ポリフェノール0.0001〜0.2重量%、d.キレート剤0.1〜2重量%含有することを特徴とする皮膚外用剤である。
本発明においては植物抽出物から精製または合成したポリフェノールを使用することも可能であるが、ポリフェノールを含有した植物エキスとして使用しても良い。
[a成分(アルギニン誘導体)の合成]
<アルギニン誘導体1(モノヒドロキシプロピルアルギニン)>
L−アルギニン174g(1モル)をイオン交換水406gに溶解し、オートクレーブに仕込み、オートクレーブ内の空気を乾燥窒素で置換した。次に60℃にオートクレーブを加温し、滴下装置によりプロピレンオキシド58g(1モル)を1時間かけて徐々に滴下し、滴下終了後、さらに6時間攪拌した。反応終了後、30分間乾燥窒素でバブリングして未反応のプロピレンオキシドを除去し、オートクレーブから反応生成物を取り出した。この反応生成物に対し、イオン交換水を加え、アルギニン誘導体1の25重量%水溶液を調製し、以下の検討に用いた。なお、L−アルギニンと、アルギニン誘導体1の25重量%水溶液の全アミン価を、「医薬部外品原料規格2006(薬事日報社編) 別記II 規格各条」掲載の「L−アルギニン」の「定量法」に従い測定したところ、L−アルギニンは642.0(理論全アミン価644.2)、アルギニン誘導体1の25重量%水溶液は113.4であった。
L−アルギニン174g(1モル)をイオン交換水406gに溶解し、オートクレーブに仕込み、オートクレーブ内の空気を乾燥窒素で置換した。次に60℃にオートクレーブを加温し、滴下装置によりプロピレンオキシド116g(2モル)を1時間かけて徐々に滴下し、滴下終了後、さらに6時間攪拌した。反応終了後、30分間乾燥窒素でバブリングして未反応のプロピレンオキシドを除去し、オートクレーブから反応生成物を取り出した。この反応生成物に対し、イオン交換水を加え、アルギニン誘導体2の25重量%水溶液を調製し、以下の検討に用いた。L−アルギニンと、アルギニン誘導体2の25重量%水溶液の全アミン価を、「医薬部外品原料規格2006(薬事日報社編) 別記II 規格各条」掲載の「L−アルギニン」の「定量法」に従い測定したところ、L−アルギニンは642.0(理論全アミン価644.2)、アルギニン誘導体2の25重量%水溶液は87.5であった。
表1に示す化粧水を調整し、7項目について下記の評価基準により評価を行なった。結果を表1に示す。
(1)肌へのなじみ性
20名の女性(28才〜61才)をパネラーとし、洗顔した後に皮膚外用剤を使用した時の感触について下記のように判定し、20名の平均値を求めて、平均値1.5点以上を使用時の感触の良好な皮膚外用剤であると評価した。
2点:使用時に肌へのなじみが良いと感じた場合。
1点:使用時にやや肌へのなじみが悪いと感じた場合。
0点:使用時に明らかに肌へのなじみが悪いと感じた場合。
20名の女性(28才〜61才)をパネラーとし、洗顔した後に皮膚外用剤を使用して10分後の肌の感触について下記のように判定し、20名の平均値を求めて、平均値1.5点以上を使用後のべたつきがない皮膚外用剤であると評価した。
2点:べたつきが無いと感じた場合。
1点:肌がややべたつくと感じた場合。
0点:肌が非常にべたつくと感じた場合。
肌荒れを生じている10名の女性(32才〜50才)をパネラーとし、皮膚外用剤を一日2回ずつ連日2週間に至って使用した時の肌の状態について官能検査し、下記のように判定し、10名の平均値を求めて、平均値1.5点以上を肌荒れ改善効果のある皮膚外用剤であると評価した。
2点:肌荒れが明らかに治ってきたと感じた場合。
1点:肌荒れがやや治ってきたと感じた場合。
0点:肌荒れ改善効果が全く見られないと感じた場合。
肌荒れを生じている20名の女性(28才〜61才)をパネラーとし、皮膚外用剤を一日2回ずつ連日4週間に至って使用した時の肌の状態について官能検査し、下記のように判定し、20名の平均値を求めて、平均値1.5点以上をシワ防止・改善効果のある皮膚外用剤であると評価した。
2点:シワが明らかに少なくなったと感じた場合。
1点:シワがやや少なくなってきたと感じた場合。
0点:シワが減少しない、もしくは増えたと感じた場合。
20名の女性(28才〜61才)をパネラーとし、皮膚外用剤を一日2回ずつ連日2週間に至って使用した時の肌の状態について官能検査し、下記のように判定し、20名の平均値を求めて、平均値1.5点以上を肌にはりと透明感を与える効果のある皮膚外用剤であると評価した。
2点:明らかに肌にはりがでたと感じた場合。
1点:やや肌にはりがでたと感じた場合。
0点:肌にはりがないと感じた場合。
20名の女性(28才〜61才)をパネラーとし、皮膚外用剤を一日2回ずつ連日4週間に至って使用した時の肌の状態について官能検査し、下記のように判定し、20名の平均値を求めて、平均値1.5点以上を肌に透明感を与え、明るくする効果のある皮膚外用剤であると評価した。
2点:明らかに肌に透明感が出て、明るくなったと感じた場合。
1点:やや肌に透明感が出て、明るくなったと感じた場合。
0点:肌の透明感、明るさに変化が無いと感じた場合。
化粧料を透明ガラス容器に密封して0℃、25℃、40℃で3ヶ月間保存し、その外観を観察して、下に示す3段階で評価した。
○:安定性良好(いずれの温度においても外観の変化がない。)
△:安定性やや不良(いずれかの温度において若干おり、沈殿を生じるまたは若干変色を生じる。)
×:安定性不良(いずれかの温度においており、沈殿を生じるまたは分離する。もしくは変色が著しい。)
注2;「PF-TP90」(株式会社ファーマフーズ研究所製)
表2に示す水中油型乳化の乳液を調整し、実施例1〜3と同様の方法により評価を行なった。結果を表2に示す。
注2;「PF-TP90」(株式会社ファーマフーズ研究所製)
注3;「クミスクチンエキスBG」(日油株式会社製)
注4;「カーボポール #941」(BF-Goodrich社製)
表3に示す水中油型乳化のクリームを調製し、評価項目(1)〜(6)は実施例1〜3の方法により、そして評価項目(7)の経時安定性については下記の方法により評価を行なった。但し、共通添加成分として表4に示す10成分を使用した。結果を表3に示す。
化粧料を透明ガラス容器に密封して−5℃、25℃、45℃で1ヶ月間保存したときの状態を調査し、下に示す3段階で評価した。
○:安定性良好(いずれの温度においても外観の変化がなくブツ等も生じない。)
△:安定性やや不良(いずれかの温度において僅かに沈殿を生じるか僅かに分離が見られる。または僅かにブツ、ダマを生じている。)
×:安定性不良(いずれかの温度において明らかに沈殿を生じるか分離する。
注5;「Resveratrox De-Colored 2% SOL.」(香栄興業株式会社製)
表3に示す油中水型乳化のクリームを調整し、実施例7、8に示す評価方法により評価を行なった。但し、共通添加成分として表5に示す10成分を使用した。結果を表3に示す。
Claims (1)
- 全組成物当たり、a.下記一般式(1)で示されるアルギニン誘導体0.05〜20重量%、
(R1、R2は水素原子又はヒドロキシプロピル基であり、R1、R2の少なくともどちらかはヒドロキシプロピル基を示す。R3は水素原子、アルカリ金属原子、アンモニウム基又はアルカノールアミンのカチオン性残基を示す。)
b.炭素数4〜8のグリコール2〜15重量%、c.ポリフェノール0.0001〜0.2重量%、d.キレート剤0.1〜2重量%含有することを特徴とする皮膚外用剤。
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