JP5286081B2 - 還元型補酵素q10の安定化方法 - Google Patents
還元型補酵素q10の安定化方法 Download PDFInfo
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- JP5286081B2 JP5286081B2 JP2008513310A JP2008513310A JP5286081B2 JP 5286081 B2 JP5286081 B2 JP 5286081B2 JP 2008513310 A JP2008513310 A JP 2008513310A JP 2008513310 A JP2008513310 A JP 2008513310A JP 5286081 B2 JP5286081 B2 JP 5286081B2
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- reduced coenzyme
- coenzyme
- reduced
- composition
- oxidized
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- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- YJMNOKOLADGBKA-UHFFFAOYSA-N naphthalene-1-carbonitrile Chemical compound C1=CC=C2C(C#N)=CC=CC2=C1 YJMNOKOLADGBKA-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 description 1
- PLZZPPHAMDJOSR-UHFFFAOYSA-N nonanenitrile Chemical compound CCCCCCCCC#N PLZZPPHAMDJOSR-UHFFFAOYSA-N 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- YSIMAPNUZAVQER-UHFFFAOYSA-N octanenitrile Chemical compound CCCCCCCC#N YSIMAPNUZAVQER-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- JCGNDDUYTRNOFT-UHFFFAOYSA-N oxolane-2,4-dione Chemical compound O=C1COC(=O)C1 JCGNDDUYTRNOFT-UHFFFAOYSA-N 0.000 description 1
- 239000006201 parenteral dosage form Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- BNIXVQGCZULYKV-UHFFFAOYSA-N pentachloroethane Chemical compound ClC(Cl)C(Cl)(Cl)Cl BNIXVQGCZULYKV-UHFFFAOYSA-N 0.000 description 1
- KRKQHNVYOWTEQO-UHFFFAOYSA-N pentadecanenitrile Chemical compound CCCCCCCCCCCCCCC#N KRKQHNVYOWTEQO-UHFFFAOYSA-N 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- XQZYPMVTSDWCCE-UHFFFAOYSA-N phthalonitrile Chemical compound N#CC1=CC=CC=C1C#N XQZYPMVTSDWCCE-UHFFFAOYSA-N 0.000 description 1
- 229920006391 phthalonitrile polymer Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- TVDSBUOJIPERQY-UHFFFAOYSA-N prop-2-yn-1-ol Chemical compound OCC#C TVDSBUOJIPERQY-UHFFFAOYSA-N 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 150000003151 propanoic acid esters Chemical class 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 229930195734 saturated hydrocarbon Natural products 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229940001607 sodium bisulfite Drugs 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- JVBXVOWTABLYPX-UHFFFAOYSA-L sodium dithionite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])=O JVBXVOWTABLYPX-UHFFFAOYSA-L 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 229940001474 sodium thiosulfate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- RHSBIGNQEIPSCT-UHFFFAOYSA-N stearonitrile Chemical compound CCCCCCCCCCCCCCCCCC#N RHSBIGNQEIPSCT-UHFFFAOYSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- IAHFWCOBPZCAEA-UHFFFAOYSA-N succinonitrile Chemical compound N#CCCC#N IAHFWCOBPZCAEA-UHFFFAOYSA-N 0.000 description 1
- HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical compound O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
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- 238000012360 testing method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
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- 230000008719 thickening Effects 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000005809 transesterification reaction Methods 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- WKJHMKQSIBMURP-UHFFFAOYSA-N tridecanenitrile Chemical compound CCCCCCCCCCCCC#N WKJHMKQSIBMURP-UHFFFAOYSA-N 0.000 description 1
- JLGLQAWTXXGVEM-UHFFFAOYSA-N triethylene glycol monomethyl ether Chemical compound COCCOCCOCCO JLGLQAWTXXGVEM-UHFFFAOYSA-N 0.000 description 1
- RNUCUWWMTTWKAH-JLHYYAGUSA-N ubiquinol-2 Chemical compound COC1=C(O)C(C)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1OC RNUCUWWMTTWKAH-JLHYYAGUSA-N 0.000 description 1
- SZKKNEOUHLFYNA-UHFFFAOYSA-N undecanenitrile Chemical compound CCCCCCCCCCC#N SZKKNEOUHLFYNA-UHFFFAOYSA-N 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
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- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/34—Separation; Purification; Stabilisation; Use of additives
- C07C41/46—Use of additives, e.g. for stabilisation
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Description
〔1〕以下の(a)および/または(b)を共存させることを特徴とする還元型補酵素Q10の安定化方法:
(a)還元型補酵素Q10に対し、0.6重量%以上の還元型補酵素Q9:
(b)還元型補酵素Q11。
〔2〕前記(a)還元型補酵素Q9が1重量%以上である〔1〕記載の方法。
〔3〕前記(a)還元型補酵素Q9および(b)還元型補酵素Q11が別途調製され添加されたものである〔1〕または〔2〕記載の方法。
〔4〕酸化型補酵素Q9および/または酸化型補酵素Q11を含有する酸化型補酵素Q10を還元することにより、前記共存状態とする〔1〕または〔2〕記載の方法。
〔5〕脱酸素雰囲気下で共存させる〔1〕〜〔4〕のいずれか1項に記載の方法。
〔6〕以下の(a)および/または(b)を共存させることを特徴とする還元型補酵素Q10含有組成物:
(a)還元型補酵素Q10に対し、0.6重量%以上の還元型補酵素Q9:
(b)還元型補酵素Q11。
〔7〕前記(a)還元型補酵素Q9が1重量%以上である〔6〕記載の組成物。
〔8〕還元型補酵素Q10が結晶形態である、〔6〕または〔7〕記載の組成物。
〔9〕還元型補酵素Q10が溶媒に溶解または懸濁された形態である〔6〕または〔7〕記載の組成物。
〔10〕還元型補酵素Q10が溶融液の形態である〔6〕または〔7〕記載の組成物。
〔11〕還元型補酵素Q10を有効成分とし、哺乳類に投与される形態である〔6〕または〔7〕記載の組成物。
〔12〕賦形剤、崩壊剤、滑沢剤、結合剤、酸化防止剤、着色剤、凝集防止剤、吸収促進剤、有効成分の溶解補助剤、安定化剤、または還元型補酵素Q10以外の他の活性成分よりなる群から選ばれる少なくとも一種が含まれる〔6〕または〔7〕記載の組成物。
〔13〕カプセル剤である〔12〕記載の組成物。
〔14〕カプセル剤が、マイクロカプセル、ソフトカプセルまたはハードカプセルである〔13〕記載の組成物。
〔15〕以下の(a)および/または(b)が共存する還元型補酵素Q10含有組成物の製造方法であって、(a)および/または(b)が別途調製および添加される工程を含む製造方法:
(a)還元型補酵素Q10に対し、0.6重量%以上の還元型補酵素Q9:
(b)還元型補酵素Q11。
〔16〕以下の(a)および/または(b)が共存する還元型補酵素Q10含有組成物の製造方法であって、酸化型補酵素Q9を酸化型補酵素Q10に対し0.6重量%以上、および/または酸化型補酵素Q11を含む、酸化型補酵素Q10を還元する工程を含む製造方法:
(a)還元型補酵素Q10に対し、0.6重量%以上の還元型補酵素Q9:
(b)還元型補酵素Q11。
還元型補酵素Q11の量は、還元型補酵素Q10に対し、通常約0.1重量%以上であり、好ましくは約0.5重量%以上であり、より好ましくは約1重量%以上である。
還元型補酵素Q10に含まれる還元型補酵素Q9および/または還元型補酵素Q11の好適な量は上記で述べた通りである。
還元型補酵素Q10に別途調製された還元型補酵素Q9および/または還元型補酵素Q11を添加し、本発明の組成物としても良いし、酸化型補酵素Q9および/または酸化型補酵素Q11を含有する酸化型補酵素Q10を還元することにより、本発明の組成物としても良い。
還元型補酵素Q9および/または還元型補酵素Q11を含有する還元型補酵素Q10の製造法としては特に制限されない。(a)および/または(b)が別途調製および添加される工程とは、上記で述べた通りに別途調製された(a)および/または(b)を添加する工程であり、調製および添加は公知の方法により行う。
言うまでもなく、酸化型補酵素Q9および/または酸化型補酵素Q11を含む酸化型補酵素Q10を還元する方法(工程)と、別途調製した還元型補酵素Q9および/または還元型補酵素Q11を添加する方法(工程)とを併用することもできる。
タン、ノナン、2,2,5−トリメチルヘキサン、デカン、ドデカン、2−ペンテン、1−ヘキセン、1−ヘプテン、1−オクテン、1−ノネン、1−デセン、シクロペンタン、メチルシクロペンタン、シクロヘキサン、メチルシクロヘキサン、エチルシクロヘキサン、p−メンタン、シクロヘキセン等を挙げることができる。
ン、p−シメン、シクロヘキシルベンゼン、ジエチルベンゼン、ペンチルベンゼン等が好ましく、特に、トルエン、キシレン、o−キシレン、m−キシレン、p−キシレン、クメン、テトラリン等が好ましい。最も好ましくは、クメンである。
カラム:SYMMETRY C18(Waters製)250mm(長さ)4.6mm(内径)、移動相;C2H5OH:CH3OH=4:3(v:v)、検出波長;210nm、流速;1ml/min、還元型補酵素Q10の保持時間;9.1min、酸化型補酵素Q10の保持時間;13.3min。
1000gのエタノール中に、100gの酸化型補酵素Q10、60gのL−アスコルビン酸を加え、78℃にて攪拌し、還元反応を行った。30時間後、50℃まで冷却し、同温を保持しながらエタノール400gを添加した。このエタノール溶液(還元型補酵素Q10を100g含む)を攪拌しながら、10℃/時間の冷却速度で2℃まで冷却し、白色のスラリーを得た。得られたスラリーを減圧ろ過し、湿結晶を冷エタノール、冷水、冷エタノールの順で洗浄(洗浄に用いた冷溶媒の温度は2℃)して、さらに、湿結晶を減圧乾燥(20〜40℃、1〜30mmHg)することにより、白色の乾燥結晶95gを得た。なお、減圧乾燥を除くすべての操作は窒素雰囲気下で実施した。得られた結晶の還元型補酵素Q10/酸化型補酵素Q10の重量比は99.4/0.6であった。
100gのエタノール中に、10gの酸化型補酵素Q9、7gのL−アスコルビン酸を加え、78℃にて攪拌し、還元反応を行った。30時間後、50℃まで冷却し、同温を保持しながらエタノール40g、ヘキサン140g、水140gをこの順に添加した。水層を除去した後、有機層を減圧下にて濃縮し、還元型補酵素Q9の結晶を得た。
製造例1で得られた還元型補酵素Q10 9.85gと製造例2で得られた還元型補酵素Q9 0.15gを混合し、還元型補酵素Q9を1.5重量%含有する還元型補酵素Q10(還元型補酵素Q10/酸化型補酵素Q10=99.4/0.6)を得た。
100gのエタノール中に、酸化型補酵素Q110.1重量%を含む酸化型補酵素Q1010gおよび6gのL−アスコルビン酸を加え、78℃にて攪拌し、還元反応を行った。30時間後、50℃まで冷却し、同温を保持しながらエタノール40g及び水10gを添加した。このエタノール溶液(還元型補酵素Q10を10g含む)を攪拌しながら、10℃/時間の冷却速度で2℃まで冷却し、白色のスラリーを得た。得られたスラリーを減圧ろ過し、湿結晶を冷エタノール、冷水、冷エタノールの順に洗浄(洗浄に用いた冷溶媒の温度は2℃)して、さらに、湿結晶を減圧乾燥(20〜40℃、1〜30mmHg)することにより、白色の乾燥結晶9.5gを得た。尚、減圧乾燥を除くすべての操作は窒素雰囲気下で実施した。得られた結晶には還元型補酵素Q11が0.1重量%含まれており、還元型補酵素Q10/酸化型補酵素Q10の重量比は99.4/0.6であった。
製造例3で得られた還元型補酵素Q9を1.5重量%含有する還元型補酵素Q10(還元型補酵素Q10/酸化型補酵素Q10=99.4/0.6)、および、製造例1で得られた還元型補酵素Q9を含まない還元型補酵素Q10(還元型補酵素Q10/酸化型補酵素Q10=99.4/0.6)の結晶を、それぞれ、25℃、空気中にて保存した。24時間経過後の還元型補酵素Q10/酸化型補酵素Q10比の結果を表1に示す。
5gのエタノールに、製造例3で得られた還元型補酵素Q9を1.5重量%含有する、50mgの還元型補酵素Q10(還元型補酵素Q10/酸化型補酵素Q10=99.4/0.6)、および、製造例1で得られた還元型補酵素Q9を含まない50mgの還元型補酵素Q10(還元型補酵素Q10/酸化型補酵素Q10=99.4/0.6)を加え、それぞれ25℃、空気中にて撹拌した。6時間撹拌後の還元型補酵素Q10/酸化型補酵素Q10比の結果を表2に示す。
Crj:CD(SD)ラット(5週齢、雄15匹、雌15匹、体重260g〜300g)を雄、雌それぞれについて、5匹ずつ3群に分けた。一つめの群は、対照群としてコーン油を3ml/kgの投与量で14日間、一日一回経口投与した。二つめの群には、製造例2で得られた還元型補酵素Q9を用いて、還元型補酵素Q9の投与量が600mg/kgとなるように調製した還元型補酵素Q9のコーン油溶液を3ml/kgの投与量で14日間、一日一回経口投与した。三つめの群には、製造例1で得られた還元型補酵素Q10を用いて、還元型補酵素Q10の投与量が600mg/kgとなるように調製した還元型補酵素Q10のコーン油溶液を3ml/kgの投与量で14日間、一日一回経口投与した。最終投与終了から24時間後に採血を行い、血漿試料を得た。HPLCを用いて得られた血漿中の補酵素Q濃度を測定した。
菜種油、ジグリセリンモノオレエート(理研ビタミン製ポエムDO−100V)、硬化油、蜜蝋、レシチンからなる混合物に、還元型補酵素Q11を0.1重量%、酸化型補酵素Q10を0.6重量%含む還元型補酵素Q10の結晶を添加し、定法により、下記成分からなる還元型補酵素Q10を30mg含有するゼラチンのソフトカプセルを得た。
還元型補酵素Q10 10.0重量%
ジグリセリンモノオレエート 32.0重量%
菜種油 33.0重量%
硬化油 17.0重量%
蜜蝋 6.0重量%
レシチン 2.0重量%
Crj:CD(SD)ラット(およそ77週齢)雄10匹を用意し、5匹には還元型補酵素Q10、残りの5匹には還元型補酵素Q10と還元型補酵素Q11の混合物(還元型補酵素Q11を0.1重量%含む)を、それぞれ25mg/mlの大豆油溶液として、4.0ml/kgの投与量で経口投与した。投与から2時間後に採血を行い、遠心分離により血漿試料を得た。HPLCを用いて、得られた血漿中の補酵素Q10濃度を測定した。結果を図2に示した。図2より明らかなように、還元型補酵素Q10、還元型補酵素Q10と還元型補酵素Q11の混合物のいずれの投与においても、血漿中補酵素Q10濃度は、3.4μg/ml程度であった。
Claims (14)
- 以下の(a)および/または(b)を共存させることを特徴とする還元型補酵素Q10の安定化方法:
(a)還元型補酵素Q10に対し、0.6重量%以上の還元型補酵素Q9:
(b)還元型補酵素Q11。 - 前記(a)還元型補酵素Q9が1重量%以上である請求項1記載の方法。
- 前記(a)還元型補酵素Q9および(b)還元型補酵素Q11が別途調製され添加されたものである請求項1または2記載の方法。
- 酸化型補酵素Q9および/または酸化型補酵素Q11を含有する酸化型補酵素Q10を還元することにより、前記共存状態とする請求項1または2記載の方法。
- 脱酸素雰囲気下で共存させる請求項1〜4のいずれか1項に記載の方法。
- 以下の(a)および/または(b)を共存させることを特徴とする還元型補酵素Q10含有組成物:
(a)還元型補酵素Q10に対し、1.5重量%以上、99重量%以下の還元型補酵素Q9:
(b)還元型補酵素Q11。 - 還元型補酵素Q10が結晶形態である、請求項6記載の組成物。
- 還元型補酵素Q10が溶媒に溶解または懸濁された形態である請求項6記載の組成物。
- 還元型補酵素Q10が溶融液の形態である請求項6記載の組成物。
- 還元型補酵素Q10を有効成分とし、哺乳類に投与される形態である請求項6〜9のいずれか1項に記載の組成物。
- 賦形剤、崩壊剤、滑沢剤、結合剤、酸化防止剤、着色剤、凝集防止剤、吸収促進剤、有効成分の溶解補助剤、安定化剤、または還元型補酵素Q10以外の他の活性成分よりなる群から選ばれる少なくとも一種が含まれる請求項6〜10のいずれか1項に記載の組成物。
- カプセル剤である請求項11記載の組成物。
- カプセル剤が、マイクロカプセル、ソフトカプセルまたはハードカプセルである請求項12記載の組成物。
- 以下の(a)および/または(b)が共存する還元型補酵素Q10含有組成物の製造方法であって、(a)および/または(b)が別途調製および添加される工程を含む製造方法:
(a)還元型補酵素Q10に対し、0.6重量%以上の還元型補酵素Q9:
(b)還元型補酵素Q11。
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US20070053985A1 (en) * | 2005-08-24 | 2007-03-08 | Kaneka Corporation | Coenzyme Q10-containing fine particle with excellent dispersibility |
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