JP5253148B2 - 脂質二重層への分子の送達 - Google Patents
脂質二重層への分子の送達 Download PDFInfo
- Publication number
- JP5253148B2 JP5253148B2 JP2008502471A JP2008502471A JP5253148B2 JP 5253148 B2 JP5253148 B2 JP 5253148B2 JP 2008502471 A JP2008502471 A JP 2008502471A JP 2008502471 A JP2008502471 A JP 2008502471A JP 5253148 B2 JP5253148 B2 JP 5253148B2
- Authority
- JP
- Japan
- Prior art keywords
- probe
- lipid bilayer
- membrane protein
- carrier surface
- planar lipid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Sustainable Development (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0505971.2 | 2005-03-23 | ||
| GBGB0505971.2A GB0505971D0 (en) | 2005-03-23 | 2005-03-23 | Delivery of molecules to a lipid bilayer |
| PCT/GB2006/001057 WO2006100484A2 (en) | 2005-03-23 | 2006-03-22 | Deliver of molecules to a li id bila |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008537106A JP2008537106A (ja) | 2008-09-11 |
| JP2008537106A5 JP2008537106A5 (https=) | 2009-10-15 |
| JP5253148B2 true JP5253148B2 (ja) | 2013-07-31 |
Family
ID=34531741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008502471A Expired - Fee Related JP5253148B2 (ja) | 2005-03-23 | 2006-03-22 | 脂質二重層への分子の送達 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7939270B2 (https=) |
| EP (1) | EP1861071B1 (https=) |
| JP (1) | JP5253148B2 (https=) |
| AT (1) | ATE473438T1 (https=) |
| DE (1) | DE602006015292D1 (https=) |
| GB (1) | GB0505971D0 (https=) |
| WO (1) | WO2006100484A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8627531B2 (en) | 2001-09-04 | 2014-01-14 | Sharp Kabushiki Kaisha | Vacuum cleaner and device having ion generator |
Families Citing this family (170)
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| US9233846B2 (en) | 2005-10-14 | 2016-01-12 | The Regents Of The University Of California | Formation and encapsulation of molecular bilayer and monolayer membranes |
| GB0523282D0 (en) | 2005-11-15 | 2005-12-21 | Isis Innovation | Methods using pores |
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| US8889348B2 (en) * | 2006-06-07 | 2014-11-18 | The Trustees Of Columbia University In The City Of New York | DNA sequencing by nanopore using modified nucleotides |
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| WO2008102120A1 (en) * | 2007-02-20 | 2008-08-28 | Oxford Nanopore Technologies Limited | Lipid bilayer sensor system |
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| GB0716264D0 (en) | 2007-08-21 | 2007-09-26 | Isis Innovation | Bilayers |
| GB2453377A (en) | 2007-10-05 | 2009-04-08 | Isis Innovation | Transmembrane protein pores and molecular adapters therefore. |
| US8124191B2 (en) | 2007-11-30 | 2012-02-28 | Electronic Bio Sciences, Llc | Method and apparatus for single side bilayer formation |
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| US8772041B2 (en) * | 2008-05-22 | 2014-07-08 | The Regents Of The University Of California | Membrane precursors and membranes formed therefrom |
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| GB0905140D0 (en) | 2009-03-25 | 2009-05-06 | Isis Innovation | Method |
| US8324914B2 (en) * | 2010-02-08 | 2012-12-04 | Genia Technologies, Inc. | Systems and methods for characterizing a molecule |
| US9605307B2 (en) | 2010-02-08 | 2017-03-28 | Genia Technologies, Inc. | Systems and methods for forming a nanopore in a lipid bilayer |
| US9678055B2 (en) | 2010-02-08 | 2017-06-13 | Genia Technologies, Inc. | Methods for forming a nanopore in a lipid bilayer |
| EP2614156B1 (en) | 2010-09-07 | 2018-08-01 | The Regents of The University of California | Control of dna movement in a nanopore at one nucleotide precision by a processive enzyme |
| EP2652153B1 (en) | 2010-12-17 | 2017-07-05 | The Trustees of Columbia University in the City of New York | Dna sequencing by synthesis using modified nucleotides and nanopore detection |
| WO2012088339A2 (en) | 2010-12-22 | 2012-06-28 | Genia Technologies, Inc. | Nanopore-based single dna molecule characterization using speed bumps |
| GB201100516D0 (en) | 2011-01-12 | 2011-02-23 | Isis Innovation | Method using fluorinated amphiphiles |
| US8962242B2 (en) | 2011-01-24 | 2015-02-24 | Genia Technologies, Inc. | System for detecting electrical properties of a molecular complex |
| US9110478B2 (en) | 2011-01-27 | 2015-08-18 | Genia Technologies, Inc. | Temperature regulation of measurement arrays |
| AU2012215135B9 (en) | 2011-02-11 | 2017-03-09 | Oxford Nanopore Technologies Limited | Mutant pores |
| US8968539B2 (en) | 2011-03-08 | 2015-03-03 | Electronic Biosciences, Inc. | Methods for voltage-induced protein incorporation into planar lipid bilayers |
| SG10201604316WA (en) | 2011-05-27 | 2016-07-28 | Oxford Nanopore Tech Ltd | Coupling method |
| AU2012288629B2 (en) | 2011-07-25 | 2017-02-02 | Oxford Nanopore Technologies Limited | Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores |
| EP2578207A3 (en) * | 2011-10-05 | 2015-10-07 | Jacob J. Schmidt | Masking apertures enabling automation and solution exchange in sessile droplet lipid bilayers |
| JP6226869B2 (ja) | 2011-10-21 | 2017-11-08 | オックスフォード ナノポール テクノロジーズ リミテッド | 酵素法 |
| GB201119032D0 (en) | 2011-11-03 | 2011-12-14 | Isis Innovation | Multisomes: encapsulated droplet networks |
| BR112014016112B8 (pt) | 2011-12-29 | 2022-12-27 | Oxford Nanopore Tech Ltd | Método e aparelho para caracterizar um polinucleotídeo alvo, kit, e, uso de uma helicase |
| US9617591B2 (en) | 2011-12-29 | 2017-04-11 | Oxford Nanopore Technologies Ltd. | Method for characterising a polynucleotide by using a XPD helicase |
| GB201202519D0 (en) | 2012-02-13 | 2012-03-28 | Oxford Nanopore Tech Ltd | Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules |
| WO2013121201A1 (en) | 2012-02-15 | 2013-08-22 | Oxford Nanopore Technologies Limited | Aptamer method |
| BR112014020211A2 (pt) | 2012-02-16 | 2017-07-04 | Oxford Nanopore Tech Ltd | métodos para analisar uma série ordenada por tempo de medições de um polímero, para estimar a presença, ausência ou quantidade de um polímero alvo, e para determinar uma alteração em um polímero, programa de computador, e, dispositivos de análise e de diagnóstico |
| US8986629B2 (en) | 2012-02-27 | 2015-03-24 | Genia Technologies, Inc. | Sensor circuit for controlling, detecting, and measuring a molecular complex |
| WO2013154999A2 (en) | 2012-04-09 | 2013-10-17 | The Trustees Of Columbia University In The City Of New York | Method of preparation of nanopore and uses thereof |
| JP6271505B2 (ja) | 2012-04-10 | 2018-01-31 | オックスフォード ナノポール テクノロジーズ リミテッド | 変異体ライセニンポア |
| CA2876095A1 (en) | 2012-06-15 | 2013-12-19 | Genia Technologies, Inc. | Chip set-up and high-accuracy nucleic acid sequencing |
| EP3674412A1 (en) | 2012-06-20 | 2020-07-01 | The Trustees of Columbia University in the City of New York | Nucleic acid sequencing by nanopore detection of tag molecules |
| EP2875128B8 (en) | 2012-07-19 | 2020-06-24 | Oxford Nanopore Technologies Limited | Modified helicases |
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| KR102168813B1 (ko) | 2013-03-08 | 2020-10-22 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 효소 정지 방법 |
| GB201318465D0 (en) | 2013-10-18 | 2013-12-04 | Oxford Nanopore Tech Ltd | Method |
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| US10732183B2 (en) | 2013-03-15 | 2020-08-04 | The Trustees Of Columbia University In The City Of New York | Method for detecting multiple predetermined compounds in a sample |
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| US11169138B2 (en) | 2015-04-14 | 2021-11-09 | Katholieke Universiteit Leuven | Nanopores with internal protein adaptors |
| KR102837999B1 (ko) | 2015-12-08 | 2025-07-24 | 카트호리이케 유니버시타이트 로이펜 | 변형된 나노세공, 그를 포함하는 조성물, 및 그의 용도 |
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| GB201609220D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| GB201609221D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
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| GB201611770D0 (en) | 2016-07-06 | 2016-08-17 | Oxford Nanopore Tech | Microfluidic device |
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| JP2018059786A (ja) * | 2016-10-04 | 2018-04-12 | 住友化学株式会社 | 嗅覚受容体複合体を用いた標的物質の検出装置及び検出方法並びに該検出装置の製造方法 |
| GB201617886D0 (en) | 2016-10-21 | 2016-12-07 | Oxford Nanopore Technologies Limited | Method |
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| GB201707122D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Pore |
| GB201707140D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Method |
| WO2019002893A1 (en) | 2017-06-30 | 2019-01-03 | Vib Vzw | NEW PROTEIN PORES |
| JP7012841B2 (ja) * | 2017-10-23 | 2022-01-28 | エフ.ホフマン-ラ ロシュ アーゲー | 浸透性の不均衡を利用した膜内のタンパク質ナノポアの除去および再挿入 |
| GB2568895B (en) | 2017-11-29 | 2021-10-27 | Oxford Nanopore Tech Ltd | Microfluidic device |
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| GB201807793D0 (en) | 2018-05-14 | 2018-06-27 | Oxford Nanopore Tech Ltd | Method |
| GB201808556D0 (en) | 2018-05-24 | 2018-07-11 | Oxford Nanopore Tech Ltd | Method |
| GB2574048B (en) | 2018-05-24 | 2021-06-16 | Oxford Nanopore Tech Ltd | Nanopore sensor component with electrostatic discharge protection |
| GB201809323D0 (en) | 2018-06-06 | 2018-07-25 | Oxford Nanopore Tech Ltd | Method |
| GB201811623D0 (en) | 2018-07-16 | 2018-08-29 | Univ Oxford Innovation Ltd | Molecular hopper |
| WO2020025909A1 (en) | 2018-07-30 | 2020-02-06 | Oxford University Innovation Limited | Assemblies |
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| GB201821155D0 (en) | 2018-12-21 | 2019-02-06 | Oxford Nanopore Tech Ltd | Method |
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| GB2580988B (en) | 2019-03-19 | 2022-04-13 | Oxford Nanopore Tech Ltd | Current measurement apparatus, molecular entity sensing apparatus, method of measuring a current, method of sensing a molecular entity |
| JP2022529623A (ja) | 2019-04-09 | 2022-06-23 | オックスフォード ナノポール テクノロジーズ ピーエルシー | 細孔 |
| GB201907244D0 (en) | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Method |
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| GB201913997D0 (en) | 2019-09-27 | 2019-11-13 | Oxford Nanopore Tech Ltd | Method |
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| GB201917060D0 (en) | 2019-11-22 | 2020-01-08 | Oxford Nanopore Tech Ltd | Method |
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| GB201917742D0 (en) | 2019-12-04 | 2020-01-15 | Oxford Nanopore Tech Ltd | Method |
| GB202004944D0 (en) | 2020-04-03 | 2020-05-20 | King S College London | Method |
| GB202016874D0 (en) | 2020-10-23 | 2020-12-09 | Oxford Nanopore Tech Ltd | Nanopore support structure and manufacture thereof |
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| US20230295712A1 (en) | 2020-06-18 | 2023-09-21 | Oxford Nanopore Technologies Plc | A method of selectively characterising a polynucleotide using a detector |
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| GB202015993D0 (en) | 2020-10-08 | 2020-11-25 | Oxford Nanopore Tech Ltd | Method |
| WO2022243692A1 (en) | 2021-05-19 | 2022-11-24 | Oxford Nanopore Technologies Plc | Methods for complement strand sequencing |
| GB202107192D0 (en) | 2021-05-19 | 2021-06-30 | Oxford Nanopore Tech Ltd | Method |
| GB202107354D0 (en) | 2021-05-24 | 2021-07-07 | Oxford Nanopore Tech Ltd | Method |
| GB202112235D0 (en) | 2021-08-26 | 2021-10-13 | Oxford Nanopore Tech Ltd | Nanopore |
| GB202118908D0 (en) | 2021-12-23 | 2022-02-09 | Oxford Nanopore Tech Ltd | Method |
| GB202118939D0 (en) | 2021-12-23 | 2022-02-09 | Oxford Nanopore Tech Plc | Pore |
| GB202118906D0 (en) | 2021-12-23 | 2022-02-09 | Oxford Nanopore Tech Ltd | Method |
| GB202204919D0 (en) | 2022-04-04 | 2022-05-18 | Oxford Nanopore Tech Plc | Method |
| GB202205617D0 (en) | 2022-04-14 | 2022-06-01 | Oxford Nanopore Tech Plc | Novel modified protein pores and enzymes |
| AU2023270700A1 (en) | 2022-05-17 | 2024-10-31 | Oxford Nanopore Technologies Plc | Method and adaptors |
| WO2024033443A1 (en) | 2022-08-09 | 2024-02-15 | Oxford Nanopore Technologies Plc | Novel pore monomers and pores |
| GB202211602D0 (en) | 2022-08-09 | 2022-09-21 | Oxford Nanopore Tech Plc | Novel pore monomers and pores |
| GB202211607D0 (en) | 2022-08-09 | 2022-09-21 | Oxford Nanopore Tech Plc | Novel pore monomers and pores |
| EP4569331A1 (en) | 2022-08-09 | 2025-06-18 | Oxford Nanopore Technologies PLC | De novo pores |
| KR20250096716A (ko) | 2022-10-28 | 2025-06-27 | 옥스포드 나노포어 테크놀로지즈 피엘씨 | 포어 단량체 및 포어 |
| GB202216162D0 (en) | 2022-10-31 | 2022-12-14 | Oxford Nanopore Tech Plc | Method |
| GB202216905D0 (en) | 2022-11-11 | 2022-12-28 | Oxford Nanopore Tech Plc | Novel pore monomers and pores |
| EP4662489A1 (en) | 2023-02-07 | 2025-12-17 | Oxford University Innovation Limited | Method of characterising a peptide, polypeptide or protein using a nanopore |
| GB202304324D0 (en) | 2023-03-24 | 2023-05-10 | Oxford Nanopore Tech Plc | Method and kits |
| GB202305524D0 (en) | 2023-04-14 | 2023-05-31 | Oxford Nanopore Tech Plc | Novel pore monomers and pores |
| GB202307141D0 (en) | 2023-05-12 | 2023-06-28 | Oxford Nanopore Tech Plc | Modified helicases |
| GB202307486D0 (en) | 2023-05-18 | 2023-07-05 | Oxford Nanopore Tech Plc | Method |
| GB202312709D0 (en) | 2023-08-18 | 2023-10-04 | Univ Oxford Innovation Ltd | Nanopore |
| GB202313035D0 (en) | 2023-08-25 | 2023-10-11 | Univ Oxford Innovation Ltd | Power unit |
| GB202315935D0 (en) | 2023-10-18 | 2023-11-29 | Oxford Nanopore Tech Ltd | Novel enzymes |
| GB202317028D0 (en) | 2023-11-06 | 2023-12-20 | Oxford Nanopore Tech Ltd | Method |
| WO2025160387A1 (en) * | 2024-01-24 | 2025-07-31 | The Rockefeller University | Microscope for freestanding bilayer illumination |
| GB202405960D0 (en) | 2024-04-29 | 2024-06-12 | Oxford Nanopore Tech Plc | Photo-active conjugates and their uses |
| GB202407055D0 (en) | 2024-05-17 | 2024-07-03 | Oxford Nanopore Tech Plc | Enhanced polynucleotide sequencing |
| GB202407247D0 (en) | 2024-05-21 | 2024-07-03 | Oxford Nanopore Tech Plc | Method |
| GB202407228D0 (en) | 2024-05-21 | 2024-07-03 | Oxford Nanopore Tech Plc | Method |
| WO2026052811A2 (en) | 2024-09-06 | 2026-03-12 | Oxford Nanopore Technologies Plc | Method |
| WO2026052817A1 (en) | 2024-09-06 | 2026-03-12 | Oxford Nanopore Technologies Plc | Method |
| WO2026057755A1 (en) | 2024-09-13 | 2026-03-19 | Oxford Nanopore Technologies Plc | Adaptors and kits for rna molecules labelling and characterising |
| GB202413506D0 (en) | 2024-09-13 | 2024-10-30 | Oxford Nanopore Tech Plc | Pore monomers and their uses |
| GB202413618D0 (en) | 2024-09-16 | 2024-10-30 | Oxford Nanopore Tech Plc | peptide characterisation |
| GB202414993D0 (en) | 2024-10-11 | 2024-11-27 | Univ Oxford Innovation Ltd | Method |
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| US3799743A (en) * | 1971-11-22 | 1974-03-26 | Alexander James | Stable lysis responsive lipid bilayer |
| US6327410B1 (en) * | 1997-03-14 | 2001-12-04 | The Trustees Of Tufts College | Target analyte sensors utilizing Microspheres |
| GB9712386D0 (en) * | 1997-06-14 | 1997-08-13 | Univ Coventry | Biosensor |
| ATE294240T1 (de) * | 1998-02-17 | 2005-05-15 | Univ Cardiff | Verfahren und kit, um biologische substanzen in plasmamembran und/oder zytosol einzuführen |
| EP1107979B1 (en) * | 1998-08-31 | 2006-07-05 | Gryphon Therapeutics, Inc. | Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides |
| JP3665720B2 (ja) * | 1999-09-24 | 2005-06-29 | 株式会社東芝 | センサデバイス |
| EP1352245B1 (en) * | 2001-01-18 | 2006-08-16 | Newcastle University Ventures Limited | Biosensor with covalently attached membrane-spanning proteins |
| WO2003095669A1 (en) | 2002-05-10 | 2003-11-20 | The Texas A & M University System | Stochastic sensing through covalent interactions |
| JP4394916B2 (ja) * | 2003-09-19 | 2010-01-06 | 独立行政法人科学技術振興機構 | 人工脂質二重膜の形成装置および人工脂質二重膜の形成方法、並びにその利用 |
| EP1712909B1 (en) * | 2004-01-21 | 2012-09-19 | Japan Science and Technology Agency | Method of forming planar lipid double membrane for membrane protein analysis and apparatus therefor |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8627531B2 (en) | 2001-09-04 | 2014-01-14 | Sharp Kabushiki Kaisha | Vacuum cleaner and device having ion generator |
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| EP1861071B1 (en) | 2010-07-07 |
| DE602006015292D1 (de) | 2010-08-19 |
| GB0505971D0 (en) | 2005-04-27 |
| JP2008537106A (ja) | 2008-09-11 |
| ATE473438T1 (de) | 2010-07-15 |
| US20080153150A1 (en) | 2008-06-26 |
| WO2006100484A3 (en) | 2008-05-29 |
| US7939270B2 (en) | 2011-05-10 |
| EP1861071A2 (en) | 2007-12-05 |
| WO2006100484A2 (en) | 2006-09-28 |
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