JP5241728B2 - Ｃ型肝炎ウイルス阻害剤としての大環状ペプチド - Google Patents

Ｃ型肝炎ウイルス阻害剤としての大環状ペプチド Download PDF

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Publication number
JP5241728B2
JP5241728B2 JP2009537352A JP2009537352A JP5241728B2 JP 5241728 B2 JP5241728 B2 JP 5241728B2 JP 2009537352 A JP2009537352 A JP 2009537352A JP 2009537352 A JP2009537352 A JP 2009537352A JP 5241728 B2 JP5241728 B2 JP 5241728B2
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Japan
Prior art keywords
alkyl
cycloalkyl
tert
mmol
compound
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Expired - Fee Related
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JP2009537352A
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English (en)
Japanese (ja)
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JP2010510967A5 (enExample
JP2010510967A (ja
Inventor
ワン・アラン・シャンドン
バーバラ・ジジェン・ジェン
スタンリー・ダンドレア
ニコラス・エイ・ミーンウェル
ポール・マイケル・スコーラ
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of JP2010510967A5 publication Critical patent/JP2010510967A5/ja
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2009537352A 2006-11-16 2007-11-15 Ｃ型肝炎ウイルス阻害剤としての大環状ペプチド Expired - Fee Related JP5241728B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US86612006P 2006-11-16 2006-11-16
US60/866,120 2006-11-16
US11/939,753 2007-11-14
US11/939,753 US8003604B2 (en) 2006-11-16 2007-11-14 Hepatitis C virus inhibitors
PCT/US2007/084777 WO2008064057A1 (en) 2006-11-16 2007-11-15 Macrocyclic peptides as hepatitis c virus inhibitors

Publications (3)

Publication Number Publication Date
JP2010510967A JP2010510967A (ja) 2010-04-08
JP2010510967A5 JP2010510967A5 (enExample) 2010-12-24
JP5241728B2 true JP5241728B2 (ja) 2013-07-17

Family

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JP2009537352A Expired - Fee Related JP5241728B2 (ja) 2006-11-16 2007-11-15 Ｃ型肝炎ウイルス阻害剤としての大環状ペプチド

Country Status (7)

Country Link
US (1) US8003604B2 (enExample)
EP (1) EP2089020B1 (enExample)
JP (1) JP5241728B2 (enExample)
AT (1) ATE492559T1 (enExample)
DE (1) DE602007011493D1 (enExample)
NO (1) NO20091846L (enExample)
WO (1) WO2008064057A1 (enExample)

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Also Published As

Publication number Publication date
NO20091846L (no) 2009-06-08
JP2010510967A (ja) 2010-04-08
EP2089020A1 (en) 2009-08-19
US8003604B2 (en) 2011-08-23
DE602007011493D1 (de) 2011-02-03
WO2008064057A1 (en) 2008-05-29
EP2089020B1 (en) 2010-12-22
ATE492559T1 (de) 2011-01-15
US20080159982A1 (en) 2008-07-03

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