JP5226986B2 - 液体口腔用組成物 - Google Patents
液体口腔用組成物 Download PDFInfo
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- JP5226986B2 JP5226986B2 JP2007216885A JP2007216885A JP5226986B2 JP 5226986 B2 JP5226986 B2 JP 5226986B2 JP 2007216885 A JP2007216885 A JP 2007216885A JP 2007216885 A JP2007216885 A JP 2007216885A JP 5226986 B2 JP5226986 B2 JP 5226986B2
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- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229940005740 hexametaphosphate Drugs 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000001115 mace Substances 0.000 description 1
- 229930007503 menthone Natural products 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000001702 nutmeg Substances 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229930007459 p-menth-8-en-3-one Natural products 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 235000011197 perejil Nutrition 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
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- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 235000007686 potassium Nutrition 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 235000019982 sodium hexametaphosphate Nutrition 0.000 description 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
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- 239000005720 sucrose Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- UDEJEOLNSNYQSX-UHFFFAOYSA-J tetrasodium;2,4,6,8-tetraoxido-1,3,5,7,2$l^{5},4$l^{5},6$l^{5},8$l^{5}-tetraoxatetraphosphocane 2,4,6,8-tetraoxide Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])(=O)O1 UDEJEOLNSNYQSX-UHFFFAOYSA-J 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 239000001585 thymus vulgaris Substances 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
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- 229940082509 xanthan gum Drugs 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Description
従って、本発明の目的は、歯の着色防止効果に優れるとともに、組成物の安定性も良好な液体口腔用組成物を提供することにある。
(A)ポリリン酸又はその塩 0.6〜5質量%
(B)アシルタウリン塩 0.01〜5質量%
を含有し、かつpH7〜9である液体口腔用組成物を提供するものである。
ポリリン酸塩としては、ピロリン酸ナトリウム、ピロリン酸カリウム、トリポリリン酸ナトリウム、トリポリリン酸カリウム、テトラポリリン酸ナトリウム、テトラポリリン酸カリウム、メタリン酸ナトリウムなどの直鎖状のポリリン酸塩、トリメタリン酸ナトリウム、トリメタリン酸カリウム、テトラメタリン酸ナトリウム、テトラメタリン酸カリウム、ヘキサメタリン酸ナトリウム、ヘキサメタリン酸カリウムなどの環状のポリリン酸塩が使用される。これらポリリン酸又はその塩はその1種を単独で配合してもよく、また2種以上を混合して配合してもよい。これらの中では直鎖状のポリリン酸塩が好ましく、特に重合度2〜4のものが好ましい。成分(A)の含有量は口腔用組成物全体に対して0.6〜5質量%であるが、歯の着色防止効果の点から、好ましくは0.6〜3質量%、特に好ましくは0.6〜2質量%である。
ハイドロキシアパタイトペレット(PENTAX製APP-100 1cm×1cm)を研磨し、液体口腔用組成物、タンパク質溶液(BSA 10000ppm溶液)、紅茶(ティーバッグ1つに対して
50mLの湯で抽出)、人工唾液(20mM HEPES、1.5mM CaCl2、0.9mM KH2PO4)各10mLに順に5分ずつ浸漬させた。この処理を10サイクル行い、ハイドロキシアパタイトペレットのb*値を歯科用色彩系シェードアイ(松風製)で測定した。処理前のb*値を100%、液体口腔用組成物としてイオン交換水を用いた場合のb*値を0%として、着色防止効果を算出した。
表1の液体口腔用組成物を、PET製容器に入れ、40℃で6ヶ月保存した後の液の色や油滴の有無を目視観察した。保存前と比べて変化がなかったものを○、濁りや油滴の浮遊が見られたものを×とした。
Claims (3)
- 下記成分(A)、(B)及び(C):
(A)ポリリン酸又はその塩 0.6〜3質量%
(B)アシルタウリン塩 0.01〜0.5質量%
(C)メントール、サリチル酸メチル、スペアミント油、ペパーミント油、バート、シナモン及びアニスから選ばれる香料
を含有し、成分(A)と成分(B)の重量比(A/B)が6〜25であり、かつpH7〜9である液体口腔用組成物。 - さらにHLBが12〜20の非イオン界面活性剤を含有する請求項1記載の液体口腔用組成物。
- さらにポリエチレングリコールを0.5〜5質量%含有する請求項1又は2に記載の液体口腔用組成物。
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