JP5912035B2 - 液体口腔用組成物 - Google Patents
液体口腔用組成物 Download PDFInfo
- Publication number
- JP5912035B2 JP5912035B2 JP2011260985A JP2011260985A JP5912035B2 JP 5912035 B2 JP5912035 B2 JP 5912035B2 JP 2011260985 A JP2011260985 A JP 2011260985A JP 2011260985 A JP2011260985 A JP 2011260985A JP 5912035 B2 JP5912035 B2 JP 5912035B2
- Authority
- JP
- Japan
- Prior art keywords
- composition
- liquid oral
- mass
- salt
- content
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims description 61
- 239000007788 liquid Substances 0.000 title claims description 51
- -1 acyl sarcosine Chemical compound 0.000 claims description 61
- 150000003839 salts Chemical class 0.000 claims description 48
- 210000000214 mouth Anatomy 0.000 claims description 29
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N N-methylaminoacetic acid Natural products C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims description 20
- 108010077895 Sarcosine Proteins 0.000 claims description 19
- 229940043230 sarcosine Drugs 0.000 claims description 19
- 229920000137 polyphosphoric acid Polymers 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 239000003945 anionic surfactant Substances 0.000 claims description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 claims description 6
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims description 6
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims description 6
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 5
- 235000019477 peppermint oil Nutrition 0.000 claims description 5
- 235000011187 glycerol Nutrition 0.000 claims description 4
- 239000002736 nonionic surfactant Substances 0.000 claims description 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 3
- 239000005973 Carvone Substances 0.000 claims description 3
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 3
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims description 3
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 3
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 3
- 229930007050 cineol Natural products 0.000 claims description 3
- 229960005233 cineole Drugs 0.000 claims description 3
- 229940087305 limonene Drugs 0.000 claims description 3
- 235000001510 limonene Nutrition 0.000 claims description 3
- 239000001683 mentha spicata herb oil Substances 0.000 claims description 3
- 229940041616 menthol Drugs 0.000 claims description 3
- 229960001047 methyl salicylate Drugs 0.000 claims description 3
- 235000019721 spearmint oil Nutrition 0.000 claims description 3
- 239000004793 Polystyrene Substances 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- 230000003287 optical effect Effects 0.000 claims description 2
- 229920002223 polystyrene Polymers 0.000 claims description 2
- 238000002834 transmittance Methods 0.000 claims description 2
- 239000002304 perfume Substances 0.000 claims 1
- 238000004040 coloring Methods 0.000 description 31
- 230000000694 effects Effects 0.000 description 23
- 244000269722 Thea sinensis Species 0.000 description 15
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 14
- 235000014113 dietary fatty acids Nutrition 0.000 description 14
- 229930195729 fatty acid Natural products 0.000 description 14
- 239000000194 fatty acid Substances 0.000 description 14
- 241000208125 Nicotiana Species 0.000 description 13
- 235000019640 taste Nutrition 0.000 description 12
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 11
- 235000013616 tea Nutrition 0.000 description 11
- 235000019504 cigarettes Nutrition 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 10
- 238000004042 decolorization Methods 0.000 description 9
- 239000003205 fragrance Substances 0.000 description 9
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 9
- 239000008188 pellet Substances 0.000 description 9
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 9
- 239000002244 precipitate Substances 0.000 description 8
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- 239000003212 astringent agent Substances 0.000 description 6
- 239000003921 oil Substances 0.000 description 6
- 235000019198 oils Nutrition 0.000 description 6
- 239000000779 smoke Substances 0.000 description 6
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000019634 flavors Nutrition 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 235000006468 Thea sinensis Nutrition 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 150000004671 saturated fatty acids Chemical class 0.000 description 4
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 3
- 235000020279 black tea Nutrition 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000000551 dentifrice Substances 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 239000001630 malic acid Substances 0.000 description 3
- 235000011090 malic acid Nutrition 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 239000011591 potassium Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 235000019832 sodium triphosphate Nutrition 0.000 description 3
- 238000013112 stability test Methods 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- XHXUANMFYXWVNG-ADEWGFFLSA-N (-)-Menthyl acetate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(C)=O XHXUANMFYXWVNG-ADEWGFFLSA-N 0.000 description 2
- NGOZDSMNMIRDFP-UHFFFAOYSA-N 2-[methyl(tetradecanoyl)amino]acetic acid Chemical compound CCCCCCCCCCCCCC(=O)N(C)CC(O)=O NGOZDSMNMIRDFP-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- 239000004166 Lanolin Substances 0.000 description 2
- 235000006679 Mentha X verticillata Nutrition 0.000 description 2
- 235000002899 Mentha suaveolens Nutrition 0.000 description 2
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 2
- 235000009421 Myristica fragrans Nutrition 0.000 description 2
- BACYUWVYYTXETD-UHFFFAOYSA-N N-Lauroylsarcosine Chemical compound CCCCCCCCCCCC(=O)N(C)CC(O)=O BACYUWVYYTXETD-UHFFFAOYSA-N 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 125000004442 acylamino group Chemical group 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 230000001680 brushing effect Effects 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N formaldehyde Natural products O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 229940039717 lanolin Drugs 0.000 description 2
- 235000019388 lanolin Nutrition 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 2
- 229940005657 pyrophosphoric acid Drugs 0.000 description 2
- 235000019643 salty taste Nutrition 0.000 description 2
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 2
- 229940048086 sodium pyrophosphate Drugs 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 150000005846 sugar alcohols Chemical class 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 2
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- NFLGAXVYCFJBMK-RKDXNWHRSA-N (+)-isomenthone Natural products CC(C)[C@H]1CC[C@@H](C)CC1=O NFLGAXVYCFJBMK-RKDXNWHRSA-N 0.000 description 1
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- 239000001605 (5-methyl-2-propan-2-ylcyclohexyl) acetate Substances 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- DORBKQIZZTWKOR-UHFFFAOYSA-N 2-(2-oxotridecylamino)ethanesulfonic acid;sodium Chemical compound [Na].CCCCCCCCCCCC(=O)CNCCS(O)(=O)=O DORBKQIZZTWKOR-UHFFFAOYSA-N 0.000 description 1
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- LFJJOPDNPVFCNZ-UHFFFAOYSA-N 2-[hexadecanoyl(methyl)amino]acetic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N(C)CC(O)=O LFJJOPDNPVFCNZ-UHFFFAOYSA-N 0.000 description 1
- RJYOKYDKKOFLBT-UHFFFAOYSA-N 2-[methyl(octadecanoyl)amino]acetic acid Chemical compound CCCCCCCCCCCCCCCCCC(=O)N(C)CC(O)=O RJYOKYDKKOFLBT-UHFFFAOYSA-N 0.000 description 1
- DIOYAVUHUXAUPX-ZHACJKMWSA-N 2-[methyl-[(e)-octadec-9-enoyl]amino]acetic acid Chemical compound CCCCCCCC\C=C\CCCCCCCC(=O)N(C)CC(O)=O DIOYAVUHUXAUPX-ZHACJKMWSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- PVXPPJIGRGXGCY-DJHAAKORSA-N 6-O-alpha-D-glucopyranosyl-alpha-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](O)(CO)O1 PVXPPJIGRGXGCY-DJHAAKORSA-N 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 244000099147 Ananas comosus Species 0.000 description 1
- 235000007119 Ananas comosus Nutrition 0.000 description 1
- 240000007087 Apium graveolens Species 0.000 description 1
- 235000015849 Apium graveolens Dulce Group Nutrition 0.000 description 1
- 235000010591 Appio Nutrition 0.000 description 1
- 240000001851 Artemisia dracunculus Species 0.000 description 1
- 239000000120 Artificial Saliva Substances 0.000 description 1
- 235000010082 Averrhoa carambola Nutrition 0.000 description 1
- 240000006063 Averrhoa carambola Species 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 235000019499 Citrus oil Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 240000000560 Citrus x paradisi Species 0.000 description 1
- 235000002787 Coriandrum sativum Nutrition 0.000 description 1
- 244000018436 Coriandrum sativum Species 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- XHXUANMFYXWVNG-UHFFFAOYSA-N D-menthyl acetate Natural products CC(C)C1CCC(C)CC1OC(C)=O XHXUANMFYXWVNG-UHFFFAOYSA-N 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 240000002943 Elettaria cardamomum Species 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- 244000004281 Eucalyptus maculata Species 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 235000017858 Laurus nobilis Nutrition 0.000 description 1
- 244000108452 Litchi chinensis Species 0.000 description 1
- 241000220225 Malus Species 0.000 description 1
- 235000011430 Malus pumila Nutrition 0.000 description 1
- 235000015103 Malus silvestris Nutrition 0.000 description 1
- NFLGAXVYCFJBMK-UHFFFAOYSA-N Menthone Chemical compound CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-N Metaphosphoric acid Chemical compound OP(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-N 0.000 description 1
- 240000005561 Musa balbisiana Species 0.000 description 1
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 1
- 244000270834 Myristica fragrans Species 0.000 description 1
- 240000009023 Myrrhis odorata Species 0.000 description 1
- 235000007265 Myrrhis odorata Nutrition 0.000 description 1
- 235000015742 Nephelium litchi Nutrition 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000010676 Ocimum basilicum Nutrition 0.000 description 1
- 240000007926 Ocimum gratissimum Species 0.000 description 1
- 239000006002 Pepper Substances 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 244000062780 Petroselinum sativum Species 0.000 description 1
- 235000012550 Pimpinella anisum Nutrition 0.000 description 1
- 235000016761 Piper aduncum Nutrition 0.000 description 1
- 240000003889 Piper guineense Species 0.000 description 1
- 235000017804 Piper guineense Nutrition 0.000 description 1
- 235000008184 Piper nigrum Nutrition 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- 240000001890 Ribes hudsonianum Species 0.000 description 1
- 235000016954 Ribes hudsonianum Nutrition 0.000 description 1
- 235000001466 Ribes nigrum Nutrition 0.000 description 1
- 244000178231 Rosmarinus officinalis Species 0.000 description 1
- 240000007651 Rubus glaucus Species 0.000 description 1
- 235000011034 Rubus glaucus Nutrition 0.000 description 1
- 235000009122 Rubus idaeus Nutrition 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000004376 Sucralose Substances 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 1
- 244000223014 Syzygium aromaticum Species 0.000 description 1
- 235000005212 Terminalia tomentosa Nutrition 0.000 description 1
- 244000125380 Terminalia tomentosa Species 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- 235000007303 Thymus vulgaris Nutrition 0.000 description 1
- 240000002657 Thymus vulgaris Species 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 240000000851 Vaccinium corymbosum Species 0.000 description 1
- 235000003095 Vaccinium corymbosum Nutrition 0.000 description 1
- 235000017537 Vaccinium myrtillus Nutrition 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000003973 alkyl amines Chemical class 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 239000010516 ayurvedic herbal oil Substances 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000021014 blueberries Nutrition 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 235000005300 cardamomo Nutrition 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 239000010500 citrus oil Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000008369 fruit flavor Substances 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 239000001115 mace Substances 0.000 description 1
- 229930007503 menthone Natural products 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 239000001702 nutmeg Substances 0.000 description 1
- 235000020333 oolong tea Nutrition 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 235000011197 perejil Nutrition 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229960003975 potassium Drugs 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229950005425 sodium myristyl sulfate Drugs 0.000 description 1
- UPUIQOIQVMNQAP-UHFFFAOYSA-M sodium;tetradecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCOS([O-])(=O)=O UPUIQOIQVMNQAP-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 239000001585 thymus vulgaris Substances 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
(A)アシルサルコシン又はその塩 0.02〜0.5質量%、
(B)ポリリン酸又はその塩 0.5〜5質量%、及び
(C)水 75〜95質量%
を含有し、かつ(D)アニオン界面活性剤としての硫酸エステル又はその塩を含有しないか、或いは含有量が0.001質量%以下であり、
成分(B)と成分(A)の含有量の質量比(B/A)が2〜50である液体口腔用組成物を提供するものである。
本発明の液体口腔用組成物は、アシルサルコシン又はその塩(A)を0.02〜0.5質量%含有する。アシルサルコシン又はその塩(A)はアニオン界面活性剤の一種であり、この特定量のアシルサルコシン又はその塩(A)と、特定の質量比を有する特定量のポリリン酸又はその塩(B)とが相まって、歯における茶渋等の着色汚れ、なかでも茶渋等と飲食物やタバコのヤニ等のように、ポリフェノールとタール等の油汚れの複数の成分が混在して歯に付着した着色汚れに対しても、充分な除去効果を発揮することができる。
表1に示す処方にしたがって、液体口腔用組成物を調製した。これらの液体口腔用組成物を以下の外因性着色除去試験、保存安定性試験を行い、保存安定性試験前の組成物について以下の基準で味を評価した。結果を表1に示す。
1 外因性着色モデルの作成
ハイドロキシアパタイトペレット(PENTAX製APP-100 1cm×1cm)を耐水性の研磨紙(360番)で研磨する。これを外因性着色前のハイドロキシアパタイトペレットとする。次に、ハイドロキシアパタイトペレットを、タンパク質溶液(BSA 10000ppm溶液)、紅茶(日東紅茶製 デイリークラブ)ティバッグ1つに対して50mLの沸騰させた熱湯で抽出した抽出液、人工唾液(20mM HEPES、1.5mL CaCl2、0.9mM KH2PO4)の各10mLに順に5分ずつ浸漬させた。この処理を10サイクル行った後に3時間自然乾燥させた。処理後のハイドロキシアパタイトペレットを、吸入路と吸引路とを備える密封容器(容量3L、プラスチック製)内におき、2本のタバコ(ピース 日本たばこ産業製)を1本づつ、一端を容器の外側から嵌めこみ、吸引路から1本が約2分で燃え尽きる程度に空気を吸引した。これにより、タバコを通して吸入路から密封容器内に空気が吸引される際に、タバコの煙が容器内に吸引され、容器内にタバコの煙が広がるが、吸入路から煙が積極的に排出されることを防止しつつ、密封容器内をタバコの煙で充満させることができる。1本目のタバコが消えてからすぐに2本目のタバコを挿入し、同様に吸引しつつタバコの煙で密封容器内を満たした。2本目のタバコの火が消えてから吸引を止めて1時間置くとタバコの煙が密封容器の下方に沈んだ状態となった。このように1時間置いた後に、ハイドロキシアパタイトペレットを密封容器から取り出し、外因性着色モデルとして、茶渋とタバコの汚れとが付着したハイドロキシアパタイトペレットを得た。
外因性着色モデルのハイドロキシアパタイトペレットを、室温(25℃)において表1に示す各実施例又は比較例の液体口腔用組成物に30秒間浸漬して取り出し、水で洗った後、自然乾燥させた。
外因性着色の程度は、ハイドロキシアパタイトペレットのL*a*b*表示におけるb*の値により判断した。b*は、歯科用色彩系シェードアイ(松風製)で測定し、外因性着色前のハイドロキシアパタイトペレットのb*値をb*0、着色汚れが付着した後の外因性着色モデルのb*値をb*1、実施例又は比較例の液体口腔用組成物により外因性着色除去処理を行った後の外因性着色モデルのb*値をb*2とし、以下の式(1)により外因性着色の除去率を求めた。
外因性着色の除去率=100×(1−(b*2−b*0)/(b*1−b*0))
・・・(1)
保存安定性は、各液体組成物を5℃で1ヶ月保存し、保存後の組成物の状態を確認した。評価は以下の基準により行った。
○ :析出物、濁り、分離などがなく透明である。
× :析出物、濁り、分離などがみられた。
味は、塩味がするか否かにより以下の基準で判断した。判断は専門パネラー2名により行い、協議により以下の基準で判断した。
4 :塩味は感じない。
3 :塩味を殆ど感じない(わずかには感じる)。
2 :塩味を感じる。
1 :塩味を強く感じる。
実施例1と同様にして、表2に示す処方にしたがって液体口腔用組成物を製造した。次いで、収容容器への充填性と、使用時における爽快感の有無によって使用感を評価した。収容容器への充填性は、製造した液体口腔用組成物を450gとり、500mLの収容容器(ポリエチレンテレフタレート製、容器本体は横断面が楕円の円柱型で吐出口の直径が20mmの容器)の吐出口から泡があふれることなく充填する際に要する最短時間について、20秒を基準時間として評価した。20秒よりも充填時間が長い場合を×とし、20秒以内に充填が可能な場合を○とした。評価結果を表2に示す。
Claims (7)
- 次の成分(A)、(B)、(C)、(E)及び(F):
(A)アシルサルコシン又はその塩 0.05〜0.4質量%、
(B)ポリリン酸又はその塩 0.8〜5質量%、
(C)水 75〜95質量%、
(E)香料、及び
(F)ノニオン界面活性剤 0.01〜1質量%
を含有し、かつ(D)アニオン界面活性剤としての硫酸エステル又はその塩を含有しないか、或いは含有量が0.001質量%以下であり、
成分(B)と成分(A)の含有量の質量比(B/A)が3〜40であり、
成分(E)の含有量に対する、成分(B)の含有量の質量比(B/E)が2〜20である透明液体口腔用組成物。 - 成分(A)の含有量に対する、成分(B)及び成分(E)の含有量の合計の質量比((B+E)/A)が3〜50である請求項1に記載の透明液体口腔用組成物。
- 成分(E)が、メントール、カルボン、ペパーミント油、スペアミント油、ハッカ油、サリチル酸メチル、シネオール、リモネン、及びピネンから選ばれる1種又は2種以上である請求項1又は2に記載の透明液体口腔用組成物。
- 成分(A)及び成分(D)以外の他のアニオン界面活性剤を含有しないか、或いは含有量が1質量%以下である請求項1〜3のいずれか1項に記載の透明液体口腔用組成物。
- pHが5.5〜9である請求項1〜4のいずれか1項に記載の透明液体口腔用組成物。
- グリセリン及び/又はトレハロースを含有する請求項1〜5のいずれか1項に記載の透明液体口腔用組成物。
- 光路長10mmのセル(ポリスチレン製)における吸収波長550nmの光の透過率が、80%以上である請求項1〜6のいずれか1項に記載の透明液体口腔用組成物。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011260985A JP5912035B2 (ja) | 2011-11-29 | 2011-11-29 | 液体口腔用組成物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011260985A JP5912035B2 (ja) | 2011-11-29 | 2011-11-29 | 液体口腔用組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2013112650A JP2013112650A (ja) | 2013-06-10 |
JP5912035B2 true JP5912035B2 (ja) | 2016-04-27 |
Family
ID=48708518
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011260985A Active JP5912035B2 (ja) | 2011-11-29 | 2011-11-29 | 液体口腔用組成物 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP5912035B2 (ja) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6050943B2 (ja) * | 2012-03-30 | 2016-12-21 | サンスター株式会社 | 保存安定性に優れたステイン形成阻害用液体口腔用組成物 |
WO2014050851A1 (ja) * | 2012-09-27 | 2014-04-03 | 大正製薬株式会社 | 内服液体組成物 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08301742A (ja) * | 1995-04-28 | 1996-11-19 | Ezaki Glico Co Ltd | だ液のpH低下を防止する口腔用組成物 |
JPH10182387A (ja) * | 1996-12-25 | 1998-07-07 | Lion Corp | 舌苔除去剤 |
JPH1121216A (ja) * | 1997-06-30 | 1999-01-26 | Lion Corp | 口腔用組成物 |
JP2010143843A (ja) * | 2008-12-18 | 2010-07-01 | Lion Corp | 液体口腔用組成物 |
JP5624773B2 (ja) * | 2010-02-16 | 2014-11-12 | ライオン株式会社 | 口腔用組成物の製造方法 |
-
2011
- 2011-11-29 JP JP2011260985A patent/JP5912035B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
JP2013112650A (ja) | 2013-06-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5320776B2 (ja) | 歯磨製品 | |
JP5891749B2 (ja) | 歯磨剤組成物 | |
ES2686645T3 (es) | Composiciones para el cuidado bucal que contienen polietilenglicol para la estabilidad física | |
JP6985786B2 (ja) | 歯磨組成物及び歯磨組成物における容器へのイソプロピルメチルフェノールの吸着抑制方法 | |
JP5720546B2 (ja) | 歯磨剤組成物及び歯牙の再石灰化促進剤 | |
ES2686269T3 (es) | Composiciones para el cuidado bucal que contienen polietilenglicol para la estabilidad física | |
JP7173043B2 (ja) | 口腔用ステイン除去剤、口腔用ステイン形成抑制剤及び口腔用組成物 | |
KR101624764B1 (ko) | 치아 연마제 조성물 | |
JP5912035B2 (ja) | 液体口腔用組成物 | |
JP5226986B2 (ja) | 液体口腔用組成物 | |
WO2016121650A1 (ja) | 歯磨組成物 | |
CN109069363A (zh) | 包含凝胶网络和硝酸钾的口腔护理组合物 | |
WO2012103264A1 (en) | Dental cleaning composition comprising purple carrot extract | |
JP5948903B2 (ja) | 歯磨剤組成物及び歯磨剤組成物の防腐力向上方法 | |
KR20110129046A (ko) | 기능성 치약조성물 | |
JP6459781B2 (ja) | 口腔用組成物 | |
JP5516796B2 (ja) | 歯磨組成物 | |
TWI630919B (zh) | Oral composition | |
JP2010037297A (ja) | 口腔用組成物 | |
JP6444620B2 (ja) | 液体口腔用組成物 | |
JP3961479B2 (ja) | 液体口腔用組成物 | |
JP7120087B2 (ja) | 口腔用組成物 | |
KR100494287B1 (ko) | 은입자가 함유된 건강치약의 제조방법 | |
JP3821553B2 (ja) | 液体歯磨剤 | |
JP7000823B2 (ja) | 練歯磨剤組成物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20140919 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20150529 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150609 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20150806 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150908 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20160301 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20160331 |
|
R151 | Written notification of patent or utility model registration |
Ref document number: 5912035 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R151 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |