JP5218051B2 - 新規環状ペプチド化合物 - Google Patents

新規環状ペプチド化合物 Download PDF

Info

Publication number
JP5218051B2
JP5218051B2 JP2008521463A JP2008521463A JP5218051B2 JP 5218051 B2 JP5218051 B2 JP 5218051B2 JP 2008521463 A JP2008521463 A JP 2008521463A JP 2008521463 A JP2008521463 A JP 2008521463A JP 5218051 B2 JP5218051 B2 JP 5218051B2
Authority
JP
Japan
Prior art keywords
compound
salt
solution
reaction
production example
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2008521463A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009513562A (ja
JP2009513562A5 (enExample
Inventor
正博 閨
誠司 吉村
一紀 上條
拓也 牧野
実 安田
敏夫 山中
栄作 辻井
幸子 山岸
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of JP2009513562A publication Critical patent/JP2009513562A/ja
Publication of JP2009513562A5 publication Critical patent/JP2009513562A5/ja
Application granted granted Critical
Publication of JP5218051B2 publication Critical patent/JP5218051B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2008521463A 2005-10-26 2006-10-26 新規環状ペプチド化合物 Expired - Fee Related JP5218051B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US73001105P 2005-10-26 2005-10-26
US60/730,011 2005-10-26
US75120405P 2005-12-19 2005-12-19
US60/751,204 2005-12-19
PCT/JP2006/321924 WO2007049803A1 (en) 2005-10-26 2006-10-26 New cyclic peptide compounds

Publications (3)

Publication Number Publication Date
JP2009513562A JP2009513562A (ja) 2009-04-02
JP2009513562A5 JP2009513562A5 (enExample) 2009-11-19
JP5218051B2 true JP5218051B2 (ja) 2013-06-26

Family

ID=37847219

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008521463A Expired - Fee Related JP5218051B2 (ja) 2005-10-26 2006-10-26 新規環状ペプチド化合物

Country Status (17)

Country Link
US (2) US7872097B2 (enExample)
EP (1) EP1957518B1 (enExample)
JP (1) JP5218051B2 (enExample)
KR (1) KR101273681B1 (enExample)
CN (1) CN101305019B (enExample)
AU (1) AU2006306974B2 (enExample)
BR (1) BRPI0617781A2 (enExample)
CA (1) CA2623898C (enExample)
ES (1) ES2557477T3 (enExample)
IL (1) IL190286A0 (enExample)
NO (1) NO20082354L (enExample)
PL (1) PL1957518T3 (enExample)
PT (1) PT1957518E (enExample)
RU (1) RU2423377C2 (enExample)
TW (1) TWI391403B (enExample)
WO (1) WO2007049803A1 (enExample)
ZA (1) ZA200803525B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8603975B2 (en) 2007-05-02 2013-12-10 Astellas Pharma Inc. Cyclic peptide compounds
MX2011003259A (es) * 2008-09-24 2011-04-21 Astellas Pharma Inc Compuesto de peptido y metodo para producir el mismo.
CA2751210C (en) * 2009-01-30 2015-04-21 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis c infection
US8481483B2 (en) 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
CN102459160A (zh) * 2009-05-15 2012-05-16 荷兰癌症研究所基金会 赖氨酸化合物和其在肽和蛋白质的位点选择性和化学选择性修饰中的用途
US8349312B2 (en) 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
US8685917B2 (en) 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8367053B2 (en) 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
CN102834409A (zh) * 2009-12-30 2012-12-19 西尼克斯公司 环孢菌素类似物
US20150218103A1 (en) 2012-08-25 2015-08-06 The Johns Hopkins University Gapdh cascade inhibitor compounds and methods of use and treatment of stress induced disorders including mental illness
WO2014049540A2 (en) 2012-09-29 2014-04-03 Novartis Ag Cyclic peptides and use as medicines
US8906853B2 (en) 2012-11-28 2014-12-09 Enanta Pharmaceuticals, Inc. [N-Me-4-hydroxyleucine]-9-cyclosporin analogues for treatment and prevention of hepatitis C infection
EP3038626A4 (en) * 2013-08-26 2017-04-19 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis c
WO2016073480A1 (en) 2014-11-03 2016-05-12 Enanta Pharmaceuticals, Inc. Novel cyclosporin analogues for preventing or treating hepatitis c infection

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05271267A (ja) * 1991-04-23 1993-10-19 Fujisawa Pharmaceut Co Ltd Ｆｒ９０１４５９物質、その製法及び用途
BR9911724A (pt) 1998-07-01 2001-03-20 Debiopharm Sa Ciclosporina que tem um perfil de atividade melhorado
JP4232866B2 (ja) * 2000-10-19 2009-03-04 有限会社 ケアティス 細胞障害抑制剤
RU2337106C2 (ru) * 2001-10-19 2008-10-27 Изотехника Инк. Смесь аналогов циклоспорина и ее применение в качестве иммуномодулирующего агента
GB0320638D0 (en) * 2003-09-03 2003-10-01 Novartis Ag Organic compounds
JP2007015926A (ja) * 2003-10-06 2007-01-25 Fujisawa Pharmaceut Co Ltd Ｃ型肝炎治療剤
SG139750A1 (en) 2004-10-01 2008-02-29 Debiopharm Sa Ch Use of [d-meala]3-[etval]4-cyclosporin for the treatment of hepatitis c infection and pharmaceutical composition comprising said [d-meala]3- [etval]4-cyclosporin
PL1802650T3 (pl) 2004-10-01 2012-04-30 Scynexis Inc 3-Etero i 3-tioetero podstawione pochodne cyklosporyny do leczenia i zapobiegania zakażeniu wirusem zapalenia wątroby typu C
WO2006054801A1 (en) 2004-11-22 2006-05-26 Astellas Pharma Inc. New cyclic peptide compound

Also Published As

Publication number Publication date
CA2623898A1 (en) 2007-05-03
EP1957518B1 (en) 2015-12-09
NO20082354L (no) 2008-07-01
EP1957518A1 (en) 2008-08-20
WO2007049803A1 (en) 2007-05-03
US8252895B2 (en) 2012-08-28
ZA200803525B (en) 2009-08-26
US20100286033A1 (en) 2010-11-11
PL1957518T3 (pl) 2016-07-29
TW200732351A (en) 2007-09-01
ES2557477T3 (es) 2016-01-26
JP2009513562A (ja) 2009-04-02
CN101305019B (zh) 2012-12-12
PT1957518E (pt) 2016-02-26
IL190286A0 (en) 2011-08-01
RU2423377C2 (ru) 2011-07-10
CA2623898C (en) 2013-12-24
BRPI0617781A2 (pt) 2011-08-09
TWI391403B (zh) 2013-04-01
RU2008116674A (ru) 2009-10-27
KR101273681B1 (ko) 2013-06-25
AU2006306974B2 (en) 2011-09-22
KR20080065297A (ko) 2008-07-11
AU2006306974A1 (en) 2007-05-03
US20090170755A1 (en) 2009-07-02
CN101305019A (zh) 2008-11-12
US7872097B2 (en) 2011-01-18

Similar Documents

Publication Publication Date Title
CN114681443B (zh) 含腈的抗病毒化合物
US8252895B2 (en) Cyclic peptide compounds
CN101443350B (zh) 作为抗病剂的大环化合物
JP5459545B2 (ja) 新規環状ペプチド化合物
US20110218175A1 (en) Antiviral agents
CN102365094A (zh) 用于预防或者治疗肝炎感染的环孢菌素类似物
TW201216979A (en) Macrocyclic proline derived HCV serine protease inhibitors
EP1893573A1 (en) Inhibitors of hcv replication
CN102015652A (zh) 作为丙型肝炎病毒抑制剂的氟化大环化合物
TW202321251A (zh) 新穎螺環吡咯啶衍生的抗病毒劑
TW201119667A (en) Bismacrocyclic compounds as hepatitis C virus inhibitors
RU2845865C2 (ru) Нитрилсодержащие противовирусные соединения
AU2006200519A1 (en) New compound
HK40073397B (zh) 含腈的抗病毒化合物
WO2016074596A1 (zh) 核苷氨基磷酸酯衍生物及其应用
TW200927751A (en) Antiviral compounds
TW200817031A (en) Triazolyl acyclic hepatitis C serine protease inhibitors

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091001

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20091001

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120417

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120613

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20130205

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20130218

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20160315

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Ref document number: 5218051

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20160315

Year of fee payment: 3

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20160315

Year of fee payment: 3

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees