KR101273681B1 - 신규 시클릭 펩티드 화합물 - Google Patents

신규 시클릭 펩티드 화합물 Download PDF

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Publication number
KR101273681B1
KR101273681B1 KR1020087012431A KR20087012431A KR101273681B1 KR 101273681 B1 KR101273681 B1 KR 101273681B1 KR 1020087012431 A KR1020087012431 A KR 1020087012431A KR 20087012431 A KR20087012431 A KR 20087012431A KR 101273681 B1 KR101273681 B1 KR 101273681B1
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KR
South Korea
Prior art keywords
solution
compound
methyl
vacuo
reaction
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KR1020087012431A
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English (en)
Korean (ko)
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KR20080065297A (ko
Inventor
마사히로 네야
세이지 요시무라
가즈노리 가미죠
다쿠야 마키노
미노루 야스다
도시오 야마나카
에이사쿠 쯔지
유키꼬 야마기시
Original Assignee
아스텔라스세이야쿠 가부시키가이샤
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Publication of KR20080065297A publication Critical patent/KR20080065297A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR1020087012431A 2005-10-26 2006-10-26 신규 시클릭 펩티드 화합물 Expired - Fee Related KR101273681B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US73001105P 2005-10-26 2005-10-26
US60/730,011 2005-10-26
US75120405P 2005-12-19 2005-12-19
US60/751,204 2005-12-19
PCT/JP2006/321924 WO2007049803A1 (en) 2005-10-26 2006-10-26 New cyclic peptide compounds

Publications (2)

Publication Number Publication Date
KR20080065297A KR20080065297A (ko) 2008-07-11
KR101273681B1 true KR101273681B1 (ko) 2013-06-25

Family

ID=37847219

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087012431A Expired - Fee Related KR101273681B1 (ko) 2005-10-26 2006-10-26 신규 시클릭 펩티드 화합물

Country Status (17)

Country Link
US (2) US7872097B2 (enExample)
EP (1) EP1957518B1 (enExample)
JP (1) JP5218051B2 (enExample)
KR (1) KR101273681B1 (enExample)
CN (1) CN101305019B (enExample)
AU (1) AU2006306974B2 (enExample)
BR (1) BRPI0617781A2 (enExample)
CA (1) CA2623898C (enExample)
ES (1) ES2557477T3 (enExample)
IL (1) IL190286A0 (enExample)
NO (1) NO20082354L (enExample)
PL (1) PL1957518T3 (enExample)
PT (1) PT1957518E (enExample)
RU (1) RU2423377C2 (enExample)
TW (1) TWI391403B (enExample)
WO (1) WO2007049803A1 (enExample)
ZA (1) ZA200803525B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8603975B2 (en) 2007-05-02 2013-12-10 Astellas Pharma Inc. Cyclic peptide compounds
MX2011003259A (es) * 2008-09-24 2011-04-21 Astellas Pharma Inc Compuesto de peptido y metodo para producir el mismo.
CA2751210C (en) * 2009-01-30 2015-04-21 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis c infection
US8481483B2 (en) 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
CN102459160A (zh) * 2009-05-15 2012-05-16 荷兰癌症研究所基金会 赖氨酸化合物和其在肽和蛋白质的位点选择性和化学选择性修饰中的用途
US8349312B2 (en) 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
US8685917B2 (en) 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8367053B2 (en) 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
CN102834409A (zh) * 2009-12-30 2012-12-19 西尼克斯公司 环孢菌素类似物
US20150218103A1 (en) 2012-08-25 2015-08-06 The Johns Hopkins University Gapdh cascade inhibitor compounds and methods of use and treatment of stress induced disorders including mental illness
WO2014049540A2 (en) 2012-09-29 2014-04-03 Novartis Ag Cyclic peptides and use as medicines
US8906853B2 (en) 2012-11-28 2014-12-09 Enanta Pharmaceuticals, Inc. [N-Me-4-hydroxyleucine]-9-cyclosporin analogues for treatment and prevention of hepatitis C infection
EP3038626A4 (en) * 2013-08-26 2017-04-19 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis c
WO2016073480A1 (en) 2014-11-03 2016-05-12 Enanta Pharmaceuticals, Inc. Novel cyclosporin analogues for preventing or treating hepatitis c infection

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005032576A1 (ja) * 2003-10-06 2005-04-14 Astellas Pharma Inc. Ｃ型肝炎治療剤

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05271267A (ja) * 1991-04-23 1993-10-19 Fujisawa Pharmaceut Co Ltd Ｆｒ９０１４５９物質、その製法及び用途
BR9911724A (pt) 1998-07-01 2001-03-20 Debiopharm Sa Ciclosporina que tem um perfil de atividade melhorado
JP4232866B2 (ja) * 2000-10-19 2009-03-04 有限会社 ケアティス 細胞障害抑制剤
RU2337106C2 (ru) * 2001-10-19 2008-10-27 Изотехника Инк. Смесь аналогов циклоспорина и ее применение в качестве иммуномодулирующего агента
GB0320638D0 (en) * 2003-09-03 2003-10-01 Novartis Ag Organic compounds
SG139750A1 (en) 2004-10-01 2008-02-29 Debiopharm Sa Ch Use of [d-meala]3-[etval]4-cyclosporin for the treatment of hepatitis c infection and pharmaceutical composition comprising said [d-meala]3- [etval]4-cyclosporin
PL1802650T3 (pl) 2004-10-01 2012-04-30 Scynexis Inc 3-Etero i 3-tioetero podstawione pochodne cyklosporyny do leczenia i zapobiegania zakażeniu wirusem zapalenia wątroby typu C
WO2006054801A1 (en) 2004-11-22 2006-05-26 Astellas Pharma Inc. New cyclic peptide compound

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005032576A1 (ja) * 2003-10-06 2005-04-14 Astellas Pharma Inc. Ｃ型肝炎治療剤

Also Published As

Publication number Publication date
CA2623898A1 (en) 2007-05-03
EP1957518B1 (en) 2015-12-09
NO20082354L (no) 2008-07-01
EP1957518A1 (en) 2008-08-20
WO2007049803A1 (en) 2007-05-03
US8252895B2 (en) 2012-08-28
ZA200803525B (en) 2009-08-26
US20100286033A1 (en) 2010-11-11
PL1957518T3 (pl) 2016-07-29
TW200732351A (en) 2007-09-01
ES2557477T3 (es) 2016-01-26
JP2009513562A (ja) 2009-04-02
CN101305019B (zh) 2012-12-12
PT1957518E (pt) 2016-02-26
IL190286A0 (en) 2011-08-01
RU2423377C2 (ru) 2011-07-10
CA2623898C (en) 2013-12-24
BRPI0617781A2 (pt) 2011-08-09
TWI391403B (zh) 2013-04-01
RU2008116674A (ru) 2009-10-27
JP5218051B2 (ja) 2013-06-26
AU2006306974B2 (en) 2011-09-22
KR20080065297A (ko) 2008-07-11
AU2006306974A1 (en) 2007-05-03
US20090170755A1 (en) 2009-07-02
CN101305019A (zh) 2008-11-12
US7872097B2 (en) 2011-01-18

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