JP5185630B2 - 医療器具およびその製造方法 - Google Patents
医療器具およびその製造方法 Download PDFInfo
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- JP5185630B2 JP5185630B2 JP2007556276A JP2007556276A JP5185630B2 JP 5185630 B2 JP5185630 B2 JP 5185630B2 JP 2007556276 A JP2007556276 A JP 2007556276A JP 2007556276 A JP2007556276 A JP 2007556276A JP 5185630 B2 JP5185630 B2 JP 5185630B2
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- Prior art keywords
- balloon
- nanomaterial
- wall
- medical device
- medical
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/104—Balloon catheters used for angioplasty
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L29/126—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/958—Inflatable balloons for placing stents or stent-grafts
- A61F2002/9583—Means for holding the stent on the balloon, e.g. using protrusions, adhesives or an outer sleeve
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
- A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1086—Balloon catheters with special features or adapted for special applications having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Description
好ましい破裂圧力および可撓性の特性を示すバルーンが提供される。バルーンの空洞および/またはアブショーションされた領域(以下「アブレーション領域」と称する)へのナノ材料の付加により、バルーンの外形および/または可撓性を維持しながらも、バルーンの破裂圧力を改善することができる。実施形態において、空洞および/またはアブレーション領域にナノ材料を含むバルーンは、相対的に高い破裂圧力、良好な可撓性、および相対的に小さな外形を有することができる。ナノ材料は相対的に生体適合性を有し得る。一部の実施形態においては、ナノ材料は、治療薬、薬剤、および/または、薬学的活性化合物を体内の目的部位に送達することができる。空洞またはアブレーション領域は、比較的迅速にかつ容易にバルーン壁に形成することができる。空洞またはアブレーション領域は、(例えば空洞またはアブレーション領域がレーザアブレーションによって形成される実施形態においては)相対的に高い精度で形成され得る。
例として、単層バルーンが示されているが、一部の実施形態においては、アブレーション領域を備えるバルーンは、多層バルーンであってもよい。例えば、バルーンは、2層、3層、4層、5層、または6層を有し得る。多層バルーンは、例えば、共押出成形によって形成することができる。バルーンが多層バルーン(例えば5層を有するバルーン)である特定の実施形態においては、アブレーション領域は、バルーンの最上層または上から2つの層のみに延び得る。
他の実施形態も特許請求の範囲の範囲内に含まれる。
Claims (21)
- 間に壁厚を画定する内面および外面を備える壁部を有する膨張可能なバルーンと、
該バルーンの外面に前記壁厚を減少させるように形成され、複数の交点にて交差する複数の溝から構成されるとともに溝のない複数のランド領域を形成するパターンと、
前記ランド領域の少なくともいくつかの周囲を包囲するようにパターン内に配置されるとともにパターンを充填するコーティングとを備え、
前記コーティングは、ナノ材料から構成される医療器具。 - 前記溝の深さは前記壁部の厚さの5〜75%である、請求項1に記載の医療器具。
- 前記溝の幅対深さの比率は10:1以下である、請求項1に記載の医療器具。
- 前記ナノ材料は複数のナノチューブを含む、請求項1に記載の医療器具。
- 前記ナノ材料はナノ材料を含有する繊維を含む、請求項1に記載の医療器具。
- 前記ナノ材料は、マトリックスポリマー内に配置される、請求項1に記載の医療器具。
- 前記溝は壁部の外面と同じ高さとなるように充填される、請求項1に記載の医療器具。
- 前記溝は、壁部の外面よりも低く、または高く充填される、請求項1に記載の医療器具。
- 前記バルーンは少なくとも1MPa(約10atm)の破裂圧力を有する、請求項1に記載の医療器具。
- 前記バルーンは二軸配向材料から形成される、請求項1に記載の医療器具。
- バルーンは、ペバックス、PET、PEN、PBT、PEEK、ハイトレル、ポリウレタン、またはナイロンから選択されるポリマーから形成される、請求項1に記載の医療器具。
- ステントをさらに備える、請求項1に記載の医療器具。
- 前記ステントは薬剤を含む、請求項12に記載の医療器具。
- 医療用バルーンの壁部の内面と外面との間に画定される壁厚を減少させるように、該壁部の外面に空洞を設ける工程と、
前記空洞にナノ材料を付加する工程と
を含み、
前記空洞は複数の交点にて交差する溝のパターンを形成するとともに溝のない複数のランド領域を形成し、
ナノ材料が前記ランド領域の少なくともいくつかの周囲を包囲するようにナノ材料がパターン内に配置されるとともにパターンを充填する方法。 - 前記医療用バルーンが膨張するときに、前記空洞が該医療用バルーンの壁部に形成される、請求項14に記載の方法。
- 前記医療用バルーンの壁部に空洞を設ける工程は、医療用バルーンの壁をアブレーションする工程を含む、請求項14に記載の方法。
- 前記空洞にナノ材料を付加する工程は、ナノ材料を含む溶液に前記空洞を接触させる工程を含む、請求項14に記載の方法。
- 前記医療用バルーンの壁部に空洞を設ける工程は、医療用バルーンパリソンの壁部に空洞を形成する工程と、その医療用バルーンパリソンを拡張する工程とを含む、請求項14に記載の方法。
- 前記医療用バルーンパリソンの壁部に空洞を形成する工程は、医療用バルーンパリソンの壁部をアブレーションする工程を含む、請求項18に記載の方法。
- 前記空洞にナノ材料を付加する工程の後に、そのナノ材料をポリマーで被覆する工程をさらに含む、請求項14に記載の方法。
- 前記ポリマーはエラストマーを含む、請求項20に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/060,093 | 2005-02-17 | ||
US11/060,093 US8048028B2 (en) | 2005-02-17 | 2005-02-17 | Reinforced medical balloon |
PCT/US2006/005400 WO2006088989A1 (en) | 2005-02-17 | 2006-02-16 | Medical devices |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2008529733A JP2008529733A (ja) | 2008-08-07 |
JP5185630B2 true JP5185630B2 (ja) | 2013-04-17 |
Family
ID=36293504
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007556276A Expired - Fee Related JP5185630B2 (ja) | 2005-02-17 | 2006-02-16 | 医療器具およびその製造方法 |
Country Status (6)
Country | Link |
---|---|
US (2) | US8048028B2 (ja) |
EP (1) | EP1858441B1 (ja) |
JP (1) | JP5185630B2 (ja) |
AT (1) | ATE552802T1 (ja) |
CA (1) | CA2597597C (ja) |
WO (1) | WO2006088989A1 (ja) |
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US8048028B2 (en) | 2011-11-01 |
JP2008529733A (ja) | 2008-08-07 |
CA2597597A1 (en) | 2006-08-24 |
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