JP5179354B2 - スーパーオキサイド抑制効果を有するプロブコールおよびテトラゾリルアルコキシ−ジヒドロカルボスチリル誘導体を含む併用薬 - Google Patents
スーパーオキサイド抑制効果を有するプロブコールおよびテトラゾリルアルコキシ−ジヒドロカルボスチリル誘導体を含む併用薬 Download PDFInfo
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- JP5179354B2 JP5179354B2 JP2008514987A JP2008514987A JP5179354B2 JP 5179354 B2 JP5179354 B2 JP 5179354B2 JP 2008514987 A JP2008514987 A JP 2008514987A JP 2008514987 A JP2008514987 A JP 2008514987A JP 5179354 B2 JP5179354 B2 JP 5179354B2
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- probucol
- cilostazol
- dihydrocarbostyril
- bond
- tetrazolylalkoxy
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US71695405P | 2005-09-15 | 2005-09-15 | |
| US60/716,954 | 2005-09-15 | ||
| US76177506P | 2006-01-25 | 2006-01-25 | |
| US60/761,775 | 2006-01-25 | ||
| PCT/JP2006/318675 WO2007032557A1 (en) | 2005-09-15 | 2006-09-14 | Combination drug containing probucol and a tetrazolylalkoxy-dihydrocarbostyril derivative with superoxide supressant effects |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2012199804A Division JP5603393B2 (ja) | 2005-09-15 | 2012-09-11 | スーパーオキサイド抑制効果を有するプロブコールおよびテトラゾリルアルコキシ−ジヒドロカルボスチリル誘導体を含む併用薬 |
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| JP2009508804A JP2009508804A (ja) | 2009-03-05 |
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| JP2008514987A Expired - Fee Related JP5179354B2 (ja) | 2005-09-15 | 2006-09-14 | スーパーオキサイド抑制効果を有するプロブコールおよびテトラゾリルアルコキシ−ジヒドロカルボスチリル誘導体を含む併用薬 |
| JP2012199804A Expired - Fee Related JP5603393B2 (ja) | 2005-09-15 | 2012-09-11 | スーパーオキサイド抑制効果を有するプロブコールおよびテトラゾリルアルコキシ−ジヒドロカルボスチリル誘導体を含む併用薬 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2012199804A Expired - Fee Related JP5603393B2 (ja) | 2005-09-15 | 2012-09-11 | スーパーオキサイド抑制効果を有するプロブコールおよびテトラゾリルアルコキシ−ジヒドロカルボスチリル誘導体を含む併用薬 |
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| Country | Link |
|---|---|
| US (2) | US8580818B2 (enExample) |
| EP (2) | EP2275106A1 (enExample) |
| JP (2) | JP5179354B2 (enExample) |
| KR (1) | KR101299320B1 (enExample) |
| AR (1) | AR057520A1 (enExample) |
| AU (1) | AU2006289752B2 (enExample) |
| BR (1) | BRPI0616223A2 (enExample) |
| CA (1) | CA2620296C (enExample) |
| CY (1) | CY1112716T1 (enExample) |
| DK (1) | DK1942895T3 (enExample) |
| ES (1) | ES2378896T3 (enExample) |
| IL (1) | IL189751A0 (enExample) |
| MY (1) | MY145787A (enExample) |
| NO (1) | NO20081811L (enExample) |
| PL (1) | PL1942895T3 (enExample) |
| PT (1) | PT1942895E (enExample) |
| RU (1) | RU2411945C2 (enExample) |
| SG (1) | SG165379A1 (enExample) |
| TW (1) | TWI372053B (enExample) |
| WO (1) | WO2007032557A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| AR065588A1 (es) * | 2007-03-09 | 2009-06-17 | Otsuka Pharma Co Ltd | Un medicamento para tratar enfermedad pulmonar obstructiva cronica |
| AR070816A1 (es) * | 2008-03-14 | 2010-05-05 | Otsuka Pharma Co Ltd | Farmaco de combinacion para tratar trastornos vasculares |
| CN120441542B (zh) * | 2025-05-08 | 2025-09-30 | 安徽益普克医药科技发展有限公司 | 一种西洛他唑衍生物及其制备方法与用途 |
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| JPS5535019A (en) * | 1978-09-01 | 1980-03-11 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
| JPH04193836A (ja) * | 1990-11-26 | 1992-07-13 | Banyu Pharmaceut Co Ltd | 抗高脂血症剤 |
| JPH107590A (ja) | 1996-06-24 | 1998-01-13 | Chugai Pharmaceut Co Ltd | 脳循環障害後遺症または脳虚血後の脳神経障害の治療剤 |
| FR2751540B1 (fr) * | 1996-07-26 | 1998-10-16 | Sanofi Sa | Composition pharmaceutique antithrombotique |
| JP2001500875A (ja) | 1996-09-18 | 2001-01-23 | メルク エンド カンパニー インコーポレーテッド | 心臓血管系疾患関連の危険性を減らす併用治療法 |
| US6245797B1 (en) * | 1997-10-22 | 2001-06-12 | Merck & Co., Inc. | Combination therapy for reducing the risks associated with cardio-and-cerebrovascular disease |
| WO1999024400A1 (en) | 1997-11-10 | 1999-05-20 | Vyrex Corporation | Probucol esters and uses thereof |
| US6235311B1 (en) * | 1998-03-18 | 2001-05-22 | Bristol-Myers Squibb Company | Pharmaceutical composition containing a combination of a statin and aspirin and method |
| AU5965399A (en) | 1998-10-12 | 2000-05-01 | Andreas Bockelmann | Pharmaceutically active composition |
| CA2406077C (en) | 2000-04-10 | 2010-07-20 | Nicholas J. Wald | Formulation for the prevention of cardiovascular disease |
| US20020115728A1 (en) * | 2000-09-05 | 2002-08-22 | Roland Stocker | Compositions and methods for treating cardiovascular disorders |
| CA2434436A1 (en) * | 2001-01-26 | 2002-08-01 | Teddy Kosoglou | Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions |
| US6576256B2 (en) * | 2001-08-28 | 2003-06-10 | The Brigham And Women's Hospital, Inc. | Treatment of patients at elevated cardiovascular risk with a combination of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin |
| JP2003192573A (ja) * | 2001-12-25 | 2003-07-09 | Otsuka Pharmaceut Factory Inc | 経口ゲル製剤 |
| TW200301135A (en) * | 2001-12-27 | 2003-07-01 | Otsuka Maryland Res Inst Inc | Pharmaceutical compositions comprising a multifunctional phosphodiesterase inhibitor and an adenosine uptake inhibitor |
| US20030181461A1 (en) * | 2002-01-25 | 2003-09-25 | Lautt Wilfred Wayne | Use of phosphodiesterase antagonists to treat insulin resistance |
| US6743806B2 (en) * | 2002-10-23 | 2004-06-01 | Otsuka Pharmaceutical Company, Limited | Active oxygen scavenger |
| JP2005232059A (ja) * | 2004-02-18 | 2005-09-02 | Iichiro Shimomura | 低アディポネクチン血症予防・治療剤 |
| PT1894576E (pt) | 2005-06-08 | 2011-07-29 | Kowa Co | Novo agente redutor dos níveis de triglicéridos |
| JP4193836B2 (ja) | 2005-10-24 | 2008-12-10 | ブラザー工業株式会社 | インク噴射装置の製造方法 |
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- 2006-09-14 US US12/065,619 patent/US8580818B2/en not_active Expired - Fee Related
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- 2006-09-14 SG SG201006668-6A patent/SG165379A1/en unknown
- 2006-09-14 TW TW095134039A patent/TWI372053B/zh not_active IP Right Cessation
- 2006-09-14 DK DK06810355.5T patent/DK1942895T3/da active
- 2006-09-14 ES ES06810355T patent/ES2378896T3/es active Active
- 2006-09-14 CA CA2620296A patent/CA2620296C/en not_active Expired - Fee Related
- 2006-09-14 JP JP2008514987A patent/JP5179354B2/ja not_active Expired - Fee Related
- 2006-09-14 AU AU2006289752A patent/AU2006289752B2/en not_active Ceased
- 2006-09-14 MY MYPI20080610A patent/MY145787A/en unknown
- 2006-09-14 WO PCT/JP2006/318675 patent/WO2007032557A1/en not_active Ceased
- 2006-09-14 PL PL06810355T patent/PL1942895T3/pl unknown
- 2006-09-14 AR ARP060104020A patent/AR057520A1/es unknown
- 2006-09-14 RU RU2008114512/15A patent/RU2411945C2/ru not_active IP Right Cessation
- 2006-09-14 PT PT06810355T patent/PT1942895E/pt unknown
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2008
- 2008-02-25 IL IL189751A patent/IL189751A0/en unknown
- 2008-04-14 NO NO20081811A patent/NO20081811L/no not_active Application Discontinuation
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2012
- 2012-04-20 CY CY20121100376T patent/CY1112716T1/el unknown
- 2012-09-11 JP JP2012199804A patent/JP5603393B2/ja not_active Expired - Fee Related
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2013
- 2013-10-21 US US14/059,368 patent/US20140045889A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MY145787A (en) | 2012-04-30 |
| NO20081811L (no) | 2008-04-14 |
| KR20080049822A (ko) | 2008-06-04 |
| PT1942895E (pt) | 2012-03-29 |
| CA2620296C (en) | 2013-10-22 |
| JP2009508804A (ja) | 2009-03-05 |
| US8580818B2 (en) | 2013-11-12 |
| TW200744597A (en) | 2007-12-16 |
| AU2006289752A1 (en) | 2007-03-22 |
| EP1942895B1 (en) | 2012-02-01 |
| JP5603393B2 (ja) | 2014-10-08 |
| US20140045889A1 (en) | 2014-02-13 |
| ES2378896T3 (es) | 2012-04-18 |
| AU2006289752B2 (en) | 2011-06-09 |
| TWI372053B (en) | 2012-09-11 |
| BRPI0616223A2 (pt) | 2011-06-14 |
| WO2007032557A1 (en) | 2007-03-22 |
| PL1942895T3 (pl) | 2012-07-31 |
| CA2620296A1 (en) | 2007-03-22 |
| US20090176826A1 (en) | 2009-07-09 |
| DK1942895T3 (da) | 2012-03-05 |
| EP1942895A1 (en) | 2008-07-16 |
| KR101299320B1 (ko) | 2013-09-03 |
| SG165379A1 (en) | 2010-10-28 |
| EP2275106A1 (en) | 2011-01-19 |
| CY1112716T1 (el) | 2016-02-10 |
| IL189751A0 (en) | 2008-12-29 |
| JP2013014605A (ja) | 2013-01-24 |
| AR057520A1 (es) | 2007-12-05 |
| RU2008114512A (ru) | 2009-10-20 |
| HK1122996A1 (en) | 2009-06-05 |
| RU2411945C2 (ru) | 2011-02-20 |
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