NO20081811L - Kombinasjonslegemiddel inneholdende probucol og et tetrazolylalkoksy-dihydrokarbostyrilderivat med superoksid-undertrykkende effekt - Google Patents
Kombinasjonslegemiddel inneholdende probucol og et tetrazolylalkoksy-dihydrokarbostyrilderivat med superoksid-undertrykkende effektInfo
- Publication number
- NO20081811L NO20081811L NO20081811A NO20081811A NO20081811L NO 20081811 L NO20081811 L NO 20081811L NO 20081811 A NO20081811 A NO 20081811A NO 20081811 A NO20081811 A NO 20081811A NO 20081811 L NO20081811 L NO 20081811L
- Authority
- NO
- Norway
- Prior art keywords
- combination drug
- drug containing
- combination
- cerebral infarction
- probucol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Oppfinnelsen angår et kombinasjonslegemiddel omfattende en kombinasjon av et tetrazolylalkoksy-dihydrokarbostyrilderivat av formelen: hvori R er sykloalkyl, A er lavere alkylen, og bindingen mellom 3- og 4-stillingene av karbostyrilkjernen er en enkeltbinding eller dobbeltbinding, eller et salt derav, og probukol, som er anvendbar for forhindring og behandling av cerebralt infarkt innbefattende akutt, cerebralt infarkt og kronisk cerebralt infarkt, arteriosklerose, nyresykdommer (for eksempel diabetisk nefropati, nyresvikt, nefritt), og diabetes på grunn av synergistisk superoksidundertrykkende effekt av kom-binasjonen.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71695405P | 2005-09-15 | 2005-09-15 | |
US76177506P | 2006-01-25 | 2006-01-25 | |
PCT/JP2006/318675 WO2007032557A1 (en) | 2005-09-15 | 2006-09-14 | Combination drug containing probucol and a tetrazolylalkoxy-dihydrocarbostyril derivative with superoxide supressant effects |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20081811L true NO20081811L (no) | 2008-04-14 |
Family
ID=37420867
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20081811A NO20081811L (no) | 2005-09-15 | 2008-04-14 | Kombinasjonslegemiddel inneholdende probucol og et tetrazolylalkoksy-dihydrokarbostyrilderivat med superoksid-undertrykkende effekt |
Country Status (21)
Country | Link |
---|---|
US (2) | US8580818B2 (no) |
EP (2) | EP1942895B1 (no) |
JP (2) | JP5179354B2 (no) |
KR (1) | KR101299320B1 (no) |
AR (1) | AR057520A1 (no) |
AU (1) | AU2006289752B2 (no) |
BR (1) | BRPI0616223A2 (no) |
CA (1) | CA2620296C (no) |
CY (1) | CY1112716T1 (no) |
DK (1) | DK1942895T3 (no) |
ES (1) | ES2378896T3 (no) |
HK (1) | HK1122996A1 (no) |
IL (1) | IL189751A0 (no) |
MY (1) | MY145787A (no) |
NO (1) | NO20081811L (no) |
PL (1) | PL1942895T3 (no) |
PT (1) | PT1942895E (no) |
RU (1) | RU2411945C2 (no) |
SG (1) | SG165379A1 (no) |
TW (1) | TWI372053B (no) |
WO (1) | WO2007032557A1 (no) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR065588A1 (es) * | 2007-03-09 | 2009-06-17 | Otsuka Pharma Co Ltd | Un medicamento para tratar enfermedad pulmonar obstructiva cronica |
AR070816A1 (es) * | 2008-03-14 | 2010-05-05 | Otsuka Pharma Co Ltd | Farmaco de combinacion para tratar trastornos vasculares |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5535019A (en) * | 1978-09-01 | 1980-03-11 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
JPH04193836A (ja) | 1990-11-26 | 1992-07-13 | Banyu Pharmaceut Co Ltd | 抗高脂血症剤 |
JPH107590A (ja) | 1996-06-24 | 1998-01-13 | Chugai Pharmaceut Co Ltd | 脳循環障害後遺症または脳虚血後の脳神経障害の治療剤 |
FR2751540B1 (fr) * | 1996-07-26 | 1998-10-16 | Sanofi Sa | Composition pharmaceutique antithrombotique |
CA2265827A1 (en) | 1996-09-18 | 1998-03-26 | Merck & Co., Inc. | Combination therapy for reducing the risks associated with cardiovascular disease |
US6245797B1 (en) * | 1997-10-22 | 2001-06-12 | Merck & Co., Inc. | Combination therapy for reducing the risks associated with cardio-and-cerebrovascular disease |
WO1999024400A1 (en) * | 1997-11-10 | 1999-05-20 | Vyrex Corporation | Probucol esters and uses thereof |
US6235311B1 (en) * | 1998-03-18 | 2001-05-22 | Bristol-Myers Squibb Company | Pharmaceutical composition containing a combination of a statin and aspirin and method |
AU5965399A (en) | 1998-10-12 | 2000-05-01 | Andreas Bockelmann | Pharmaceutically active composition |
DK1272220T4 (en) | 2000-04-10 | 2016-11-28 | Nicholas John Wald | Cardiovascular disease prevention formulation |
US20020115728A1 (en) * | 2000-09-05 | 2002-08-22 | Roland Stocker | Compositions and methods for treating cardiovascular disorders |
WO2002058731A2 (en) * | 2001-01-26 | 2002-08-01 | Schering Corporation | Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions |
US6576256B2 (en) * | 2001-08-28 | 2003-06-10 | The Brigham And Women's Hospital, Inc. | Treatment of patients at elevated cardiovascular risk with a combination of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin |
JP2003192573A (ja) * | 2001-12-25 | 2003-07-09 | Otsuka Pharmaceut Factory Inc | 経口ゲル製剤 |
US20030181461A1 (en) * | 2002-01-25 | 2003-09-25 | Lautt Wilfred Wayne | Use of phosphodiesterase antagonists to treat insulin resistance |
US6743806B2 (en) * | 2002-10-23 | 2004-06-01 | Otsuka Pharmaceutical Company, Limited | Active oxygen scavenger |
JP2005232059A (ja) | 2004-02-18 | 2005-09-02 | Iichiro Shimomura | 低アディポネクチン血症予防・治療剤 |
PT1894576E (pt) | 2005-06-08 | 2011-07-29 | Kowa Co | Novo agente redutor dos níveis de triglicéridos |
JP4193836B2 (ja) | 2005-10-24 | 2008-12-10 | ブラザー工業株式会社 | インク噴射装置の製造方法 |
-
2006
- 2006-09-14 US US12/065,619 patent/US8580818B2/en not_active Expired - Fee Related
- 2006-09-14 JP JP2008514987A patent/JP5179354B2/ja not_active Expired - Fee Related
- 2006-09-14 AR ARP060104020A patent/AR057520A1/es unknown
- 2006-09-14 TW TW095134039A patent/TWI372053B/zh not_active IP Right Cessation
- 2006-09-14 CA CA2620296A patent/CA2620296C/en not_active Expired - Fee Related
- 2006-09-14 RU RU2008114512/15A patent/RU2411945C2/ru not_active IP Right Cessation
- 2006-09-14 DK DK06810355.5T patent/DK1942895T3/da active
- 2006-09-14 EP EP06810355A patent/EP1942895B1/en not_active Not-in-force
- 2006-09-14 EP EP10177619A patent/EP2275106A1/en not_active Withdrawn
- 2006-09-14 BR BRPI0616223-1A patent/BRPI0616223A2/pt not_active IP Right Cessation
- 2006-09-14 PL PL06810355T patent/PL1942895T3/pl unknown
- 2006-09-14 SG SG201006668-6A patent/SG165379A1/en unknown
- 2006-09-14 PT PT06810355T patent/PT1942895E/pt unknown
- 2006-09-14 KR KR1020087008859A patent/KR101299320B1/ko not_active IP Right Cessation
- 2006-09-14 ES ES06810355T patent/ES2378896T3/es active Active
- 2006-09-14 WO PCT/JP2006/318675 patent/WO2007032557A1/en active Application Filing
- 2006-09-14 AU AU2006289752A patent/AU2006289752B2/en not_active Ceased
- 2006-09-14 MY MYPI20080610A patent/MY145787A/en unknown
-
2008
- 2008-02-25 IL IL189751A patent/IL189751A0/en unknown
- 2008-04-14 NO NO20081811A patent/NO20081811L/no not_active Application Discontinuation
-
2009
- 2009-01-09 HK HK09100257.9A patent/HK1122996A1/xx not_active IP Right Cessation
-
2012
- 2012-04-20 CY CY20121100376T patent/CY1112716T1/el unknown
- 2012-09-11 JP JP2012199804A patent/JP5603393B2/ja not_active Expired - Fee Related
-
2013
- 2013-10-21 US US14/059,368 patent/US20140045889A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20090176826A1 (en) | 2009-07-09 |
AU2006289752A1 (en) | 2007-03-22 |
SG165379A1 (en) | 2010-10-28 |
RU2008114512A (ru) | 2009-10-20 |
US8580818B2 (en) | 2013-11-12 |
US20140045889A1 (en) | 2014-02-13 |
EP1942895B1 (en) | 2012-02-01 |
HK1122996A1 (en) | 2009-06-05 |
JP5603393B2 (ja) | 2014-10-08 |
DK1942895T3 (da) | 2012-03-05 |
EP1942895A1 (en) | 2008-07-16 |
IL189751A0 (en) | 2008-12-29 |
KR20080049822A (ko) | 2008-06-04 |
PT1942895E (pt) | 2012-03-29 |
MY145787A (en) | 2012-04-30 |
CA2620296C (en) | 2013-10-22 |
PL1942895T3 (pl) | 2012-07-31 |
BRPI0616223A2 (pt) | 2011-06-14 |
TW200744597A (en) | 2007-12-16 |
CA2620296A1 (en) | 2007-03-22 |
RU2411945C2 (ru) | 2011-02-20 |
CY1112716T1 (el) | 2016-02-10 |
EP2275106A1 (en) | 2011-01-19 |
AR057520A1 (es) | 2007-12-05 |
TWI372053B (en) | 2012-09-11 |
JP2009508804A (ja) | 2009-03-05 |
ES2378896T3 (es) | 2012-04-18 |
AU2006289752B2 (en) | 2011-06-09 |
WO2007032557A1 (en) | 2007-03-22 |
KR101299320B1 (ko) | 2013-09-03 |
JP2013014605A (ja) | 2013-01-24 |
JP5179354B2 (ja) | 2013-04-10 |
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Legal Events
Date | Code | Title | Description |
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |