JP5175196B2 - アミノペプチダーゼｐのチオ含有インヒビター、その組成物および使用法 - Google Patents

アミノペプチダーゼｐのチオ含有インヒビター、その組成物および使用法 Download PDF

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Publication number
JP5175196B2
JP5175196B2 JP2008531140A JP2008531140A JP5175196B2 JP 5175196 B2 JP5175196 B2 JP 5175196B2 JP 2008531140 A JP2008531140 A JP 2008531140A JP 2008531140 A JP2008531140 A JP 2008531140A JP 5175196 B2 JP5175196 B2 JP 5175196B2
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carbonyl
carbon atoms
alkyl
compound
pharmaceutical composition
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JP2008531140A
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English (en)
Japanese (ja)
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JP2009507917A (ja
Inventor
ウィリアム エイチ． シモンズ，
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ウィリアム エイチ． シモンズ，
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/556—Angiotensin converting enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2008531140A 2005-09-13 2006-08-28 アミノペプチダーゼｐのチオ含有インヒビター、その組成物および使用法 Active JP5175196B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/225,748 2005-09-13
US11/225,748 US7390789B2 (en) 2005-09-13 2005-09-13 Thio-containing inhibitors of aminopeptidase P, and compositions thereof
PCT/US2006/033398 WO2007032887A2 (fr) 2005-09-13 2006-08-28 Inhibiteurs contenant un compose thio d'une aminopeptidase p, leurs compositions et procede d'utilisation associes

Publications (2)

Publication Number Publication Date
JP2009507917A JP2009507917A (ja) 2009-02-26
JP5175196B2 true JP5175196B2 (ja) 2013-04-03

Family

ID=37856081

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008531140A Active JP5175196B2 (ja) 2005-09-13 2006-08-28 アミノペプチダーゼｐのチオ含有インヒビター、その組成物および使用法

Country Status (6)

Country Link
US (1) US7390789B2 (fr)
EP (1) EP1924275B1 (fr)
JP (1) JP5175196B2 (fr)
AU (1) AU2006291293B2 (fr)
CA (1) CA2621262C (fr)
WO (1) WO2007032887A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9212206B1 (en) * 2014-11-24 2015-12-15 William H Simmons 4-Fluoro-Thio-containing inhibitors of APP2, compositions thereof and method of use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684660A (en) * 1979-04-02 1987-08-04 E. R. Squibb & Sons, Inc. Mercaptoacyldepeptides
AU537592B2 (en) * 1979-04-02 1984-07-05 E.R. Squibb & Sons, Inc. Mercaptoacyldipeptides
US4549992A (en) 1979-07-13 1985-10-29 Usv Pharmaceutical Corp. Antihypertensive amides
US4507312A (en) 1979-07-13 1985-03-26 Usv Pharmaceutical Corporation Antihypertensive amides
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
US5508272A (en) 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
US5656603A (en) 1995-05-31 1997-08-12 Loyola University Of Chicago Aminopeptidase P inhibitors and uses thereof
US6486193B2 (en) * 1998-12-31 2002-11-26 Aventis Pharmaceuticals Inc. 3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases
US6777443B2 (en) 2001-05-15 2004-08-17 Novartis Ag Dipeptide derivatives

Also Published As

Publication number Publication date
EP1924275B1 (fr) 2012-08-08
JP2009507917A (ja) 2009-02-26
US20070060525A1 (en) 2007-03-15
EP1924275A4 (fr) 2009-07-29
WO2007032887A2 (fr) 2007-03-22
US7390789B2 (en) 2008-06-24
CA2621262A1 (fr) 2007-03-22
WO2007032887A3 (fr) 2007-10-04
AU2006291293A1 (en) 2007-03-22
EP1924275A2 (fr) 2008-05-28
AU2006291293B2 (en) 2012-02-09
CA2621262C (fr) 2014-07-22

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