JP5142713B2 - 新規ピリドジヒドロピラジノン、その製造方法及びその薬物としての使用 - Google Patents

新規ピリドジヒドロピラジノン、その製造方法及びその薬物としての使用 Download PDF

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JP5142713B2
JP5142713B2 JP2007519725A JP2007519725A JP5142713B2 JP 5142713 B2 JP5142713 B2 JP 5142713B2 JP 2007519725 A JP2007519725 A JP 2007519725A JP 2007519725 A JP2007519725 A JP 2007519725A JP 5142713 B2 JP5142713 B2 JP 5142713B2
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JP2008505157A5 (enExample
JP2008505157A (ja
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マティアス ホフマン
マティアス グラウエルト
トリクシー ブラントル
ルドルフ ハウプトマン
マルティン シュティークマイアー
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ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2007519725A 2004-07-09 2005-07-07 新規ピリドジヒドロピラジノン、その製造方法及びその薬物としての使用 Expired - Lifetime JP5142713B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004033670.9 2004-07-09
DE102004033670A DE102004033670A1 (de) 2004-07-09 2004-07-09 Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
PCT/EP2005/007347 WO2006005510A1 (de) 2004-07-09 2005-07-07 Neue pyridodihydropyrazinone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (3)

Publication Number Publication Date
JP2008505157A JP2008505157A (ja) 2008-02-21
JP2008505157A5 JP2008505157A5 (enExample) 2008-09-04
JP5142713B2 true JP5142713B2 (ja) 2013-02-13

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JP2007519725A Expired - Lifetime JP5142713B2 (ja) 2004-07-09 2005-07-07 新規ピリドジヒドロピラジノン、その製造方法及びその薬物としての使用

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US (2) US7625899B2 (enExample)
EP (1) EP1768981B1 (enExample)
JP (1) JP5142713B2 (enExample)
CA (1) CA2573092C (enExample)
DE (1) DE102004033670A1 (enExample)
WO (1) WO2006005510A1 (enExample)

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US8546566B2 (en) 2010-10-12 2013-10-01 Boehringer Ingelheim International Gmbh Process for manufacturing dihydropteridinones and intermediates thereof
US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
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HK1211033A1 (en) * 2012-12-20 2016-05-13 Bayer Pharma Aktiengesellschaft Bet-protein-inhibiting dihydroquinoxalinones
WO2015011084A1 (de) * 2013-07-23 2015-01-29 Bayer Pharma Aktiengesellschaft Substituierte dihydropyrido[3,4-b]pyrazinone als duale inhibitoren von bet-proteinen und polo-like kinasen
JP2016525532A (ja) 2013-07-26 2016-08-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 骨髄異形成症候群の処置
WO2015193229A1 (de) * 2014-06-19 2015-12-23 Bayer Pharma Aktiengesellschaft Bet-proteininhibitorische 1,4-dihydropyrido[3,4-b]pyrazinone mit meta-substituierter aromatischer amino- oder ethergruppe
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DE102017005091A1 (de) 2016-05-30 2017-11-30 Bayer Pharma Aktiengesellschaft Substituierte 3,4-Dihydropyrido[2,3-b]pyrazin-2(1H)-one

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Also Published As

Publication number Publication date
US20060009457A1 (en) 2006-01-12
US20100029642A1 (en) 2010-02-04
DE102004033670A1 (de) 2006-02-02
EP1768981A1 (de) 2007-04-04
US7625899B2 (en) 2009-12-01
EP1768981B1 (de) 2012-09-12
WO2006005510A1 (de) 2006-01-19
JP2008505157A (ja) 2008-02-21
CA2573092C (en) 2013-05-28
US8193188B2 (en) 2012-06-05
CA2573092A1 (en) 2006-01-19

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