JP5139065B2 - Ｃ型肝炎感染の治療及び予防のための３−エーテル及び３−チオエーテル置換シクロスポリン誘導体 - Google Patents
Ｃ型肝炎感染の治療及び予防のための３−エーテル及び３−チオエーテル置換シクロスポリン誘導体 Download PDFInfo
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- WVWZXTJUCNEUAE-UHFFFAOYSA-M potassium;1,2-bis(ethenyl)benzene;2-methylprop-2-enoate Chemical compound [K+].CC(=C)C([O-])=O.C=CC1=CC=CC=C1C=C WVWZXTJUCNEUAE-UHFFFAOYSA-M 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
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- 125000006410 propenylene group Chemical group 0.000 description 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
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- 229940076788 pyruvate Drugs 0.000 description 1
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- 229960000948 quinine Drugs 0.000 description 1
- ZHNFLHYOFXQIOW-LPYZJUEESA-N quinine sulfate dihydrate Chemical compound [H+].[H+].O.O.[O-]S([O-])(=O)=O.C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21.C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 ZHNFLHYOFXQIOW-LPYZJUEESA-N 0.000 description 1
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- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
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- 235000010413 sodium alginate Nutrition 0.000 description 1
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- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- ILJOYZVVZZFIKA-UHFFFAOYSA-M sodium;1,1-dioxo-1,2-benzothiazol-3-olate;hydrate Chemical compound O.[Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 ILJOYZVVZZFIKA-UHFFFAOYSA-M 0.000 description 1
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- WGTYBPLFGIVFAS-UHFFFAOYSA-M tetramethylammonium hydroxide Chemical class [OH-].C[N+](C)(C)C WGTYBPLFGIVFAS-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61515204P | 2004-10-01 | 2004-10-01 | |
| US60/615,152 | 2004-10-01 | ||
| US70762605P | 2005-08-11 | 2005-08-11 | |
| US60/707,626 | 2005-08-11 | ||
| PCT/US2005/035533 WO2006039668A2 (en) | 2004-10-01 | 2005-09-30 | 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis c infection |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012106395A Division JP2012167113A (ja) | 2004-10-01 | 2012-05-08 | Ｃ型肝炎感染の治療及び予防のための３−エーテル及び３−チオエーテル置換シクロスポリン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008514732A JP2008514732A (ja) | 2008-05-08 |
| JP2008514732A5 JP2008514732A5 (OSRAM) | 2008-11-13 |
| JP5139065B2 true JP5139065B2 (ja) | 2013-02-06 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007534872A Expired - Fee Related JP5139065B2 (ja) | 2004-10-01 | 2005-09-30 | Ｃ型肝炎感染の治療及び予防のための３−エーテル及び３−チオエーテル置換シクロスポリン誘導体 |
| JP2012106395A Pending JP2012167113A (ja) | 2004-10-01 | 2012-05-08 | Ｃ型肝炎感染の治療及び予防のための３−エーテル及び３−チオエーテル置換シクロスポリン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012106395A Pending JP2012167113A (ja) | 2004-10-01 | 2012-05-08 | Ｃ型肝炎感染の治療及び予防のための３−エーテル及び３−チオエーテル置換シクロスポリン誘導体 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20100167996A1 (OSRAM) |
| EP (1) | EP1802650B1 (OSRAM) |
| JP (2) | JP5139065B2 (OSRAM) |
| KR (1) | KR101309409B1 (OSRAM) |
| CN (1) | CN101773661B (OSRAM) |
| AT (1) | ATE530561T1 (OSRAM) |
| AU (1) | AU2005292162B2 (OSRAM) |
| BR (1) | BRPI0516737A (OSRAM) |
| CA (1) | CA2583494C (OSRAM) |
| DK (1) | DK1802650T3 (OSRAM) |
| ES (1) | ES2373450T3 (OSRAM) |
| IL (1) | IL182315A (OSRAM) |
| MX (1) | MX2007003538A (OSRAM) |
| NZ (1) | NZ554514A (OSRAM) |
| PL (1) | PL1802650T3 (OSRAM) |
| PT (1) | PT1802650E (OSRAM) |
| RU (1) | RU2399628C2 (OSRAM) |
| SI (1) | SI1802650T1 (OSRAM) |
| WO (1) | WO2006039668A2 (OSRAM) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7196161B2 (en) | 2004-10-01 | 2007-03-27 | Scynexis Inc. | 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection |
| ES2314731T3 (es) | 2004-11-22 | 2009-03-16 | Astellas Pharma Inc. | Analogo de ciclosporina. |
| DE602006020152D1 (de) | 2005-09-30 | 2011-03-31 | Scynexis Inc | Arylalkyl- und heteroarylalkyl-derivate von cyclosporin a bei der behandlung und vorbeugung einer virusinfektion |
| KR20080059270A (ko) * | 2005-09-30 | 2008-06-26 | 싸이넥시스, 인크. | Ｃ형 간염 감염의 치료 및 예방을 위한 방법 및 제약조성물 |
| PT1957518E (pt) | 2005-10-26 | 2016-02-26 | Astellas Pharma Inc | Novos compostos peptídicos cíclicos |
| KR101059593B1 (ko) | 2006-04-11 | 2011-08-25 | 노파르티스 아게 | Ｈｃｖ/ｈｉｖ 억제제 및 이들의 용도 |
| CN101511357B (zh) * | 2006-05-19 | 2011-11-02 | 西尼克斯公司 | 环孢菌素类化合物及其组合物在制备治疗和预防眼部疾病的药物中的应用 |
| EP2027761A1 (fr) * | 2006-06-02 | 2009-02-25 | Claude Annie Perrichon | Gestion des electrons actifs |
| BRPI0719189A2 (pt) * | 2006-10-12 | 2018-08-14 | Univ Kyushu Nat Univ Corp | uso de ciclosporinas modificadas |
| WO2008069917A2 (en) | 2006-11-20 | 2008-06-12 | Scynexis, Inc. | Novel cyclic peptides |
| WO2008127613A1 (en) * | 2007-04-11 | 2008-10-23 | Scynexis, Inc. | New pharmaceutical compositions |
| KR20100017547A (ko) | 2007-05-02 | 2010-02-16 | 아스텔라스세이야쿠 가부시키가이샤 | 신규 시클릭 펩티드 화합물 |
| US9090671B2 (en) | 2008-06-06 | 2015-07-28 | Scynexis, Inc. | Macrocyclic peptides |
| US20090306033A1 (en) * | 2008-06-06 | 2009-12-10 | Keqiang Li | Novel cyclic peptides |
| US20130190223A1 (en) | 2008-07-30 | 2013-07-25 | Isotechnika Pharma Inc. | Nonimmunosuppressive cyclosporine analogue molecules |
| CA2748389A1 (en) * | 2008-12-31 | 2010-07-08 | Scynexis, Inc. | Derivatives of cyclosporin a |
| CN102271699A (zh) * | 2009-01-07 | 2011-12-07 | 西尼克斯公司 | 用于治疗hcv和hiv感染的环孢菌素衍生物 |
| KR20110111321A (ko) | 2009-01-30 | 2011-10-10 | 이난타 파마슈티칼스, 인코포레이티드 | Ｃ형 간염을 예방하거나 치료하기 위한 사이클로스포린 유사체 |
| US8481483B2 (en) | 2009-02-19 | 2013-07-09 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| US20110182850A1 (en) | 2009-04-10 | 2011-07-28 | Trixi Brandl | Organic compounds and their uses |
| US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
| US8349312B2 (en) | 2009-07-09 | 2013-01-08 | Enanta Pharmaceuticals, Inc. | Proline substituted cyclosporin analogues |
| US8367053B2 (en) | 2009-07-09 | 2013-02-05 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| US8685917B2 (en) | 2009-07-09 | 2014-04-01 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| AU2010313497B2 (en) | 2009-10-30 | 2013-08-01 | Boehringer Ingelheim International Gmbh | Dosage regimens for HCV combination therapy comprising BI201335, interferon alpha and ribavirin |
| JP2013513595A (ja) | 2009-12-09 | 2013-04-22 | サイネクシス，インコーポレーテッド | 新規環状ペプチド |
| JP5536229B2 (ja) * | 2009-12-18 | 2014-07-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｈｃｖ併用療法 |
| AU2010339460A1 (en) | 2009-12-30 | 2012-07-19 | Scynexis Inc. | Cyclosporine analogues |
| US8623814B2 (en) | 2010-02-23 | 2014-01-07 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
| WO2012009715A2 (en) | 2010-07-16 | 2012-01-19 | S&T Global Inc. | Novel cyclosporin derivatives for the treatment and prevention of a viral infection |
| US9573978B2 (en) | 2010-08-12 | 2017-02-21 | S&T Global, Inc. | Cyclosporin derivatives for the treatment and prevention of a viral infection |
| EA201390532A1 (ru) | 2010-10-08 | 2013-09-30 | Новартис Аг | Композиции сульфамидых ингибиторов ns3, содержащие витамин е |
| US9890198B2 (en) | 2010-12-03 | 2018-02-13 | S&T Global Inc. | Cyclosporin derivatives and uses thereof |
| WO2012075494A1 (en) * | 2010-12-03 | 2012-06-07 | S&T Global Inc. | Novel cyclosporin derivatives for the treatment and prevention of a viral infection |
| KR102011339B1 (ko) | 2010-12-15 | 2019-08-16 | 콘트라빌 파마슈티컬스, 인코퍼레이티드 | 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자 |
| RU2448690C1 (ru) * | 2011-03-15 | 2012-04-27 | Открытое акционерное общество "Биосинтез" | Твердая лекарственная форма пролонгированного действия нестероидного противовоспалительного средства кетопрофен, способ получения |
| WO2013028615A2 (en) * | 2011-08-19 | 2013-02-28 | S&T Golbal Inc. | Novel cyclosporin derivatives for the treatment and prevention of viral infections |
| EP3263587A1 (en) | 2012-06-01 | 2018-01-03 | Allergan, Inc. | Cyclosporin a analogs |
| WO2014085623A1 (en) | 2012-11-28 | 2014-06-05 | Enanta Pharmaceuticals, Inc. | Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues |
| US20140205566A1 (en) | 2012-11-30 | 2014-07-24 | Novartis Ag | Cyclic nucleuoside derivatives and uses thereof |
| RU2016110247A (ru) | 2013-08-26 | 2017-10-02 | Энанта Фармасьютикалс, Инк. | Аналоги циклоспорина для предупреждения или лечения гепатита с |
| WO2016073480A1 (en) | 2014-11-03 | 2016-05-12 | Enanta Pharmaceuticals, Inc. | Novel cyclosporin analogues for preventing or treating hepatitis c infection |
| TW201639873A (zh) | 2015-01-08 | 2016-11-16 | 歐樂根公司 | Ｍｅｂｍｔ側鏈已環化之環孢菌素衍生物 |
| US10077289B2 (en) | 2015-03-31 | 2018-09-18 | Allergan, Inc. | Cyclosporins modified on the MeBmt sidechain by heterocyclic rings |
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| CN101773661A (zh) | 2010-07-14 |
| KR101309409B1 (ko) | 2013-09-23 |
| ATE530561T1 (de) | 2011-11-15 |
| AU2005292162A1 (en) | 2006-04-13 |
| WO2006039668B1 (en) | 2007-05-31 |
| PL1802650T3 (pl) | 2012-04-30 |
| US20100167996A1 (en) | 2010-07-01 |
| JP2012167113A (ja) | 2012-09-06 |
| ES2373450T3 (es) | 2012-02-03 |
| RU2007116119A (ru) | 2008-11-10 |
| KR20070073841A (ko) | 2007-07-10 |
| EP1802650B1 (en) | 2011-10-26 |
| DK1802650T3 (da) | 2012-02-06 |
| IL182315A0 (en) | 2007-07-24 |
| JP2008514732A (ja) | 2008-05-08 |
| EP1802650A4 (en) | 2008-08-20 |
| MX2007003538A (es) | 2008-01-16 |
| EP1802650A2 (en) | 2007-07-04 |
| CA2583494A1 (en) | 2006-04-13 |
| RU2399628C2 (ru) | 2010-09-20 |
| WO2006039668A2 (en) | 2006-04-13 |
| BRPI0516737A (pt) | 2008-04-29 |
| PT1802650E (pt) | 2011-12-30 |
| IL182315A (en) | 2013-08-29 |
| HK1108703A1 (en) | 2008-05-16 |
| US20120264679A1 (en) | 2012-10-18 |
| CA2583494C (en) | 2014-01-21 |
| AU2005292162B2 (en) | 2011-11-10 |
| CN101773661B (zh) | 2013-09-25 |
| NZ554514A (en) | 2010-10-29 |
| SI1802650T1 (sl) | 2012-03-30 |
| WO2006039668A3 (en) | 2007-04-19 |
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