JP5129286B2 - マイクロフルイディック・デバイスにおける流体制御方法及びシステム - Google Patents
マイクロフルイディック・デバイスにおける流体制御方法及びシステム Download PDFInfo
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
- F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
- F15C3/00—Circuit elements having moving parts
- F15C3/002—Circuit elements having moving parts using fluid droplets or similar deformable bodies
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
- F04B19/006—Micropumps
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
- F04B19/20—Other positive-displacement pumps
- F04B19/24—Pumping by heat expansion of pumped fluid
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
- F16K99/0017—Capillary or surface tension valves, e.g. using electro-wetting or electro-capillarity effects
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0034—Operating means specially adapted for microvalves
- F16K99/0036—Operating means specially adapted for microvalves operated by temperature variations
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0034—Operating means specially adapted for microvalves
- F16K99/0042—Electric operating means therefor
- F16K99/0044—Electric operating means therefor using thermo-electric means
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0442—Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0073—Fabrication methods specifically adapted for microvalves
- F16K2099/0074—Fabrication methods specifically adapted for microvalves using photolithography, e.g. etching
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0073—Fabrication methods specifically adapted for microvalves
- F16K2099/0076—Fabrication methods specifically adapted for microvalves using electrical discharge machining [EDM], milling or drilling
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
- Y10T137/218—Means to regulate or vary operation of device
- Y10T137/2191—By non-fluid energy field affecting input [e.g., transducer]
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/4456—With liquid valves or liquid trap seals
- Y10T137/4643—Liquid valves
Description
ける反応)と題する米国特許第6,057,149号、2000年4月11日に発行され、"Thermal Microvalves in a Fluid Flow Method"(流体流動法における熱微小バルブ)と題する米国特許第6,048,734号、及び2000年10月10日に発行された米国特許第6,130,098号に開示されている。これらのデバイスでは、ガス圧力のような機動力を用いて、物質をデバイスのある領域から別の領域に推進させる。例えば、サンプルを処理チャンバまで推進又は牽引し、処理チャンバ内で、同様にチャンバ内に持ち込まれた試薬と反応させることができる。各デバイスは、他に多くのチャンバ又はチャネルを有することができ、これらが処理チャンバと交差するので、バルブを用いることによって、デバイスの1つの領域にある物質を、デバイスの別の領域から隔離することができる。理想的なバルブの場合、閉鎖すると漏れを防止し、過剰な圧力が閉鎖中のバルブに作用しても閉鎖したままとなっている。
この章又は本願のいずれの章においても、いずれの参考文献の引用又は特定も、このような参考文献が本発明に対する従来技術として使用可能であるとは解釈しないこととする。
通路は更に、縦横軸に対して第2角度をなしている第2表面も備えることができる。通路を遮断するTRSの少なくとも第2部分が、第2表面と接触する。第1及び第2表面は通路に迫り出していてもよい。第1及び第2表面は、それらの間に絞りを形成する。
通路を遮断するTRSの少なくとも約75%は、通路の解放時に、下流チャネルに流入することができる。
も大きいときである。例えば、過剰な上流圧力は、上流チャネルからバルブの上流側に作用する圧力が、下流チャネルからバルブの下流側に作用する圧力よりも大きいことを意味する。この少なくとも1つのエレメントは、好適には、物質運搬通路に対向して配置された表面である。物質運搬経路は、開放状態のバルブを通過する物質が進む経路のことである。バルブが閉鎖すると、過剰な上流圧力は、対向する表面に向けてTRSを押圧し、遮断された通路を通じた漏洩を引き起こすことはない。
と熱的に接触している熱源47の作動によって、十分な熱エネルギが供給され、TRSの加熱部分の物理的又は化学的特性を変化させる。好ましくは、特性の変化は、少なくともTRS56の通路68に対する運動を可能にする程度の軟化又はサイズの縮小である。バルブ50は、物質56の多大な損失を生ずることなく、また閉鎖しているときのバルブを通じた物質の通過を防止する能力を著しく損なうことなく、開放状態及び閉鎖状態の間で繰り返し切り換えることができる。
の収縮は、当該ガスを冷却してガスの温度を低下させ、体積を縮小させることによって得ることができる。ガス32を冷却するには、ガス32と熱的に接触しているペルチェ冷却器(Peltier cooler)のような冷却器を作動させることが好ましい。冷却器は、バルブ50を構成する基板及び熱源36と一体であることが好ましい。しかしながら、冷却器は、別個のデバイス内に配置し、動作中、基板を受け入れるようにすることも可能であることは言うまでもない。
通路68’の開放時にTRS56’の少なくとも一部が下流側チャネルに進入するが、本発明のバルブ50’のようなゲート型バルブは、一旦開放されると、閉鎖状態に戻すことができる。例えば、追加のTRSをゲート・バルブに付随するリザーバから通路内に、少なくとも付随するリザーバを加熱することによって、流入させることができる。
流チャネル内部に残しておくことができる。また、TRS56’は、溶融することによってではなく、通路68’を開放する物質で形成することもできる。例えば、代替実施形態の1つでは、遮断TRSは、粒子の凝集体で形成する。より高い温度への遷移時に、凝集された粒子が下流に分散することによって、バルブを開放する。
56は、リザーバ255内にほぼ完全に後退し、通路268を開放することにより、バルブ250を通じた物質の通過を可能とする。TRS256は、ほぼ完全にリザーバ255内に後退しており、下流方向に分散したり、通路268内に残留していないので、衝合部276、277は、突出部280の窪み形状を呈し続けることができる。
バルブ350は、第2対向壁部386を含むことが好ましく、この第2対向壁部386も物質運搬経路360内には達していない。第1及び第2対向壁部374、386は、互いに対向しているので、バルブ350は双方向バルブとして動作する。したがって、TRS356の第2面378に大きな上流圧力があると、TRS356の第2衝合部377を第2対向壁部386に向けて押圧する。
図9bに示したバルブ350の開放状態では、TRS356はリザーバ355内に後退することによって通路368を開放し、これにより物質の通過が可能となる。
入するTRSの量を制限するように構成されている。通路468と第1チャネル452との間にある開口515により、断面積516が規定される。この断面積は、第1チャネル452内部の隣接する断面積518よりも少なくとも40%小さく、好ましくは少なくとも50%小さい。同様に、通路468と第2チャネル454との間にある開口520の断面積は、第2チャネル454内の隣接する断面積よりも小さいことが好ましい。
バルブ450は、前述した対向壁部のような、少なくとも1つの対向面を含み、バルブが閉鎖するときにいずれかのチャネルに存在する過剰圧力に応答して漏洩を防止することができる。
バルブ1001に装荷するには、TRSの先端が装荷面1000の縁1016に達するまで、ある量のTRSを孔1015を通じて導入する。縁1016に達すると、毛細管作用がTRSを装荷部1012及び通路1004内に引き込む。第1及び第2縁1017及び1018に達すると、表面張力によって、TRSが第1及び第2チャネル1006、1008に流入するのを防止する。図12bに示すように、TRSの一部が突出部1010の表面に接触すると、バルブは閉鎖状態となり、第1及び第2チャネル1006、1008間の物質の通過を防止する。
、通路1004を遮断しているTRSの少なくとも一部が分散又は溶融して、第1及び第2チャネル1006、1008の少なくとも一方に流入することができるのに十分な温度とする。温度が上昇したならば、空気又は液体の圧力等が、第1及び第2チャネルの一方から、チャネルを遮断しているTRSを変位させることが好ましい。開放動作の間、リザーバ内のTRSの温度は、TRSを分散又は溶融するのに十分な値まで上昇させないことが好ましい。バルブ1001は、リザーバ1002内にあるTRSを加熱することによって、閉鎖状態に戻すことができる。毛細管作用がTRSを通路1004に引き込むのは、先に論じた通りである。
また、バルブ1001は、図11a〜図11dに示すような対向面も含み、バルブが閉鎖状態にあるときに、物質の通過を防止するのに役立てるようにすることができる。また、バルブ1001は、毛細管補助装荷バルブとして構成しないことも可能であり、その場合装荷面1000は設けられない。
択した物質のみを、チャネル710を通ってチャンバ704から排出できるようにする。バルブ714は、チャンバ704内の物質が下流チャネル716に流入するのを防止する。バルブ718は、チャンバ704内の物質を機内圧力源(on-board pressure source)720に流入するのを防止する。機内圧力源720は、先に論じたような、熱作動型とすることが好ましい。圧力源720は、十分なガス圧力及びガス体積を供給し、チャンバ70
4内にある物質を下流チャンバ716内に導入させるようにすることが好ましい。
ングによって、レジストを基板の区域から除去し、基板にエッチングを行う。
低温酸化物層を、基板上に堆積する。クロム−金層のような金属層を、酸化物層の上に堆積する。金属層にレジストを被覆し、第3マスク954を用いてパターニングする。第3マスク954は、貫通部材を受容する凹陥となるパターンを規定することが好ましい。クロム金層をエッチングして、凹陥を形成する。
。奥行きが長い場合、鋼鉄の成型品を作成するのが好ましい。射出成形部品は、フォトリソグラフィック・プロセスによってガラスやクオーツ内に作成する部品に対して、劇的なコスト節約をもたらす。
ものであり、その範囲は特許請求の範囲に規定されている通りである。
Claims (22)
- マイクロフルイディック・システムにおいて用いるバルブであって、
通路によって接続される上流チャネル及び下流チャネルを規定する基板と、
前記バルブが閉鎖状態にあるときに、前記通路を遮断するように設けられた感熱物質と、
前記通路内に突き出した第1の壁及び該第1の壁に対向する第2の壁を備える突出部であって、前記第1の壁側のチャネルの圧力が大きい場合には該圧力が前記感熱物質を前記第1の壁に向かって押圧し、前記第2の壁側のチャネルの圧力が大きい場合には該圧力が前記感熱物質を前記第2の壁に向かって押圧し、それによって、漏洩が防止される、突出部と、
前記通路に隣接して設けられたリザーバであって、該感熱物質のうち前記通路を遮断しない一部を包含する、リザーバと、
前記感熱物質と熱的に接触した熱源であって、該熱源の作動時に、前記感熱物質の少なくとも一部が前記下流チャネルに入ることによって前記通路を開放するようにするための熱源と
からなることを特徴とするバルブ。 - 請求項1記載のバルブにおいて、前記熱源は、前記下流チャネルの少なくとも一部を加熱して、前記下流チャネルに入った前記感熱物質が前記下流チャネルを遮断するのを防止するよう構成されていることを特徴とするバルブ。
- 請求項1記載のバルブにおいて、前記熱源は、フォトリソグラフィック・マスクを用いて形成されていることを特徴とするバルブ。
- 請求項1記載のバルブにおいて、前記基板は平面基板であり、該平面基板上に、前記上流及び下流チャネル並びに前記通路が形成されていることを特徴とするバルブ。
- 請求項1記載のバルブにおいて、前記基板はポリマ材で構成されていることを特徴とするバルブ。
- 請求項1記載のバルブにおいて、該バルブはさらに別の基板を備え、該別の基板の第1の表面に、前記熱源が配置されていることを特徴とするバルブ。
- 請求項1記載のバルブにおいて、前記基板は、シリコン、クオーツ、ガラス、ポリマ材から選択された材料で構成されていることを特徴とするバルブ。
- 請求項1記載のバルブにおいて、該バルブはさらに別の基板を備え、該別の基板の表面に前記熱源が形成されていることを特徴とするバルブ。
- 請求項1記載のバルブにおいて、該バルブはさらに、前記リザーバ中のガスを冷却するための冷却手段を備え、該冷却手段の駆動により、前記ガスが収縮し、前記通路を遮断している前記感熱物質の少なくとも一部を前記リザーバに引き込むことにより、前記通路が開放されるように構成されていることを特徴とするバルブ。
- 請求項9記載のバルブにおいて、前記冷却手段は、前記ガスと熱的に接触するペルチェ冷却器であることを特徴とするバルブ。
- 請求項1記載のバルブにおいて、前記感熱物質は、ワックス又は共晶合金で構成されていることを特徴とするバルブ。
- 請求項1記載のバルブにおいて、前記感熱物質の前記少なくとも一部は、該感熱物質の75%以上であることを特徴とするバルブ。
- 請求項1記載のバルブにおいて、前記突出部は、正方形、長方形、3角形、又はアーチ型の形状を有することを特徴とするバルブ。
- 請求項1記載のバルブにおいて、前記突出部は、前記通路に沿った材料移動経路に整列されている前記感熱物質の寸法の中心に位置していることを特徴とするバルブ。
- 請求項1記載のバルブにおいて、前記突出部の幅は、前記通路に沿った材料移動経路に整列されている前記感熱物質の寸法の幅よりも狭いことを特徴とするバルブ。
- 請求項1記載のバルブにおいて、前記感熱物質は、第1の温度の場合に前記通路を遮断するように配置され、前記感熱物質の前記少なくとも一部が、第2の温度の場合に前記下流チャネルに入り込むよう構成されていることを特徴とするバルブ。
- 請求項16記載のバルブにおいて、前記第2の温度は、約40℃〜約90℃の範囲内の温度であることを特徴とするバルブ。
- 請求項16記載のバルブにおいて、前記第2の温度は、前記感熱物質の前記少なくとも一部を溶解することができる温度であることを特徴とするバルブ。
- 請求項16記載のバルブにおいて、前記感熱物質は、粒状体の塊で構成されており、前記第2の温度は、前記感熱物質の前記少なくとも一部を分散することができる温度であることを特徴とするバルブ。
- 請求項1記載のバルブにおいて、該バルブはさらに、前記リザーバを加熱するための外部熱源を備えていることを特徴とするバルブ。
- 請求項1記載のバルブにおいて、前記リザーバはさらに、前記感熱物質を前記通路及び前記リザーバに導入するためのアクセス・ポートを備えていることを特徴とするバルブ。
- 請求項1乃至21のいずれか1項に記載のマイクロフルイディック・システムにおいて用いる前記バルブを作成する方法であって、
前記上流チャネル及び前記下流チャネルを接続する通路を規定する基板を準備するステップと、
感熱材料の塊を前記通路に隣接する前記リザーバに導入するステップと
を含む方法。
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2008
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JP5536819B2 (ja) | 2014-07-02 |
JP2009019776A (ja) | 2009-01-29 |
WO2003012325A1 (en) | 2003-02-13 |
EP1425528A4 (en) | 2005-07-20 |
ATE530825T1 (de) | 2011-11-15 |
JP2012149773A (ja) | 2012-08-09 |
JP2010181031A (ja) | 2010-08-19 |
JP4892528B2 (ja) | 2012-03-07 |
US6575188B2 (en) | 2003-06-10 |
JP2004537695A (ja) | 2004-12-16 |
US20030019522A1 (en) | 2003-01-30 |
EP1425528B1 (en) | 2011-10-26 |
EP1425528A1 (en) | 2004-06-09 |
JP4519462B2 (ja) | 2010-08-04 |
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