JP5085138B2 - 高濃度でミダゾラムを含む製薬組成物 - Google Patents
高濃度でミダゾラムを含む製薬組成物 Download PDFInfo
- Publication number
- JP5085138B2 JP5085138B2 JP2006548318A JP2006548318A JP5085138B2 JP 5085138 B2 JP5085138 B2 JP 5085138B2 JP 2006548318 A JP2006548318 A JP 2006548318A JP 2006548318 A JP2006548318 A JP 2006548318A JP 5085138 B2 JP5085138 B2 JP 5085138B2
- Authority
- JP
- Japan
- Prior art keywords
- midazolam
- composition
- composition according
- intranasal
- patent document
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Description
Allonen H, Ziegler G and Klotz U, Midazolam kinetics. Clin. Pharmacol. Ther. 30: 653-661 (1981). Bjorkman S, Rigemar G and Idvall J, Pharmacokinetics of midazolam given as an intranasal spray to adult surgical patients. Br. J. Anaesth. 79: 575-580 (1997). Burstein A H, Modica R, Hatton M, Forrest A and Gengo F M, Pharmacokinetics and pharmacodynamics of midazolam after intranasal administration. J. Clin. Pharmacol. 37: 711-718 (1997). Cheng ACK, Intranasal midazolam for rapidly sedating an adult patient. Anesth. Analg. 76: 904 (1993). Crevoisier Ch, Ziegler W H, Eckert M and Heizmann P, Relationship between plasma concentration and effect of midazolam after oral and intravenous administration. Br. J. Clin. Pharmacol. 16: 51S-61S (1983). Davis P J, Tome J A, McGowan F X, Cohen I T, Latta K and Felder H, Preanesthetic medication with intranasal midazolam for brief pediatric surgical procedures. Anesthesiology 82: 2-5 (1995). Gerecke M, Chemical structure and properties of midazolam compared with other benzodiazepines. Br. J. Clin. Pharmacol. 16: 11S-16S (1983). Gudmundsdottir H, Sigurjonsdottir J F, Masson M, Fjalldal O, Stefansson E and Loftsson T, Intranasal administration of midazolam in a cyclodextrin based formulation: bioavailability and clinical evaluation in humans. Pharmazie 56: 963-966 (2001). Heizmann P, Eckert M and Ziegler W H, Pharmacokinetics and bioavailability of midazolam in man. Br. J. Clin. Pharmacol. 16: 43S-49S (1983). Karl H W, Keifer A T, Rosenberger J L, Larach M G and Ruffle J M, Comparison of the safety and efficacy of intranasal midazolam or sufentanil for preinduction of anesthesia in pediatric patients. Anesthesiology 76: 209-215 (1992). Kendall J, Reynolds M and Goldberg R, Intranasal midazolam in patients with status epilepticus. Ann. Emerg. Med. 29: 415-417 (1997). Knoester P D, Jonker D M, Van der Hoeven R T M, Vermeij T A C, Edelbroek P M, and De Haan G J, Midazolam intranasaal toegepast, eventueel als noodmedicatie (in Dutch). Pharmaceutisch Weekblad 137: 112-117 (2002a) Knoester P D, Jonker D M, Van der Hoeven R T M, Vermeij T A C, Edelbroek P M, Brekelmans G J and De Haan G J, Pharmacokinetics and pharmacodynamics of midazolam administered as a concentrated nasal spray. A study in healthy volunteers. Br. J. Clin. Pharmacol. 53: 501-507 (2002). Kogan A, Katz J, Efrat R and Eidelman L A, Premedication with midazolam in young children: a comparison of four routes of administration. Paediatric Anaesthesia 12: 685-689 (2002). Lahat E, Goldman M, Barr J, Eshel G and Berkovitch M, Intranasal midazolam for childhood seizures. The Lancet 352: 620 (1998). Lahat E, Goldman M, Barr J, Bistritzer T and Berkovitch M, Comparison of intranasal midazolam with intravenous diazepam for treating febrile seizures in children: prospective randomised study. Br. Med. J. 321: 83-86 (2000). Loftsson T, Gudmundsdottir H, Sigurjonsdottir F J, Sigurosson H H, Sigfusson S D, Masson M and Stefansson E, Cyclodextrin solubilization of benzodiazepines: formulation of midazolam nasal spray. Int. J. Pharm. 212: 29-40 (2001). Lugo R A, Fishbein M, Nahata M C and Lininger B, Complication of intranasal midazolam. Pediatrics 92: 638 (1993). Lui C Y, Amidon G L and Goldberg A, Intranasal absorption of flurazepam, midazolam and triazolam in dogs. J. Pharm. Sci. 80: 1125-1129 (1991). Malinovsky J M, Lejus C, Servin F, Lepage J Y, Le Normand Y, Testa S, Cozian A and Pinaud M, Plasma concentrations after i.v., nasal or rectal administration in children. Br. J. Anaesth. 70: 617-620 (1993). Malinovsky J M, Populaire C, Cozian A, Lepage J Y, Lejus C and Pinaud M, Premedication with midazolam in children. Effect of intranasal, rectal and oral routes on plasma midazolam concentrations. Anaesthesia 50: 351-354 (1995). Marttin E, Schipper N G, Verhoef J C and Merkus FWHM, Nasal mucociliary clearance as a factor in nasal drug delivery. Adv. Drug Del. Rev. 29: 13-38 (1998). Merkus P, Romeijn S G, Verhoef J C and Merkus FWHM, Classification of cilio inhibiting effects of nasal drugs. Laryngoscope 111: 595-602 (2001). Olivier J C, Djilani M, Fahmy S and Couet W, In situ nasal absorption of midazolam in rats. Int. J. Pharm. 213: 187-192 (2001). O'Regan M E, Brown J K and Clarke M, Nasal rather than rectal benzodiazepines in the management of acute childhood seizures? Develop. Med. Child Neurol. 38: 1037-1045 (1996). Payne K, Mattheyse F J, Liebenbenberg D and Dawes T, The pharmacokinetics of midazolam in paediatric patients. Eur. J. Clin. Pharmacol. 37: 267-272 (1989). Persson M P, Nilsson A and Hartvig P, Relation of sedation and amnesia to plasma concentrations of midazolam in surgical patients. Clin. Pharmacol. Ther. 43: 324-331 (1988). Randell T T and Kytt, Conscious sedation in patients undergoing surgical and investigational procedures. A guide to drug choice. CNS Drugs 10: 329-342 (1998). Rey E, Delaunay L, Pons G, Murat I, Richard M O, Saint-Maurice C and Olive G, Pharmacokinetics of midazolam in children: comparative study of intranasal and intravenous administration. Eur. J. Clin. Pharmacol. 41: 355-357 (1991). Saint-Maurice C, Meistelman C, Rey E, Esteve C, De Lauture D and Olive G, The pharmacokinetics of rectal midazolam for premedication in children. Anesthesiology 65: 536-538 (1986). Scheepers M, Scheepers B, Clarke M, Comish S and Ibitoye M, Is intranasal midazolam an effective rescue medication in adolescents and adults with severe epilepsy? Seizure 9: 417-422 (2000). Smith M T, Eadie M J and O'Rourke Brophy T, The pharmacokinetics of midazolam in man. Eur. J. Clin. Pharmacol. 19: 271-278 (1981). Taylor M B, Vine P R and Hatch D J, Intramuscular midazolam premedication in young children. Anaesthesia 41: 21-26 (1986). Tenk H, Jonker D M, Van der Hoeven R T M, Vermeij T A C, Edelbroek P M and De Haan G J, Midazolam neusspray bij patinten met epilepsie. Pharm. Weekbl. 138: 99-103 (2003). Theroux M C, West D W, Corddry D H, Hyde P M, Bachrach S J, Croman K M and Kettrick R G, Efficacy of intranasal midazolam in facilitating suturing of lacerations in preschool children in the emergency department. Pediatrics 91: 624-627 (1993). Tolle-Sander S, Rautio J, Wring S, Polli J W and Polli J E, Midazolam exhibits characteristics of a highly permeable P-glycoprotein substrate. Pharm. Res. 20: 757-764 (2003). Uygur-Bayramicli O, Dabak R, Kuzucuoglu T and Kavakli B, Sedation with intranasal midazolam in adults undergoing upper gastrointestinal endoscopy. J. Clin. Gastroenterol. 35: 133-137 (2002). Walbergh E J, Wills R J and Eckhert J, Plasma concentrations of midazolam following intranasal administration. Anesthesiology 74: 233-235 (1991). Wilton N C T, Leigh J, Rosen D R and Pandit U A, Preanesthetic sedation of preschool children using intranasal midazolam. Anesthesiology 69: 972-975 (1988).
35-75mg/mlのミダゾラム(遊離塩基)に相当する塩酸ミダゾラム
適量(ミダゾラムを可溶化するのに十分な量)のプロピレングリコール
水
ポリエチレングリコール、グリセロール、ポビドン、エタノール、甘味料、香料物質、防腐剤、pH調節剤、及び安定化剤。
35-75mg/mlのミダゾラムに相当する塩酸ミダゾラム
プロピレングリコール5-50%(v/v)
グリセロール5-50%(v/v)
ポリエチレングリコール5-50%(v/v)
ポビドン1-20%(v/v)
水
35、40、45、または50mg/mlのミダゾラムに相当する塩酸ミダゾラム
プロピレングリコール15-30%(v/v)
グリセロール15-30%(v/v)
サッカリンナトリウム10-50mg/ml
水
35、40、45、または50mg/mlのミダゾラムに相当する塩酸ミダゾラム
プロピレングリコール20-50%(v/v)
ポビドン1-10%(w/v)
水
50g/mlのミダゾラムに相当する塩酸ミダゾラム
プロピレングリコール45%(v/v)
水55%(v/v)
この溶液のpHを3に調節する。
1)診断術及び手術を受けた子供用の鎮静剤及び抗不安剤として;
2)胃腸内視鏡及び他の診断術を受けた成人用の鎮静剤及び抗不安剤として;
3)医療センター及び過程での子供の急性癲癇性発作及び発熱性発作の処理として;
4)医療センター及び過程での重度の癲癇を有する成人における発作の治療のための短期的な管理として。
Claims (20)
- 少なくとも35mg/mlの濃度のミダゾラムと、プロピレングリコール、グリセロール、ポリエチレングリコール、ポビドン、エタノール及びそれらの組み合わせから選択される可溶化剤とを含む水溶液であり、pHが少なくとも2.5から4未満である鼻腔内投与用製薬組成物。
- pHが少なくとも3から4未満である、請求項1に記載の組成物。
- ミダゾラムの濃度が少なくとも40mg/mlである請求項1または2に記載の組成物。
- ミダゾラムの濃度が少なくとも50mg/mlである請求項1または2に記載の組成物。
- ミダゾラムが製薬学的に許容可能なその塩の形態で使用される請求項1から4のいずれか一項に記載の組成物。
- 製薬学的に許容可能なミダゾラムの塩が塩酸ミダゾラム、マレイン酸ミダゾラム、または乳酸ミダゾラムである請求項5に記載の組成物。
- 前記可溶化剤がプロピレングリコールを含み、任意にグリセロール、ポリエチレングリコール、ポビドン、及びエタノールの一つ以上を含む請求項1から6のいずれか一項に記載の組成物。
- 前記可溶化剤がグリセロールを含み、任意にプロピレングリコール、ポリエチレングリコール、ポビドン、及びエタノールの一つ以上を含む請求項1から6のいずれか一項に記載の組成物。
- 20-80%(v/v)の水と80-20%(v/v)の可溶化剤とを含むミダゾラムの溶液である請求項1から6のいずれか一項に記載の組成物。
- 前記可溶化剤がポリエチレングリコールを含む請求項9に記載の組成物。
- 40-50%(v/v)のプロピレングリコールと50-60%(v/v)の水とを含む請求項9または10に記載の組成物。
- 40-75mg/mlの濃度のミダゾラム
40-50%(v/v)のプロピレングリコール、及び
50-60%(v/v)の水
を含み、pHが少なくとも2.5から4未満に調節されている請求項11に記載の組成物。 - 40-75mg/mlの濃度のミダゾラム、
40-50%(v/v)のプロピレングリコール、及び
50-60%(v/v)の水、並びに
pHを少なくとも2.5から4未満に調節するのに十分な量の任意の製薬学的に許容可能な酸または塩基
からなる請求項11に記載の組成物。 - 一つ以上の甘味剤を含む請求項1から13のいずれか一項に記載の組成物。
- 香料剤、防腐剤、緩衝剤、安定化剤及びpH調節剤から選択される一つ以上の添加成分を含む請求項1から14のいずれか一項に記載の組成物。
- スプレー、鼻腔液、または鼻腔小滴の形態である請求項1から15のいずれか一項に記載の組成物。
- 鎮静剤もしくは抗不安剤としての、急性癲癇性もしくは発熱性発作の治療のための医薬としての、または癲癇に罹患している患者における発作の短期的な管理のための医薬としての使用のための請求項1から16のいずれか一項に記載の組成物。
- 鎮静剤もしくは抗不安剤の製造における、急性癲癇性もしくは発熱性発作の治療のための医薬の製造における、または癲癇に罹患している患者における発作の短期的な管理のための医薬の製造における請求項1から16のいずれか一項に記載の組成物の使用であって、前記鎮痛剤もしくは抗不安剤または前記医薬が鼻腔内投与用である、使用。
- 前記鎮痛剤もしくは抗不安剤または前記医薬が鼻孔当り50-100μlの量での投与用である、請求項18に記載の使用。
- 請求項1から17のいずれか一項に記載の組成物を含む鼻腔内送達用装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0400804.1A GB0400804D0 (en) | 2004-01-14 | 2004-01-14 | Pharmaceutical compositions |
GB0400804.1 | 2004-01-14 | ||
PCT/EP2005/050133 WO2005067893A2 (en) | 2004-01-14 | 2005-01-13 | Pharmaceutical compositions comprising midazolam in a high concentration |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2007534660A JP2007534660A (ja) | 2007-11-29 |
JP5085138B2 true JP5085138B2 (ja) | 2012-11-28 |
Family
ID=31726180
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006548318A Active JP5085138B2 (ja) | 2004-01-14 | 2005-01-13 | 高濃度でミダゾラムを含む製薬組成物 |
Country Status (23)
Country | Link |
---|---|
US (2) | US7700588B2 (ja) |
EP (1) | EP1703896B1 (ja) |
JP (1) | JP5085138B2 (ja) |
KR (1) | KR20060130175A (ja) |
CN (1) | CN1929816B (ja) |
AT (1) | ATE417600T1 (ja) |
AU (1) | AU2005205072B2 (ja) |
BR (1) | BRPI0506868A (ja) |
CA (1) | CA2553890C (ja) |
DE (1) | DE602005011753D1 (ja) |
DK (1) | DK1703896T3 (ja) |
EA (1) | EA014096B1 (ja) |
ES (1) | ES2319667T3 (ja) |
FI (2) | FIC20230023I1 (ja) |
GB (1) | GB0400804D0 (ja) |
IL (1) | IL176774A0 (ja) |
MX (1) | MXPA06008086A (ja) |
NO (3) | NO336916B1 (ja) |
NZ (1) | NZ548454A (ja) |
PL (1) | PL1703896T3 (ja) |
PT (1) | PT1703896E (ja) |
WO (1) | WO2005067893A2 (ja) |
ZA (1) | ZA200606310B (ja) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040176359A1 (en) * | 2001-02-20 | 2004-09-09 | University Of Kentucky Research Foundation | Intranasal Benzodiazepine compositions |
PL2623113T3 (pl) | 2005-11-09 | 2018-05-30 | Onyx Therapeutics, Inc. | Związek do hamowania enzymu |
EP2484688B1 (en) | 2006-06-19 | 2016-06-08 | Onyx Therapeutics, Inc. | Peptide epoxyketones for proteasome inhibition |
ES2611995T3 (es) * | 2007-01-19 | 2017-05-11 | Hananja Ehf | Métodos y composiciones para el suministro de un agente terapéutico |
US20080275030A1 (en) | 2007-01-19 | 2008-11-06 | Sveinbjorn Gizurarson | Methods and Compositions for the Delivery of a Therapeutic Agent |
JP5539875B2 (ja) | 2007-08-31 | 2014-07-02 | アルキメデス・デベロップメント・リミテッド | 非水性医薬組成物 |
US8507468B2 (en) * | 2007-10-02 | 2013-08-13 | Robert Orr | Intranasal anti-convulsive compositions and methods |
US8367617B2 (en) | 2007-10-04 | 2013-02-05 | Onyx Therapeutics, Inc. | Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides |
US20090258865A1 (en) | 2008-03-28 | 2009-10-15 | Hale Biopharma Ventures, Llc | Administration of benzodiazepine compositions |
EP3090737A1 (en) | 2008-10-21 | 2016-11-09 | Onyx Therapeutics, Inc. | Combination therapy with peptide epoxyketones |
AR075899A1 (es) | 2009-03-20 | 2011-05-04 | Onyx Therapeutics Inc | Tripeptidos epoxicetonas cristalinos inhibidores de proteasa |
US8853147B2 (en) | 2009-11-13 | 2014-10-07 | Onyx Therapeutics, Inc. | Use of peptide epoxyketones for metastasis suppression |
JP6042724B2 (ja) | 2010-03-01 | 2016-12-14 | オニキス セラピューティクス, インク.Onyx Therapeutics, Inc. | イムノプロテアソーム阻害のための化合物 |
EP2555621A4 (en) | 2010-04-07 | 2014-07-02 | Onyx Therapeutics Inc | CRYSTALLINE EPOXYCETONE PEPTIDE IMMUNOPROTEASOME INHIBITOR |
GB2481407B (en) * | 2010-06-22 | 2012-05-23 | Special Products Ltd | A rapid onset liquid midazolam composition for buccal administration |
CN102309438B (zh) * | 2010-07-02 | 2013-04-17 | 中国人民解放军军事医学科学院毒物药物研究所 | 一种咪达唑仑药物组合物及其用途 |
CN102335430B (zh) * | 2010-07-14 | 2013-07-31 | 中国人民解放军军事医学科学院毒物药物研究所 | 包含咪达唑仑与神经保护剂的复方药物组合物 |
CN102462685B (zh) * | 2010-11-10 | 2014-07-30 | 中国人民解放军军事医学科学院毒物药物研究所 | 一种咪达唑仑组合物、其制备方法及用途 |
CN107260672A (zh) | 2011-05-13 | 2017-10-20 | 欧洲凯尔特公司 | 包含纳洛酮的鼻内药物剂型 |
TW201414751A (zh) | 2012-07-09 | 2014-04-16 | 歐尼克斯治療公司 | 肽環氧酮蛋白酶抑制劑之前驅藥物 |
US9561177B2 (en) | 2014-03-14 | 2017-02-07 | Adapt Pharma Limited | Nasal drug products and methods of their use |
US10085937B2 (en) | 2014-03-14 | 2018-10-02 | Adapt Pharma Limited | Nasal drug products and methods of their use |
US20200297734A1 (en) * | 2015-06-19 | 2020-09-24 | Melt Pharmaceuticals, Inc. | Pharmaceutical compositions and methods for anesthesiological applications |
US11045462B2 (en) * | 2016-06-14 | 2021-06-29 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods for treating neurological conditions and exposure to nerve agents |
WO2019226753A1 (en) | 2018-05-25 | 2019-11-28 | Ucb Biopharma Sprl | Benzodiazepine formulations |
WO2020129085A1 (en) | 2018-12-18 | 2020-06-25 | Cipla Limited | Intranasal formulation |
US20210322343A1 (en) * | 2020-04-15 | 2021-10-21 | Farzana Shaheen | Nasally administered pharmaceutical composition for the treatment of epilepsy and related disorders |
CN113209013B (zh) * | 2021-06-24 | 2023-04-07 | 新疆特丰药业股份有限公司 | 一种咪达唑仑液体制剂及其制备方法和用途 |
NL2031332B1 (en) | 2022-03-18 | 2023-09-29 | Plethora Therapeutics B V | Transmucosal delivery of psychoactive compounds |
NL2031331B1 (en) | 2022-03-18 | 2023-09-29 | Plethora Therapeutics B V | Transmucosal delivery of a short-acting psychedelic compound |
Family Cites Families (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3812853A (en) | 1971-11-17 | 1974-05-28 | P Crain | Apparatus for applying medication or the like to human nasal passages |
US4464378A (en) | 1981-04-28 | 1984-08-07 | University Of Kentucky Research Foundation | Method of administering narcotic antagonists and analgesics and novel dosage forms containing same |
US5132114A (en) | 1985-05-01 | 1992-07-21 | University Of Utah Research Foundation | Compositions and methods of manufacture of compressed powder medicaments |
US4889860A (en) | 1985-09-23 | 1989-12-26 | Nova Pharmaceutical Corporation | Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists |
ATE60226T1 (de) | 1986-03-10 | 1991-02-15 | Kurt Burghart | Pharmazeutikum sowie verfahren zu seiner herstellung. |
US4673679A (en) | 1986-05-14 | 1987-06-16 | E. I. Du Pont De Nemours And Company | Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration |
US4782047A (en) | 1986-05-22 | 1988-11-01 | Syntex Pharmaceuticals International Ltd. | Aqueous steroid formulations for nasal administration |
DE3734306A1 (de) | 1987-10-10 | 1989-04-27 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung fuer fliessfaehige medien |
US4973596A (en) | 1988-05-20 | 1990-11-27 | Barr Laboratories, Inc. | Method of administering a narcotic analgesic and dosage forms therefor |
US4950664A (en) * | 1988-09-16 | 1990-08-21 | Rugby-Darby Group Companies, Inc. | Nasal administration of benzodiazepine hypnotics |
US5766573A (en) | 1988-12-06 | 1998-06-16 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
US5225183A (en) | 1988-12-06 | 1993-07-06 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
US5397771A (en) * | 1990-05-10 | 1995-03-14 | Bechgaard International Research And Development A/S | Pharmaceutical preparation |
WO1991016929A1 (en) * | 1990-05-10 | 1991-11-14 | Novo Nordisk A/S | A pharmaceutical preparation containing n-glycofurols and n-ethylene glycols |
FR2662672B1 (fr) | 1990-05-31 | 1992-08-21 | Aerosols & Bouchage | Dispensateur de melange. |
US5166202A (en) * | 1990-09-19 | 1992-11-24 | Trustees Of The University Of Pennsylvania | Method for the treatment of panic disorder |
PT656207E (pt) | 1991-06-10 | 2001-11-30 | Schering Corp | Formulacoes de aerossois sem clorofluorocarbonetos |
GB9125699D0 (en) | 1991-12-03 | 1992-01-29 | Glaxo Group Ltd | Device |
GB9202464D0 (en) | 1992-02-05 | 1992-03-18 | Danbiosyst Uk | Composition for nasal administration |
ES2127837T3 (es) | 1992-10-19 | 1999-05-01 | Dura Pharma Inc | Inhalador para polvo seco. |
US5543434A (en) | 1994-02-25 | 1996-08-06 | Weg; Stuart L. | Nasal administration of ketamine to manage pain |
US6228383B1 (en) | 1994-03-03 | 2001-05-08 | Gs Development Ab | Use of fatty acid esters as bioadhesive substances |
GB9409778D0 (en) | 1994-05-16 | 1994-07-06 | Dumex Ltd As | Compositions |
CA2152684A1 (en) | 1994-07-01 | 1996-01-02 | Richard Anthony Henry | Aerosol delivery of midazolam |
US5529787A (en) | 1994-07-07 | 1996-06-25 | Alza Corporation | Hydromorphone therapy |
CA2201358C (en) | 1994-09-30 | 2004-06-08 | Jurgen Regenold | Pharmaceutical composition |
US5866143A (en) | 1995-03-24 | 1999-02-02 | El Khoury And Stein, Ltd. | Topical application of opioid drugs such as morphine for relief of itching and skin disease |
US5622166A (en) | 1995-04-24 | 1997-04-22 | Dura Pharmaceuticals, Inc. | Dry powder inhaler delivery system |
US5637314A (en) | 1995-06-07 | 1997-06-10 | Beth Israel Deaconess Medical Center, Inc. | Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis |
US5948389A (en) | 1995-06-07 | 1999-09-07 | El Khoury & Stein, Ltd. | Method of enhancing the analgesic efficacy of locally and topically administered opioids and other local anesthetics |
US6017963A (en) | 1995-11-14 | 2000-01-25 | Euro-Celtique, S.A. | Formulation for intranasal administration |
WO1998002186A1 (en) | 1996-07-11 | 1998-01-22 | Farmarc Nederland B.V. | Inclusion complex containing indole selective serotonin agonist |
DE19709702A1 (de) | 1997-03-10 | 1998-09-17 | Wolff Walsrode Ag | Lackbindemittelzubereitungen, deren Herstellung und Verwendung |
US5855907A (en) | 1997-03-24 | 1999-01-05 | Peyman; Gholam A. | Method of treatment of migraine |
FR2772271B1 (fr) | 1997-12-11 | 2000-09-01 | Union Pharma Scient Appl | Nouvelle association pharmaceutique a activite analgesique |
JP2003522207A (ja) * | 1998-02-23 | 2003-07-22 | サイクロプス・イーエイチエフ | 高エネルギーシクロデキストリン複合体 |
US6699849B1 (en) | 1998-02-23 | 2004-03-02 | Cyclops, Ehf. | Cyclodextrin complexes of benzodiazepines |
DE19807921A1 (de) | 1998-02-25 | 1999-08-26 | Pfeiffer Erich Gmbh & Co Kg | Austrag-Steuerung für einen Medien-Spender |
US6608073B1 (en) | 1998-10-14 | 2003-08-19 | New Millennium Pharmaceutical Research, Inc. | Intranasal codeine for the rapid suppression of cough and rapid relief of pain |
US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
US6383471B1 (en) | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
WO2000074651A1 (de) | 1999-06-02 | 2000-12-14 | Hexal Ag | Pharmazeutische zusammensetzung zur nasalen anwendung von wasserunlöslichen und/oder schwer wasserlöslichen wirkstoffen |
ES2304969T3 (es) | 1999-07-26 | 2008-11-01 | Sk Holdings Co., Ltd. | Composiciones anticonvulsivas transnasales. |
US6720001B2 (en) | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
AU7937500A (en) | 1999-10-27 | 2001-05-08 | Farmarc Nederland Bv | Pharmaceutical composition containing midazolam |
US6610271B2 (en) | 2000-05-10 | 2003-08-26 | University Of Kentucky Research Foundation | System and method for intranasal administration of lorazepam |
US20040176359A1 (en) | 2001-02-20 | 2004-09-09 | University Of Kentucky Research Foundation | Intranasal Benzodiazepine compositions |
WO2002089849A1 (en) | 2001-05-07 | 2002-11-14 | Corium International | Compositions and delivery systems for administration of a local anesthetic agent |
ATE415155T1 (de) | 2001-05-24 | 2008-12-15 | Alexza Pharmaceuticals Inc | Verabreichung von alprazolam, estazolam, midazolam oder triazolam durch inhalation |
GB0116107D0 (en) | 2001-06-30 | 2001-08-22 | West Pharm Serv Drug Res Ltd | Pharmaceutical composition |
GB0130964D0 (en) | 2001-12-24 | 2002-02-13 | Special Products Ltd | Pharmaceutical composition |
US20060039869A1 (en) | 2004-08-17 | 2006-02-23 | Daniel Wermeling | Intranasal delivery of antipsychotic drugs |
-
2004
- 2004-01-14 GB GBGB0400804.1A patent/GB0400804D0/en not_active Ceased
-
2005
- 2005-01-13 CN CN2005800078503A patent/CN1929816B/zh active Active
- 2005-01-13 BR BRPI0506868-1A patent/BRPI0506868A/pt not_active Application Discontinuation
- 2005-01-13 NZ NZ548454A patent/NZ548454A/en unknown
- 2005-01-13 JP JP2006548318A patent/JP5085138B2/ja active Active
- 2005-01-13 US US11/034,474 patent/US7700588B2/en active Active
- 2005-01-13 PT PT05701515T patent/PT1703896E/pt unknown
- 2005-01-13 PL PL05701515T patent/PL1703896T3/pl unknown
- 2005-01-13 WO PCT/EP2005/050133 patent/WO2005067893A2/en active Application Filing
- 2005-01-13 CA CA2553890A patent/CA2553890C/en active Active
- 2005-01-13 MX MXPA06008086A patent/MXPA06008086A/es unknown
- 2005-01-13 DE DE602005011753T patent/DE602005011753D1/de active Active
- 2005-01-13 EA EA200601309A patent/EA014096B1/ru not_active IP Right Cessation
- 2005-01-13 KR KR1020067016194A patent/KR20060130175A/ko not_active Application Discontinuation
- 2005-01-13 AT AT05701515T patent/ATE417600T1/de active
- 2005-01-13 AU AU2005205072A patent/AU2005205072B2/en active Active
- 2005-01-13 DK DK05701515T patent/DK1703896T3/da active
- 2005-01-13 ES ES05701515T patent/ES2319667T3/es active Active
- 2005-01-13 EP EP05701515A patent/EP1703896B1/en active Active
- 2005-09-08 US US11/221,663 patent/US20060009447A1/en not_active Abandoned
-
2006
- 2006-07-10 IL IL176774A patent/IL176774A0/en unknown
- 2006-07-26 NO NO20063453A patent/NO336916B1/no active Protection Beyond IP Right Term
- 2006-07-31 ZA ZA200606310A patent/ZA200606310B/xx unknown
-
2023
- 2023-03-16 NO NO2023011C patent/NO2023011I1/no unknown
- 2023-03-21 NO NO2023014C patent/NO2023014I1/no unknown
- 2023-07-11 FI FIC20230023C patent/FIC20230023I1/fi unknown
- 2023-07-19 FI FIC20230024C patent/FIC20230024I1/fi unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5085138B2 (ja) | 高濃度でミダゾラムを含む製薬組成物 | |
US11744895B2 (en) | Intranasal epinephrine formulations and methods for the treatment of disease | |
JP2007529525A (ja) | 鼻腔内ベンゾジアゼピン組成物 | |
TW200824693A (en) | Pharmaceutical compositions of clonazepam and methods of use thereof | |
JP2005041884A (ja) | 鼻内薬剤組成物およびその製造方法 | |
JP2014501779A (ja) | ベポタスチン組成物 | |
US9326935B2 (en) | Atomoxetine solution | |
EP2958593B1 (en) | Pharmaceutical composition for transmucosal administration of lorazepam | |
WO2001030391A2 (en) | Pharmaceutical composition containing midazolam | |
US20220339139A1 (en) | Novel n,n-dimethyltryptamine compositions and methods | |
CN102970991A (zh) | 异常性疼痛和痛觉增敏的治疗 | |
KR100807480B1 (ko) | 피리베딜의 경비 투여용 약제 조성물 | |
GB2619970A (en) | An orodispersible pharmaceutical composition of baclofen and its process of preparation | |
Chakraborty et al. | Pharmaceutical Dosage Forms and Their Route of Administrations with the Aspects of Their Applications: An Overview | |
EA037259B1 (ru) | Применение фармацевтической композиции с фиксированной дозой, содержащей мометазон и азеластин, для лечения аллергического ринита и способ лечения аллергического ринита | |
DE112019000683T5 (de) | Intranasale epinephrin-formulierungen und verfahren zur behandlung von erkrankungen | |
KR20060123329A (ko) | 월경 곤란증의 예방 및/또는 치료제 | |
Mallick et al. | STUDY OF INTRANASAL MIDAZOLAM TO ABORT CHILDHOOD SEIZURE |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20070830 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20101124 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110224 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110303 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110524 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110906 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20111121 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20120807 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20120905 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5085138 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20150914 Year of fee payment: 3 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |