US3812853A - Apparatus for applying medication or the like to human nasal passages - Google Patents

Apparatus for applying medication or the like to human nasal passages Download PDF

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US3812853A
US3812853A US00199658A US19965871A US3812853A US 3812853 A US3812853 A US 3812853A US 00199658 A US00199658 A US 00199658A US 19965871 A US19965871 A US 19965871A US 3812853 A US3812853 A US 3812853A
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solution
housing
impeller
lower portion
upper portion
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0001Details of inhalators; Constructional features thereof
    • A61M15/0005Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A61M15/0006Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means

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  • ABSTRACT Apparatus for applying a solution in particle form to a body cavity such as the nasal passage for medicinal, therapeutic and hygiene purposes.
  • An electrically powered battery operated pump is provided in a solution holding housing which is provided with a tubular opening into which the nose of the user for example, is inserted. The actuation of the pump disperses particles of the solution in the housing toward the nose of the user.
  • a small opening to the atmosphere is also provided in the tubular opening to enable the user to deeply inhale, thereby drawing the solution particles deep into the nasal passages.
  • inhalers available or known in the prior art which essentially consist of a housing for a medicated vapor emitting chemical which is in communication with a receptacle that is inserted into or fits over the nostrils so that when the user inhales, the medicated vapors are drawn into the nasal passages. While devices of this type provide certain benefits, the amount of vapor applied to the nasal passages is very unpredictable due to the amount of vapor being dependent on the degree of inhaling of the user, and of the depletion of the vapor emitting chemical.
  • nasal medications available in a container so as to be sprayed into the nostrils, however, in many instances, it has been found that certain medications applied by vapor inhaling or spray while providing initial and temporary relief, tend to eventually dry out sensitive nasal membranes and diminish effectiveness.
  • vaporizers which generate a steady output of steam in a sick room which is laden with some form of medicated vapors.
  • Apparatus of this type utilize submersed electrical elements having a current applied thereto which results in converting a medicated laden reservoir of water into steam. While satisfactory results may be obtained by these types of devices in a sick room, they present considerable problems after they have been in use for prolonged periods as the emersed contacts tend to diminish in conductivity resulting in a substantial reduction in the efficiency of the apparatus if not in a total failure.
  • a related object of the invention is to provide an improved apparatus which is capable of thoroughly cleansing nasal passages in a fast and efficient manner to reduce the discomforting effects of pollutants, dryness, smoking and dried or thickened mucous.
  • the present invention is concerned with the application of medicinal, therapeutic and cleansing solutions to the nasal passages, it is nevertheless, an object of the invention to provide an improved apparatus which enables the user to quickly and conveniently prepare the solution desired to be applied to the nasal passages and to maintain the solution at a desired temperature range during the use of the apparatus.
  • FIG. 1 is a perspective view of an exemplary nasal passage hygiene unit embodying the features of the present invention and here showing said unit in use;
  • FIG. 2 is an exploded view of the hygiene unit shown in FIG. 1;
  • FIG. 3 is a side elevation sectional view depicting the hygiene unit shown in FIG. 1 in operation;
  • FIG. 4 is a sectional view, taken substantially along the line 4-4 of FIG. 3;
  • FIG. 5 is a sectional view, taken substantially along the line 5--5 of FIG. 3.
  • an exemplary hygiene unit for dispersing medicinal, therapeutic or cleansing solutions in the upper nasal passage is illustrated, the unit including cylindrical housing 11 having a lower portion which serves as a reservoir for the solution to be applied to' nasal passages, a nose piece 12 which receives the nose of the user and accommodates the surrounding portion of the users face to form an effective seal with the lower portion thereof in communication with and extending upwardly from the housing 11, and an electrically powered pump 13 for dispersing the solution in the housing 11 towards the nasal passages of the user.
  • the pump 13 includes a housing 15 which is slidably received by and generally coaxial with the housing 11, the fractional high speed battery operated motor 16 (FlG.
  • a cover 22 movably attachable to the upper portion of the pump housing is provided.
  • the impeller 18 includes an elongated tapered opening with its smaller diameter end depending downwardly below the level of the solution in the lower portion of the housing 11 and its upper and larger diameter end opening into a 360 spaced opening 23 which is supported by four strut members 24 as shown in section in FIG. 5. Still referring to FIG. 3,
  • the opening 23 in the upper portion of the impeller 28 has the effect of slinging the solution located in the lower portion of the housing 11 and drawn up through the tapered lower portion of the impeller in a generally 360 direction at right angles to the shaft of the motor 16 and by virtue of aligning the opening 23 of the impeller 18 with the major axis of the nose piece 12, the solution drawn up into the impeller and dispersed out of the opening 23, will be directed upwardly into the nose piece and correspondingly into the nostrils of the user.
  • a vent hole 26 (H6. 3) is provided and is specifically sized to prevent an excessive amount of dispersed solution from entering the nostrils irrespective of how hard or deeply the user inhales while his nose is in the nose piece 12.
  • the temperature of the solution is further able to be maintained at a desired range for a longer period of time.
  • the water or other solution utilized in the instant apparatus is able to diminish in volume slightly during use of the device and the impeller will still be capable of picking up the solution.
  • the dispersed solution entering the nasal passage tends to flow back and return to the reservoir, it will be appreciated that some is lost and accordingly to utilize the instant device for a longer period, the user couldtip his head back slightly, thus insuring that the lower portion of the impeller is submerged even if a slight amount of fluid below the operating level shown in H0. 3 is lost.
  • the housing ll is provided with a plurality of spaced ribs 27 (FlG. 4) which serve to index the legs 28 of the pump housing 15.
  • a cup 29 is integrally formed in the base of the housing 11 so that when this cup is filled with salt and the lower portion of the housing 11 is filled with warm water to its designated level indicated in FIG. 3, a saline solution of conventional strength will result thereby significantly simplifying the overall use of the instant device.
  • Apparatus for projecting droplets of a solution into the nasal passages comprising:
  • a housing including an upper portion and a lower portion, said lower portion being adapted to serve as a reservoir for said solution and said upper portion being adapted to receive a pump therein; conduit means extending outwardly from an upper portion of said housing located above said lower portion, said conduit means having a first end thereof affixed to and opening into said housing and extending upwardly and outwardly therefrom and a second end remote from said housing and adapted to surround the nasal passages intended to be provided with the solution in droplet form;
  • centrifugal pump means supported within said upper portion of housing and including an impeller depending into said lower portion of said housing whereby when solution is placed therein, the lower portion of said impeller upon rotation will draw the solution into same and the upper portion of said impeller will disperse the solution in droplet form into and through said conduit means and into a nasal passage surrounded by second end thereof, said upper portion of said impeller disposed substantially perpendicular to and in alignment with the major axis of said conduit means and adjacent to said first end and proximate to said second end thereof;
  • a support connected to said pump means removably inserted into said lower portion, and supporting said pump with the lower end of said impeller immersed in said solution; said support being independent of said impeller;
  • conduit means is provided with an opening to the atmosphere whereby, when the apparatus is in actuation, the user by inhaling through his nose through said opening thereby assists the particles of solution being dispersed through the conduit means being drawn deep into the nasal passages.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Apparatus for applying a solution in particle form to a body cavity such as the nasal passage for medicinal, therapeutic and hygiene purposes. An electrically powered battery operated pump is provided in a solution holding housing which is provided with a tubular opening into which the nose of the user for example, is inserted. The actuation of the pump disperses particles of the solution in the housing toward the nose of the user. A small opening to the atmosphere is also provided in the tubular opening to enable the user to deeply inhale, thereby drawing the solution particles deep into the nasal passages.

Description

ilnited States Patent Crain 1 APPARATUS FOR APPLYING MEDICATION OR THE LIKE TO HUMAN NASAL PASSAGES [56] References Cited UNITED STATES PATENTS 1,488,356 3/1924 Linke 239/219 2,607,571 8/1952 Hession, .lr 128/173 R X 2,763,510 9/1956 Nicola 239/220 3,001,524 9/1961 Maison et a1. 128/173 R 3,324,852 6/1967 lwai 128/173 R FOREIGN PATENTS OR APPLICATIONS 150,224 2/1953 Australia 128/173 R [451 May28,1974
Primary Examiner-Richard A. Gaudet Assistant Examiner-Lee S. Cohen [57] ABSTRACT Apparatus for applying a solution in particle form to a body cavity such as the nasal passage for medicinal, therapeutic and hygiene purposes. An electrically powered battery operated pump is provided in a solution holding housing which is provided with a tubular opening into which the nose of the user for example, is inserted. The actuation of the pump disperses particles of the solution in the housing toward the nose of the user. A small opening to the atmosphere is also provided in the tubular opening to enable the user to deeply inhale, thereby drawing the solution particles deep into the nasal passages.
4 Claims. 5 Drawing Figures m fi as y i w l u J5 1a s02 (07a A APPARATUS FOR APPLYING MEDICATION OR THE LIKE TO HUMAN NASAL PASSAGES BACKGROUND OF THE INVENTION The present invention relates generally to nasal hygiene and more particularly, to an improved apparatus for applying medication, cleansing, and other therapeutic fluids to the nasal passages.
Throughout the United States and the rest of the world, there are large numbers of individuals who are afflicted with sinus conditions, respiratory allergies and other discomforts of the nasal passages from viral infections, irritating air polution, and the like.
While many different types of devices for applying mists, sprays and vapors to the nasal passages and respiratory tract are known in the prior art, for one or more reasons, they possess inherent objectionable features with respect to their use, operation, and versatility.
There are a large number of inhalers available or known in the prior art which essentially consist of a housing for a medicated vapor emitting chemical which is in communication with a receptacle that is inserted into or fits over the nostrils so that when the user inhales, the medicated vapors are drawn into the nasal passages. While devices of this type provide certain benefits, the amount of vapor applied to the nasal passages is very unpredictable due to the amount of vapor being dependent on the degree of inhaling of the user, and of the depletion of the vapor emitting chemical. There are also a number of nasal medications available in a container so as to be sprayed into the nostrils, however, in many instances, it has been found that certain medications applied by vapor inhaling or spray while providing initial and temporary relief, tend to eventually dry out sensitive nasal membranes and diminish effectiveness.
Another method of applying medication to the nasal passages is by vaporizers which generate a steady output of steam in a sick room which is laden with some form of medicated vapors. Apparatus of this type utilize submersed electrical elements having a current applied thereto which results in converting a medicated laden reservoir of water into steam. While satisfactory results may be obtained by these types of devices in a sick room, they present considerable problems after they have been in use for prolonged periods as the emersed contacts tend to diminish in conductivity resulting in a substantial reduction in the efficiency of the apparatus if not in a total failure.
More recently, a number of vaporizers have become available which utilize cool water and tend to disperse same much in the manner as a humidifier does by interjecting the medicated solution into a path of flowing air. This type of apparatus has been found to yield satisfactory results when a large area is required to be laden with a medicated vapor. However, in apparatus of this type designed for individual inhalation it has been found to be extremely difficult to control the rate of application of the medicinal or therapeutic vapor due to the large amounts of air that must be passed over same.
In addition to the hereinbefore discussed problems encountered with prior art devices for applying medication and therapeutic chemicals to the nasal passages, the majority of these devices with the exception of the vapor inhalation and medicinal spray products, require an electrical outlet for their operation. In addition,
many of the prior art devices cannot utilize salt water which when warm has been found to possess certain therapeutic and other desirable properties in relieving various types of discomfort in the nasal passages.
SUMMARY OF THE INVENTION Accordingly, it is the general aim of the present invention to provide a new and improved apparatus for applying medicinal, therapeutic and cleansing solutions to the nasal passages which is compact, portable and yet more effective than apparatus that has heretofore been available. A related object of the invention is to provide an improved apparatus which is capable of thoroughly cleansing nasal passages in a fast and efficient manner to reduce the discomforting effects of pollutants, dryness, smoking and dried or thickened mucous.
It is another object of the invention to provide a relatively low cost, power operated apparatus that may be readily disassembled for refilling purposes, and which enjoys a greater life expectancy than does conventional power operated apparatus of this type.
While the present invention is concerned with the application of medicinal, therapeutic and cleansing solutions to the nasal passages, it is nevertheless, an object of the invention to provide an improved apparatus which enables the user to quickly and conveniently prepare the solution desired to be applied to the nasal passages and to maintain the solution at a desired temperature range during the use of the apparatus.
BRIEF DESCRIPTION OF THE DRAWINGS:
Other objects and advantages of the present invention, along with the interrelationship between the elements of the preferred embodiment, will become more apparent when considered in connection with the specification and accompanying drawings in which:
FIG. 1 is a perspective view of an exemplary nasal passage hygiene unit embodying the features of the present invention and here showing said unit in use;
FIG. 2 is an exploded view of the hygiene unit shown in FIG. 1;
FIG. 3 is a side elevation sectional view depicting the hygiene unit shown in FIG. 1 in operation;
FIG. 4 is a sectional view, taken substantially along the line 4-4 of FIG. 3; and
FIG. 5 is a sectional view, taken substantially along the line 5--5 of FIG. 3.
While the present invention is susceptible of various modifications and alternative constructions and can be used with various types or solutions such as of a medicinal, therapeutic of cleansing nature, and can be utilized for applying solutions of such nature to various portions of the anatomy, illustrative embodiments are shown in the drawings and will hereinafter be described in detail. It should be understood, however, that it is not intended to limit the invention to the particular embodiment disclosed, but, on the contrary, the intention is to cover all equivalents and alternative constructions falling within the spirit and scope of the invention as expressed in the appended claims.
DESCRIPTION OF THE PREFERRED EMBODIMENT:
Referring now to FIGS. 1 and 2, an exemplary hygiene unit for dispersing medicinal, therapeutic or cleansing solutions in the upper nasal passage, generally indicated at 10, is illustrated, the unit including cylindrical housing 11 having a lower portion which serves as a reservoir for the solution to be applied to' nasal passages, a nose piece 12 which receives the nose of the user and accommodates the surrounding portion of the users face to form an effective seal with the lower portion thereof in communication with and extending upwardly from the housing 11, and an electrically powered pump 13 for dispersing the solution in the housing 11 towards the nasal passages of the user. As here shown, the pump 13 includes a housing 15 which is slidably received by and generally coaxial with the housing 11, the fractional high speed battery operated motor 16 (FlG. 3) mounted on said housing, an impeller 18 rotatably mounted on the shaft of the motor 16 and depending downwardly into the lower portion of the housing 11, and a battery 19 and switch 20 operatively connected to the motor whereby a user can selectively actuate the pump by closing switch 20.
in order to both close the upper portion of the pump housing 15 and yet maintain access to the interior of the housing for replacing the battery or other maintenance, a cover 22 movably attachable to the upper portion of the pump housing is provided.
In accordance with one of the important aspects of the present invention, provision is made for dispersing a solution, usually water based, towards the upper nasal passage of the user in a steady and effective directed rate of dispersal. This is accomplished by utilizing an impeller which in operation, picks up the solution from the lower portion of the housing 11 and certrifugally slings or throws the solution in a droplet solution towards the nostrils of the user which are inserted into the nose piece 12.
As best seen in FIG. 3, the impeller 18 includes an elongated tapered opening with its smaller diameter end depending downwardly below the level of the solution in the lower portion of the housing 11 and its upper and larger diameter end opening into a 360 spaced opening 23 which is supported by four strut members 24 as shown in section in FIG. 5. Still referring to FIG. 3, the opening 23 in the upper portion of the impeller 28 has the effect of slinging the solution located in the lower portion of the housing 11 and drawn up through the tapered lower portion of the impeller in a generally 360 direction at right angles to the shaft of the motor 16 and by virtue of aligning the opening 23 of the impeller 18 with the major axis of the nose piece 12, the solution drawn up into the impeller and dispersed out of the opening 23, will be directed upwardly into the nose piece and correspondingly into the nostrils of the user.
In order to enable the user to inhale with his nose inserted into the nose piece 12 thereby facilitating the dispersed solution being drawn up into the nasal passage area. a vent hole 26 (H6. 3) is provided and is specifically sized to prevent an excessive amount of dispersed solution from entering the nostrils irrespective of how hard or deeply the user inhales while his nose is in the nose piece 12. it will be readily appreciated by those skilled in the art that this feature is particularly advantageous inasmuch as it prevents considerable discomfort which could be caused if an excessive amount 6 While the impeller 18 can be provided so as to dispersing the solution in any desired size, it has been found that a dispersal of droplets rather than a fine mist or vapor yields highly desirable results with the instant device and it is found that the droplets are bothfreely drawn into the nasal passage when the user inhales the ambient air through the opening 26, and additionally tends to enable heated solutions to maintain its desired temperature range for a longer period since the droplets have a substantially smaller amount of surface area than a corresponding mist or vapor. Inasmuch as many of the solutions utilized with a device of the instant type are applied to the nasal passage in a warm or hot state, this feature is of particular importance.
Furthermore, by providing a substantial reservior for the solution at the lower portion of housing 11, the temperature of the solution is further able to be maintained at a desired range for a longer period of time. In connection with the solution in the reservoir, it will be seen in FIG. 3 that the water or other solution utilized in the instant apparatus is able to diminish in volume slightly during use of the device and the impeller will still be capable of picking up the solution. While in use, the dispersed solution entering the nasal passage tends to flow back and return to the reservoir, it will be appreciated that some is lost and accordingly to utilize the instant device for a longer period, the user couldtip his head back slightly, thus insuring that the lower portion of the impeller is submerged even if a slight amount of fluid below the operating level shown in H0. 3 is lost.
To insure that the pump housing is inserted in a manner whereby the impeller will be disposed in its proper operating position, the housing ll is provided with a plurality of spaced ribs 27 (FlG. 4) which serve to index the legs 28 of the pump housing 15.
Inasmuch as one of the most common solutions utilized with devices of the instant type is a warm saline solution, a cup 29 is integrally formed in the base of the housing 11 so that when this cup is filled with salt and the lower portion of the housing 11 is filled with warm water to its designated level indicated in FIG. 3, a saline solution of conventional strength will result thereby significantly simplifying the overall use of the instant device.
While the exemplary device has been described in connection with dispersing solution for therapeutically treating or cleaning the nasal passages by virtue of being drawn up into same along with ambient air entering through opening 26, it will be readily apparent to those skilled in the art that the instant device without opening 26 could be modified for use in applying dispersed solutions to other portions of the anatomy without departing from the spirit and scope of the present invention.
I claim:
1. Apparatus for projecting droplets of a solution into the nasal passages comprising:
a housing including an upper portion and a lower portion, said lower portion being adapted to serve as a reservoir for said solution and said upper portion being adapted to receive a pump therein; conduit means extending outwardly from an upper portion of said housing located above said lower portion, said conduit means having a first end thereof affixed to and opening into said housing and extending upwardly and outwardly therefrom and a second end remote from said housing and adapted to surround the nasal passages intended to be provided with the solution in droplet form;
centrifugal pump means supported within said upper portion of housing and including an impeller depending into said lower portion of said housing whereby when solution is placed therein, the lower portion of said impeller upon rotation will draw the solution into same and the upper portion of said impeller will disperse the solution in droplet form into and through said conduit means and into a nasal passage surrounded by second end thereof, said upper portion of said impeller disposed substantially perpendicular to and in alignment with the major axis of said conduit means and adjacent to said first end and proximate to said second end thereof;
a support connected to said pump means removably inserted into said lower portion, and supporting said pump with the lower end of said impeller immersed in said solution; said support being independent of said impeller;
an electric motor operatively connected to said impeller; and
means to power said ,motor.
2. The apparatus as set forth in claim 1 wherein the means to power said motor is a replaceable battery and a switch to activate said motor.
3. The apparatus as set forth in claim 1 wherein said conduit means is provided with an opening to the atmosphere whereby, when the apparatus is in actuation, the user by inhaling through his nose through said opening thereby assists the particles of solution being dispersed through the conduit means being drawn deep into the nasal passages.
4 The apparatus as set forth in claim 1 wherein said lower portion of said housing includes integral cup means of a volume substantially less than the solution capacity of said housing to provide means for mixing predetermined water based solution for use in the apparatus.

Claims (3)

1. Apparatus for projecting droplets of a solution into the nasal passages comprising: a housing including an upper portion and a lower portion, said lower portion being adapted to serve as a reservoir for said solution and said upper portion being adapted to receive a pump therein; conduit means extending outwardly from an upper portion of said housing located above said lower portion, said conduit means having a first end thereof affixed to and opening into said housing and extending upwardly and outwardly therefrom and a second end remote from said housing and adapted to surround the nasal passages intended to be provided with the solution in droplet form; centrifugal pump means supported within said upper portion of housing and including an impeller depending into said lower portion of said housing whereby when solution is placed therein, the lower portion of said impeller upon rotation will draw the solution into same and the upper portion of said impeller will disperse the solution in droplet form into and through said conduit means and into a nasal passage surrounded by second end thereof, said upper portion of said impeller disposed substantially perpendicular to and in alignment with the major axis of said conduit means and adjacent to said first end and proximate to said second end thereof; a support connected to said pump means removably inserted into said lower portion, and supporting said pump with the lower end of said impeller immersed in said solution; said support being independent of said impeller; an electric motor operatively connected to said impeller; and means to power said motor.
2. The apparatus as set forth in claim 1 wherein the means to power said motor is a replaceable battery and a switch to activate said motor.
3. The apparatus aS set forth in claim 1 wherein said conduit means is provided with an opening to the atmosphere whereby, when the apparatus is in actuation, the user by inhaling through his nose through said opening thereby assists the particles of solution being dispersed through the conduit means being drawn deep into the nasal passages. 4 The apparatus as set forth in claim 1 wherein said lower portion of said housing includes integral cup means of a volume substantially less than the solution capacity of said housing to provide means for mixing predetermined water based solution for use in the apparatus.
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US4300546A (en) * 1978-11-15 1981-11-17 Carl Heyer Gmbh Inhalationstechnik Hand-held atomizer especially for dispensing inhalation-administered medicaments
US4334531A (en) * 1979-06-19 1982-06-15 Bosch-Siemens Hausgerate Gmbh Inhalator
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US20040115133A1 (en) * 2000-05-10 2004-06-17 Wermeling Daniel P. Intranasal opioid compositions
US20040176359A1 (en) * 2001-02-20 2004-09-09 University Of Kentucky Research Foundation Intranasal Benzodiazepine compositions
US20050045181A1 (en) * 2001-10-19 2005-03-03 Tom Philipps Nasal spray
US6951215B1 (en) * 2000-07-14 2005-10-04 Tufts University Drug delivery device for animals
US20060045849A1 (en) * 2004-08-24 2006-03-02 Farhan Taghizadeh Method of customizing the fragrance of nasal medications
US20060083691A1 (en) * 2000-05-10 2006-04-20 Wermeling Daniel P Intranasal opioid compositions, delivery devices and methods of using same
US20090159081A1 (en) * 2007-12-20 2009-06-25 Peter Stadelhofer Discharge device for nasal application
US20090221987A1 (en) * 2008-02-29 2009-09-03 Mansur Syeda J Z Portable sinus and throat cleansing system and method
US20090227568A1 (en) * 2007-01-19 2009-09-10 Sveinbjorn Gizurarson Methods and compositions for the delivery of a therapeutic agent
US7700588B2 (en) 2004-01-14 2010-04-20 Merkus Franciscus Wilhelmus He Pharmaceutical compositions comprising midazolam in a high concentration
USD666706S1 (en) * 2008-09-23 2012-09-04 Earl Vaughn Sevy Aroma nebulizing diffuser
US20140221905A1 (en) * 2009-05-19 2014-08-07 Eduard N. Lerner Device and Methods for Enhanced Multi-Delivery of Biologically Active Substances Into an Organism and To Prevent Local Irritation
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USD887554S1 (en) 2015-06-09 2020-06-16 Lincoln Global, Inc. Belt bracket of a powered air purifying respirator
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US11213642B2 (en) 2016-09-14 2022-01-04 Healthy Humming, LLC Therapeutic device for treatment of conditions relating to the sinuses, nasal cavities, ear, nose and throat
US11305077B2 (en) 2016-09-14 2022-04-19 Healthy Humming, LLC Therapeutic device for treatment of conditions relating to the sinuses, nasal cavities, ear, nose and throat
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