JP5073771B2 - 薬剤を均等に送達させるためのカテーテル - Google Patents
薬剤を均等に送達させるためのカテーテル Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0074—Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
- A61M25/0069—Tip not integral with tube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
- A61M25/007—Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
- A61M2025/0037—Multi-lumen catheters with stationary elements characterized by lumina being arranged side-by-side
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
- A61M2025/0039—Multi-lumen catheters with stationary elements characterized by lumina being arranged coaxially
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
- A61M2025/0073—Tip designed for influencing the flow or the flow velocity of the fluid, e.g. inserts for twisted or vortex flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
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- Health & Medical Sciences (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Radiation-Therapy Devices (AREA)
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Description
部に流体薬剤を送達させるための注液カテーテルは当業者では公知である。そのようなカテーテルは解剖学的なある部位に挿入する可撓性の中空チューブでできている。そのチューブは通常、その中を流体が流動するための、軸に沿って1つまたは複数の管腔を有している。カテーテルチューブの近位端を流体容器に接続し、そこからカテーテルチューブの中に流体を送り込む。流体はチューブの近位端で加えられる圧力によって管腔の1つの中を流れていく。それぞれの管腔では、チューブの遠位端近傍の注液部のところに1つまたは複数の出口孔が設けられており、そこを通って流体がチューブから出ていく。そのような出口孔は中空チューブの側壁に孔を開けて作られる。
るいは好ましい場合であっても、従来技術のカテーテルではカテーテルの注液部で均等に流体を送達させることはできなかった。むしろ、注液部の近位端に近い出口孔での流速ほど、遠位端に近い出口孔の場合よりは大きくなる傾向がある。これは、近位端に近い孔を通過する流体ほど、小さな流動抵抗および圧力低下しか受けないからである。逆に、遠位端に近い孔を通過する流体ほど、より大きな流動抵抗と圧力低下を受けるので、その結果流れ出す速度も小さいものとなる。孔が遠位にあるほど、流体の流出速度は小さくなる。その結果、創傷部分全体では薬剤の送達にむらができる。
達させる改良されたカテーテルを提供することである。
含まれる。
spensation pressure)以下の流体は、コイルの間を半径方向に流れ
て管腔から流出することが防がれている。このスプリングは流体の圧力が分配閾圧以上になると伸びるような性質を持っており、コイルの間を半径方向に流れて管腔から流体が流れ出すようになっている。すなわち、スプリングの間を通って「ウィーピング」するわけである。それとは別の方法で、スプリングコイルの欠陥部分から流体をウィープさせてもよい。流体はスプリング部分の長さ方向および外周全体に実質的に均等に分配されるのが好ましい。使用にあたっては、流体をチューブの開放された近位端に導入し、スプリングの部分にまで流し、分配閾圧以上の圧力にして流体がスプリングからウィープするようにする。
ら実質的に均等な速度で流れ出すように設計されているのが好ましい。
膜26によって支持体20の全部の長さを覆うようにすることもできる。この実施態様では、支持体22の長さの全てが注液部32に相当することになる。また別の実施態様では、支持体22を注液部32の内部だけに設置し、流体供給容器34から支持体22の近位端まではチューブを使用することもできる。この実施態様ではチューブが、非孔質膜24および好ましい実施態様で非注液部28にまで延びていた支持体22の代わりをはたす。言い換えれば、このチューブが非注液部28を定めているのである。
の材料には生体適合性がある。この多孔質膜26は、流体薬剤が膜26を通過するときに、好ましからざる細菌を濾去することができる。公知のことであるが、どのような小さな細菌であっても、0.23ミクロン未満の細孔は通過できない。したがって、多孔質膜26の平均細孔サイズあるいは細孔径は0.23ミクロン未満として、細菌が膜26を通過しないようにすることができる。多孔質膜26の平均細孔サイズあるいは細孔径は、好ましくは約0.1から1.2ミクロンの範囲、より好ましくは約0.3から1ミクロンの範囲、さらにより好ましくは約0.8ミクロンである。
31インチの20ゲージのカテーテルチューブであることが好ましい。チューブ52にある出口孔56は好ましくはその直径が約0.015インチで、チューブ52の長さ方向に沿って等しい間隔をあけて設けておく。孔56はチューブ52の長さ方向の軸に対して、それぞれの孔がその隣の孔とは約120度の角度でずれているように配列しておくのが好ましい。隣接する孔56の軸方向での間隔は、約0.125から0.25インチの範囲にあるのが好ましいが、約3/16インチであればさらに好ましい。また、注液部の長さには制限はない。この構成にすることによって、創傷部分の通常線状になった部位全体にわたって、広く均等に流体を送達させることが可能となる。もちろん、この出口孔56は、その他各種の配置方法で並べてもよい。
いる。カテーテル60では、チューブ62に複数の出口孔64があって、その大きさが次第に大きくなるようにしてある。さらに詳しく言えば、近位にある出口孔よりも、孔が遠位にあればあるほど、孔の径がより大きくなっている。チューブ62の出口孔64の位置によって、カテーテル60の注液部の長さが定まる。注液部の長さには制限はない。カテーテル60の近位端を流体供給容器に接続する。解剖学的構造中にカテーテル60を挿入するのを助けるために、ガイドワイヤーおよび/またはガイドワイヤー用管腔を設けておいてもよい
2の遠位端にはめられており、それにより、チューブとスプリングのそれぞれが中央管腔の位置を定めている。ドーム状の形状のあたり止め86がスプリング84の遠位端に取りつけられ、封止しているのが好ましい。チューブ82に対して遠位にあるスプリング84の部分がカテーテル80の注液部となっている。図10Aに示されたような未伸張の状態では、スプリング84には互いに接触している隣接のコイルを有しており、その結果スプリングの内部にあって分配閾圧以下である流体がコイルの間を半径方向に移動して管腔から出ていくようなことが、起きないようになっている。スプリング84は図10Bに示されているように、長さ方向に伸張する性質を有しているので、流体の圧力が分配閾圧以上に上がると、「ウィーピング」、すなわちコイルの間から外へ半径方向に漏れ出して、管腔から流体が流れ出すようになる。これとは別な方法で、スプリングが伸張するのではなく、半径方向に拡がって、スプリングのコイルの間から流体をウィープさせることもできる。さらに、スプリングが長さ方向、半径方向の両方に伸張してウィーピングをさせることも可能であるが、これについては当業者のよく知るところである。好適なことに、スプリングのコイルの間の流体は、チューブ82に対して遠位にあるスプリングの部分、すなわち注液部で、その長さ方向および外周方向全体にわたって実質的に均等に流れる。このカテーテル80は、流体を送達させるのが低圧、高圧いずれの場合であっても使用することができる。
せておくこともでき、それには、たとえばUV接着剤、ポッティング材料、その他の接着材料が使用できる。別な方法で、スプリングをチューブ82の中にハンダ付けしたり、近位プラグを装着してチューブ82の中にしっかりと止めておいたりすることも可能である。
一端をチューブ92の内壁にハンダ付けしておいてもよい。このチューブ92は適切な材料なら何を使用して作ってもよい。チューブ92の内壁は滑らかにしておくのが好ましく、それによりスプリングがより自由に伸縮することができる。
点が存在する。利点の1つは、出口孔204を通る流れを最適に均等化するようはたらくことである。また、部材206は、液体で飽和させると膨張する傾向のある多孔質材料から作ることができる。そのような場合、部材206はリング状領域208に膨張していくが、チューブ202を圧迫することがないのが好ましい。これにより、チューブ202の内部表面が高圧領域となって、創傷部位内部で薬剤が不均等に流れ出す原因となりうる可能性を抑えることになる。それとは別に、部材206が膨張してチューブ202と接触してもよく、それでも本発明の目的はやはり達成できる。
餅240の内部に入っていることが好ましい。液状の薬剤をカテーテルチューブの近位端から導入するのが好ましい。好適には、薬剤が均等な速度で注液部全体を通ってカテーテル20から出ていき、血餅240を溶解させる。
Claims (9)
- 解剖学的領域全体に流体を送達させるためのカテーテルであって、
閉止された遠位端を有する、延伸されたチューブ状のカテーテル体であって、該カテーテル体の遠位端部分が前記カテーテルの注液部を定め、該注液部は流体が該カテーテル体を通って流れることが可能なように構成されたカテーテル体と、
隣接するコイルを有する部材であって、該部材が未伸長の状態にあるときに該隣接するコイル同士が互いに接触し、第一端部と第二端部を有し、前記カテーテル体の管腔内部に封入され、少なくとも前記注液部の長さにわたって延在する部材と、を備え、
前記部材の前記第一端部と前記第二端部のうち少なくとも一方は、前記カテーテル体に固定される、
カテーテル。 - 前記部材の前記第一端部および前記第二端部のうち一方のみが、前記カテーテル体に固定される、
請求項1に記載のカテーテル。 - 前記カテーテルの前記注液部は、前記カテーテル体に複数の出口孔を有する、
請求項1または2に記載のカテーテル。 - 前記カテーテルは、前記カテーテル体の近位端に導入された流体が、前記部材のコイルの間および前記出口孔を通って流れるように構成されている、
請求項3に記載のカテーテル。 - 前記部材は、長さ2.54cmあたり200巻きのコイルを有する、
請求項1から4の何れか一項に記載のカテーテル。 - 前記部材の外表面の一部分は、前記カテーテル体の内表面の一部分に接触する、
請求項1から5の何れか一項に記載のカテーテル。 - 前記部材は、UV接着剤を使って前記カテーテル体に固定される、
請求項1から6の何れか一項に記載のカテーテル。 - 前記第一端部と前記第二端部の間の、前記部材の一部分における前記隣接するコイルは、前記カテーテル体に固定されない、
請求項1から7の何れか一項に記載のカテーテル。 - 前記部材は、ステンレススチールである、
請求項1から8の何れか一項に記載のカテーテル。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/363,228 US6350253B1 (en) | 1999-07-19 | 1999-07-19 | Catheter for uniform delivery of medication |
US09/363,228 | 1999-07-19 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2009128003A Division JP4755271B2 (ja) | 1999-07-19 | 2009-05-27 | 薬剤を均等に送達させるためのカテーテル |
Publications (2)
Publication Number | Publication Date |
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JP2010148906A JP2010148906A (ja) | 2010-07-08 |
JP5073771B2 true JP5073771B2 (ja) | 2012-11-14 |
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Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
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JP2001510290A Expired - Lifetime JP4387626B2 (ja) | 1999-07-19 | 2000-07-19 | 薬剤を均等に送達させるためのカテーテル |
JP2009128003A Expired - Lifetime JP4755271B2 (ja) | 1999-07-19 | 2009-05-27 | 薬剤を均等に送達させるためのカテーテル |
JP2010044534A Expired - Lifetime JP5073771B2 (ja) | 1999-07-19 | 2010-03-01 | 薬剤を均等に送達させるためのカテーテル |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
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JP2001510290A Expired - Lifetime JP4387626B2 (ja) | 1999-07-19 | 2000-07-19 | 薬剤を均等に送達させるためのカテーテル |
JP2009128003A Expired - Lifetime JP4755271B2 (ja) | 1999-07-19 | 2009-05-27 | 薬剤を均等に送達させるためのカテーテル |
Country Status (25)
Country | Link |
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US (11) | US6350253B1 (ja) |
EP (2) | EP2135633B1 (ja) |
JP (3) | JP4387626B2 (ja) |
KR (3) | KR20020035104A (ja) |
CN (3) | CN1295001C (ja) |
AT (1) | ATE449626T1 (ja) |
AU (3) | AU777560B2 (ja) |
BR (1) | BR0012686B1 (ja) |
CA (2) | CA2375930C (ja) |
CZ (1) | CZ2002215A3 (ja) |
DE (1) | DE60043389D1 (ja) |
DK (1) | DK2135633T3 (ja) |
ES (1) | ES2450369T3 (ja) |
HK (1) | HK1046507B (ja) |
HU (1) | HU226403B1 (ja) |
IL (1) | IL147713A0 (ja) |
MX (1) | MXPA02000637A (ja) |
NO (1) | NO20020284L (ja) |
NZ (2) | NZ527985A (ja) |
PL (2) | PL203349B1 (ja) |
PT (1) | PT2135633E (ja) |
RU (1) | RU2303468C2 (ja) |
TR (2) | TR200200373T2 (ja) |
UA (1) | UA74552C2 (ja) |
WO (1) | WO2001005210A2 (ja) |
Families Citing this family (292)
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---|---|---|---|---|
US8177762B2 (en) | 1998-12-07 | 2012-05-15 | C. R. Bard, Inc. | Septum including at least one identifiable feature, access ports including same, and related methods |
US7452353B2 (en) * | 1999-07-19 | 2008-11-18 | I-Flow Corporation | Catheter for uniform delivery of medication |
US7547302B2 (en) * | 1999-07-19 | 2009-06-16 | I-Flow Corporation | Anti-microbial catheter |
US7510550B2 (en) * | 1999-07-19 | 2009-03-31 | I-Flow Corporation | Catheter for uniform delivery of medication |
US7004923B2 (en) * | 1999-07-19 | 2006-02-28 | I-Flow Corporation | Catheter for uniform delivery of medication |
US6350253B1 (en) * | 1999-07-19 | 2002-02-26 | I-Flow Corporation | Catheter for uniform delivery of medication |
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