JP5072355B2 - 有効成分輸送のための新規なガレヌス製剤系、調製方法及び使用 - Google Patents
有効成分輸送のための新規なガレヌス製剤系、調製方法及び使用 Download PDFInfo
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- JP5072355B2 JP5072355B2 JP2006505750A JP2006505750A JP5072355B2 JP 5072355 B2 JP5072355 B2 JP 5072355B2 JP 2006505750 A JP2006505750 A JP 2006505750A JP 2006505750 A JP2006505750 A JP 2006505750A JP 5072355 B2 JP5072355 B2 JP 5072355B2
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- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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Landscapes
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0303568A FR2852843B1 (fr) | 2003-03-24 | 2003-03-24 | Systeme galenique permettant le masquage du gout |
| FR03/03568 | 2003-03-24 | ||
| PCT/FR2004/000729 WO2004084856A2 (fr) | 2003-03-24 | 2004-03-24 | Nouveau systeme galenique pour le transport d’actif, procede de preparation et utilisation |
Publications (3)
| Publication Number | Publication Date |
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| JP2006521334A JP2006521334A (ja) | 2006-09-21 |
| JP2006521334A5 JP2006521334A5 (https=) | 2011-03-31 |
| JP5072355B2 true JP5072355B2 (ja) | 2012-11-14 |
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| JP2006505750A Expired - Fee Related JP5072355B2 (ja) | 2003-03-24 | 2004-03-24 | 有効成分輸送のための新規なガレヌス製剤系、調製方法及び使用 |
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|---|---|
| US (3) | US20070116728A1 (https=) |
| EP (1) | EP1605918B1 (https=) |
| JP (1) | JP5072355B2 (https=) |
| KR (1) | KR20060012576A (https=) |
| AU (1) | AU2004224601A1 (https=) |
| CA (1) | CA2519962C (https=) |
| FR (1) | FR2852843B1 (https=) |
| MX (1) | MXPA05010217A (https=) |
| NZ (1) | NZ542590A (https=) |
| WO (1) | WO2004084856A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150072422A (ko) * | 2012-10-18 | 2015-06-29 | 디에스엠 아이피 어셋츠 비.브이. | 카로티노이드를 포함하는 비들렛 |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2852843B1 (fr) | 2003-03-24 | 2008-05-23 | Karim Ioualalen | Systeme galenique permettant le masquage du gout |
| FR2879930B1 (fr) * | 2004-12-23 | 2007-08-31 | Oralance Pharma Sa | Nouveau systeme galenique pour le transport d'actif, procede de preparation et utilisation |
| FR2913884A1 (fr) * | 2007-03-21 | 2008-09-26 | Oralance Pharma Sa | Systeme galenique hydrophobe non ionisable |
| US8613956B2 (en) * | 2008-06-23 | 2013-12-24 | International Flora Technologies, Ltd. | Cosmetic particles that transform from hard to soft particles comprising hydrogenated long-chain triglyceride oils |
| FR2935270A1 (fr) * | 2008-08-28 | 2010-03-05 | Oralance Pharma | Composition pharmaceutique de temozolomide pour usage pediatrique |
| EP2964243B1 (en) * | 2013-03-06 | 2022-11-23 | Capsugel Belgium NV | Curcumin solid lipid particles and methods for their preparation and use |
| EP3766480A1 (en) | 2014-06-10 | 2021-01-20 | Capsugel Belgium NV | Orally disintegrating tablet containing solid lipid particles and methods for their preparation and use |
| US11324699B2 (en) | 2014-12-04 | 2022-05-10 | Capsugel Belgium Nv | Lipid multiparticulate formulations |
| EP3236993B1 (en) | 2014-12-23 | 2023-09-13 | Theriva Biologics, Inc. | Methods and compositions for inhibiting or preventing adverse effects of oral antibiotics |
| FR3059903B1 (fr) * | 2016-12-08 | 2019-03-22 | Salsarulo Pharma | Medicament oral comprenant un laxatif osmotique incorpore dans une matrice a base de matieres grasses vegetales |
| PL3551164T3 (pl) * | 2016-12-08 | 2021-09-27 | Salsarulo Pharma | Lek doustny zawierający osmotyczny środek przeczyszczający wprowadzony do w matrycy na bazie tłuszczów roślinnych |
| US10639607B2 (en) | 2017-06-16 | 2020-05-05 | Matralix Pte Ltd | Systems and methods for preparing wax and lipid particles |
| WO2019032573A1 (en) | 2017-08-07 | 2019-02-14 | Finch Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR MAINTAINING AND RESTORING A HEALTHY INTESTINAL BARRIER |
| CA3087569A1 (en) | 2018-01-09 | 2019-07-18 | Synthetic Biologics, Inc. | Alkaline phosphatase agents for treatment of neurodevelopmental disorders |
| BR112020017090A8 (pt) | 2018-02-23 | 2022-07-05 | Crestovo Holdings Llc | Imunoterapias relacionadas com microbioma |
| FR3078630B1 (fr) * | 2018-03-08 | 2021-05-14 | Karim Ioualalen | Mode de formulation sous forme de solide divise hydrophobe |
| WO2019183208A1 (en) | 2018-03-20 | 2019-09-26 | Synthetic Biologics, Inc. | Intestinal alkaline phosphatase formulations |
| EP4275761A3 (en) | 2018-03-20 | 2024-02-28 | Theriva Biologics, Inc. | Alkaline phosphatase agents for treatment of radiation disorders |
| FR3079146B1 (fr) * | 2018-03-23 | 2020-04-17 | Karim Ioualalen | Formulation gastroprotectrice de complexes d’enzymes permettant de restaurer la fonction digestive. |
| CA3146738A1 (en) | 2019-07-18 | 2021-01-21 | Synthetic Biologics, Inc. | Intestinal alkaline phosphatase-based treatments of metabolic disorders |
| US12290538B2 (en) | 2019-07-19 | 2025-05-06 | Finch Therapeutics Holdings Llc | Methods and products for treatment of gastrointestinal disorders |
| CN114650833A (zh) | 2019-09-13 | 2022-06-21 | 芬奇治疗控股有限责任公司 | 用于治疗孤独症谱群障碍的组合物和方法 |
| AU2020366529A1 (en) | 2019-10-18 | 2022-05-19 | Finch Therapeutics Holdings Llc | Compositions and methods for delivering a bacterial metabolite to a subject |
| WO2021097288A1 (en) | 2019-11-15 | 2021-05-20 | Finch Therapeutics Holdings Llc | Compositions and methods for treating neurodegenerative diseases |
| WO2021142347A1 (en) | 2020-01-10 | 2021-07-15 | Finch Therapeutics Holdings Llc | Compositions and methods for non-alcoholic steatohepatitis (nash) |
| TW202140049A (zh) | 2020-01-10 | 2021-11-01 | 美商芬奇治療控股有限責任公司 | 用於治療ｂ型肝炎（ｈｂｖ）及ｄ型肝炎（ｈｄｖ）之組合物及方法 |
| WO2021142358A1 (en) | 2020-01-10 | 2021-07-15 | Finch Therapeutics Holdings Llc | Compositions and methods for treating hepatic encephalopathy (he) |
| WO2021202806A1 (en) | 2020-03-31 | 2021-10-07 | Finch Therapeutics Holdings Llc | Compositions comprising non-viable fecal microbiota and methods of use thereof |
| US20240263251A1 (en) | 2021-02-19 | 2024-08-08 | Finch Therapeutics Holdings Llc | Compositions and methods for providing secondary bile acids to a subject |
| CN113308045B (zh) * | 2021-05-28 | 2022-03-22 | 宁波市鑫晟工贸实业有限公司 | 一种抗老化的塑料盒及其制备方法 |
| IT202100014330A1 (it) * | 2021-06-01 | 2022-12-01 | The Ubeauty Com Llc | Prodotto per la cura della pelle e procedimento per la sua realizzazione. |
| JP2025506168A (ja) * | 2022-02-11 | 2025-03-07 | インシツ バイオロジクス、インク． | 持続放出癌治療用製剤 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3146167A (en) * | 1961-10-05 | 1964-08-25 | Smith Kline French Lab | Method of preparing sustained release pellets and products thereof |
| US4132753A (en) * | 1965-02-12 | 1979-01-02 | American Cyanamid Company | Process for preparing oral sustained release granules |
| GB1323161A (en) * | 1970-02-16 | 1973-07-11 | Wyeth John & Brother Ltd | Penicillin composition |
| US4132375A (en) * | 1976-01-21 | 1979-01-02 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Vortex-lift roll-control device |
| US4590062A (en) * | 1984-04-16 | 1986-05-20 | Tech Trade Corp. | Dry direct compression compositions for controlled release dosage forms |
| JPS63301815A (ja) * | 1987-01-29 | 1988-12-08 | Taisho Pharmaceut Co Ltd | 経口製剤の製造方法 |
| JP2700662B2 (ja) * | 1988-06-22 | 1998-01-21 | 大正製薬株式会社 | 被覆製剤 |
| JPH02200639A (ja) * | 1989-01-31 | 1990-08-08 | Shinfusou Seiyaku Kk | 脂質被覆細菌製剤 |
| IT1229856B (it) | 1989-04-20 | 1991-09-13 | Recordati Chem Pharm | Compresse a rilascio controllato contenenti flavossato. |
| US5213810A (en) | 1990-03-30 | 1993-05-25 | American Cyanamid Company | Stable compositions for parenteral administration and method of making same |
| ES2086022T3 (es) | 1991-07-23 | 1996-06-16 | American Cyanamid Co | Composiciones estables para administracion parenteral y su uso. |
| DE4131562A1 (de) | 1991-09-18 | 1993-03-25 | Medac Klinische Spezialpraep | Arzneistofftraeger aus festen lipidteilchen-feste lipidnanosphaeren (sln) |
| ES2194863T3 (es) * | 1992-11-30 | 2003-12-01 | Kv Pharm Co | Materiales farmaceuticos con enmascarado de sabor. |
| CA2091152C (en) | 1993-03-05 | 2005-05-03 | Kirsten Westesen | Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof |
| DE4308282C2 (de) | 1993-03-16 | 1994-12-22 | Beiersdorf Ag | Vorzugsweise in Form von Mikrosphärulen vorliegende galenische Matrices |
| KR20010012402A (ko) | 1997-05-09 | 2001-02-15 | 세이지 파마슈티칼스, 인크. | 안정한 약제학적 경구 투여형 |
| WO1999013864A2 (en) * | 1997-09-19 | 1999-03-25 | Shire Laboratories, Inc. | Solid solution beadlet |
| FR2769839B1 (fr) * | 1997-10-21 | 1999-12-17 | Odette Mercedes Salsarulo | Composition anhydre a base de lactulose |
| FR2779962B1 (fr) * | 1998-06-17 | 2002-12-06 | Karim Ioualalen | Composition cosmetique ou dermopharmaceutique sous forme de perles et procedes pour la preparation |
| MXPA01011343A (es) | 1999-05-07 | 2002-06-04 | Pharmasol Gmbh | Particulas de lipidos a base de mezclas de lipidos liquidos y solidos asi como procedimiento para su produccion. |
| EP1183014B1 (en) | 1999-06-14 | 2003-10-08 | Cosmo S.p.A. | Controlled release and taste masking oral pharmaceutical compositions |
| ITMI991316A1 (it) | 1999-06-14 | 2000-12-14 | Cip Ninety Two 92 S A | Composizioni farmaceutiche orali a rilascio modificato di mesalazina |
| EP1197207B1 (en) * | 2000-10-10 | 2008-04-23 | Wyeth Holdings Corporation | Stable compositions for parenteral administration |
| JP3597823B2 (ja) | 2002-02-07 | 2004-12-08 | 沢井製薬株式会社 | 固形製剤 |
| FR2852843B1 (fr) | 2003-03-24 | 2008-05-23 | Karim Ioualalen | Systeme galenique permettant le masquage du gout |
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2003
- 2003-03-24 FR FR0303568A patent/FR2852843B1/fr not_active Expired - Lifetime
-
2004
- 2004-03-24 MX MXPA05010217A patent/MXPA05010217A/es active IP Right Grant
- 2004-03-24 JP JP2006505750A patent/JP5072355B2/ja not_active Expired - Fee Related
- 2004-03-24 EP EP04742337.1A patent/EP1605918B1/fr not_active Expired - Lifetime
- 2004-03-24 NZ NZ542590A patent/NZ542590A/en unknown
- 2004-03-24 CA CA2519962A patent/CA2519962C/fr not_active Expired - Fee Related
- 2004-03-24 WO PCT/FR2004/000729 patent/WO2004084856A2/fr not_active Ceased
- 2004-03-24 KR KR1020057017992A patent/KR20060012576A/ko not_active Ceased
- 2004-03-24 US US10/550,027 patent/US20070116728A1/en not_active Abandoned
- 2004-03-24 AU AU2004224601A patent/AU2004224601A1/en not_active Abandoned
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2010
- 2010-04-26 US US12/767,248 patent/US8911788B2/en not_active Expired - Lifetime
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150072422A (ko) * | 2012-10-18 | 2015-06-29 | 디에스엠 아이피 어셋츠 비.브이. | 카로티노이드를 포함하는 비들렛 |
| JP2016500025A (ja) * | 2012-10-18 | 2016-01-07 | ディーエスエム アイピー アセッツ ビー．ブイ． | カロテノイドを含むビードレット |
| KR102221655B1 (ko) | 2012-10-18 | 2021-03-03 | 디에스엠 아이피 어셋츠 비.브이. | 카로티노이드를 포함하는 비들렛 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2519962C (fr) | 2015-03-10 |
| FR2852843A1 (fr) | 2004-10-01 |
| US9192679B2 (en) | 2015-11-24 |
| CA2519962A1 (fr) | 2004-10-07 |
| AU2004224601A1 (en) | 2004-10-07 |
| JP2006521334A (ja) | 2006-09-21 |
| NZ542590A (en) | 2009-02-28 |
| FR2852843B1 (fr) | 2008-05-23 |
| US8911788B2 (en) | 2014-12-16 |
| US20150044297A1 (en) | 2015-02-12 |
| MXPA05010217A (es) | 2006-03-28 |
| US20100221298A1 (en) | 2010-09-02 |
| EP1605918A2 (fr) | 2005-12-21 |
| WO2004084856A3 (fr) | 2004-11-25 |
| WO2004084856A2 (fr) | 2004-10-07 |
| KR20060012576A (ko) | 2006-02-08 |
| EP1605918B1 (fr) | 2016-09-28 |
| US20070116728A1 (en) | 2007-05-24 |
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